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Interest in components with detailed structures increased with the progress in advanced manufacturing techniques. Parts with lattice elements can provide improved global buckling stability compared to solid structures of the same weight. However, thin features are prone to local buckling. We present a two-scale optimization approach that simultaneously improves the local and global stability of parametrized graded lattice structures. Elastic properties and local buckling behavior are upscaled via homogenization based on geometric exact beam theory. To reduce computational effort, we construct a worst-case model for the homogenized buckling load factor, which acts as a safeguard against local buckling. We briefly discuss advantages and limitations by means of numerical examples. [ABSTRACT FROM AUTHOR]