1. Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8.
- Author
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Wasai M, Nonaka H, Murata M, Kitamura R, Sato Y, and Tachibana H
- Subjects
- Acetylcholinesterase metabolism, Amyloid beta-Peptides metabolism, Amyloid beta-Protein Precursor metabolism, Animals, Brain enzymology, Enzymes genetics, Enzymes metabolism, Male, Mice, Mice, Mutant Strains, Neprilysin genetics, Peptide Fragments metabolism, Aging psychology, Cognition Disorders prevention & control, Dietary Supplements, Tea chemistry
- Abstract
A majority of the potential health benefits of green tea, including the potential to prevent cognitive decline, have been attributed to epigallocatechin gallate (EGCG). Sunrouge is a green tea cultivar that contains EGCG and several other bioactive components such as quercetin, myricetin, cyanidin and delphinidin. We compared the effects of Sunrouge and Yabukita, the most popular Japanese green tea cultivar, on cognitive function in the senescence-accelerated mouse Prone8. These mice were fed an experimental diet containing Sunrouge extract (SRE) or Yabukita extract (YBE). SRE feeding significantly prevented cognitive decline, whereas YBE feeding had little effect. Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. These preventive effects of SRE against cognitive decline were attributed to the characteristic composition of Sunrouge and strongly suggest that consumption of this cultivar could protect against age-related cognitive decline.
- Published
- 2019
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