Search

Your search keyword '"Zhan, Lijie"' showing total 4 results
Start Over Author "Zhan, Lijie" Topic c-met Publication Type Academic Journals
4 results on '"Zhan, Lijie"'

1. N 3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases

Author

Saavedra, Oscar, Claridge, Stephen, Zhan, Lijie, Raeppel, Franck, Granger, Marie-Claude, Raeppel, Stéphane, Mannion, Michael, Gaudette, Frédéric, Zhou, Nancy, Isakovic, Ljubomir, Bernstein, Naomy, Déziel, Robert, Nguyen, Hannah, Beaulieu, Normand, Beaulieu, Carole, Dupont, Isabelle, Wang, James, Macleod, A. Robert, Besterman, Jeffrey M., and Vaisburg, Arkadii

Subjects
*PYRIDINE, *VASCULAR endothelial growth factor antagonists, *PROTEIN-tyrosine kinase inhibitors, *ONCOGENES, *XENOGRAFTS, *LABORATORY mice, *DRUG design, *AMIDES, *DRUG efficacy, *TUMOR treatment, *THERAPEUTICS
Abstract

Abstract: A family of thieno[3,2-b]pyridine based small molecule inhibitors of c-Met and VEGFR2 were designed based on lead structure 2. These compounds were shown to have IC50 values in the low nanomolar range in vitro and were efficacious in human tumor xenograft models in mice in vivo. [Copyright &y& Elsevier]

Published
2009
Full Text
View/download PDF

2. N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

Author

Mannion, Michael, Raeppel, Stéphane, Claridge, Stephen, Zhou, Nancy, Saavedra, Oscar, Isakovic, Ljubomir, Zhan, Lijie, Gaudette, Frédéric, Raeppel, Franck, Déziel, Robert, Beaulieu, Normand, Nguyen, Hannah, Chute, Ian, Beaulieu, Carole, Dupont, Isabelle, Robert, Marie-France, Lefebvre, Sylvain, Dubay, Marja, Rahil, Jubrail, and Wang, James

Subjects
*PROTEIN-tyrosine kinase inhibitors, *DRUG development, *VASCULAR endothelial growth factors, *AMIDES, *XENOGRAFTS, *PHARMACOKINETICS, *LABORATORY mice, *TARGETED drug delivery, *DRUG design, *SUBSTITUTION reactions
Abstract

Abstract: A series of N-(4-(6,7-disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting c-Met and VEGFR2 tyrosine kinases was designed and synthesized. The compounds were potent against these two enzymes with IC50 values in the low nanomolar range in vitro, possessed favorable pharmacokinetic profiles and showed high efficacy in vivo in several human tumor xenograft models in mice. [Copyright &y& Elsevier]

Published
2009
Full Text
View/download PDF

3. N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

Author

Raeppel, Stéphane, Claridge, Stephen, Saavedra, Oscar, Gaudette, Frédéric, Zhan, Lijie, Mannion, Michael, Zhou, Nancy, Raeppel, Franck, Granger, Marie-Claude, Isakovic, Ljubomir, Déziel, Robert, Nguyen, Hannah, Beaulieu, Normand, Beaulieu, Carole, Dupont, Isabelle, Robert, Marie-France, Lefebvre, Sylvain, Dubay, Marja, Rahil, Jubrail, and Wang, James

Subjects
*PROTEIN-tyrosine kinase inhibitors, *MET receptor, *VASCULAR endothelial growth factors, *AMIDES, *ORGANIC synthesis, *PHARMACOKINETICS, *XENOGRAFTS, *LABORATORY mice, *THERAPEUTICS
Abstract

Abstract: A series of N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting c-Met and VEGFR2 tyrosine kinases was designed and synthesized. The compounds were potent against these two enzymes with IC50 values in the low nanomolar range in vitro, possessed favorable pharmacokinetic profiles and showed high efficacy in vivo in several human tumor xenograft models in mice. [Copyright &y& Elsevier]

Published
2009
Full Text
View/download PDF

4. Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

Author

Claridge, Stephen, Raeppel, Franck, Granger, Marie-Claude, Bernstein, Naomy, Saavedra, Oscar, Zhan, Lijie, Llewellyn, David, Wahhab, Amal, Deziel, Robert, Rahil, Jubrail, Beaulieu, Normand, Nguyen, Hannah, Dupont, Isabelle, Barsalou, Annie, Beaulieu, Carole, Chute, Ian, Gravel, Serge, Robert, Marie-France, Lefebvre, Sylvain, and Dubay, Marja

Subjects
*PROTEIN-tyrosine kinases, *AMINO acids, *TYROSINE, *LEAD compounds
Abstract

Abstract: A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway. [Copyright &y& Elsevier]

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results