Search

Your search keyword '"Carlà, Alessandra"' showing total 13 results
Start Over Author "Carlà, Alessandra" Search Limiters Peer Reviewed Publication Type Academic Journals
13 results on '"Carlà, Alessandra"'

3. Granule cell dispersion is associated with hippocampal neuronal cell loss, initial precipitating injury, and other clinical features in mesial temporal lobe epilepsy and hippocampal sclerosis

Author

Jardim, Anaclara Prada, Duarte, Jeana Torres Corso, Lancellotti, Carmen Lúcia Penteado, Carrete, Henrique, Jr., Centeno, Ricardo Silva, Scorza, Carla Alessandra, Cavalheiro, Esper Abrão, Guaranha, Mirian Salvadori Bittar, and Yacubian, Elza Márcia Targas

Published
2021
Full Text
View/download PDF

5. Shape-Driven Response of Gold Nanoparticles to X-rays.

Author

Tarantino, Simona, Capomolla, Caterina, Carlà, Alessandra, Giotta, Livia, Cascione, Mariafrancesca, Ingrosso, Chiara, Scarpa, Edoardo, Rizzello, Loris, Caricato, Anna Paola, Rinaldi, Rosaria, and De Matteis, Valeria

Subjects
GOLD nanoparticles, PHOTOELECTRICITY, X-rays, TRANSMISSION electron microscopy, IRRADIATION, ZETA potential, ABSORPTION coefficients
Abstract

Radiotherapy (RT) involves delivering X-ray beams to the tumor site to trigger DNA damage. In this approach, it is fundamental to preserve healthy cells and to confine the X-ray beam only to the malignant cells. The integration of gold nanoparticles (AuNPs) in the X-ray methodology could be considered a powerful tool to improve the efficacy of RT. Indeed, AuNPs have proven to be excellent allies in contrasting tumor pathology upon RT due to their high photoelectric absorption coefficient and unique physiochemical properties. However, an analysis of their physical and morphological reaction to X-ray exposure is necessary to fully understand the AuNPs' behavior upon irradiation before treating the cells, since there are currently no studies on the evaluation of potential NP morphological changes upon specific irradiations. In this work, we synthesized two differently shaped AuNPs adopting two different techniques to achieve either spherical or star-shaped AuNPs. The spherical AuNPs were obtained with the Turkevich–Frens method, while the star-shaped AuNPs (AuNSs) involved a seed-mediated approach. We then characterized all AuNPs with Transmission Electron Microscopy (TEM), Uv-Vis spectroscopy, Dynamic Light Scattering (DLS), zeta potential and Fourier Transform Infrared (FTIR) spectroscopy. The next step involved the treatment of AuNPs with two different doses of X-radiation commonly used in RT, namely 1.8 Gy and 2 Gy, respectively. Following the X-rays' exposure, the AuNPs were further characterized to investigate their possible physicochemical and morphological alterations induced with the X-rays. We found that AuNPs do not undergo any alteration, concluding that they can be safely used in RT treatments. Lastly, the actin rearrangements of THP-1 monocytes treated with AuNPs were also assessed in terms of coherency. This is a key proof to evaluate the possible activation of an immune response, which still represents a big limitation for the clinical translation of NPs. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

6. Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis

Author

Jardim, Anaclara Prada, Corso, Jeana Torres, Garcia, Maria Teresa Fernandes Castilho, Gaça, Larissa Botelho, Comper, Sandra Mara, Lancellotti, Carmen Lúcia Penteado, Centeno, Ricardo Silva, Carrete, Henrique, Júnior, Cavalheiro, Esper Abrão, Scorza, Carla Alessandra, and Yacubian, Elza Márcia Targas

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results