1. Electrochemical sensor using cobalt oxide-modified porous carbon for uric acid determination.
- Author
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Quan, Changyun, Chen, Wenxuan, Yang, Minghui, and Hou, Yi
- Subjects
- *
ELECTROCHEMICAL sensors , *CARBON nanotubes , *DETECTION limit , *CARBON , *URIC acid , *CARBONIZATION - Abstract
An electrochemical sensor for the detection of uric acid was constructed using cobalt oxide-modified porous carbon@multi-walled carbon nanotube (MWCNTs) composite material for the modification of the electrode. Firstly, ZIF-67 is generated on carbon nanotubes using the surfactant cetylammonium bromide (CTAB) as template. The vesicles generated by CTAB act as nucleation sites for the in situ growth of ZIF-67. Then, cobalt oxide-modified porous carbon was obtained after high-temperature carbonization of ZIF-67, leading to the formation of cobalt oxide-modified porous carbon@MWCNT composite materials. Co-N and Co-O active sites on the composite material can improve the oxidation of uric acid on the electrode surface, leading to enhanced sensitivity and selectivity for uric acid detection. The sensor has a good linear range from 1 to 40 μM for uric acid detection with a detection limit of 0.09 μM. The sensor was utilized for determination of uric acid in actual serum samples. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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