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Concerns over water conflicts between human beings and ecosystems are increasing. Also, wastewater discharged by manufacturing industries is causing multiple ecological and environmental impacts in many regions. In this research, to comprehensively assess ecological and environmental impacts of wastewater discharged from large-scale industries, a hybrid life-cycle and fuzzy-set-pair analyses (HLCA-FSPA) approach was proposed. This approach represented an integration of life cycle analysis, set pair analysis, and fuzzy sets theory. The developed method could improve previous studies in systematically reflecting impacts of industrial wastewater in terms of multiple dimensions, and considering uncertain parameters in the evaluation process. It could give a complete and robust assessment of wastewater environmental and ecological impacts based on life cycle inventory/database and uncertainty analyses. The developed HLCA-FSPA method was then applied to a pulp and paper mill in Shandong Province of China. The results indicated that the impact of wastewater at the stage of pulp production was under the limit of China's wastewater discharge standard (i.e., level III) with the connection degree of 0.47. Comparatively, the impact level of the entire life cycle of copying paper production was III with a slightly decreased connection degree (i.e., 0.38). Such a difference reflected possibility variations of the impacts at different stages. The results also indicated that the developed method can be expanded to other areas based on the corresponding LCA database. Thus, the results could provide scientific bases for supporting decision-making in industrial wastewater management to mitigate the associated ecological and environmental impacts. [ABSTRACT FROM AUTHOR]