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Juvenile female rainbow trout was exposed for 4.5 months (June to October) to two dilutions of untreated and activated sludge treated whole mill effluent from a pulp mill producing bleached ECF pulp. Two controls were used, on fed ad libitum and a second receiving 0.5% feed of the body weight. All effluent exposed groups were fed ad libitum. Mean weight of the fish was measured monthly. At the end of the experiment a number of physiological and biochemical parameters were analyzed in order to establish the physiological status of the exposed fish in comparison with unexposed fish that obtained ad libitum or restricted amount of feed. The fish exposed to treated effluent grew significantly more than ad libitum control fish until August, whereupon growth retarded in fish exposed to the lower effluent dilution (400 v/v). The growth of fish exposed to untreated effluent did not deviate significantly from the control fed ad libitum. The results from the hematological analysis clearly showed that fish fed restricted amount of feed deviated significantly in most parameters compared with the control fed ad libitum. Fish exposed to treated effluent showed a response pattern similar to that of the control fed restricted amount of feed, whereas the fish exposed to untreated effluent showed a response pattern that did not deviate from that of the ad libitum control. The metabolic parameters suggested that fish exposed to treated effluent had a higher metabolic demand than ad libitum control and that the energy allocation at the end of the experiment was directed to processes other than growth. The responses on hematology were mainly a consequence of the increased energy demand and were not primary effects. The implications of using feed related parameters at field studies are discussed., (Copyright 2001 Academic Press.)

Thermal effects on the nest sizes constructed by Polistes riparius foundresses, their nesting activities, and colony compositions were determined in laboratory conditions during the pre-emergence period. In this study, foundresses were placed in cold (20°C) and warm conditions (27°C), and ample food and nest materials were supplied. Nest sizes were larger in the cold condition; particularly, the elongation of cells was remarkable. The number of cells between the 2 conditions was not significantly different. Inter-condition colony composition was similar, while more honey drops were observed in the cold condition nests. A positive relation was observed when the relationships between body weight and developmental days were investigated, i.e., small offspring required shorter developmental days in both thermal conditions. In the cold condition, the first offspring were very small, whereas offspring size increased steeply after the second order, and was comparable to that of the foundresses; the size increase in the warm group was slight. This result indicates that the cold condition foundresses manipulated the sizes of their offspring. When inter-condition foundresses activities were compared , cold condition foundresses spent more time and energy on flight activities. Theseresults support the view that foundresses change nesting activities in relation to environmental temperatures, i.e., they can improve the thermal condition of nests by adding extra cells and manipulate the sizes of adult offspring.

In this study, we aimed to investigate static and dynamic balance, reaction time, attention and BMI values at the athletes being in the individual and team sport. 78 individual athletes (karate 17, judo 15, Gymnastics 14, table tennis 12, wrestling 20) and 58 team athletes (handball 23, basketball 13, volleyball 10, football 12) with formal licensed and average ages 13.08±1.36 years were participated as voluntarily. For demographic characteristics, participants have filled in questionnaires and Bass Stick static balance, Y dynamic balance, Nelson hand reaction time and D2 attention test were applied. First, we have applied the Kolmogorov-Smirnov test for normality of the data, the normal distribution is observed and then independent t test was used. In order to see the relationship between data, Pearson's correlation test was applied. The average sporting age of participants was 4.32±1.87 years, height 1.59±0.11m, body weight 50.18±12.74 kg and per week training time 10.33±4.41 hours. In addition, their BMI values were19.49±3.10 kg/m2 which is in the normal range, i.e., no difference between individual and team athletes was observed. It has been observed that for individual athletes, total number of items is 525.42±108.29, total number of errors is 454.04±105.86, concentration performance is 182.14±62.53, reaction rime is 0.29±0.06 sec, static balance is 7.10±4.49 sec, dynamic balance is 208.37±32.20 cm. On the other hand, for team athletes, these values were 500.59±79.70, 382.31±93.60, 168.35±56.51, 0.26±0.05 sec, 5.68±2.67 sec and 187.15±29.99 cm, respectively. We have found that while age increased the static and dynamic balance increased, but training time increased solely the dynamic balance increased. In addition, when taking into account the static and dynamic balance, it has been observed that the individual athletes were better than the team athletes but for the reaction time was contrary, i.e., team athletes were better than the individual ones. [This paper will be presented as an oral presentation at the 17th International Congress of Sport Sciences (Antalya, November 13-16, 2019).]

Physical activity (PA) habit decreases and Body Image (BI) becomes important during adolescence. This paper focuses on determining two things: whether the level of participation in PA contributes to adolescents' PA attitudes and their quality of life-related body image and to examine whether there is a difference. The study utilized the cross-sectional design. 1281 individuals in the middle adolescence period participated in the study. Participants were between 15 and 17 years. International Physical Activity Questionnaire Short Form (IPAQ-SF), Cognitive Behavioral Physical Activity Questionnaire (CBPAQ), and Body Image Quality of Life Inventory (BIQLI) were used as data collection tools. According to the study findings, there were significant differences in the BIQLI total, interaction with the opposite sex, and influence behavior/attitude between those who engaged in regular or irregular PA and those who did not engage in PA at all. Difference in the effect on self-efficacy and daily life sub-dimension was found between those who engaged in regular PA and those who did not. Outcome expectation and self-regulation items of those who engaged in PA were higher than for those who did not. Since adolescents are expected to engage in regular or irregular PA, personal barriers in front of them must be removed. It is therefore important to support their attitudes, which positively affects their PA, because participation in PA contributes positively to their PA and BI-related quality of life.

Bisphenol A (BPA) is an endocrine disrupting chemical used in a wide range of consumer products including photoactive dyes used in thermal paper. Recent studies have shown that dermal absorption of BPA can occur when handling these papers. Yet, regulatory agencies have largely dismissed thermal paper as a major source of BPA exposure. Exposure estimates provided by agencies such as the European Food Safety Authority (EFSA) are based on assumptions about how humans interact with this material, stating that ‘typical’ exposures for adults involve only one handling per day for short periods of time (<1 minute), with limited exposure surfaces (three fingertips). The objective of this study was to determine how individuals handle thermal paper in one common setting: a cafeteria providing short-order meals. We observed thermal paper handling in a college-aged population (n = 698 subjects) at the University of Massachusetts’ dining facility. We find that in this setting, individuals handle receipts for an average of 11.5 min, that >30% of individuals hold thermal paper with more than three fingertips, and >60% allow the paper to touch their palm. Only 11% of the participants we observed were consistent with the EFSA model for time of contact and dermal surface area. Mathematical modeling based on handling times we measured and previously published transfer coefficients, concentrations of BPA in paper, and absorption factors indicate the most conservative estimated intake from handling thermal paper in this population is 51.1 ng/kg/day, similar to EFSA’s estimates of 59 ng/kg/day from dermal exposures. Less conservative estimates, using published data on concentrations in thermal paper and transfer rates to skin, indicate that exposures are likely significantly higher. Based on our observational data, we propose that the current models for estimating dermal BPA exposures are not consistent with normal human behavior and should be reevaluated. [ABSTRACT FROM AUTHOR]

The aim of this study was to examine the effect of administering an anti-gonadotropin-releasing hormone vaccine (Improvac ® , developed for pigs) on the performance, temperament, testicular development, and hormone and metabolite profiles of feral bulls (Bos taurus) vaccinated at two different live weights (LW). In all, 16 Serrana de Teruel animals were involved in this 2 x 2 factorial design using the factors LW (LIGHT vs. HEAVY) and vaccine treatment (control, C vs. vaccinated, VA). All animals received the same diet (ad libitum concentrate plus straw) over a 164-day fattening period. Temperament was assessed using chute and flight speed tests. Testicular diameter and subcutaneous fat thickness were recorded. Testosterone, IGF-1, urea, NEFA, and creatinine profiles were analyzed. Bull weight gain was reduced in VA compared to C animals, regardless of the initial LW. The vaccine did not affect the temperament tests, subcutaneous fat thickness or NEFA and creatinine concentrations and had minor effects on linear body measures. The vaccine inhibited testicular growth, reduced plasma testosterone to residual levels, and increased urea concentrations. LIGHT-C animals exhibited increased mean plasma IGF-1 concentrations compared to LIGHT-VA animals. In conclusion, vaccination reduced bull growth and sexual development irrespective of LW at immunization., (© 2019 Japanese Society of Animal Science.)

Microplastics (MPs) have been found in many packaged food products such as salt, tea bags, milk, and fish. In a previous study by this group, MPs were found to leach into hot water from the plastic lining of disposable paper cups. No studies were found in the literature quantifying health risks or lifetime intake of MPs. At present, it is not possible to quantify health risks due to MPs because dose-response and toxicity assessments are not available. Therefore, the objective of the current study was to assess the intake of MPs and associated contaminants like fluoride that are released into these hot beverages. MPs in the previous study were quantified in terms of particle counts only and a simple method was adopted in the present study to convert the microplastics count into its respective mass. Chronic daily intake (CDI) and lifetime intake (LTI) of MPs through the ingestion pathway were calculated. CDI and Hazard Quotient (HQ) due to fluoride ingestion were also estimated following USEPA guidelines. Monte Carlo (MC) simulations were used to account for the variability in input variables such as concentration of MPs, body weight, averaging time, exposure duration, exposure frequency and ingestion rate to evaluate the impact on CDI and LTI values. The CDI was used to estimate the LTI of MPs and HQ for fluoride ingestion. MC simulations with 100,000 iterations resulted in an average CDI of 0.03 ± 0.025 mg of microplastic per kg of body weight per day and 7.04 ± 8.8 μg fluoride per kg body weight per day. This study takes us one step closer to estimating the human health risk due to the ingestion of microplastics and other contaminants through food items. [Display omitted] • Mass of microplastics from paper cups into hot beverages was estimated. • Chronic daily intake analysed using Monte Carlo simulations. • Average chronic daily intake was 0.03 ± 0.025 mg microplastic/kg body weight day−1. • Chronic daily intake of fluoride was 7.04 ± 8.8 μg/kg body weight per day. • Fluoride levels were higher or close to drinking water standard of 1.5 mg/L. [ABSTRACT FROM AUTHOR]

The paper is aimed to determine whether there is a loss of performance by comparing the competition values of the Super League team before and after the COVID-19 epidemic. In order to reduce the performance losses of the athletes due to lack of training, 60-75 minutes of self-weight training was applied during the quarantine period. Paired t test was used for statistical analysis. A statistically significant difference was found in the Total Distance, High Intensity Distance, Sprint Distance, High Speed Distance, Number of High Intensity Runs, Number of Sprints, Number of High Speed Runs, Average Speed, Total Distance in Possession, Total Distance Out of Possession, Total Distance Ball Out of Play, High Intensity Distance in Possession, High Intensity Distance Out of Possession, High Intensity Distance Ball Out of Play, Sprint in Possession, Sprint Out of Possession, Sprint Ball Out of Play, High Speed Distance in Possession, High Speed Distance Out of Possession, High Speed Distance Ball Out of Play values of the athletes compared to p < 0.05. As a result, it has been observed that the training of super league football players with their own body weight during the quarantine period positively affects their performance during the season.

The most important nutrition goals in rehabilitation nutrition are improving function and quality of life, and they are useful to set body weight goals to further improve these aspects. In this paper, we clarified our position, as the Japanese Association of Rehabilitation Nutrition, on body weight goal setting. Body weight goals should be SMART (Specific, Measurable, Achievable, Realistic/Relevant, and Timed). The standard amount of energy accumulation/deficit needed to gain/lose 1 kg body weight is 7500 kcal. In other words, if the nutrition goal is set at 1 kg body weight gain per month, daily energy accumulation can be calculated as approximately 250 kcal. It is necessary to reconcile the rehabilitation goal setting, the content, quantity, and quality of physical activity and exercise therapy, and the patient's general condition and intentions to set nutrition goals. Body weight goal setting is more variable than rehabilitation goal setting, and it is important to confirm the degree of achievement through rehabilitation nutrition monitoring. [ABSTRACT FROM AUTHOR]

Low physical activity and sedentary lifestyle have been contributing to overweight/obesity in children worldwide. In response to this, school health and physical education (HPE) programmes have been introduced to assist children to adopt and maintain healthy lifestyles. Teacher education colleges have been introducing training programmes to prepare teachers. Paro College of Education (PCE), Bhutan, is one such college where the HPE training programme was introduced in 2003. This paper reports on the impact of the HPE programme on the preservice teachers of PCE in relation to their personal and professional competencies. The participants were the final and second-year Bachelor of Education (primary) pre-service student teachers and Diploma in Physical Education and Sports Coaching students. Results revealed that the HPE programme had a significant impact on pre-service teachers' personal and professional competencies. Male participants were highly motivated to teach HPE as well as participating regularly in physical activities compared to their female counterparts. Further, the study revealed differences in personal and professional competencies, pedagogical knowledge, and self-efficacy beliefs amongst the pre-service teachers. Implications for the teacher training programme and recommendations for future research are presented.

Introduction: The most significant clinical challenges in people living with HIV/AIDS (PLWHA) are decline in CD4+ T helper cells and abnormal weight reduction. Consequently, PLWHA who are on Anti-Retroviral Therapy (ART) or Highly Active Anti-Retroviral Therapy (HAART) are usually predisposed to coronary artery diseases due to abnormal weight gain (lipohypertrophy), though with improved and unstable Cluster of Differentiation 4 (CD4) counts.The main aim of this study was to compare the effects of 6 weeks progressive resistance exercise (PRE) and moderate intensity aerobic exercise (MIAE) on CD4 count, and weight of PLWHA in Alex-Ekwueme Federal University Teaching Hospital Ebonyi State., Method: The study adopted quasi experimental research design. The population of the study was 60 Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome patients that attended HIV clinics at Alex-Ekwueme Federal University Teaching Hospital Abakaliki (AE-FUTHA) which formed 58 sample sizes for this study.Simple random sampling technique was adopted for the study and flow cytometry, Heel Densitometer (X-rite 331C), and Omron BF 400 were the instrument used for data collection of CD4 counts and weight respectively; and they are standardized hence not validated. Mean, standard deviation and Analysis of Co-variance (ANCOVA) were used to analyze the data obtained. The reliability coefficient obtained from the pilot study was 0.848 and 0.994 for CD4 and WEIGHT respectively., Results: The major findings revealed a significant difference after 6 weeks' PRE and MIAE on CD4 and Weight of PLWHA., Conclusion: Health promotion policy maker's arm of the government and Healthcare givers should integrate and enforce the use of exercises either as a single regimen or combined exercises into the management plan of PLWHA for greater boost in absolute CD4 count bearing in mind that both have positive effects. Physiotherapist should be integrated in the managements of PLWHA for appropriate prescription and education of therapeutic exercises for body weight., Competing Interests: The authors have no conflicts of interests to disclose., (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)

OBJECTIVE:: To investigate the methods and results used and conclusions found in available published papers on childhood overweight and obesity in Europe. SURVEYS:: This paper compares the two available published papers on the prevalence of child and adolescent overweight and obesity in Europe. The first paper was published in November 2003 and was based on 20 previously conducted surveys performed from 1992 to 2001. The other paper was published in January 2004 and was based on data from the WHO collaborative survey‘Health Behaviour in School Children’, which collected the data in 1997-1998 within a period of 9 months. Height and weight were included as optional questions and 13 European countries, Israel and United States participated. METHODS:: In both papers, body mass index (BMI) was used. In the first paper, measured BMI was used and prevalence of overweight was calculated using IOTF cutoff points. In the other paper, overweight and obesity prevalences were calculated from self-reported height and weight using an internal study reference standard. RESULTS:: The first paper found a north-south trend in overweight in Europe, whereas the second found a more equal distribution of overweight in European children. Thus, overweight was significantly increased among 13?y olds of both sexes in Finland, Ireland, and Greece, and in Portuguese girls. Among 15?y olds, the prevalence of overweight was significantly increased in Greek boys, and in Danish and Portuguese girls. On the contrary, in Lithuania, there was a significantly low prevalence of overweight among both ages and both sexes. CONCLUSION:: Critical reviews of the results of the two published papers show that the year of data collection, methods and use of appropriate statistics are of critical importance for the conclusion drawn from comparative epidemiological surveys on the prevalence of overweight.International Journal of Obesity (2004) 28, S10-S15. doi:10.1038/sj.ijo.0802822 [ABSTRACT FROM AUTHOR]

In this paper, comparison of somatotype characteristics and anthropometric proportional relations of elite wrestlers at the level of styles and weights and, contribution to improvement and orientation of sport is aimed. 57 elite wrestlers took place in the European Championship Preparatory Camp of Turkish National Adults Wrestling Team (31 greco-roman style with 7 light weight, 14 medium weight and 10 heavy weight--with av. height: 168.9 cm. and av. weight: 81.1 kg.; 26 free style with 8 light weight, 12 are medium weight and 6 heavy weight--with av. height: 173.0 cm. and av. weight: 87.9 kg), analyzed in this study. As a result of anthropometric measurements, there are no meaningful differences between free style and greco-roman elite wrestlers both in style and weigh. Wrestlers, as evaluated in somatotype, free and greco-roman styles are characterized as endomorphic mesomorphy, lightweight wrestlers are measured as balanced mesomorphy, medium-weight wrestlers are found endomorphic mesomorphy and heavy-weight wrestlers are characterized as endomorphic mesomorphy. Meaningful difference have found between weights. In spite of there is no differentiate effect of styles for wrestlers, partake in the similar training, nutrition and competition programs from childhood, weight, leaning on differentiates of somatotypes in the frame of the components like height, weight, length of bust and arm etc., emanates differences.

Background: Nuclear magnetic resonance (NMR) metabolic profiling quantifies a large number of metabolites. From adolescence, specific metabolites are influenced by age, sex and body mass index; data on early-life metabolic profiles are limited. We investigated associations between sex, birth weight, weight and adiposity with NMR metabolic profile at age 12 months., Methods: The plasma NMR metabolic profile was quantified in infants (n = 485) from the Barwon Infant Study. Associations between 74 metabolites and sex, birth weight z-score and 12-month measures (weight z-score, skinfold thickness, weight-for-length z-score) were examined using linear regression models., Results: Several cholesterol and fatty acid measures were higher (0.2-0.3 SD) in girls than in boys; we observed modest sex-specific associations of birth weight z-scores and 12-month sum of skinfold thicknesses with metabolites. The pattern of associations between weight z-score and weight-for-length z-score with metabolites at 12 months was more pronounced in girls, particularly for fatty acid ratios., Conclusions: We identified sex differences in the infant metabolic profile. Sex-specific patterns observed differ from those reported in older children and adults. We also identified modest cross-sectional associations between anthropometric and adiposity measures and metabolites, some of which were sex specific.

Mongoose is a common name for 30 species of the family Herpestidae found in a vast area of southwestern Asia, especially Iran. Morphometric studies of the brain have been topics of interest to anatomy researchers due to their high importance in veterinary and zoology fields. The present study was conducted to better understand the brain's morphometric features in Mongoose because of the lack of information about the brain structure in wild carnivores. For this purpose, eight carcasses of adult mongooses were used. They were found in different Fars province areas in Iran, which were dead due to natural causes. The brain was then carefully separated from the skull, and all the measurements and observations related to different parts of the brain were recorded. The values entered the computer separated by gender, and SPSS 22 and T. student tests were used for statistical analysis while the significance level of P ≤ 0.05 was considered. This study showed that the ratio of brain weight to body weight (EQ) and the ratio of cerebellum weight to total brain weight in mongoose are higher than other carnivores. All the brain's morphometric findings in mongooses are in unparalleled harmony with their lifestyle. Also, no difference was found between the mongoose and other carnivores such as dogs and cats regarding the gyri and sulci's number and pattern. The current work is a preliminary assessment, and new imaging methods are suggested for more advanced studies. [ABSTRACT FROM AUTHOR]

Objective: The aim of the study was to use a meta-analysis to identify the correlation between linear body measurements, including body length (BL), wither height (WH), heart girth (HG), and body volume (BV), and body weight in beef cattle by breed, sex, and age as categories. Materials and Methods: These results can be used as a method for predicting beef cattle body weight. This study used systematic review and meta-analysis guidelines to create a checklist. The first stage was searching for papers relevant to the study objectives. The second stage was searching using the keywords beef cattle, body weight, body measurement, and correlation. The third stage was reviewing the title and abstract. The fourth stage was abstracting information from selected papers, and the last stage was tabulating data. Results: The results from this study were obtained, and 32 papers were eligible for the meta-analysis stage. The correlation between linear body measurement and body weight of beef cattle showed that HG (r = 0.88) and BV (r = 0.97) were significantly (p < 0.05) different compared to BL (r = 0.74) and WH (r = 0.72). The correlation between HG and body weight, and the categorization of cattle breeds showed significantly (p < 0.05) different results. The correlation between BV and body weight of cattle according to breed categories showed results that were not significantly (p > 0.05) different, while age was significantly (p < 0.05). Conclusion: In conclusion, to predict beef cattle body weight, it is necessary to use HG or BV, with breed, sex, and age of cattle as categories. [ABSTRACT FROM AUTHOR]

Problem Statement: This cross-sectional study was conducted to determine the relationship established between self-esteem and body image dissatisfaction, as subjective variables among young, female Romanian university students. Purpose of Study: We hypothesize that young women's body dissatisfaction is related to their self-esteem level. The second purpose of this study is to verify whether self-esteem level and body size acceptance, which are subjective variables, are significantly correlated with BMI as an objective variable. Subsequently, we intend to estimate which range self-esteem in our research group is determined by self-perception of the body and what role BMI plays in this equation. Methods: The data were collected using measurements and questionnaires from a random sample of 160 female students (19-21 y.o.) assumed to be healthy and educated, with constant physical activity and having an urban lifestyle. Using descriptive statistics for each variable, we analyzed summaries of the sample and the collected data. For pairs of variables we calculated the Pearson correlation coefficient (r), and we tested its statistical significance using the "t" test. Findings and Results: The BMI mean value--20.93 kg/cm[superscript 2] (SD = 3.30) is equivalent to a slander figure, corresponding to an average height of 1.65 m (SD = 0.06) and an average weight of ~ 57 kg (56.99 kg; SD = 9.70). A prevalence of body dissatisfaction was reported, with 79% of girls reporting being unpleased with their physical appearance. Self-esteem and body dissatisfaction were in a significant negative correlation: r (158) = -0.36, p < 0.0005. We found a consistent, statistically significant correlation between BMI and body dissatisfaction (r (158) = 0.56, p < 0.0005). An important part (31%) of body dissatisfaction is determined by BMI and subsequently by weight and fat deposits. Conclusions and Recommendations: Due the statistical correlations calculated for self-esteem, body image dissatisfaction and BMI, we can conclude that self-esteem is better correlated with other subjective parameters (body image) than with objective and relatively stable measurements (BMI in our research). BMI values are useful predictors of body dissatisfaction risk among young females. Physical activity results in certain improvements in the physical and psychological parameters researched in the present paper. Therefore, we made some recommendations regarding motivation, exercise enjoyment and communication techniques aimed at promoting physical activities among young women.

The development of desert areas in the industrial and tourist and educational purposes related to the implementation of physical activity in extreme conditions. A complex set of hot climate causes the body deep adaptive adjustment, impact on health, human physical performance. Optimization of physical activity in hot climates is of particular importance for the tourists and military personnel, the specific activity of which is related to the foot movement with different masses carried goods on different terrain. The methodology is based on the analysis of the results of experimental studies of the optimum speed of movement of a person walking in a desert area, taking into account temperature and weight of cargo carried. The purpose of the study--assessment of the severity of muscle work, depending on the weight of transported cargo, the nature of the soil and the air temperature at the time of walking alone in a desert area. The paper presents experimental data to evaluate the severity of muscle work, depending on the weight of transported cargo, the nature of the soil and the air temperature at the time of walking alone in a desert area.

The increasing prevalence of obesity, type 2 diabetes mellitus (T2DM), and gestational diabetes (GDM) among pregnant women has risen dramatically worldwide. The antihyperglycemic drug metformin is the most common drug for T2DM treatment in non-pregnant individuals; nevertheless, it is increasingly being used for diabetes-complicated pregnancies. Studies on the long-term metabolic effects of this drug in offspring remain scarce. This work aimed to determine the effect of metformin exposure during pregnancy and lactation on the offspring of a model of diet-induced maternal hyperglycemia. Cohorts of pregnant mice were fed a 46% fat diet (HFD) or a control standard diet (SD). A group of dams were exposed to metformin during pregnancy and lactation. After weaning, the offspring were fed SD for 8 weeks and then challenged with a 46% HFD after puberty for 12 weeks. Irrespective of the maternal diet, offspring of metformin-exposed mothers had a lower body weight and reduced inguinal white adipose tissue (iWAT) mass after HFD challenge. This was associated with increased expression of Pparg, Fabp4, Glut4, Srebp1, and Fasn in the iWAT during adulthood in the metabolically impaired dams exposed to metformin, suggesting increased adipogenesis and de novo lipogenesis. Increased expression of Fasn associated with decreased methylation levels at its promoter and proximal coding region in the iWAT was found. These results suggest that metformin modulates gene expression levels by epigenetic mechanisms in maternal metabolic-impaired conditions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)

Large literatures have shown important links between the quantity of completed education and health outcomes on one hand and the quality or selectivity of schooling on a host of adult outcomes, such as wages, on the other hand. However, little research attempts to produce evidence of the link between school quality and health. The paper presents the first evidence in the literature on the potential short and intermediate term effects of attending a selective college on health behaviors during and following college attendance. Using a variety of empirical methods, this paper shows strong evidence that college selectivity reduces tobacco and marijuana use but has small and possibly positive effects on binge drinking. The effects on weight behaviors are suggestive of reduced weight, potentially through diet, but not exercise change. (Contains 8 tables.)

The aim of this study was to evaluate a procedure of weighing live fish larvae and to determine its impact on the survival and growth rates based on the example of ide Leuciscus idus (L.). A 14-day rearing was conducted. Larvae were randomly divided into two groups - control (C) and experimental (E). During the experiment, 10% of larvae from the E group were sampled and weighed (with experimental method) daily. An integral part of weighing method was to place the anaesthetized larvae onto a nylon net platform. The platform with larvae was then dried on the blotting paper and next weighed together with larvae. The weight of the larvae was calculated by deducting the weight of the platform from the total weight recorded. After weighing, the fish were returned to the rearing tank. Fish from the control group were not manipulated during the whole experiment. At the end of the experiment 90 randomly chosen fish from each group were measured and weighted. No significant differences were recorded in larvae survival, weight and length (91.33±4.73%; 41.69±10.70 mg; 17.56±1.44 mm and 94.00±4.00%; 49.40±10.79 mg; 18.41±1.24 mm in E group and C group, respectively). Significant differences were recorded in case of SGR that reached 15.80±0.29 in C group and 14.60±0.17 in E group. The described method may be a useful tool for determining fish larvae weight. Although it requires conducting further researches in order to establish the influence of accompanying factors such as e.g. kind and concentration of anaesthetic. [ABSTRACT FROM AUTHOR]

One-third of the population of US children is considered obese and two-thirds of the adult population falls into the same category. These figures have tripled over the last 30 years. This demonstrates that the existing strategies to combat obesity do not work and it is time to look for alternatives. The recommendation is to turn the problem into a solution--give children an activity they WANT TO DO, NOT HAVE TO DO. Today's younger generation is "hard wired to technology", so take advantage of this fact. Several entrepreneurs have developed new technologies that combine physical activity, technology, and learning that "appeal" to this Generation Z and they are demonstrating promising results. In this paper, we have included details of the childhood obesity epidemic, the problem, costs and consequences, and have provided a new successful avenue to pursue. Results to date are positive and encouraging. We have identified a new strategy which, in a limited time, has been embraced by children, incorporates new technology, and has the potential for huge benefits for those who choose.

Poor adherence to physical activity programmes during pregnancy is a serious national issue, one that has detrimental effects on a large percentage of the population. Not only does a lack of activity result in a decrease in quality of life for women during term, but the effects can carry over well after pregnancy, potentially leading to increased morbidity and mortality. What's more, reduced prenatal activity can cause adverse effects on the foetus, with impairments seen in physical health as well as cognition. Accordingly, the purpose of this paper is twofold: first, to examine the socio-demographic data and psychosocial influences that modify exercise behaviours in pregnant women and, second, to make recommendations as to effective intervention strategies that can be adopted by health and fitness professionals to help improve maternal exercise participation and adherence.

A combined (enzymatic and chemical) process using a Bacillus pumilus strain (DKS1), isolated from the soil, was used to degum ramie bast fibres. After 24 h of incubation with the isolated pectinolytic strain using a low-cost medium, the weight loss of the ramie fibre was found to be 25% under small scale. High activity of pectate lyase was detected in the culture supernatants; 400 kg of ramie fibres was degummed with 24% weight loss in large-scale degumming under field conditions. No cellulase activity was found. Microbial intervention followed by mild (0.1%) alkali treatment showed high percentage of weight loss from the ramie fibre. Bacterial degumming followed by chemical treatment resulted in an increase of single fibre tenacity (cN/tex) by more than 20.81% as compared to non-degummed (decorticated) fibre samples. Scanning electron micrographs (SEM) and fluorescence microscope showed that after Bacillus pumilus DKS1 treatment the surface of the decorticated ramie fibre becomes very smooth. These results indicate the process provides an economical and eco-friendly method for the small scale as well as large-scale degumming of decorticated ramie fibre. This study has great relevance to the textile as well as paper industry. [ABSTRACT FROM AUTHOR]

Childhood overweight is one of the most serious problems currently affecting individual and public health. Schools represent a logical site for prevention because children spend 6-8 hours a day there during most of the year. Although reports of school-based overweight or obesity prevention programs exist, there are no summaries specifying which interventions are effective in preventing weight gain in the school environment. Researchers generally consider randomized controlled trials to be the most reliable and valid findings; so, naturally they are the best for providing evidence on which to base curriculum and policy guidelines. Consequently, the purpose of this paper is to provide an overview of school-based randomized controlled studies intended to prevent increases in schoolchildren's body weight or body mass index. This paper addresses the successes and other positive health outcomes, as well as the limitations of the school-based research. The goal of this paper is to assist school health administrators with curriculum decisions related to overweight or obesity prevention in schools. Following the critique, the challenges of childhood overweight or obesity prevention are discussed, and recommendations for further research, school activities, and policy changes are made.

The purpose of this paper was to review the physical activity, exercise, and nutrition related weight control interventions done with African American women that were published between 2006 and 2010 and suggest ways of enhancing these interventions. A total of 13 studies met the inclusion criteria. The review found significant results with regard to impact of intervention. Twelve of those studies revealed significant increase in physical activity and weight reduction behavior. In terms of use of theory in designing the interventions only five interventions used a theory. In three of those cases social cognitive theory was used. Appropriate sample size was found to be the major strength of most of the interventions. Six interventions used randomized controlled design. Recommendations for enhancing the effectiveness of physical activity interventions in African American women are presented.

Background: Although females have a higher incidence of eating disorders than males, there is evidence that among college students both males and females are vulnerable to risk factors associated with eating disorders. Purpose: To explore the relationship between sociocultural attitudes towards appearance (SCATA), body shape (dis)satisfaction (BSD), and attempts to change body weight among male and female college students. Methods: Participants were undergraduates (n=224) attending a large southeastern university. A paper-pencil survey was completed that included demographic information, SATAQ-R, the Contour Drawing Rating Scale, and a single item assessing current attempts at changing body weight. Results: Logistic regression models revealed that factors related to current attempt to change body weight differed by gender. The two significant factors observed for males included Internalization of SCATA (OR=1.18) and BSD (OR=3.16). Significant factors for females included awareness of SCATA (OR=1.10) and BSD (OR=8.09). Discussion: Although both males and females exhibit SCATA and body shape dissatisfaction, the specific factors related to their current attempts to change body weight differed. Translation to Health Education Practice: College eating disorder prevention should be directed and tailored to all students regardless of gender. Specifically, primary and secondary prevention programs for males should be tailored to explore internalization of SCATA and body image. (Contains 4 tables.)

The aims of this paper are (a) to investigate how adolescents perceive and represent the body form with respect to being fat or thin, and (b) to describe the process of how they constructed the social representations for these latter two body conditions. The data were collected by means of individual and focus group interviews with adolescent female students in Brazil who were from 11 to 21 years of age. When the adolescents were questioned about their bodies, they talked about "being fat" or "being thin", even though they were not asked about weight issues. Following their own logic, they did not portray "feeling fat" and "feeling thin" as related to their "real" body condition or weight. Furthermore, in the adolescents' discourse, the concept of "normal weight" was virtually non-existent and was characterised as "nothing" or "more or less". By the end of the interviews, their depictions of these conditions of body weight included links from the body to their social relationships in the form of perceived group exclusion or inclusion. In our discussion we describe the adolescents' collective discourses on being fat or thin as integrated social representations, which incorporate both the physical and interpersonal dimensions of their experiences. We conclude by examining the practical implications of our findings for female adolescent behaviour, especially with respect to obsessive dieting and possible eating disorders. Finally we explore the possibility of educational programs to counter the media and other influences which give rise to the negative aspects of social representations of the body by adolescents. (Contains 4 tables and 6 figures.)

Introduction: This paper proposes a model of information behaviour of women during their lifelong struggle to maintain normal weight. Method: The model is integrative and contextual, built on existing models in information science and several other disciplines, and the life stories of about fifty Israeli women aged 25-55 and interviews with professionals. Analysis: The life stories of the participating women were analyzed qualitatively, major themes and phases were identified. Results: Weight loss and/or maintenance behaviour is a lifetime process in which distinctive stages were identified. In most cases the weight gain--weight loss--maintenance cycle is a recurring cycle. Information is a major resource during the process: several roles of information were defined: enabling, motivating, reinforcing, providing background information related to weight problems and creating the internal cognitive schema related to food and weight. Information behaviour and the roles of information vary with the different stages. Information needs are also influenced by the specific stage of the process. Information gathered at previous cycles is reused, and information gained through previous experience effects behaviour in the current cycle. Conclusion: Weight loss and/or maintenance behaviour is a lifetime process in which distinctive stages were identified. In most cases the weight gain--weight loss--maintenance cycle is a recurring cycle. Information is a major resource during the process. Several roles of information were defined: enabling, motivating, reinforcing, providing background information related to weight problems, and creating the internal cognitive schema related to food and weight. Information behaviour and the roles of information vary with the different stages. Information needs are also influenced by the specific stage of the process. Information gathered at previous cycles is reused, and information gained through previous experience effects behaviour in the current cycle.

Intuitive eating (an anti-dieting, hunger-based approach to eating) has been popularized as a viable approach to healthy weight management. The purpose of this study was to evaluate the relationship between intuitive eating, diet composition, and the meaning of food. The convenience sample included 343 students enrolled in a general education course at a Western university. Participants were given paper-and-pencil surveys containing the Intuitive Eating Scale and a variety of diet-related scales adapted from other studies. Each scale/subscale was evaluated for internal consistency and deemed acceptable. Those scoring high in intuitive eating had lower BMI scores (r = -0.327, p less than 0.001), less health-consciousness in relation to food (r = -0.209, p less than 0.001), and higher levels of pleasure associated with food and eating (r = 0.484, p less than 0.001). No negative aspect of diet composition was correlated with intuitive eating or any of its sub-scales. Mean comparisons showed a significant difference between males and females in intuitive eating, dieting, health consciousness, and eating for pleasure (p less than 0.001). In general, high intuitive eating scores were associated with an increase in the enjoyment and pleasure of food, lower BMI scores, and fewer dieting behaviors and food anxieties. The promotion of intuitive eating as one approach to healthy weight management should continue to be explored. (Contains 3 tables.)

Rates of overweight children and adolescents have nearly tripled over the past 30 years. Many barriers exist to healthy eating and physical activity for children and adolescents, including factors in the school and community environment. It is these modifiable school environmental factors that led to the development of the Nutrition Friendly Schools and Communities (NFSC) model to prevent the development of overweight in children and adolescents. Development of the NFSC model built upon the Coordinated School Health Program, the Baby Friendly Hospital Initiative, Participatory Research, and Empowerment Evaluation. The purpose of the NFSC environmental intervention is to actively engage the school community to prevent overweight in students through a multi-level participative intervention that facilitates coordinated changes in the school environment in the following areas: health education, physical education, health services, food services, school policy, staff wellness, psychosocial services, and family/community involvement. The NFSC model is the basis by which school communities develop a plan and evaluation that lead to a healthy school environment and prevent the development of overweight in children. A pilot study of the NFSC model is currently being conducted in eight low-income, minority, urban schools. This paper describes the development of the NFSC model and criteria. (Contains 1 table and 1 figure.)

Behavioral treatments are perhaps the cornerstone of modern obesity treatment. Maintenance of weight lost via behavioral treatments has been less than hoped for, however. Weight regain is the result of complex interactions between physiological, behavioral, cognitive, and environmental factors; in this paper we review some of these factors and discuss current efforts to improve the long-term outcome of behavioral weight loss treatments

Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight and glucose control via GIPR signaling in cells that express the leptin receptor (Lepr)., Methods: Hypothalamic, hindbrain, and pancreatic co-expression of Gipr and Lepr was assessed using single cell RNAseq analysis. Mice with deletion of Gipr in Lepr cells were generated and metabolically characterized for alterations in diet-induced obesity (DIO), glucose control and leptin sensitivity. Long-acting single- and dual-agonists at GIPR and GLP-1R were further used to assess drug effects on energy and glucose metabolism in DIO wildtype (WT) and Lepr-Gipr knock-out (KO) mice., Results: Gipr and Lepr show strong co-expression in the pancreas, but not in the hypothalamus and hindbrain. DIO Lepr-Gipr KO mice are indistinguishable from WT controls related to body weight, food intake and diet-induced leptin resistance. Acyl-GIP and the GIPR:GLP-1R co-agonist MAR709 remain fully efficacious to decrease body weight and food intake in DIO Lepr-Gipr KO mice. Consistent with the demonstration that Gipr and Lepr highly co-localize in the endocrine pancreas, including the β-cells, we find the superior glycemic effect of GIPR:GLP-1R co-agonism over single GLP-1R agonism to vanish in Lepr-Gipr KO mice., Conclusions: GIPR signaling in cells/neurons that express the leptin receptor is not implicated in the control of body weight or food intake, but is of crucial importance for the superior glycemic effects of GIPR:GLP-1R co-agonism relative to single GLP-1R agonism., Competing Interests: Declaration of competing interest MHT is a member of the scientific advisory board of ERX Pharmaceuticals, Cambridge, Mass. He was a member of the Research Cluster Advisory Panel (ReCAP) of the Novo Nordisk Foundation between 2017 and 2019. He attended a scientific advisory board meeting of the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, in 2016. He received funding for his research projects by Novo Nordisk (2016–2020) and Sanofi-Aventis (2012–2019). He was a consultant for Bionorica SE (2013–2017), Menarini Ricerche S.p.A. (2016), and Bayer Pharma AG Berlin (2016). As former Director of the Helmholtz Diabetes Center and the Institute for Diabetes and Obesity at Helmholtz Zentrum München (2011–2018), and since 2018, as CEO of Helmholtz Zentrum München, he has been responsible for collaborations with a multitude of companies and institutions, worldwide. In this capacity, he discussed potential projects with and has signed/signs contracts for his institute(s) and for the staff for research funding and/or collaborations with industry and academia, worldwide, including but not limited to pharmaceutical corporations like Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Medigene, Arbormed, BioSyngen, and others. In this role, he was/is further responsible for commercial technology transfer activities of his institute(s), including diabetes related patent portfolios of Helmholtz Zentrum München as, e.g., WO/2016/188932 A2 or WO/2017/194499 A1. MHT confirms that to the best of his knowledge none of the above funding sources were involved in the preparation of this paper. TDM and K.S. receive research funding by Novo Nordisk but these funds are unrelated the here described work. DJD has received speaking and consulting fees from Merck and Novo Nordisk Inc and consulting fees from Forkhead Biopharmaceuticals and Kallyope Inc. R.D.D is a co-inventor on intellectual property owned by Indiana University and licensed to Novo Nordisk. He was previously employed by Novo Nordisk. P.J.K, S.M., and B.F. are current employees of Novo Nordisk. TDM receives funding from Novo Nordisk and received speaking fees within the last 3 years from Novo Nordisk, Eli Lilly, AstraZeneca, Merck, Berlin Chemie AG, and Mercodia., (Copyright © 2024 The Author(s). Published by Elsevier GmbH.. All rights reserved.)

Background: During pregnancy, women's bodies undergo rapid body weight and size changes within a relatively short period. Pregnancy may therefore, be associated with an increased vulnerability for developing body image dissatisfaction linked to adverse health outcomes for the mother (e.g., depression, eating disorders) and child (e.g., impaired self-regulation, childhood obesity). The present study aims to examine the prevalence and trajectories of body image dissatisfaction during pregnancy and postpartum and its relationship to pre-pregnancy BMI. This is the first study that investigates prevalence rates of body image dissatisfaction not only ante- but also postpartum, and that compares trajectories of women with normal weight and overweight. Methods: A prospective longitudinal design with a quantitative approach was applied. Healthy pregnant women (N = 136) answered paper-pencil or online questionnaires at four time points (18th-22nd and 33rd-37th week of gestation, 3 and 6 months postpartum). Body image dissatisfaction was assessed using the German version of the Body Shape Questionnaire (BSQ) and the Eating Disorder Examination Questionnaire (EDE-Q). Both questionnaires are considered reliable and valid measures of several aspects of body image, and the BSQ allows for calculating prevalence rates by providing cut-off values. Using not just one but two body image questionnaires, trajectories of body image dissatisfaction can be compared. Pre-pregnancy BMI was assessed retrospectively via self-reported weight and height. Results: The proportion of women reporting elevated levels of body image dissatisfaction was 6.6% (n = 9) in the second trimester, 2.9% (n = 4) in the third trimester, 11.0% (n = 15) three months postpartum, and 10.3% (n = 14) six months postpartum. Repeated measures ANOVA revealed that body image dissatisfaction significantly decreased from pre-pregnancy to pregnancy, remained stable during pregnancy, and returned to pre-pregnancy levels three to six months postpartum. Mixed between-within ANOVA showed that the overweight/obese group reported significantly higher levels of body image dissatisfaction at each measurement point except during the third trimester than women in the normal weight group. Significant but small interaction effects between time and pre-pregnancy BMI were found. Conclusions: The results revealed that approximately every tenth woman is affected by body image dissatisfaction after childbirth. Women with a higher BMI level before pregnancy are particularly at risk of experiencing body image dissatisfaction. Healthcare providers should screen for body image dissatisfaction, in particular after childbirth, and inform affected women about possible adverse health outcomes and treatment options. Study limitations concern the drop-out rate of 51.4% and the retrospective and self-reported assessment of pre-pregnancy BMI. Future studies should include additional assessment points in the first trimester and more than six months postpartum and try to include a matched control group of non-pregnant women to compare prevalence rates and trajectory of body image dissatisfaction. [ABSTRACT FROM AUTHOR]

Backgrounds: Freezing of gait (FoG) is a common and debilitating symptom of Parkinson's disease (PD) that can lead to falls and reduced quality of life. Wearable sensors have been used to detect FoG, but current methods have limitations in accuracy and practicality. In this paper, we aimed to develop a deep learning model using pressure sensor data from wearable insoles to accurately detect FoG in PD patients. Methods: We recruited 14 PD patients and collected data frommultiple trials of a standardized walking test using the Pedar insole system. We proposed temporal convolutional neural network (TCNN) and applied rigorous data filtering and selective participant inclusion criteria to ensure the integrity of the dataset. We mapped the sensor data to a structured matrix and normalized it for input into our TCNN. We used a train-test split to evaluate the performance of the model. Results: We found that TCNN model achieved the highest accuracy, precision, sensitivity, specificity, and F1 score for FoG detection compared to othermodels. The TCNN model also showed good performance in detecting FoG episodes, even in various types of sensor noise situations. Conclusions: We demonstrated the potential of using wearable pressure sensors andmachine learningmodels for FoG detection in PD patients. The TCNNmodel showed promising results and could be used in future studies to develop a real-time FoG detection system to improve PD patients' safety and quality of life. Additionally, our noise impact analysis identifies critical sensor locations, suggesting potential for reducing sensor numbers. [ABSTRACT FROM AUTHOR]

The rapid evolution of 3D technology in recent years has brought about significant change in the field of agriculture, including precision livestock management. From 3D geometry information, the weight and characteristics of body parts of Korean cattle can be analyzed to improve cow growth. In this paper, a system of cameras is built to synchronously capture 3D data and then reconstruct a 3D mesh representation. In general, to reconstruct non-rigid objects, a system of cameras is synchronized and calibrated, and then the data of each camera are transformed to global coordinates. However, when reconstructing cattle in a real environment, difficulties including fences and the vibration of cameras can lead to the failure of the process of reconstruction. A new scheme is proposed that automatically removes environmental fences and noise. An optimization method is proposed that interweaves camera pose updates, and the distances between the camera pose and the initial camera position are added as part of the objective function. The difference between the camera's point clouds to the mesh output is reduced from 7.5 mm to 5.5 mm. The experimental results showed that our scheme can automatically generate a high-quality mesh in a real environment. This scheme provides data that can be used for other research on Korean cattle. [ABSTRACT FROM AUTHOR]

Formaldehyde, the simplest molecule of the aldehyde group, is a gaseous compound at room temperature and pressure, is colorless, and has a strong, pungent odor. It is soluble in water, ethanol, and diethyl ether and is used in solution or polymerized form. Its maximum daily dosage established by the EPA is 0.2 μg g−1 of body weight whereas that established by the WHO is between 1.5 and 14 mg g−1: it is in category 1A of carcinogens by IARC. From an analytical point of view, formaldehyde is traditionally analyzed by HPLC with UV-Vis detection. Nowadays, the need to analyze this compound quickly and in situ is increasing. This work proposes a critical review of methods for analyzing formaldehyde in food using sensing methods. A search carried out on the Scopus database documented more than 50 papers published in the last 5 years. The increase in interest in the recognition of the presence of formaldehyde in food has occurred in recent years, above all due to an awareness of the damage it can cause to human health. This paper focuses on some new sensors by analyzing their performance and comparing them with various no-sensing methods but focusing on the determination of formaldehyde in food products. The sensors reported are of various types, but they all share a good LOD, good accuracy, and a reduced analysis time. Some of them are also biodegradable and others have a very low cost, many are portable and easy to use, therefore usable for the recognition of food adulterations on site. [ABSTRACT FROM AUTHOR]

Background: The ultra-processed food (UPF) contributed 20-85% of total daily calories. The consumption of UPF can be triggered by food security status. Many studies revealed that UPF consumption has a direct negative impact on health, mainly in overweight and obesity. Objectives: To review published studies assessing food security, UPF consumption, and overweight or obesity and find the possible links between those three factors. Methods: A literature review of scientific articles about food security, UPF consumption, and overweight or obesity, selected systematically according to the PRISMA Diagram. All articles were gathered through medical search engines, including PubMed, ScienceDirect, and Scopus, from December 2021 to February 2022. The bias risk of each selected paper was assessed using the checklist from The Joanna Briggs Institute (JBI) Critical Appraisal. Peer review and group discussions were performed to assess the quality of all articles gathered as objectively as possible using the STROBE Checklist. A narrative synthesis approach was opted to unify all findings across included studies systematically. Results: Nineteen (19) scientific published papers were filtered. The association between food security status and UPF consumption showed inconsistent findings. However, UPF consumption revealed a consistent association with overweight/obesity, where the higher the UPF intake, the greater odds of being overweight/obese. The relationship between food security status and overweight or obesity tended to have a similar pattern. In high-income countries, the association was negative (the more food insecure, the higher overweight or obesity), while in low- and middle-income countries showed the opposite. The pathway could be: (1) food-insecure adults have higher UPF intake, hence gaining body weight, or (2) food-secure adults have higher UPF intake, hence gaining body weight. Conclusions: UPF consumption is indicated as a potential mediator for food security status and nutritional status (overweight/obesity) through two pathways involving socio-demographic factors, psychological factors, social protections, and food choice motives. [ABSTRACT FROM AUTHOR]

People fall more often when their gait stability is reduced. Gait stability can be directly manipulated by exerting forces or moments onto a person, ranging from simple walking sticks to complex wearable robotics. A systematic review of the literature was performed to determine: What is the level of evidence for different types of mechanical manipulations on improving gait stability? The study was registered at PROSPERO (CRD42020180631). Databases Embase, Medline All, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and Google Scholar were searched. The final search was conducted on the 1st of December, 2022. The included studies contained mechanical devices that influence gait stability for both impaired and non-impaired subjects. Studies performed with prosthetic devices, passive orthoses, and analysing post-training effects were excluded. An adapted NIH quality assessment tool was used to assess the study quality and risk of bias. Studies were grouped based on the type of device, point of application, and direction of forces and moments. For each device type, a best-evidence synthesis was performed to quantify the level of evidence based on the type of validity of the reported outcome measures and the study quality assessment score. Impaired and non-impaired study participants were considered separately. From a total of 4701 papers, 53 were included in our analysis. For impaired subjects, indicative evidence was found for medio-lateral pelvis stabilisation for improving gait stability, while limited evidence was found for hip joint assistance and canes. For non-impaired subjects, moderate evidence was found for medio-lateral pelvis stabilisation and limited evidence for body weight support. For all other device types, either indicative or insufficient evidence was found for improving gait stability. Our findings also highlight the lack of consensus on outcome measures amongst studies of devices focused on manipulating gait. [ABSTRACT FROM AUTHOR]

Severe acute malnutrition (SAM) remains a major global public health problem. SAM cases are treated using ready‐to‐use therapeutic food (RUTF) at a dosage of ∼200 kcal/kg/day per the standard treatment protocol (STD). Emerging evidence on simplifications to the standard protocol, which among other adaptations, includes reducing the daily RUTF dosage, indicates that it is effective and safe for treating children with SAM. In response to a foreseen stock shortage of RUTF, the government of Afghanistan endorsed the temporary use of a modified treatment protocol in which the daily RUTF dosage was prescribed at 1000 kcal/day (irrespective of body weight) until the child achieved moderate acute malnutrition status (weight‐for‐height z‐score ≥ −3 or mid‐upper arm circumference [MUAC] ≥ 115 mm), at which point 500 kcal/day was prescribed until cured (modified treatment protocol [MTP]). In this paper, we report the results of this nonweight‐based daily RUTF dosage experience. Data of 2042 children with SAM, treated using either the STD protocol (n = 269) or the MTP protocol (n = 1773) from August 2019 to March 2021 in five provinces, were analyzed. The per‐protocol analyses confirmed noninferiority of MTP protocol when compared to STD protocol for recovery rate [93.3% vs. 90.2%; ∆ (95% confidence interval, CI) = 3.1 (−0.9; 7.2) %] and length‐of‐stay [82.6 vs. 75.6 days; ∆ (95% CI) = 6.9 (3.3; 10.5) days], considering the margin of noninferiority of −10% and +14 days, respectively. Weight gain velocity was smaller in the MTP protocol group than in the STD protocol group [3.7 (1.7) vs. 5.2 (2.9) g/kg/day; ∆ (95% CI) = −1.5 (−1.8, −1.2); p < 0.001]. The STD group had a significantly higher mean than the MTP group for absolute MUAC gain [∆ (95% CI) = 1.7 (1.0; 2.3) mm; p < 0.001] and the MUAC velocity [∆ (95% CI) = 0.29 (0.20; 0.37) mm/week; p < 0.001]. Our results confirm the noninferiority of a nonweight‐based daily dosage and support the endorsement of this modification as an alternative to the standard protocol in resource‐constrained contexts. Key messages: More evidence supporting the use of the nonweight‐based daily ready‐to‐use therapeutic food (RUTF) dosage for treating uncomplicated severe acute malnutrition (SAM), in specific contexts, is needed.Our real‐world prospective nonrandomized study showed that the fixed nonweight‐based daily RUTF dosage protocol is as effective as the standard weight‐based protocol for treating uncomplicated SAM in children <5 in the Afghanistan context.Our findings support the reflection of a nonweight‐based daily RUTF dosage in resource‐constrained contexts in national and global policies and guidelines to improve coverage of all children in need of treatment. [ABSTRACT FROM AUTHOR]

Background: Ketogenic diets are increasingly popular for addressing obesity, but their impacts on the gut microbiota and metabolome remain unclear. This paper aimed to investigate how a ketogenic diet affects intestinal microorganisms and metabolites in obesity. Methods: Male mice were provided with one of the following dietary regimens: normal chow, high-fat diet, ketogenic diet, or high-fat diet converted to ketogenic diet. Body weight and fat mass were measured weekly using high-precision electronic balances and minispec body composition analyzers. Metagenomics and non-targeted metabolomics data were used to analyze differences in intestinal contents. Results: Obese mice on the ketogenic diet exhibited notable improvements in weight and body fat. However, these were accompanied by a significant decrease in intestinal microbial diversity, as well as an increase in Firmicutes abundance and a 247% increase in the Firmicutes/Bacteroidetes ratio. The ketogenic diet also altered multiple metabolic pathways in the gut, including glucose, lipid, energy, carbohydrate, amino acid, ketone body, butanoate, and methane pathways, as well as bacterial secretion and colonization pathways. These changes were associated with increased intestinal inflammation and dysbiosis in obese mice. Furthermore, the ketogenic diet enhanced the secretion of bile and the synthesis of aminoglycoside antibiotics in obese mice, which may impair the gut microbiota and be associated with intestinal inflammation and immunity. Conclusions: The study suggest that the ketogenic diet had an unfavorable risk–benefit trade-off and may compromise metabolic homeostasis in obese mice. [ABSTRACT FROM AUTHOR]

Background: According to data from the World Health Organization (WHO), there is a significant public health issue regarding the increasing number of individuals affected by obesity and overweight on an annual basis. Therefore, it is imperative to urgently identify interventions that can effectively control and improve this condition. Baduanjin, as a medium-intensity exercise, appears a suitable approach for weight reduction among individuals with obesity. This paper aimed to provide a systematic review and meta-analysis of the efficacy of Baduanjin in addressing obesity and overweight, with the ultimate goal of assisting individuals with obesity in finding an effective, safe, and engaging method for weight reduction. Methods: We conducted a comprehensive search of multiple databases including PubMed, Cochrane Library, Web of Science, Embase, The China National Knowledge Infrastructure (CNKI), The Chinese Scientific Journal Database (VIP), The Chinese Biomedical Literature Database (CBM), and WanFang Database to identify relevant articles published from the inception of each database until September 2023. Specifically, we focused on randomized controlled trials (RCTs) investigating the effects of Baduanjin on weight reduction. Data from these studies were extracted and analyzed using appropriate statistical methods. In cases where there was no significant heterogeneity (I2 < 50%, p > 0.1), we employed a fixed effects model for data synthesis; otherwise, a random effects model was selected. Funnel plots were used to assess publication bias, and the mean difference (MD) was reported as an indicator of treatment group differences. Results: A total of 420 participants were included in 10 studies. The MD results of the experimental group when compared with the control group were -3.69 (95% CI = -4.97 to -2.40, p < 0.001) for body weight (BW), -5.42 (95%CI = -6.56 to -4.28, p < 0.001) for body mass index (BMI), -1.36 (95%CI = -1.76 to -0.96, p < 0.001) for waist circumference (WC), -3.40 (95%CI = -4.43 to -2.37, p < 0.001) for hip circumference (HC), and -0.03 (95%CI = -0.04 to -0.02, p > 0.1) for the waist-to-hip ratio (WHR). All of the values in the experimental group showed significant difference. The results of the Egger's test (t = 1.43, p = 0.190) suggest that there was no substantial bias present within the data analysis process. The safety profile revealed no adverse events reported across all 10 studies. Conclusion: Baduanjin could be effective in reducing weight, and the practice of Baduanjin has the potential to regulate BW, BMI, WC, HC, and WHR. However, further well-designed RCTs are still necessary to provide more robust evidence in the future. [ABSTRACT FROM AUTHOR]

Objective: This article aims to address knowledge gaps and misconceptions among healthcare professionals regarding needle selection (specifically the length and gauge/size chosen) for intramuscular (IM) and subcutaneous (SC) injections. It investigates the impact of needle selection on injection efficacy and adverse effects, considering factors, such as, needle length, size, patient characteristics, and medication requirements. It also aims to evaluate current injection guidelines against research findings from the past two decades, identifying areas requiring revision or updating. Methods: The discussion paper employs a literature review, including an analysis of past research that employs imaging techniques, such as, CT and ultrasound to examine tissue depth in both IM and SC injection practices; the author's extensive experience across various clinical settings, including immunisation, primary care, and acute care settings. The author's roles as academic staff and a clinical facilitator allow for the identification of gaps between theoretical knowledge and practical implementation in injection practices. These insights contribute to a comprehensive understanding of the challenges faced by healthcare professionals. Results: The study reveals significant discrepancies in needle selection practices, with traditional methods often diverging from evidence-based recommendations. Challenges noted include reliance on needle hub colour coding for IM and SC injections and insufficient understanding regarding the rationale behind these injection methods. Another additional barrier is interpreting needle packaging information to identify the actual needle length for injection. Staff training and education is essential to improving accuracy and safety in injection practices. Further, patient characteristics, such as, weight, BMI, gender, and injection sites were found to impact needle selection, highlighting the need for tailored approaches. The article suggests that inconsistent and outdated guidelines from various agencies in injection practices and techniques often lack robust scientific rationale. Implications for research, policy, and practice: The findings and recommendations have significant implications for healthcare policies and guidelines. They highlight the need to incorporate research findings to update current guidelines, ensuring safe and effective injection practices across all clinical settings. An algorithmic flow chart could be developed to reflect the above concerns. What is already known about the topic? * Nursing textbooks often differ in IM and SC procedures, with some based on non-evidence-based recommendations. * Unsafe injections have severe consequences, including increased morbidity and mortality, along with substantial medical costs. * Complications like muscle fibrosis, abscesses, gangrene, and nerve injury may arise. Inappropriate injections can result in subtherapeutic absorption and reduced medication efficacy. What this paper adds: * This article highlights the overreliance on traditional practices in injection procedures and advocates for nurses to embrace evidence-based approaches in their injection techniques. * It also emphasises the importance of proper needle selection, including the correct identification of length and gauge/size (rather than relying solely on the needle colour hub for IM/SC injections), to ensure medication efficacy and patient safety. * This shift towards best practice is anticipated to enhance nursing proficiency in intramuscular and subcutaneous injections, ultimately leading to improved patient outcomes. [ABSTRACT FROM AUTHOR]

This paper presents an intelligent system for the dynamic estimation of sheep body weight (BW). The methodology used to estimate body weight is based on measuring seven biometric parameters: height at withers, rump height, body length, body diagonal length, total body length, semicircumference of the abdomen, and semicircumference of the girth. A biometric parameter acquisition system was developed using a Kinect as a sensor. The results were contrasted with measurements obtained manually with a flexometer. The comparison gives an average root mean square error (RMSE) of 9.91 and a mean R 2 of 0.81. Subsequently, the parameters were used as input in a back-propagation artificial neural network. Performance tests were performed with different combinations to make the best choice of architecture. In this way, an intelligent body weight estimation system was obtained from biometric parameters, with a 5.8% RMSE in the weight estimations for the best architecture. This approach represents an innovative, feasible, and economical alternative to contribute to decision-making in livestock production systems. [ABSTRACT FROM AUTHOR]