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1. Increased Efficacies in Magnetofection and Gene Delivery to Hepatocellular Carcinoma Cells with Ternary Organic-Inorganic Hybrid Nanocomposites.

Author

Leung, Ken Cham ‐ Fai, Chak, Chun ‐ Pong, Lee, Siu ‐ Fung, Lai, Josie M. Y., Zhu, Xiao ‐ Ming, Wang, Yi ‐ Xiang J., Sham, Kathy W. Y., Wong, Chi ‐ Hin, and Cheng, Christopher H. K.

Subjects
DEFEROXAMINE, LIVER cancer, SUPERPARAMAGNETIC materials, FERRIC oxide, MAGNETIC resonance imaging, GENE transfection
Abstract

A magnetic personality: Magnetofection and gene delivery have been investigated in HepG2 cells using ternary organic–inorganic hybrid nanocomposites that contain deferoxamine ‐ coated iron oxide nanoparticles (NPs), circular plasmid DNA, and branched polyethylenimine (PEI). It was found that the cellular uptake efficacies depend on the ratio of components in PEI/DNA/NP, as assessed by Prussian staining, magnetic resonance imaging, and luciferase expression in the presence and absence of a magnet during transfection. [ABSTRACT FROM AUTHOR]

Published
2013
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