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Ratings of appetite are commonly used to assess appetite modification following an intervention. Subjectively rated appetite is a widely employed proxy measure for energy intake (EI), measurement of which requires greater time and resources. However, the validity of appetite as a reliable predictor of EI has not yet been reviewed systematically. This literature search identified studies that quantified both appetite ratings and EI. Outcomes were predefined as: (1) agreement between self-reported appetite scores and EI; (2) no agreement between self-reported appetitescores and EI. The presence of direct statistical comparison between the endpoints, intervention type and study population were also recorded. 462 papers were included in this review. Appetite scores failed to correspond with EI in 51.3% of the total studies. Only 6% of all studies evaluated here reported a direct statistical comparison between appetite scores and EI. χ2 analysis demonstrated that any relationship between EI and appetite was independent of study type stratification by age, gender or sample size. The very substantive corpus reviewed allows us to conclude that self-reported appetite ratings of appetite do not reliably predict EI. Caution should be exercised when drawing conclusions based from self-reported appetite scores in relation to prospective EI. [ABSTRACT FROM AUTHOR]

Obesity is a global health problem. In the past decades, the prevalence rate of obesity has risen sharply in epidemiology. Obesity has become an increasingly severe epidemic burden linked with different kinds of diseases, consisting of cardiovascular disease, diabetes, metabolic associated fatty liver disease, and even in COVID-19. Beneficial flavonoids in foods, as functional ingredients, combat obesity and maintain energy balance through multiple mechanisms. This review provides a brief overview of biological targets, possible mechanisms and the current therapeutic interventions including suppressing appetite, increasing energy consumption, regulating gut microbiota, inhibiting adipogenesis, anti-inflammation. In vitro and in vivo experiments as well as available clinical evidence related to the anti-obesity effects of pure flavonoid and flavonoid-rich extracts are also summarized and depicted. Furthermore, the metabolism and bioavailability of flavonoids are also concluded and discussed. Beneficial flavonoids have become promising candidates for treating and avoiding obesity, but poor bioavailability and short elimination half-life affects the absorption and efficacy. This paper reviews the different types of flavonoids and their potential effect of preventing obesity, which provide the basis for further research. [ABSTRACT FROM AUTHOR]

This paper explores the productive tensions occurring in an interdisciplinary research project on weight loss after obesity surgery. The study was a bio-medical/anthropological collaboration investigating to what extent eating patterns, the subjective experience of hunger and physiological mechanisms are involved in appetite regulation that might determine good or poor response to the surgery. Linking biomedical and anthropological categories and definitions of central concepts about the body turned out to be a major challenge in the collaborative analysis. Notably, the conception of what constitutes ‘appetite’ was a key concern, as each discipline has its particular definition and operationalization of the term. In response, a material-semiotic approach was chosen which allowed for a reconceptualization of appetite as a ‘fractional object’, engaged in multiple relations and enacted differently in each instance. This perspective produced creative contrasts and offered alternative explorations of both scientific knowledge production and anthropological practices. The paper thereby explores the interfaces between anthropology and medical science by attending to the challenges and opportunities that result from destabilising an assumed fixed and well-defined concept associated with the body. [ABSTRACT FROM PUBLISHER]

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This paper explores the experience of playing walking football (w/f) in the south of England. Ethnographic research was carried out at a local authority leisure centre and non-league football club. Data were accumulated through an ethnographic approach which consisted of participant observation, informal conversations with walking footballers and facilitators and documentary collection. The research period ran throughout 2015–2016 for a period of 18 months. The data, which were analyzed reflectively using insights from feminist scholarship, suggest that players experienced a number of benefits from participation. Whilst some previous studies have sought primarily to measure physiological benefits, this study is suggestive of less tangible health gains. In particular, players reported an increased appetite for life and positivity engendered by playing w/f, together with enhanced levels of social engagement. They reported feelings of social connectedness, enjoyment and inclusion as members of a supportive community. However, there is some evidence of conflict over the philosophy and purpose of w/f/, especially in relation to the spirit of the game and the competitive tournament environment. Further work around these areas is recommended. [ABSTRACT FROM AUTHOR]

Inadequate regulation of food intake plays an important role in the development of overweight and obesity, and is under the influence of both the internal appetite control system and external environmental cues. Especially in environments where food is overly available, external cues seem to override and/or undermine internal signals, which put severe challenges on the accurate regulation of food intake. By structuring these external cues around five different phases in the food consumption process this paper aims to provide an overview of the wide range of external cues that potentially facilitate or hamper internal signals and with that influence food intake. For each of the five phases of the food consumption process, meal initiation, meal planning, consumption phase, end of eating episode and time till next meal, the most relevant internal signals are discussed and it is explained how specific external cues exert their influence. [ABSTRACT FROM PUBLISHER]

Food is a primary biological motivator and elicits automatic approach and consumption responses. How directly food is portrayed may alter these responses and, as a result, influence how food ads, brands and products are evaluated. This paper presents two experiments that examine how the portrayal of food in food advertisements can alter its motivational appeal, and as such, alter dynamic appetitive responses and later evaluations. The ads in this study differed in how they were produced. Some ads initially portrayed food as very appetizing and ready-to-eat while others initially portrayed foods in their packaging and not ready-to-eat. In general, results support that unpackaged food is more directly appetitive, showing better physiological appetitive responses and better attitudinal evaluations overall. [ABSTRACT FROM AUTHOR]

Patients undergoing cancer treatment experience a multitude of symptoms that can influence their ability to complete treatment as well as their quality of life during and after treatment. This cross-sectional study sought to describe the dietary changes experienced by cancer patients and to identify associations between these changes and common treatment symptoms. A convenience sample of 1199 cancer patients aged 18 yr and older undergoing active treatment were recruited from 7 cancer centers to complete a self-administered paper-and-pencil survey. Descriptive analyses were conducted to estimate prevalence of dietary changes and chi-squared tests were used to examine associations between dietary changes and health outcomes. Approximately 40% of patients reported a decreased appetite since beginning treatment, and 67.2% of patients reported at least 1 chemosensory alteration. Increased taste sensitivities were more common than decreased taste sensitivities, with increased sensitivity to metallic being the most common taste sensitivity (18.6%). Patients also had increased sensitivities to certain smells including cleaning solutions (23.4%), perfume (22.4%), and food cooking (11.4%). Patients reported a wide range of food preferences and aversions. Patients who had less energy or lost weight since beginning treatment were more likely than others to report treatment-related dietary changes. [ABSTRACT FROM PUBLISHER]

Adipokines are proteins secreted by adipose tissue to regulate glucolipid metabolism and play vital roles in our body. Different adipokines have more than one endocrine function and be divided into several different categories according to their functions, including adipokines involved in glucolipid metabolism, the inflammatory response, insulin action, activation of brown adipose tissue (BAT) and appetite regulation. Multiple adipokines interact with each other to regulate metabolic processes. Based on the recent progress of adipokine research, this article discusses the role and mechanism of various adipokines in glucolipid metabolism, which may provide new ideas for understanding the pathogenesis and improving the treatment of various metabolic diseases. [ABSTRACT FROM AUTHOR]

In the context of increasing prevalence of overweight and obesity in societies worldwide, enhancing the satiating capacity of foods may help people control their energy intake and weight. This requires an integrated approach between various food-related disciplines. By structuring this approach around the new product development process, this paper aims to present the contours of such an integrative approach by going through the current state of the art around satiety enhancing foods. It portrays actual food choice as the end result of a complex interaction between internal satiety signals, other food benefits, and environmental cues. Three interrelated routes to satiating enhancement are to change the food composition to develop stronger physiological satiation and satiety signals, anticipate and build on smart external stimuli at the moment of purchase and consumption, and improve palatability and acceptance of satiety enhanced foods. Key research challenges in achieving these routes in the field of nutrition, food technology, consumer, marketing, and communication are outlined. [ABSTRACT FROM AUTHOR]

The Tagore family had as much influence on the fine arts, music, dance, clothing and architecture as they did on Bengali cuisine. Rabindranath Tagore, born after the experiments in the bawarcheekhana (kitchen) during Dwarkanath's time and Debendranath's culture of frugal but balanced nutritious meals, was exposed to European cuisine during his visits abroad and by Jnadanandini, his sister-in-law. In this paper, I try to show, against a background of the assimilative tendencies of the Thakurbari (the Tagore household) kitchen, how Tagore's use of gastronomic tropes was at odds with his theory of internationalism, and how they are used, with their positive biases and prejudices, as cultural and category markers to differentiate Tagore's great binary of the East and West. [ABSTRACT FROM AUTHOR]

A selective and limited sample of clinical case studies of psychoanalytic psychotherapy with anorexic patients, focussing on the author/therapist's experience of working with such patients, is examined. Patients' depressive and often angry states of withdrawal, and projections, are frequently noted. A summary of more hopeful interactions, as selected from the literature reviewed, is offered. An understanding of anorexic defences is explored in relation to the 'Trojan Horse' mythology, in the sense that that which purports to be emotionally nourishing and sublime can be suspiciously viewed as seeking to enter and conquer, through subterfuge. Some existing challenges to traditional tenets of psychoanalytic clinical practice with anorexic patients are presented. [ABSTRACT FROM AUTHOR]

In recent decades, studies have addressed the issue of how migraine and obesity are related and have suggested obesity as a risk factor for migraine headache. However, the exact direction of this relationship remains under debate. In this review, the authors summarize the evidence that have suggested migraine as a risk factor for obesity and overweightness. This article reviews the results of the previous research published on PubMed and Scopus databases (from 2000 to 2020) concerning the association between migraine and obesity to determine the actual direction of their association. Special attention has been given to the common mechanistic pathways involved in the pathophysiology of migraine and obesity. The majority of research conducted thus far has considered obesity as a risk factor for migraine. However, because of the cross-sectional design of available research, we cannot be certain of the proposed direction of this association. There is evidence supporting the hypothesis that obesity can serve as a consequence of migraine through the effects of neuropeptides, inflammatory mediators, adipokines, gut microbiota and modifications in eating behavior and lifestyle. However, the real direction of the relationship between migraine and obesity should be further investigated in large prospective studies. [ABSTRACT FROM AUTHOR]

The questionnaire survey and the study of 1334 people living in the north of the European part of the Russian Federation, of which 970 are women and 364 are men, was conducted. 707 residents of the Arkhangelsk region and 627 residents of the Nenets Autonomous Okrug. The results of the questionnaire were analyzed depending on the appetite state (decreased -102 respondents, increased - 276, normal appetite – 1096, as well as dietary compliance – 124 and adherence to vegetarianism – 139). The most pronounced combined defects of immune protection (deficiency of phagocytic protection, deficiency of the content of natural killers and T-helpers) occur in people who have been eating mainly cereals and bread for a long time. Increased appetite in people over 55 years of age is associated with the frequency of chronic diseases of the gastrointestinal tract (35.7%) and increased tolerance to food antigens (52.3%). [ABSTRACT FROM AUTHOR]

A good appearance of food increases appetite. A new food product called iEat® resembles the appearance and softness of familiar foods. Previous studies have reported that iEat® foods increase appetite. However, the neuronal substrates underlying the increase in appetite following the observation of iEat® foods remain unknown. In the present study, the brain activity of 20 healthy adults during the visual presentation of iEat® and pureed foods and non-food objects was examined using functional magnetic resonance imaging. Compared with pureed foods and non-food objects, iEat® foods showed significantly greater activation in regions of the brain reward system, such as the amygdala, ventral striatum and orbital frontal cortex. In addition, individual differences in the activity of the left amygdala were positively correlated with subjective appetite ratings. These results suggest that the good appearance of foods, such as iEat® foods, may be useful for stimulating the appetite of patients with poor appetite. [ABSTRACT FROM AUTHOR]

The purpose of the present study was to examine the effect of capsiate supplementation on energy intake, self-reported appetite-related sensations, energy expenditure, fat oxidation, and autonomic parameters with and without an exercise intervention. Thirteen healthy men completed four randomized trials: two trials for the control condition (without exercise), one with capsiate supplementation (CTRLcap) and one with a placebo (CTRLpla), and two trials for the exercise condition, one with capsiate supplementation (EXcap) and one with placebo (EXpla). Exercise sessions were performed 150 min after the consumption of a standardized breakfast, and supplementation 115 min after consumption of breakfast. An ad libitum buffet was offered 200 min following the completion of the standardized breakfast, and energy intake (EI) and relative energy intake (REI) (relative energy intake = energy intake - energy expenditure related to exercise) were evaluated. There were no significant effects on EI, self-reported appetite sensations, fat oxidation, and energy expenditure. REI was reduced in conditions involving EX when compared to CTRL. A low-frequency to high-frequency ratio for heart rate variability was higher in CTRLcap (1.6 ± 1.1) vs. CTRLpla (1.2 ± 0.9) (p = 0.025; d = 0.39). Acute capsiate supplementation combined with aerobic exercise has limited effects on the examined variables (EI, REI, fat oxidation, energy expenditure, and autonomic parameters), while changes in the autonomic nervous system function in the absence of exercise may have occurred without influencing other variables. ensaiosclinicos.gov.br number, RBR-5pckyr [ABSTRACT FROM AUTHOR]

Objective: In the United States, 26,534 young women (≤45 years) were diagnosed with breast cancer in 2017. Young African American (AA) women have higher incidence and mortality rates than Whites and Hispanics. Yet, few published studies describe survivorship (life after breast cancer diagnosis) experiences among this group. Here, we explore the lived experience of young AA breast cancer survivorship (via quality of life [QOL]). Design: This phenomenological study was framed by the QOL Applied to Breast Cancer model. Fifteen young AA survivors from the Southern U. S. participated in two semi-structured interviews. Methods of transcendental phenomenology were used for data collection and analysis. Results: Five themes emerged from participants' (mean age = 35 years; survivorship = 4 years) descriptions of survivorship experience: (1) actively managing spiritual self, (2) actively managing physical self, (3) actively managing psychological self, (4) actively managing social self, and (5) seeking survivorship knowledge. Participants perceived survivorship as a labile 'new normal' and 'ongoing struggle,' in which spirituality and survivorship knowledge were key to restructuring their lives. Conclusions: Survivorship among young AA survivors was more fluid and complex than the QOL model explained. Findings describe young AA breast cancer survivorship and indicate areas of potential strengths and distress. Healthcare providers and ancillary staff must exercise cultural competence to assess and anticipate young AA survivors' needs and concerns. Implementing targeted survivorship interventions, accounting for cultural contexts (e.g. high spirituality) and need for age-specific survivorship information, may improve QOL among young AA survivors. [ABSTRACT FROM AUTHOR]

Melatonin is a hormone involved in appetite regulation and food intake. Circadian chronorrupture caused by its absence has been associated with excessive food consumption, and there is evidence that exogenous melatonin supplementation can restore homeostasis. Therefore, the aim of this systematic review was to synthesize evidence from randomized controlled clinical and preclinical trials that evaluated the effects of exogenous melatonin supplementation on eating habits and appetite-regulating hormones. The protocol was registered in PROSPERO (number 42020175809). Medline, Scopus, Web of Science and Cochrane Library were systematically searched from January 2020 to February 2021. Of 3.695 articles identified, 2 clinical and 13 preclinical trials (n = 15) met the inclusion criteria. The outcomes were total food intake, calories, macronutrients, cholesterol intake, leptin and ghrelin levels. Interventions ranged from 28 to 336 days and dose of melatonin varied between 0.2 µg/mL of drinking water and 10 mg/day. Clinical trials were conducted with healthy adults, and preclinical trials with rodents and dogs. Of the 15 articles, five assessed food intake and leptin, four assessed food intake only, five assessed leptin only, and one assessed leptin and ghrelin serum levels. The majority of the articles were judged as having low risk of bias. Although findings are heterogeneous and do not allow a robust conclusion, this review adds to the growing body of evidence suggesting that exogenous melatonin may be a potential therapeutic agent against endocrine-metabolic disorders. This reversal is not necessarily associated with changes in food consumption, signaling that melatonin's metabolic effects may occur independently of energy intake. Further studies, especially with humans, are needed provide more evidences for melatonin supplementation in clinical practice, as well as to understand its role on eating habits and appetite-regulating hormones. [ABSTRACT FROM AUTHOR]

The purpose of this study was to reveal the relationship between new fasting hormone asprosin, obesity, and acute–chronic exercise. The prisma guidelines were followed in forming the methodological model of this review. The articles between 2016 and 2020 (including March) were identified by scanning Google Scholar, Pub Med, and Science Direct databases. Thirty-five articles were defined from 188 articles. Three cross-sectional, and 1 prospective cohort design studies in adults, and 3 cross-sectional studies in children were found. Three randomised-control group designed studies which examined the effect of acute exercise on serum asprosin levels in obese individuals. Asprosin may be a new therapeutic biomarker to be considered in the development, but long-term and deep-rooted researches are needed, and increasing the number of studies examining the effect of exercise on asprosin in the future might help us to identify the mechanisms underlying the decrease or increase in asprosin after exercise. [ABSTRACT FROM AUTHOR]

The insula has long been among the least understood regions of the human brain, in part due to its restricted accessibility. Mounting evidence suggests that the insula is a prominent player in gustatory, interoceptive, and emotional processing, and likely integrates these different functions to contribute to the homeostatic control of food intake. Here we report the case of a young adult patient who lost the subjective experience of hunger following an ischemic stroke localized in the posterior left insula. The loss of hunger was not attributable to medication, substance use, or a clinical disorder, and lasted for a period of 15 months. In line with the role attributed to the insula in gustation and interoception, we suggest that the insula integrates information about taste, interoception, and the hedonic value of food in the service of homeostatic regulation. [ABSTRACT FROM AUTHOR]

Thylakoids, as the most abundant membranes on earth, are a part of the chloroplast and exist in all green plant cells. Recently, several studies have investigated the effects of thylakoid on obesity and overweight-related aspects. Therefore, the purpose of this study was to systematically review the current knowledge and related researches to evaluate the effect of thylakoid intake on obesity and its related conditions management. PubMed, SCOPUS, Google Scholar, Embase, and ProQuest databases updated until November 2019 were searched using definite keywords and without time limitation for publications. All English language original articles (in vitro, experimental, and human studies) that investigated the effects of thylakoid on obesity-related issues, including weight loss, fat mass, and appetite or food intake, were considered. Suppressed hunger motivation, reduced food intake, and weight loss were major findings of these studies. According to these studies, the proposed beneficial properties of thylakoids were increased secretion of satiety hormones, reduced intestinal fat absorption, inhibited lipase/colipase activity, improved intestinal barrier function, modulated the gut microbiota, and probable anti-inflammatory and anti-oxidative effects. Albeit current evidence supports the use of thylakoid as a complementary treatment in obesity; however, further long-term trials are required before definitive health claims can be made. Abbreviations: 5-HT: Serotonin; BMI: Body Mass Index; CCK: Cholecystokinin, Cpt1a: Carnitine palmitoyl transferase1a; CVD: Cardiovascular disease; DGDGs: Digalactosyldiacylglycerols; Fat/Cd36: fatty acid translocase; FDA: United States Food and Drug Administration; GI: Gastrointestinal, GLP-1: Glucagon-like peptide-1; Hmgcs2: 3-hydroxy-3-methylglutaryl-CoA synthase 2; HFD: High-fat diet; LPS: Lipopolysaccharide; MGDGs: Monogalactosyl diacylglycerols; OGTT: Oral glucose tolerance test; OFTT: Oral fat tolerance/loading tests; PPARγ: Peroxisome proliferator-activated receptor-gamma; PYY: Peptide YY; RCTs: Randomized control trials; SOD: Superoxide dismutase; TCA cycle: Tricarboxylic acid cycle; TNF-alpha: Tumor necrosis factor; VAS:Visual analog scale [ABSTRACT FROM AUTHOR]

In recent years, obesity has become a global public health issue. It is closely associated with the occurrence of several chronic diseases, such as diabetes and cardiovascular diseases. Some edible and medicinal plants show anti-obesity activity, such as fruits, vegetables, spices, legumes, edible flowers, mushrooms, and medicinal plants. Numerous studies have indicated that these plants are potential candidates for the prevention and management of obesity. The major anti-obesity mechanisms of plants include suppressing appetite, reducing the absorption of lipids and carbohydrates, inhibiting adipogenesis and lipogenesis, regulating lipid metabolism, increasing energy expenditure, regulating gut microbiota, and improving obesity-related inflammation. In this review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products. Further studies should focus on the exploration of safer plants with anti-obesity activity and the identification of specific anti-obesity mechanisms. [ABSTRACT FROM AUTHOR]

The objectives of this study were to assess the nutritional status and the most commonly reported nutrition-related factors contributing to nutritional risk in people living with HIV/AIDS (PLWHA) in Ghana and the specificity and sensitivity of the Rapid Nutrition Screening for HIV disease tool (RNS-H) in this population. A cross-sectional design was utilised. Patients were screened for nutritional status during a one-week period by clinic nurses using the RNS-H. Results were compared with a comprehensive nutritional assessment by a dietitian. The research was conducted in a public health clinic at the University of Ghana Hospital, Legon. Patients receiving care at the clinic were asked to participate. The nutritional screening and nutritional assessment both resulted in participants being assigned to one of three nutritional statuses: 'low risk', 'at risk' and 'high risk'. The association between the nutritional screening and nutritional assessment was measured. The results of the nutritional status assigned by the RNS-H and nutritional assessment were compared. A total of 51 patients participated. A high prevalence of nutritional risk based on the RNS-S (54.9%) was found with 33.3% of the sample being malnourished. The most common nutrition-related complications were food insecurity, poor appetite, weight loss and diarrhoea. The RNS-H was found to have a strong specificity and sensitivity in a sample of Ghanaian PLWHA. Because of the nutritional risk and complexity of HIV in Ghana, nutritional screening using the RNS-H and nutrition care by a dietitian should be a standard of care. [ABSTRACT FROM AUTHOR]

Supplemental Nutrition Assistance Program (SNAP) participation has been associated with obesity in women. The objective of this pilot study was to describe the caloric intake and dietary quality at the beginning, middle, and end of a SNAP cycle among food insecure, African-American female head-of-households with overweight/obesity (n = 12). The feasibility of obtaining appetite-regulating hormones to assess the associations between appetite regulation and caloric intake was explored as a secondary aim. Mean caloric intake and dietary quality, as measured by HEI-2010 score, did not differ among study visits. Four patterns of caloric intake among the twelve subjects were reported in which all subjects reported caloric intake less than their daily requirements for weight maintenance. Appetite-stimulating hormone, neuropeptide Y concentrations, was positively associated with percent of Estimated Energy Requirements (%EER) consumed. [ABSTRACT FROM AUTHOR]

Research has indicated that consuming medium-chain triglycerides (MCT) may be more satiating than consuming long-chain triglycerides (LCT) potentially causing a reduction in energy intake. However not all studies have demonstrated this acute reduction in energy intake and it has yet to be systematically reviewed. Our main objective was to examine how ingestion of MCT influences energy intake, subjective appetite ratings and appetite-related hormones compared to LCT. Web of Science, MEDLINE, CINHAL, and Embase were searched for publications comparing the effect of MCT on appetite (commonly hunger, fullness, desire to eat, and prospective food consumption), appetite-related hormones (pancreatic polypeptide (PP), gastric inhibitory polypeptide (GIP), peptide YY (PYY), glucagon-like peptide-1 (GLP-1), neurotensin, leptin, total ghrelin and active ghrelin) and energy intake to LCT. A random-effects meta-analysis was conducted on studies which examined energy intake. Seventeen studies (291 participants) were included in the systematic review, of which 11 were included in the energy intake meta-analysis. Synthesis of combined data showed evidence of a statistically significant moderate decrease in ad libitum energy intake after both acute and chronic ingestion of MCT compared to LCT when assessed under laboratory conditions (mean effect size: −0.444, 95% CI −0.808, −0.080, p < 0.017), despite little evidence of any effect of MCT on subjective appetite ratings or circulating hormones. The current evidence supports the notion that MCT decreases subsequent energy intake, but does not appear to affect appetite. Further research is warranted to elucidate the mechanisms by which MCT reduce energy intake. [ABSTRACT FROM AUTHOR]

Smoothies are a popular breakfast option. However, liquids may evoke weaker satiation than nutritionally comparable semi-solid and solid foods. This study examined consumption of cereal and milk (CM) or a nutritionally comparable fruit smoothie (FS) for breakfast on subsequent dietary behaviours, in a controlled laboratory setting. Twenty-five participants (age 25 ± 6 y) completed three trials, receiving either CM or FS for breakfast. Afterwards, participants remained isolated for 4 h with ad libitum access to foods/beverages. A repeat trial (CM or FS) allowed exploration of normal variability. Post-breakfast energy intake (EI) (CM = 1465(2436) vs. FS = 1787(3190) kJ, Median (IQR), p = 0.099), time to intake of next food/fluid (meal latency) (CM = 146(97) vs. FS = 180(100) min, p = 0.127), and subjective hunger, desire to eat, fullness and thirst ratings were similar between conditions (p's > 0.05). The mean coefficient of variation for EI and meal latency were 41% and 21%, respectively. Consumption of a FS does not negatively impact acute EI and meal latency. [ABSTRACT FROM AUTHOR]

Studies have shown the effects of chocolate-based products on appetite-related indicators; however, the results of these studies are equivocal. Thus, the aim of the present study was to conduct a systematic review of studies investigating the acute and long-term response of appetite-related hormones to chocolate intake in adults. A systematic search of MEDLINE and EMBASE for published studies, in English, was performed from inception up to November 2018. It appears that ghrelin and leptin are not responsible for the satiating effect of chocolate products. Gastric infusion of milk chocolate elicited a greater increase in cholecystokinin (CCK), in comparison with oral ingestion of milk chocolate and gastric infusion of non-caloric products. Moreover, viscosity seems to have no effect on active CCK and glucagon-like peptide-1. Due to the heterogeneity between studies, limited sample, low quality of evidence, and substantial variation in methods and chocolate products, caution is suggested in interpreting these results. [ABSTRACT FROM AUTHOR]

Purpose: Rehabilitation is commonly portrayed as care that seeks to enable persons who are disabled to recover as normal a state of well-being as their personal and social circumstances allow. In contrast, this article frames psychological preconditions for persons living with disabilities to flourish toward, around or even beyond recovery through health care provision before, during or after injury. Method: This conceptual article uses reasoning and creative word play, informed by experience and literature from disciplines including psychology and philosophy. Results: Ultrabilitation promotes seven psychological preconditions of flourishing by persons with disabilities. These interconnected conditions are: apprehension; appetite; "attitude"; ambiguity; autonomy; accountability and ambiopia. Conclusions: Clinicians could partner with persons living with disabilities to promote these mental preconditions for flourishing, and use ultrabilitation to resist potentially destabilizing forces such as social imperatives to recovery and normalcy. Clinicians can support persons with disabilities to optimize mental states that enable them to flourish in everyday life. Apprehension, including awareness of and anxiety about disability and its management, can motivate persons to assent to capabilities to flourish. Apprehension and ambiguity can feed an appetite for personal growth and an attitude that trusts in genuine possibilities for growth through autonomy and accountability. Autonomy frees persons to accept what they cannot change; set and implement challenging but achievable goals in creative ways; and learn to lose control without viewing disability as something that they need to get beyond in order to flourish. [ABSTRACT FROM AUTHOR]

The influence of HFCS (high fructose corn syrup – free fructose) and sucrose (bound fructose) on fetal appetite signals is unknown. This study aimed to determine the effects of HFCS or sucrose on the peptide-mediated appetite regulation in fetal programming of obesity. Sprague Dawley female rats were administered feed and plain water (control) or water containing maltodextrin (vehicle), sucrose, fructose, or HFCS (20%, w/v) for 12 weeks before mating and throughout pregnancy and lactation (ndams = 31; npups = 207). Maternal chow-feed consumption in the HFCS and sucrose groups and sugar-added drink consumption in the HFCS group were higher compared to the vehicle and control groups (P < 0.05). The total body fat accumulated in sucrose, fructose, and HFCS groups in dams and pups was higher than those in the vehicle and control groups (P < 0.05). The HFCS groups showed lower plasma leptin levels and higher ghrelin levels. Soluble CD36 levels in plasma and tongue samples were high in HFCS groups of dams and pups (P < 0.05). Rather than bound fructose, the free fructose from the maternal diet contributes to the programming of obesity through the disruption of leptin, ghrelin, and CD36 expression involved in appetite regulation. [ABSTRACT FROM AUTHOR]

A scientific workshop held in the UK explored the potential contribution of traditional dried fruits to public health, identified gaps in the evidence and addressed priorities for research. Presentations considered the categorisation and composition of dried fruits; dried fruit and gastrointestinal health; the polyphenol content of dried fruits and their potential contribution to health; dried fruit and appetite in relation to the psychology of snacking and obesity; dried fruit and dental health including its role as a snack; and conflicts in public health advice for dried fruits. A round table discussion explored the contribution of dried fruit to "five a day" fruit and vegetable intake and fibre intake, whether dried fruits have equivalence with fresh in terms of dietary advice, advice on snacking in relation to dental health and appetite control, informing the public about different types of dried fruits and avoiding consumer confusion, and future research requirements. [ABSTRACT FROM AUTHOR]

The article reports on the perinatal depression, complications during pregnancy. Topics include minor and major symptoms of depression during pregnancy and the first year after childbirth; focus of mental health literacy on individual knowledge, beliefs, and attitudes concerns mental health conditions that facilitate recognition, treatment, and management; and explores the knowledge and perceptions of pregnant and postpartum Mexican-American adolescent concerns perinatal depression.

Introduction: Fat-free mass, of which skeletal muscle is amajor component, correlates positively with energy intake at energy balance. This is due to the effects of metabolically active tissue on energy expenditure which in itself appears to signal to the brain adrive to eat to ensure cellular energy homeostasis. The mechanisms responsible for this drive to eat are unknown but are likely to be related to energy utilization. Here muscle imparts an indirect influence on hunger. The drive to eat is also enhanced after muscle loss secondary to intentional weight loss. The evidence suggests loss of both fat mass and skeletal muscle mass directly influences the trajectory and magnitude of weight regain highlighting their potential role in long-termappetite control. The mechanisms responsible for the potential direct drive to eat stemming from muscle loss are unknown. Areas covered: The literature pertaining to muscle and appetite at energy balance and after weight loss was examined. Aliterature search was conducted to identify studies related to appetite, muscle, exercise, and weight loss. Expert opinion: Understanding the mechanisms which link energy expenditure and muscle loss to hunger has the potential to positively impact both the prevention and the treatment of obesity. [ABSTRACT FROM AUTHOR]

Background: Many people receiving treatment for addiction gain an excessive amount of weight during early recovery. We outline two hypothesized mechanisms that might explain weight gain: The Addiction Transfer Hypothesis, which suggests that some individuals respond to cravings with non-nutritive eating behavior, and the Propensity for Behavioral Addiction Hypothesis, which suggests that some people are at higher risk for addiction, and that excess weight gain results from a rebound of appetitive processes that were temporarily suppressed during active addiction. Method: We evaluate the extent of support for these alternative hypotheses using repeated measures of cravings and eating behavior collected in real time using a combination of ecological momentary assessment methodology and interviewer-based 24-hour dietary recall. Participants included N = 111 individuals receiving treatment for substance use disorder who were currently abstaining from use, but who had used their primary treatment substance within the past 12 months. Results: Using linear mixed models to test the temporal effects of cravings on subsequent eating behaviors hypothesized by the Addiction Transfer Hypothesis and generalized linear models to evaluate the effect of a common propensity for behavioral addiction factor on eating behaviors (a test of the Propensity for Behavioral Addiction Hypothesis), we find no evidence to support the Addiction Transfer Hypothesis, but we find modest support for the Propensity for Behavioral Addiction Hypothesis. Findings do not account for appetitive effects of psychotropic medications. Conclusions: General nutrition education and encouragement of health eating behaviors may be useful for reducing excessive weight gain among people recovering from substance dependence. [ABSTRACT FROM AUTHOR]

Public Chef Intellectuals use restaurants as a topos to advocate for a more humane and sustainable food culture. They direct appetite both in the sense of creating delicious food and in the sense of articulating food politics. In a rhetorical analysis of Dan Barber's experimental 2015 pop-up wastED, we find he employed three topoi in his rhetorical strategy to induce appetite: a glossary that situates his project within the context of our food system, a design that drew attention to the often-invisible nature of waste, and a plate that subverted expectations. These rhetorical places became material, interlocking arguments to help diners develop an appetite for what we now label as waste. wastED allowed Barber to create a space to reflect on what separates food from waste, prompting debate. [ABSTRACT FROM AUTHOR]

The effects of 15 d polydextrose (16.7 g) consumption on energy intake (EI) and appetite feelings were investigated. Overweight adults consumed a polydextrose-bar or a control-bar matched in energy content as a midmorning snack for 15 consecutive days in a single-blind, randomised, crossover design. The two 15-d intervention periods were separated by a 15-d washout period. On the day 1 and the day 15 of each intervention period, energy intake (primary outcome) and appetite feelings (secondary outcome) were assessed. There were not significant main effects of the day, type of bar, or their interaction for EI (at lunchtime test meal, at rest of the day, or at total daily) or subjective feelings (hunger, desire to eat, fullness, and prospective food consumption) during the satiation and satiety periods. The results showed the consumption of polydextrose-bar during 15 d did not significantly affect energy intake and subjective feelings of appetite in overweight adults. [ABSTRACT FROM AUTHOR]

Three studies investigated whether thoughts and feelings generated by baby animals might oppose appetite for meat. A prestudy established babyness as an important factor predicting moral concern for farmed animals. Study 1 showed that presenting images of baby animals, versus adult animals, as the source of meat reduced appetite for meat, but this effect was weak and found exclusively among women. Study 2 replicated and extended study 1 using a larger sample and two new animal sources. Study 3 included a no animal comparison condition, and found greatest levels of reduced appetite for meat when the meat source was presented as a baby animal, as opposed to an adult animal or with no visual indication of the animal source. A meta-analysis of the results using Bayes factors revealed considerable cumulative evidence in favor of the hypothesis that images of baby animals temporarily reduce women's appetite for meat. In contrast, the evidence for men was less strong. Our results highlight a tension within some omnivores between caring for baby animals and appetite for meat. [ABSTRACT FROM AUTHOR]

Background: Underage alcohol use and depression remain public health concerns for Hispanic adolescents nationwide. Objectives: The study purpose was to identify the profiles of depression among Hispanic adolescents who reported experiencing depressive symptoms in their lifetime and classify them into groups based on their symptoms. Based on classifications, we examined the relationship between past year alcohol use and severity of depressive symptoms while controlling for sex and age. Methods: A secondary analysis of the 2013 NSDUH was conducted among Hispanic adolescents from 12 to 17 years of age (n = 585) who reported experiencing depressive symptoms. Latent class analysis was used to identify latent classes of depressive symptoms among Hispanic adolescents. A zero-inflated negative-binomial regression model was used to examine the relationship between alcohol use and depressive symptoms. Results: “High depressive” and “moderate depressive” classes were formed. The items that highly differentiated among the groups were felt worthless nearly every day, others noticed they were restless or lethargic, and had changes in appetite or weight. There was a significant difference (p = 0.03) between the classes based on alcohol use; those in the moderate depressive class were 1.71 times more likely to be identified as not reporting past alcohol use. Results indicated the high depressive class was estimated to have 1.62 more days of past year alcohol use than those in the moderate depressive class for adolescents who used alcohol (p < 0.001). Conclusions/Importance: Study findings can be used to address these significant public health issues impacting Hispanic adolescents. Recommendations are included. [ABSTRACT FROM AUTHOR]

Using a randomised cross-over design, free-living lunch intake and subjective appetite were examined in 10 children (9.8 ± 0.6 years) following high-intensity interval training (HIIT) versus a control sedentary (SED) period, within a school setting. The 22-min HIIT took place during a regular PE lesson and consisted of two rounds of 4 × 30 s sprints. Foods were offered at a regular school lunch immediately following HIIT and SED and were matched between conditions. All food was covertly weighed before and after the meal. Hunger, fullness and prospective consumption were reported immediately before and after HIIT/SED, using visual analogue scales. Heart rate was higher during HIIT than SED (159.3 ± 23.1 vs. 76.9 ± 2.2 bpm,P < 0.05). Lunch energy intake was not different (P = 0.52) following HIIT, compared to SED (2.06 ± 0.35 vs. 2.09 ± 0.29 MJ, respectively). There were no significant differences in macronutrient intake or subjective appetite (P > 0.05). Results suggest that HIIT can be implemented in a PE lesson immediately before lunch, without causing a compensatory increase in food consumption. [ABSTRACT FROM PUBLISHER]

Young residents of the European North of Russia with normal body weight (n = 66) were divided into three groups, SJL ≤ 1 h, 1 < SJL ≤ 2 h, and SJL > 2 h, using the Munich ChronoType Questionnaire. Participants consumed a breakfast consisting of pizzaad libitumand rated their appetite sensations using visual analog scales. Participants in three SJL groups consumed the same amount of thead libitummeal and reported similar levels of satiety and fullness right after food intake (intra-meal satiation). However, participants with SJL > 2 h were found to feel significantly hungrier in comparison with participants with SJL ≤ 1 h. In addition, participants with SJL > 2 h reported a diminished satisfaction with food consumption (inter-meal satiety) during 120 min after test breakfast. Thus, the study demonstrates that SJL appears to be associated with disturbance of appetite regulation in young northerners with normal body weight. [ABSTRACT FROM PUBLISHER]

Coffee and caffeine consumption has global popularity. However, evidence for the potential of these dietary constituents to influence energy intake, gut physiology, and appetite perceptions remains unclear. The purpose of this review was to examine the evidence regarding coffee and caffeine's influence on energy intake and appetite control. The literature was examined for studies that assessed the effects of caffeine and coffee on energy intake, gastric emptying, appetite-related hormones, and perceptual measures of appetite. The literature review indicated that coffee administered 3-4.5 h before a meal had minimal influence on food and macronutrient intake, while caffeine ingested 0.5-4 h before a meal may suppress acute energy intake. Evidence regarding the influence of caffeine and coffee on gastric emptying, appetite hormones, and appetite perceptions was equivocal. The influence of covariates such as genetics of caffeine metabolism and bitter taste phenotype remain unknown; longer controlled studies are needed. [ABSTRACT FROM AUTHOR]

Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review regarding the timing of macronutrients in reference to healthy, exercising adults and in particular highly trained individuals on exercise performance and body composition. The following points summarize the position of the ISSN: Nutrient timing incorporates the use of methodical planning and eating of whole foods, fortified foods and dietary supplements. The timing of energy intake and the ratio of certain ingested macronutrients may enhance recovery and tissue repair, augment muscle protein synthesis (MPS), and improve mood states following high-volume or intense exercise. Endogenous glycogen stores are maximized by following a high-carbohydrate diet (8–12 g of carbohydrate/kg/day [g/kg/day]); moreover, these stores are depleted most by high volume exercise. If rapid restoration of glycogen is required (< 4 h of recovery time) then the following strategies should be considered: aggressive carbohydrate refeeding (1.2 g/kg/h) with a preference towards carbohydrate sources that have a high (> 70) glycemic index the addition of caffeine (3–8 mg/kg) combining carbohydrates (0.8 g/kg/h) with protein (0.2–0.4 g/kg/h) Extended (> 60 min) bouts of high intensity (> 70% VO2max) exercise challenge fuel supply and fluid regulation, thus carbohydrate should be consumed at a rate of ~30–60 g of carbohydrate/h in a 6–8% carbohydrate-electrolyte solution (6–12 fluid ounces) every 10–15 min throughout the entire exercise bout, particularly in those exercise bouts that span beyond 70 min. When carbohydrate delivery is inadequate, adding protein may help increase performance, ameliorate muscle damage, promote euglycemia and facilitate glycogen re-synthesis. Carbohydrate ingestion throughout resistance exercise (e.g., 3–6 sets of 8–12 repetition maximum [RM] using multiple exercises targeting all major muscle groups) has been shown to promote euglycemia and higher glycogen stores. Consuming carbohydrate solely or in combination with protein during resistance exercise increases muscle glycogen stores, ameliorates muscle damage, and facilitates greater acute and chronic training adaptations. Meeting the total daily intake of protein, preferably with evenly spaced protein feedings (approximately every 3 h during the day), should be viewed as a primary area of emphasis for exercising individuals. Ingestion of essential amino acids (EAA; approximately 10 g)either in free form or as part of a protein bolus of approximately 20–40 g has been shown to maximally stimulate muscle protein synthesis (MPS). Pre- and/or post-exercise nutritional interventions (carbohydrate + protein or protein alone) may operate as an effective strategy to support increases in strength and improvements in body composition. However, the size and timing of a pre-exercise meal may impact the extent to which post-exercise protein feeding is required. Post-exercise ingestion (immediately to 2-h post) of high-quality protein sources stimulates robust increases in MPS. In non-exercising scenarios, changing the frequency of meals has shown limited impact on weight loss and body composition, with stronger evidence to indicate meal frequency can favorably improve appetite and satiety. More research is needed to determine the influence of combining an exercise program with altered meal frequencies on weight loss and body composition with preliminary research indicating a potential benefit. Ingesting a 20–40 g protein dose (0.25–0.40 g/kg body mass/dose) of a high-quality source every three to 4 h appears to most favorably affect MPS rates when compared to other dietary patterns and is associated with improved body composition and performance outcomes. Consuming casein protein (~ 30–40 g) prior to sleep can acutely increase MPS and metabolic rate throughout the night without influencing lipolysis. [ABSTRACT FROM AUTHOR]

The inclusion of different ingredients or the use of different baking technologies may modify the satiety response to bread, and aid in the control of food intake. The aim of this study was to perform a systematic search of randomized clinical trials on the effect of bread consumption on appetite ratings in humans. The search equation was (“Bread”[MeSH]) AND (“Satiation”[MeSH] OR “Satiety response”[MeSH]), and the filter “clinical trials.” As a result of this procedure, 37 publications were selected. The satiety response was considered as the primary outcome. The studies were classified as follows: breads differing in their flour composition, breads differing in ingredients other than flours, breads with added organic acids, or breads made using different baking technologies. In addition, we have revised the data related to the influence of bread on glycemic index, insulinemic index and postprandial gastrointestinal hormones responses. The inclusion of appropriate ingredients such as fiber, proteins, legumes, seaweeds and acids into breads and the use of specific technologies may result in the development of healthier breads that increase satiety and satiation, which may aid in the control of weight gain and benefit postprandial glycemia. However, more well-designed randomized control trials are required to reach final conclusions. [ABSTRACT FROM PUBLISHER]

Impulsiveness is the tendency to shift preference from a better, later option to a poorer, earlier option as the two get closer. Explanations have extrapolated from five piecemeal elements of psychology – failure of cognitive rationality, Pavlovian conditioning, force of habit, incentive salience, and long chains of secondary reward – but in doing so have created models that stretch the properties of these elements as observed in the laboratory. The models are hard to integrate with each other, much less with the utility-maximizing structure of microeconomics. The increasing prominence of addictions, particularly addictions that do not involve a substance, have confronted behavioral science with these shortcomings. I suggest that the roles of all five phenomena follow from the hyperbolic discounting of expected reward: rationality can be seen as maximizing expected discounted reward as seen at a distance, which can be approximated by making choices in bundles; Pavlovian conditioning reduces to reward learning when a very short-term rewarding effect of conditioning stimuli is factored in; ‘habit’ subsumes various kinds of reward-seeking, especially that which has been narrowed by failures of self-control; incentive salience is a kind of short-term reward; self-reward is possible – and probably common – without being secondary to inborn turnkeys, limited rather by not being occasioned so often that the appetite(s) for it fail to build up. [ABSTRACT FROM AUTHOR]

Highlights from the article: The second fundamental principle for using BMI as a selection criterion for bariatric surgery is that BMI reflects body fat content. However, even if BMI was a perfect measure of body fat content, the cut-offs for defining obesity and the selection criteria for bariatric surgery are entirely arbitrary. The third fundamental principle for using BMI as a selection criterion for bariatric surgery is that "excessive adiposity" is harmful to health commensurately, and therefore underlies the co-morbidity of obesity.

Introduction: With the increasing prevalence of obesity and its associated comorbidities, strides to improve treatment strategies have enhanced our understanding of the function of the gut in the regulation of food intake. The most successful intervention for obesity to date, bariatric surgery effectively manipulates enteroendocrine physiology to enhance satiety and reduce hunger. Areascovered: In the present article, we provide a detailed overview of the physiology of enteroendocrine control of food intake, and discuss its pathophysiologic correlates and therapeutic implications in both obesity and gastrointestinal disease. Expertcommentary: Ongoing research in the field of nutrient sensing by L-cells, as well as understanding the role of the microbiome and bile acid signaling may facilitate the development of novel strategies to combat the rising population health threat associated with obesity. Further refinement of post-prandial satiety gut hormone based therapies, including the development of chimeric peptides exploiting the pleiotropic nature of the gut hormone response, and identification of novel methods of delivery may hold the key to optimization of therapeutic modulation of gut hormone physiology in obesity. [ABSTRACT FROM PUBLISHER]

Yogurt is a semisolid fermented milk product that originated centuries ago and is viewed as an essential food and important source of nutrients in the diet of humans. Over the last 30 years, overweight and obesity have become characteristic of Western and developing countries, which has led to deleterious health outcomes, including cardiovascular disease, type 2 diabetes, hypertension, and other chronic conditions. Recent epidemiological and clinical evidence suggests that yogurt is involved in the control of body weight and energy homeostasis and may play a role in reducing the risk for type 2 diabetes partly via the replacement of less healthy foods in the diet, its food matrix, the effect of specific nutrients such as calcium and protein on appetite control and glycemia, and alteration in gut microbiota. This review will discuss the specific properties that make yogurt a unique food among the dairy products, epidemiological and clinical evidence supporting yogurt's role in body weight, energy balance, and type 2 diabetes, including its potential mechanisms of action and gaps that need to be explored. Key teaching points • Several epidemiological and clinical studies have suggested a beneficial effect of yogurt consumption in the control of body weight and energy homeostasis, although this remains controversial. • Yogurt possesses unique properties, including its nutritional composition; lactic acid bacteria, which may affect gut microbiota; and food matrix, which may have a potential role in appetite and glycemic control. • Potential mechanisms of action of yogurt include an increase in body fat loss, decrease in food intake and increase in satiety, decrease in glycemic and insulin response, altered gut hormone response, replacement of less healthy foods, and altered gut microbiota. • The relative energy and nutrient content and contribution of a standard portion of yogurt to the overall diet suggest that the percentage daily intake of these nutrients largely contributes to nutrient requirements and provides a strong contribution to the regulation of energy metabolism. [ABSTRACT FROM AUTHOR]

Objective: A variety of potato dishes are regularly consumed worldwide, but the satiety value of these foods is not well established. The primary objective of this study was to compare the satiating effects of 4 equi-energy meals containing different potato preparations with an equi-energy pasta control meal.Methods: This study used a randomized crossover design to assess the impact of 4 equi-energy potato-based meals (fried French fries, baked potato, mashed potato, or potato wedges) on subjective satiety sensations (visual analogue scale [VAS] ratings) and subsequent energy intake (ad libitum meal [kcal]), compared to a control pasta-based meal. Thirty-three healthy nonobese men and women participated in the study.Results: VAS ratings indicated that the meal containing fried french fries was perceived to be substantially more satiating than the equi-energy pasta control meal, with all other potato-based meals not differing overall from control. All test meals had a comparable effect on energy intake at a later ad libitum meal.Conclusions: Consumers reported higher levels of satiety following a meal where the principal carbohydrate source was fried french fries, compared to when they had consumed an energy-matched meal containing carbohydrate in the form of pasta. All other potato preparations had similar effects on satiety as pasta. It is concluded that participants perceived a meal with fried french fries as providing greater satiety than a pasta control meal. [ABSTRACT FROM AUTHOR]

Purpose: Anorexia is prevalent in cancer patients with advanced disease. In this pilot phase II, open label, nonrandomized trial, we evaluated the efficacy and safety of guarana (Paullinia cupana) in patients with cancer and weight loss. Methods: We included advanced cancer patients with decreased appetite and weight loss of more than 5% from their baseline. All of the patients received 50 mg of the crude dry extract of guarana twice a day for 4 weeks. The trial was designed in two phases (Simon model). We considered a positive response in the first phase to be at least 5% weight gain or a three-point improvement in the appetite scale in at least three of the first 18 evaluable patients. Results: Of the 34 eligible patients, 30 were included and 18 completed the protocol. Only one patient abandoned the protocol due to toxicity (grade II arthralgia). No grade 3 or 4 toxicities and no significant differences in nausea, weight loss, or quality of life (FACT-G) occurred. Only two of the 18 patients who completed the study had weight gain above 5% from their baseline, whereas six patients had at least a 3-point improvement in the visual appetite scale. The M.D. Anderson Symptom Inventory (MDASI) was used to evaluate several symptoms, and we observed a significant decrease in the lack of appetite (p = 0.02) and in somnolence (p = 0.0142). Conclusion: We concluded that the weight stabilization and increased appetite that we observed in this study justify further studies of guarana in this patient population. [ABSTRACT FROM AUTHOR]

Essence of chicken (EOC) beverage is a chicken meat extract, widely consumed in Asian countries for health benefits. EOC is a rich source of peptides and amino acids. White bread has become a popular staple food in all regions of Southeast Asia. A randomized controlled, crossover, non-blind trial was performed to investigate the role of EOC on glycaemic response (GR) of white bread. Ten healthy young subjects returned on five separate days for three glucose and two bread sessions. Subjects consumed bread or bread with EOC. The 120 min incremental area under the curve was significantly lower after consuming two bottles of EOC with bread than white bread alone. The glycaemic index (GI) of white bread was 83 and white bread with EOC 57. The co-ingestion of EOC may be a practical and simple way to reduce the GR of bread and other starch-based staples. [ABSTRACT FROM PUBLISHER]