264 results on '"COBALT TOXICITY"'
Search Results
2. Spray of Stress Protective Chemicals Alleviates Cobalt Toxicity on Growth, Water and Nutrients Status of Hybrid Maize (Zea mays L.).
- Author
-
Nazir, A. and Wahid, A.
- Subjects
- *
CORN , *POISONS , *COBALT , *INDUSTRIAL wastes , *AGRICULTURE , *SALICYLIC acid - Abstract
Frequent discharge of cobalt in ionic form (Co2+) during industrial processes is contaminating agricultural soil through the addition of industrial effluent. Cobalt is beneficial element in trace amounts but its higher concentrations in soil severely damage the growth and development of plants. In this two-year study, the pre-selected sublethal level (0.5 mM) concentration of Co2+ was applied in soil to induce toxicity on two elite maize (Zea mays L.) hybrids ('Hycorn11plus' and 'P-1429'). To encounter the toxic effects of selected sub-lethal (0.5 mM) Co2+ level (applied using CoCl2·6H2O), pre-optimized levels of three stress protective chemicals (SPCs) i.e., ascorbic acid (0.5 mM), salicylic acid (0.5 mM) and thiourea (1.0 mM) were foliar sprayed. The Co2+ and SCPs treatments were applied 10 days after seedling emergence. After ten days of treatment application, the data were recorded for the growth, nutrients and leaf water status. The shoot and root dry weights and shoot-to-root (S/R) ratio were substantially reduced by the Co2+ stress. Co2+ intoxication also enhanced the leaf water loss (LWL) while relative water contents (RWC) were reduced in Co2+ stressed plants. The Co2+ treatment reduced the intake of nitrate-N, sulfate-S, phosphate-P, K+, Ca2+, Mg2+, Zn2+, and Fe2+ contents significantly both in the shoot and root. However, from the correlation matrix, it was noted that the foliar spray of SPCs effectively alleviated the Co2+damage by preventing the influx of Co2+ ions and enhanced the growth, water and nutrient contents except for LWL. From the reduced RWC and shoot and root nutrient contents, as well as increased LWL and Co2+ contents, it is evident that Co2+ interfered with either the function or structure of water and ion-transport systems located on the plasma lemma and tonoplast of root cells. AsA was more effective among the foliar applied SPCs due to its multiple metabolic roles in plants. The foliar spray of SPCs improved the root mass and tendency to absorb essential nutrients under Co2+toxicity indicating an intimate communication between shoot and root. The use of SPCs at the selected levels is a pragmatic strategy to counteract the Co2+ damage to maize in the marginally contaminated areas. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Foliar spray of stress protective chemicals alleviates cobalt toxicity by improving root antioxidant defense in maize (Zea mays).
- Author
-
Nazir, Atia and Wahid, Abdul
- Subjects
CORN ,PRINCIPAL components analysis ,PLANT metabolism ,COBALT ,POISONOUS plants ,SALICYLIC acid ,HYBRID corn - Abstract
Cobalt (Co
2+ ) is a beneficial microelement for plants but toxic to metabolism in higher amounts. This study determined the influence of sublethal Co2+ level (0.5 mM) on the growth of maize (Zea mays L.) hybrids; Hycorn 11 plus (Co2+ sensitive) and P-1429 (Co2+ tolerant) and its alleviation with foliar spray of pre-optimized levels of stress protective chemicals (SPCs), i.e., salicylic acid (SA, 0.5 mM), thiourea (TU, 1.0 mM), and ascorbic acid (AsA, 0.5 mM) applied at seedling, vegetative, and late vegetative stages. Plants were harvested at early vegetative, late vegetative, and silking stages. Co2+ stress caused a decrease in shoot and root length, dry weight, leaf area, and culm diameter, reduced the activities of enzymatic antioxidants and concentrations of AsA and soluble phenolics more in root than shoot, but P-1429 was more tolerant of Co2+ than Hycorn 11 plus. SPCs spray alleviated oxidative damage by enhancing the antioxidant activity, AsA and soluble phenolics, sulfate-S and nitrate–N contents, which were significantly increased in roots than in shoots; P-1429 displayed better response than Hycorn 11 plus. Principal component analysis and correlation matrix revealed the profound roles of SPCs spray in improving Co2+ resistance in root leading to robust growth of hybrids. AsA was highly promising in reducing Co2+ toxicity while vegetative and silking stages were more sensitive. Results revealed that after translocation to root, the foliar-applied SPCs had individualistic modes of action in mitigating Co2+ toxicity on roots. In crux, the metabolism and phloem transport of the SPCs from shoot to root are plausible mechanism for Co2+ tolerance in maize hybrids. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
4. Clinical Features, Testing, and Management of Patients with Suspected Prosthetic Hip-Associated Cobalt Toxicity: a Systematic Review of Cases.
- Author
-
Devlin, John J., Pomerleau, Adam C., Brent, Jeffrey, Morgan, Brent W., Deitchman, Scott, and Schwartz, Michael
- Subjects
- *
METAL toxicology , *COBALT , *SYSTEMATIC reviews , *ARTIFICIAL hip joints , *MEDICAL equipment , *TOXICOLOGISTS , *NEUROLOGICAL disorders - Abstract
Safety concerns regarding cobalt-containing metal alloy hip prosthetics (Co-HP) have resulted in product recalls, a medical device alert, and issuance of guidance for clinicians. Recently, cases of suspected prosthetic hip-associated cobalt toxicity (PHACT) from Co-HP have been reported. Although little is known about suspected PHACT, these patients may be referred to medical toxicologists for evaluation and management recommendations. We searched MEDLINE, EMBASE, and unpublished abstracts from toxicology scientific meetings for references relevant to PHACT. Authors independently screened publications for inclusion criteria: publication in English, human study population, subject(s) are symptomatic (except for isolated hip pain), and cobalt values in any matrix (blood, serum, urine, CSF, synovial fluid) available for review. Data from 10 cases are reviewed. Patients with suspected PHACT had findings consistent with cobalt toxicity, including thyroid, cardiac, and neurologic dysfunction. Signs and symptoms appeared between 3 and 72 months after arthroplasty (median 19 months). Neurologic symptoms were most common. Ancillary testing varied considerably. All patients had elevated cobalt levels in one or more matrices. Enhanced elimination was attempted in 27 % of patients. At this time, the information currently available regarding patients with suspected PHACT is inadequate to guide clinical decision making. No consensus has been reached regarding the management of Co-HP patients with systemic symptoms. Indications for chelation have not been established and require further study. Improved case definitions, improved surveillance, and controlled studies are needed to elucidate the scope of this problem and guide future investigations. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
5. Ellagic Acid from Terminalia arjuna Fruits Protects Against Chromium and Cobalt Toxicity in Primary Human Lymphocytes.
- Author
-
Bodiga, Vijaya Lakshmi, Vemuri, Praveen Kumar, Kudle, Madhukar Rao, and Bodiga, Sreedhar
- Abstract
Increased accumulation of heavy metal ions such as Cr
6+ and Co2+ due to release from prostheses and metallic implants has been reported. These metal ions have been shown to affect both resting and activated lymphocytes. Natural remedies towards mitigating the cytotoxic effects of metal ions are clearly warranted. Polyphenolic compounds which are part of hydrolysable tannins from natural plant sources are considered effective in cheating heavy metal ions in a biological system. We have isolated and characterized a polyphenolic compound (ellagic acid) from Terminalia arjuna fruits that has been tested for its ability to attenuate the metal ion toxicity in primary human lymphocytes in culture. Cr6+ and Co2+ (100 μM) decreased lymphocyte viability and proliferation and increased apoptosis of resting as well as CD3 and/or CD28-stimulated lymphocytes. Metal ions markedly diminished the cytokine (interleukin-2 and interferon-γ) secretion from activated lymphocytes. Pretreatment with ellagic acid at 25, 50, and 100 μM concentrations effectively improved viability and proliferative responses of both resting and activated lymphocytes, while attenuating the apoptotic index. Ellagic acid also tended to normalize the cytokine secretion from the activated lymphocytes even in the presence of metal ions, suggesting broad effects on the adaptive immune system. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
6. Prosthetic Hip-Associated Cobalt Toxicity.
- Author
-
Pizon, Anthony F., Abesamis, Michael, King, Andrew M., and Menke, Nathan
- Subjects
- *
ARTIFICIAL hip joints , *METAL toxicology , *MEDICAL literature , *COBALT in the body , *ETIOLOGY of diseases , *TOXICOLOGISTS - Abstract
Prosthetic hip-associated cobalt toxicity (PHACT) is gaining recognition due to the use of metal-on-metal total hip replacements. Identifying true toxicity from merely elevated cobalt levels can be extremely difficult due to the lack of available data. An extensive review of the medical literature was undertaken to characterize cobalt toxicity from prosthetic hips. As an objective approach to making the diagnosis of PHACT, we suggest the following criteria: (1) elevated serum or whole blood cobalt levels due to a prosthetic hip, (2) at least two test-confirmed findings consistent with cobalt toxicity, and (3) exclusion of other etiologies. Adhering to objective diagnostic data for PHACT is a realistic and prudent method by which to eliminate the subjectivity of vague or difficult to identify complaints. These diagnostic criteria are not meant to evaluate prosthetic hardware failure, but as a means to identify systemic cobalt toxicity. Finally, assessment of cobalt toxicity from prosthetic hips should be done in conjunction with a medical toxicologist. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
7. Mechanism to combat cobalt toxicity in cobalt resistant mutants of Aspergillus nidulans.
- Author
-
Tripathi, Pushplata and Srivastava, Sheela
- Abstract
Characteristics of fungal species tolerant to high levels of metals in natural environment can be amplified by isolation and selection of resistant mutants. Step-by-step culturing led to identification of highly stable Co-resistant (Co
R ) mutants of A. nidulans. Based on two distinct morphological features, Co-resistant mutants were categorized as CoR I and CoR II. The two mutants varied in their growth behavior and colony morphology that were reflected in supplemented as well as unsupplemented growth media over the generations. As compared to the CoR I, CoR II mutant exhibited sparse mycelia and conidiation but secreted higher amount of melanin. CoR mutants could tolerate up to 2.5mM Co in the medium, however, required a threshold concentration of 0.25mM Co for optimal growth and germination. Absence of Co in the medium caused a stressful situation for the CoR mutants and led to the secretion of a white extracellular precipitate found to be a glycoprotein. In response to interactions with Co-ions, CoR mutants produced oxalic acid and bioprecipitated Co as Co-oxalate providing scope for metal reclamation as well as oxalic acid extraction. The mutants could help to recover the insoluble Co-oxalate salt from aqueous solutions by entrapping it in their growing mycelial meshwork. [ABSTRACT FROM AUTHOR]- Published
- 2007
- Full Text
- View/download PDF
8. Hydroxocobalamin vs cobalt toxicity on rat cardiac and diaphragmatic muscles.
- Author
-
Péry-Man, N., Houeto, P., Coirault, C., Suard, I., Perennec, J., Riou, B., and Lecarpentier, Y.
- Abstract
Background: Hydroxocobalamin has been shown to be a rapid and powerful antidote in acute cyanide poisoning and to prevent cyanide poisoning during sodium nitroprusside administration. This cobalt-containing compound has been shown to be devoid of significant immediate side effects during acute administration. However, its potential delayed toxicity related to cobalt accumulation in tissue remains unknown. Therefore, we evaluated the toxicity of hydroxocobalamin as compared with that of cobalt salts on rat cardiac and diaphragmatic muscles. Methods: For a 21-day period, rats were treated intraperitoneally with either hydroxocobalamin (70 mgkg per day, n=14) cobalt chloride hexahydrate (12 mg kg per day, n=14) or saline ( n=10). Hydroxocobalamin and cobalt chloride groups received equimolar doses of cobalt. We studied: (1) the mechanical properties of isolated left ventricular papillary muscles and diaphragmatic strips, (2) the cardiac and diaphragmatic cobalt tissue concentrations, and (3) the myocardial histological aspect. Results: During the study period, no significant increase in body weight was noted in the cobalttreated group (−4±1%), which was in contrast to the hydroxocobalamin-treated group (+21±2%) and the saline-treated group (22±2%). Compared with controls, the mechanical properties of cardiac and diaphragmatic muscles were unchanged after either hydroxocobalamin or cobalt salt treatments, and myocardial histological characteristics were similar in all groups. Conversely, large amounts of cobalt deposit were observed in the cobalt-treated group in both the diaphragm (41.90±16.30 vs 0.70±0.40 μmol μg in the control group, P<0.001). After hydroxocobalamin administration, cobalt concentrations were significantly lower in the diaphragm (25.10±16.50 μmol μg, P<0.001 vs cobalt-treated group) and the myocardium (4.50±1.20 μmol μg, P<0.001 vs cobalt-treated group). Conclusion: These results indicate that repeated administration of hydroxocobalamin was devoid of significant diaphragmatic and cardiac muscle toxicity and therefore remains a safe antidote for acute cyanide poisoning. [ABSTRACT FROM AUTHOR]
- Published
- 1996
- Full Text
- View/download PDF
9. 'Snake eyes' MRI sign: possible role of cobalt toxicity?
- Author
-
Briani, Chiara, Cacciavillani, Mario, Nicolli, Annamaria, Trevisan, Andrea, and Gasparotti, Roberto
- Subjects
CERVICAL vertebrae radiography ,MAGNETIC resonance imaging ,MOTOR neuron diseases ,COBALT -- Physiological effect ,NEUROTOXICOLOGY ,ARTIFICIAL hip joints - Abstract
The article discusses the case of a patient with snake eyes sign in the magnetic resonance imaging (MRI) of the cervical spine. Topics discussed include the medical history of the patient, the diagnosis of lower motor neuron (LMN) syndrome of the upper limbs, and cobalt neurotoxicity which resulted from the release of cobalt from the patient's hip prosthesis.
- Published
- 2015
- Full Text
- View/download PDF
10. Modulatory Role of Curcumin on Cobalt-Induced Memory Deficit, Hippocampal Oxidative Damage, Astrocytosis, and Nrf2 Expression.
- Author
-
Oria, Rademene S., Anyanwu, Godson E., Esom, Emmanuel A., Nto, Johnson N., Katchy, Amechi U., Agu, Augustine U., and Ijomone, Omamuyovwi M.
- Subjects
CURCUMIN ,MEMORY disorders ,NUCLEAR factor E2 related factor ,GLIOSIS ,HIPPOCAMPUS (Brain) ,COBALT chloride - Abstract
Chemical overexposure is a growing environmental risk factor for many medical issues. Cobalt toxicity from environmental, industrial, and medical exposure has previously been linked to neurological impairment. Hence, the current study looked into the neuroprotective potential of curcumin, a natural polyphenol contained in the spice turmeric, against cobalt-induced neurotoxicity. Adult rats were randomly divided into six groups as follows: control, 40 mg/kg cobalt chloride (CoCl
2 ) only, 240 mg/kg curcumin only, 120 mg/kg or 240 mg/kg curcumin, or 100 mg/kg vitamin C co-administered with CoCl2 . The administration was via oral route daily for 4 weeks. After that, neurobehavioral tests were undertaken to evaluate short-term spatial memory. Biochemical investigation was performed to determine the hippocampal levels of status via measures of SOD, CAT, GST, and LPO. Furthermore, immunohistochemical assessment of the expression of GFAP and Nrf2 in the hippocampus was carried out. In the CoCl2 group, the results showed altered behavioral responses, a decrease in antioxidant activities, increased expression of GFAP and the number of activated astrocytes, and decreased immunoexpression of Nrf2. These effects were mitigated in the curcumin- and vitamin C–treated groups. These results collectively imply that curcumin enhances memory functions in rats exposed to cobalt possibly by attenuating oxidative responses, mitigating astrocytosis, and modulating Nrf2 signaling. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
11. Evaluation of toxicity potential of cobalt in wheat irrigated with wastewater: health risk implications for public.
- Author
-
Chen, Fu, Khan, Zafar Iqbal, Zafar, Asma, Ma, Jing, Nadeem, Muhammad, Ahmad, Kafeel, Mahpara, Shehzadi, Wajid, Kinza, Bashir, Humayun, Munir, Mudasra, Malik, Ifra Saleem, Ashfaq, Asma, Ugulu, Ilker, Dogan, Yunus, and Yang, Yongjun
- Subjects
COBALT ,SEWAGE ,WHEAT ,FOOD safety ,SAFETY standards - Abstract
The use of wastewater in irrigation weakens the beneficial properties of the soil and leads to a threat to food safety standards. The present research was designed to explore the cobalt toxicity associated with the ingestion of wastewater irrigated wheat. Wheat plants of five different varieties were collected from 7 different sites of Punjab, Pakistan, which were irrigated with three different sources of water. The sampling was done in two cropping years. The cobalt values in water, soil and wheat samples (root, shoot, grain) ranged from 0.46 to 1.24 mg/l, 0.15 to 1.20, 0.29 to 1.30, 0.08 to 0.76 and 0.12 to 0.57 mg/kg, respectively. All the water samples showed high cobalt concentration than the maximum permissible value. However, all the soil and wheat plant samples were found within the maximum allowable range. The high cobalt concentration in irrigating water showed that the continuous usage of such type of water may lead to cobalt toxicity in living organisms with the passage of time and may results in severe health risks. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
12. Metal-on-Metal Hip Joint Prostheses: a Retrospective Case Series Investigating the Association of Systemic Toxicity with Serum Cobalt and Chromium Concentrations.
- Author
-
Ho, James, Leikin, Jerrold, Dargan, Paul, Archer, John, Wood, David, and Brent, Jeffrey
- Subjects
ARTIFICIAL hip joints ,HEALTH outcome assessment ,DRUG toxicity ,SQUAMOUS cell carcinoma ,COMPUTED tomography ,COBALT ,THERAPEUTICS - Abstract
Introduction: There have been concerns about prosthesis failure and the potential for systemic toxicity due to release of cobalt and chromium from metal-on-metal hip joint prostheses (MoM-HP). There is conflicting evidence on whether there is a correlation between higher cobalt and chromium concentrations and systemic toxicity. Methods: We undertook a retrospective review of consecutive patients with MoM-HP referred for outpatient review in toxicology clinics in London, UK, and in the USA recorded in the Toxicology Investigators Consortium (ToxIC) Registry from June 2011 to June 2015. Results: Thirty-one cases were identified; the median (IQR) serum cobalt concentration was 10.0 (3.8-32.8) mcg/L, and the median (IQR) serum chromium concentration was 6.9 (3.7-18.7) mcg/L. Twenty-three (74.2%) had symptoms, most commonly lethargy, hearing loss, and tinnitus. The odds ratios of symptomatic/asymptomatic patients for metal ion concentrations above/below 7 mcg/L were 1.87 (95% CI 0.37-9.57, p = 0.45) and 0.60 (95% CI 0.10-3.50, p = 0.57) for cobalt and chromium, respectively. Two (6.5%) patients with systemic cobalt toxicity had median (IQR) serum cobalt concentrations significantly higher than those without systemic features (630.4 [397.6-863.2] mcg/L versus 9.8 [2.9-16.4] mcg/L; p = 0.017). However, overall, there were no differences between cobalt ( p = 0.38) or chromium ( p = 0.92) concentrations between symptomatic and asymptomatic patients and no clinical features or investigation results correlated with cobalt or chromium concentration. Conclusion: Two (6.5%) of 31 individuals referred for assessment of MoM-HP were diagnosed with systemic cobalt toxicity. However, despite a high prevalence of reported symptoms, neither symptoms nor investigation results correlated with serum cobalt or chromium concentrations. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
13. F-18 FDG PET brain imaging in symptomatic arthroprosthetic cobaltism.
- Author
-
Bridges, Robert L., Cho, Christina S., Beck, Marc R., Gessner, Bradford D., and Tower, Stephen S.
- Subjects
BRAIN imaging ,HEARING disorders ,HEAVY metals ,DENTAL metallurgy ,BRAIN metabolism ,EXECUTIVE function ,REOPERATION ,ARTIFICIAL joints - Abstract
Purpose: Imaging studies of cobalt toxicity from cobalt-chromium alloy arthroprosthetics have focused on the local intra-articular and peri-articular presentation from failing joint replacements. Most studies investigating neurological findings have been small case series focused on the clinical findings of memory loss, diminished executive function, tremor, hearing and vision loss, depression, and emotional lability. This study utilizes software-based quantitative analysis of brain metabolism to assess the degree of hypometabolism and areas of susceptibility, determine if a pattern of involvement exists, and measure reversibility of findings after prosthetic revision to cobalt-free appliances. Methods: Over 48 months, 247 consecutive patients presenting to an orthopedic clinic with an arthroprosthetic joint containing any cobalt-chromium part were screened with whole blood and urine cobalt levels. A clinically validated inventory of 10 symptoms was obtained. Symptomatic patients with a blood cobalt level above 0.4 mcg/L or urine cobalt greater than 1 mcg/L underwent F-18 FDG PET brain imaging. Analysis was performed with FDA-approved quantitative brain analysis software with the pons as the reference region. Control group was the normal brain atlas within the software. Results: Of the 247 consecutively screened patients, 123 had blood and urine cobalt levels above the threshold. The 69 scanned patients had statistically significant regional hypometabolism and higher symptoms inventory. Fifty-seven patients were retained in the study. Distribution of hypometabolism was in descending order: temporal, frontal, Broca's areas, anterior cingulate, parietal, posterior cingulate, visual, sensorimotor, thalamic, and lastly caudate. Metal-on-metal (MoM) and metal-on-plastic (MoP) joint replacements produced similar patterns of hypometabolism. Of 15 patients with necessary revision surgery, 8 demonstrated improved metabolism when later re-scanned. Conclusion: All scanned patients had regions of significant hypometabolism. Neurological toxicity from elevated systemic cobalt levels following arthroprosthetic joint replacement has a pattern of regional susceptibility similar to heavy metals and solvents, differing from classical dementias and may occur at blood and urine cobalt levels as low as 0.4 mcg/L and 1 mcg/L, respectively. Presently accepted thresholds for cobalt exposure and monitoring may need revision. Quantitative F-18 FDG PET brain imaging may aid in the decision process for treatment options and timing of possible medical versus surgical intervention. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
14. Severe Cardiomyopathy Due to Arthroprosthetic Cobaltism: Report of Two Cases with Different Outcomes.
- Author
-
Choi, Hyo-In, Hong, Jung Ae, Kim, Min-Seok, Lee, Sang Eun, Jung, Sung-Ho, Yoon, Pil Whan, Song, Joon Seon, and Kim, Jae-Joong
- Subjects
CARDIOMYOPATHIES ,COBALT -- Physiological effect ,HEART transplantation ,HEART failure ,CARDIOTOXICITY - Abstract
Cobalt-induced cardiomyopathy is a well-known but uncommon disease, and the physician must maintain a high index of suspicion in order to make a timely diagnosis. We report two patients with cobalt-induced cardiomyopathy. Both patients developed progressively worsening symptoms of cobalt toxicity following revision of a fractured ceramic-on-ceramic total hip replacement to a metal-on-polyethylene bearing. In both patients, echocardiography showed LV hypertrophy, biventricular systolic dysfunction, and a large amount of pericardial effusion. Due to decompensated heart failure, both patients were initially considered candidates for heart transplantation. One patient was diagnosed with cobalt-induced cardiomyopathy before transplantation. He received cobalt chelation therapy and revision surgery, which led to complete recovery of heart function. In the other patient, the diagnosis was not made until the time of heart transplantation. The gross examination of the explanted heart revealed typical features of cobalt cardiotoxicity, which was then diagnosed as cobalt-induced cardiomyopathy. These cases emphasise the importance of early diagnosis and prompt treatment of cobalt intoxication. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
15. Predicting the Metal Ion Release From CoCrMo Alloy–UHMWPE Tribocorrosion Contacts.
- Author
-
Cao, Shoufan, Wang, Yunkun, Yang, Zhanpeng, Liang, Yi, and Fan, Yuanxun
- Abstract
Due to tribocorrosion, metal ions are released from metallic components in hip implants and cause adverse reactions. The adverse reaction sensitivity to metal ions showed high dependency on individual patient and it has been recognized that adverse reactions even occur in patients with metal-on-polymer articulations. In this study, based on a tribocorrosion model for CoCrMo alloy, a lubricated wear accelerated corrosion model was developed for CoCrMo alloy–UHMWPE tribocorrosion contacts. The model was verified and calibrated using laboratory tribometer experimental results and was used to predict metal ion release from CoCrMo alloy heads in MoP hip joints. The results showed correspondence between model predicted wear accelerated corrosion and literature reported material loss of CoCrMo alloy heads in MoP hip joints tested using hip joint simulators. This model provides a tool to predict the level of metal ions released from MoP hip joints and has the potential to be used by medical doctors to evaluate the risk of adverse reactions for patients planned to receive a MoP hip implant. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. Optimization of the sol–gel synthesis parameters on Zn–Cu–Co-doped silicate-based bioactive glass for tissue repair.
- Author
-
Perry, Danielle. L. and Wren, Anthony. W.
- Abstract
Sol–gel synthesis parameters can significantly influence bioactive glass's structure, dissolution rates, and biocompatibility. For this study, various drying times and calcining temperatures were explored for a Zinc (Zn
2+ ), Copper (Cu2+ ), and Cobalt (Co2+ ) doped silicate-based sol–gel bioactive glass composition. Surface area measurements showed an increase in the particle's surface area with decreased calcining temperature, whereas the particle size decreased with longer drying time and higher calcining temperature. The micropore area and volume showed an inverse relationship to the reduced particle size, with the microporosity increasing as the drying time was extended with the calcining temperature below the glasses' transition temperature (560–586 °C). A Kilchoanite (Ca3 (Si2 O7 )) crystalline phase was present in each sample, and with increased calcining temperature above the Tg of the glasses, the degree of crystallinity increased. A drying time of 72 hrs with a calcining temperature of 450 °C showed an enhanced surface area (120 m2 /g) with smaller average particle size (0.43 µm), increased microporosity, ion release rates within toxicity and pH limits, and growth inhibition for both gram-positive (S. aureus) and gram-negative (E. coli) bacteria. Highlights: A drying time of 72 hrs leads to smaller particle size and increased microporosity below the Tg . A calcining temperature of 450 °C increases surface area and decreases crystallinity. Zinc, copper, and cobalt ion releases were within the limits of cytotoxicity and pH. A drying time of 72 hrs and calcining temperature of 450 °C presented bacterial growth inhibition. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
17. Characterization of a cobalt-resistant mutant of Neurospora crassa with transport block.
- Author
-
Sajani, L.S. and Maruthi Mohan, P.
- Abstract
A cobalt-resistant strain of Neurospora crassa (cor) was obtained by repeated subculturing of the wild type on cobalt-containing agar medium. N. crassa cor is twentyfold more resistant to cobalt ions compared with the wild type. Resistance was stable on repeated subculturing of cor on cobalt-free media. N. crassa cor is also cross-resistant to nickel (fourfold), but not to zinc or copper. Higher concentrations of iron and magnesium ions are required to reverse growth inhibition due to cobalt toxicity in N. crassa cor, compared with the wild type. Germinating conidia and mycelia of the cor strain accumulated lower levels of cobalt ions compared with the parent N. crassa. The partial transport block for cobalt uptake is shown to be primarily due to decreased surface binding of cobalt to mycelia and cell walls. Efflux of mycelial cobalt was also observed in wild type and cobalt-resistant N. crassa. The characteristics of cor in comparison with wild type N. crassa are discussed in relation to the mechanisms of cobalt resistance. [ABSTRACT FROM AUTHOR]
- Published
- 1997
- Full Text
- View/download PDF
18. Investigation of metal concentration distribution and corresponding health exposure assessment of fabricated metal product manufacturers.
- Author
-
Lan, Cheng-Hang, Ou, Lun-Chun, Liu, Hung-Hsin, and Peng, Chiung-Yu
- Abstract
The fabricated metal product industries were identified as producers of variable and heterogeneous pollution. Workers in these manufacturing facilities are exposed to multiple pollutants present at variable concentrations. Specific known adverse health effects include bladder cancer associated with metalworking fluid exposure and lung cancer associated with electroplating processes. To reduce the incidence of these adverse effects, the main challenge is to identify the most hazardous pollutants within this complex exposure environment and evaluate the corresponding health potentials. In this study, exposure indices were formulated to assess multiple metal exposures with the ultimate goal of providing relevant information for exposure reduction and control measures. Fifteen plants, including metal mold manufacturing, metal casting, and surface treatment plants, were investigated in terms of total concentration, summation of corresponding ratio to threshold limit value (STLV
r ), hazard index (HI), and incremental cancer risk. The results revealed that emissions of aluminum, iron, and manganese were primarily found in the metal mold manufacturing/casting plants, while emissions of chromium, nickel, and zinc were found in surface treatment plants. STLVr and HI were more useful than the total concentration for identifying hazardous metals, which were chromium and nickel, and could specify the facilities that were in need of control measures. As for cancer risk, the metal mold manufacturing/casting plants had lower risk than the surface treatment plants, and the contributing metals for these two plant types were cobalt and chromium, respectively. This study established a useful procedure to evaluate health hazards and cancer risk. The resulting information is useful for prioritizing mitigation control of multiple metal exposures. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
19. Addition of iron ore tailings to increase the efficiency of anaerobic digestion of swine manure: ecotoxicological and elemental analyses in digestates.
- Author
-
de Castro e Silva, Hellen Luisa, Barros, Regina Mambeli, dos Santos, Ivan Felipe Silva, de Alcântara, Marco Aurélio Kondracki, Lora, Electo Eduardo Silva, Izário Filho, Hélcio José, de Menezes Oliveira, Vanessa Bezerra, Fonseca, Ana Lucia, de Oliveira, Dayane, Triques, Maria Carolina, and de Oliveira, Gabriel Caracciolo Koenigkam
- Subjects
SWINE manure ,METAL tailings ,IRON ores ,ELEMENTAL analysis ,ANALYSIS of heavy metals ,BIOGAS production ,ANAEROBIC digestion ,IRON mining - Abstract
The anaerobic digestion process (AD) occurs via series of biochemical reactions, producing biogas as a renewable fuel and digestate, a rich by-product in trace elements (TEs), which has been directly disposed on soils as organic fertilizer. The application of mineral additives can result higher biogas production and CH
4 yields in AD process; however, the chronical effects of these additives in digestates have not been reported in the literature. In this way, this research aims to analyze the chronic effects of digestates from swine manure (SD) and swine manure with iron ore tailings as additive (SDIOT) on survival and reproduction of Enchytraeus crypticus. The fresh samples were collected from sequential batch processes conducted at mesophilic conditions. The TEs and pH ranges in feedstock and digestates were determined in fresh matter (mg L−1 ), including analyses of heavy metals and nutrients, in which ranges concentrations were discussed according to biogas and CH4 productions, and compared with previous data of literature. These analyses were followed by chronic tests of digestates on reproduction of E. crypticus in Oxisols, in which tests performance met the validity criteria stablished according to ISO 16387 standard. The means of treatments were compared using the Holm–Sidak method, and the means of control groups were compared using t test (α = 0.05). The chronic effect on survival and reproduction of organisms might have occurred through synergistic effect of metals in digestates; however, more analyses must be needed to understand the toxicity effect of these products, specially under different climate conditions. Article Highlights: The application of swine manure resulted in a chronic effect to Enchytraeus crypticus. The synergistic effect of metals might have effects on organisms survival. Available fractions of metals and chemical properties of soils must also be evaluated. Climate change might influence on the speciation of metals within the soils. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
20. Cobalt intoxication: mitochondrial features and condition.
- Author
-
Heuer, Christine, Streit, Anne-Catherine, Sprengel, Kai, Hasler, Rebecca Maria, Ziegenhain, Franziska, Zahorecz, Mia, Jetter, Alexander, and Jung, Hans H.
- Subjects
COBALT ,ARTHROPLASTY ,METALS in surgery ,ARTIFICIAL hip joints ,MITOCHONDRIA ,JOINT infections ,AUDITORY neuropathy - Abstract
Cobalt intoxication is a rare complication of joint arthroplasty with a metal-on-metal prothesis or metal implants after broken ceramic implants. Patients with metal components should be monitored closely for complications. The awareness for the wide range of clinical pictures of this cobalt intoxication should be increased. We here describe the clinical presentation, diagnostic and therapeutic work-up of a 70-year-old patient with a cobalt metallosis. The patient presented with a progressive deterioration of vision and hearing, axonal sensorimotor polyneuropathy and cataract. The extensive work-up resulted in the diagnosis of a cobalt metallosis as a complication of a metal hip prosthesis. Cobalt intoxication, especially after metal-on-metal total joint arthroplasty, is a rare complication; however, there have been several reports of similar cases. It is therefore recommended to avoid the implantation of a metal-on-metal prothesis or metal implants after broken ceramic implants as in this case whenever possible. Patients with exclusively metal components should be monitored closely for complications. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
21. Bioaccumulation of Potentially Toxic Elements in Commercially Important Food Fish Species from Lower Gangetic Stretch: Food Security and Human Health Risk Assessment.
- Author
-
Kumar, Vikas, Swain, Himanshu Sekhar, Upadhyay, Aurobinda, Ramteke, Mitesh Hiradas, Sarkar, Dhruba Jyoti, Roy, Sankhajit, and Das, Basanta Kumar
- Abstract
Ganga river is the inhabitant of more than 190 fish species and important river system of India. Potentially toxic elements (PTEs) in the Gangetic riverine ecosystem are a hot environmental issue. A detailed evaluation of PTEs bioaccumulation in Gangetic fishes is required to safeguard human health. The present study investigated the bioaccumulation of PTEs (Cd, Co, Cr, Cu, Li, Ni, Pb, Se, Zn, and Mn) within 12 economic fish species (n = 72) collected from the lower Gangetic stretch. The mean concentrations of PTEs followed the order Zn > Cu > Mn > Ni > Se > Cr > Pb > Co ~ Li > Cd. Li and Se bioaccumulation were studied first time from Gangetic fishes. Results demonstrated that all the selected PTEs were below the maximum permissible limit recommended by reference standards except for Zn in L. catla and L. rohita. For all PTEs, the metal pollution index (MPI), hazard quotient (THQ), and hazard index (HI) were < 1, indicating that these PTEs do not pose a health risk to the public through the dietary intake of fish in this study area. All studied fish were acceptable in terms of carcinogenic risk (CR) from exposure to Cd, Cr, and Pb. Multivariate statistical analysis suggests that inter-correlated metals have similar dispersion properties and bioaccumulation homology within the body. This study provides a scientific basis for food safety assessment and continuous monitoring of PTEs in Gangetic fishes is suggested in the future to safeguard human health. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
22. Gel-entrapped biomass of Lactarius salmonicolor for the effective treatment of aquatic Co2+ and Mn2+ pollution.
- Author
-
Sayin, Fatih, Tunali Akar, Sibel, Tunc, Dilek, and Akar, Tamer
- Abstract
A fungal biomass, Lactarius salmonicolor (L. salmonicolor), was entrapped in a silica gel matrix to evaluate the removal of Co
2+ and Mn2+ ions from an aqueous medium and a real effluent. The batch experiments were carried out to investigate the influences of biosorbent dosage, initial pH, contact time, and temperature. The results showed that no pH adjustment was necessary to obtain maximum removal of both Co2+ and Mn2+ ions by silica gel immobilized L. salmonicolor biomass (SILSB). Thirty and ten minutes were found to be necessary time to establish biosorption equilibrium for Co2+ and Mn2+ removal, respectively. The biosorption of both metal ions was best described by the pseudo-second-order kinetic model. The data of the isotherm modeling proved that the Co2+ and Mn2+ biosorption occurred by monolayer coverage of SILSB surface with the biosorption capacities of 117.70 and 137.05 mg g−1 , respectively. The highest biosorption yields of Co2+ and Mn2+ ions in the continuous system are found using 50 mg (2 g L−1 ) of SILSB as the optimum amount. The biosorption capacity did not significantly change by increasing the flow rate from 0.5 to 4.0 mL min−1 . The real wastewater treatment also showed that SILSB had remarkable biosorption efficacy for Co2+ and Mn2+ . Metal ion-biosorbent interactions were examined by FTIR, pHZPC , SEM, EDX, elemental, and BET analyses. As a consequence of its excellent biosorption performance for the removal of Co2+ and Mn2+ ions, SILSB might be used as an efficient biosorbent in wastewater treatment. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
23. Green synthesis of silver nanoparticles and its environmental sensor ability to some heavy metals.
- Author
-
Ibrahim, Nesma H., Taha, Gharib M., Hagaggi, Noura Sh. A., and Moghazy, Marwa A.
- Subjects
HEAVY metals ,SILVER nanoparticles ,SILVER ,ULTRAVIOLET-visible spectroscopy ,SCANNING electron microscopy ,X-ray diffraction ,STABILIZING agents ,PLANT extracts - Abstract
This study marks a pioneering effort in utilizing Vachellia tortilis subsp. raddiana (Savi) Kyal. & Boatwr., (commonly known as acacia raddiana) leaves as both a reducing and stabilizing agent in the green "eco-friendly" synthesis of silver nanoparticles (AgNPs). The research aimed to optimize the AgNPs synthesis process by investigating the influence of pH, temperature, extract volume, and contact time on both the reaction rate and the resulting AgNPs' morphology as well as discuss the potential of AgNPs in detecting some heavy metals. Various characterization methods, such as UV–vis spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), infrared spectroscopy (IR), Zeta sizer, EDAX, and transmitting electron microscopy (TEM), were used to thoroughly analyze the properties of the synthesized AgNPs. The XRD results verified the successful production of AgNPs with a crystallite size between 20 to 30 nm. SEM and TEM analyses revealed that the AgNPs are primarily spherical and rod-shaped, with sizes ranging from 8 to 41 nm. Significantly, the synthesis rate of AgNPs was notably higher in basic conditions (pH 10) at 70 °C. These results underscore the effectiveness of acacia raddiana as a source for sustainable AgNPs synthesis. The study also examined the AgNPs' ability to detect various heavy metal ions colorimetrically, including Hg
2+ , Cu2+ , Pb2+ , and Co2+ . UV–Vis spectroscopy proved useful for this purpose. The color of AgNPs shifts from brownish-yellow to pale yellow, colorless, pale red, and reddish yellow when detecting Cu2+ , Hg2+ , Co2+ , and Pb2+ ions, respectively. This change results in an alteration of the AgNPs' absorbance band, vanishing with Hg2+ and shifting from 423 to 352 nm, 438 nm, and 429 nm for Cu2+ , Co2+ , and Pb2+ ions, respectively. The AgNPs showed high sensitivity, with detection limits of 1.322 × 10–5 M, 1.37 × 10–7 M, 1.63 × 10–5 M, and 1.34 × 10–4 M for Hg2+ , Cu2+ , Pb2+ , and Co2+ , respectively. This study highlights the potential of using acacia raddiana for the eco-friendly synthesis of AgNPs and their effectiveness as environmental sensors for heavy metals, showcasing strong capabilities in colorimetric detection. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
24. Metal ion release after hip resurfacing arthroplasty and knee arthroplasty: a retrospective study of one hundred ninety-five cases.
- Author
-
Lukas, S., Martinot, P., Putman, S., Lons, A., Drumez, E., Migaud, H., and Girard, J.
- Subjects
TOTAL hip replacement ,METAL ions ,ARTHROPLASTY ,KNEE ,CONGENITAL hip dislocation ,CHROMIUM ions ,HIP fractures - Abstract
Purpose: Hip arthroplasty with metal-on-metal bearings like hip resurfacing results in the release of metallic ions. In parallel, like every metallic implant, knee arthroplasty implants undergo passive corrosion. We analyzed blood levels of cobalt and chromium ions in patients who have a hip resurfacing arthroplasty and compared them to patients who have undergone knee arthroplasty at a minimum follow-up of one year. The hypothesis was that there is no difference in the ion release between hip resurfacing and knee arthroplasty. Methods: Sixty-three patients who underwent knee arthroplasty were compared to a cohort of 132 patients who underwent hip resurfacing. The blood levels of cobalt and chromium ions were determined preoperatively and at six and 12 months postoperatively and then compared between groups. We analyzed the relationship between ion release and the change in clinical outcome scores (Harris Hip score, Oxford Hip score, Merle D'Aubigné Postel score, Oxford Knee score, International Knee Society score), the BMI, sex, physical activity, implant size and inclination of the acetabular implant (hip resurfacing patients only). Mixed linear models were used to assess the changes in ion blood levels over time. Results: The cobalt blood levels were higher in the first 6 months in the resurfacing group (0.87 ug/L vs 0.67 ug/L; p = 0.011), while it was higher in the knee arthroplasty group at 12 months (1.20 ug/L vs 1.41 ug/L; p = 0.0008). There were no significant differences in chromium levels during the follow-up period. Conclusion: The increase in metal ion release after knee arthroplasty is as high as after hip resurfacing at the one year follow-up. The monitoring of this parameter probably should not be recommended in case of good clinicals outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
25. Environmental Impact Assessment in the Entire Life Cycle of Lithium-Ion Batteries.
- Author
-
Sankar, Tapan Kumar, Abhilash, and Meshram, Pratima
- Abstract
The growing demand for lithium-ion batteries (LIBs) in smartphones, electric vehicles (EVs), and other energy storage devices should be correlated with their environmental impacts from production to usage and recycling. As the use of LIBs grows, so does the number of waste LIBs, demanding a recycling procedure as a sustainable resource and safer for the environment. This review paper analyses and categorizes the environmental impacts of LIBs from mining their constituents, their usage and applications, illegal disposal, and recycling. Compared to recycling, reusing recovered materials for battery manufacturing would lessen the environmental footprints and reduce greenhouse gas emissions (GHG) and energy consumption. Thus, to prevent pollution and safeguard the environment, it is necessary to consider recycling spent LIBs and improving production and disposal methods. The present study offers a comprehensive overview of the environmental impacts of batteries from their production to use and recycling and the way forward to its importance in metal replenishment. The life cycle assessment (LCA) analysis is discussed to assess the bottlenecks in the entire cycle from cradle to grave and back to recycling (cradle). [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
26. Cross-Sectional Study of Serum Metal Ions in Patients With Metal Implants in the Maxillofacial Region.
- Author
-
Khandelwal, Garima, Alagarsamy, Ragavi, Roychoudhury, Ajoy, Bhutia, Ongkila, and Shariff, A.
- Abstract
Purpose: The purpose of the present study was to measure the serum metal ion levels (titanium, cobalt, chromium) in patients who have metal implants in the maxillofacial region. Methods: The investigators implemented a cross sectional study on patients treated with procedures requiring metal implants for management of maxillofacial trauma, fixation for orthognathic surgery, and total temporomandibular joint replacement (TJR). Inductively coupled plasma mass spectrometry was used as an analytical method to detect metal ions in serum samples. Results: The study comprised of 50 patients who were divided into 4 groups- group I- total TJR (n = 18), group II- orthognathic (n = 8), group III- trauma (n = 8), and group IV- control (n = 16). The mean values of metal ions level were raised than the control group. Conclusion: The present study's results suggest a rise in serum metal ion levels after the metal implantation in maxillofacial region. None of the patients had any abnormal signs and symptoms due to raised metal levels. Further studies are warranted to correlate the serum metal ion levels and their clinical relevance. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
27. Elucidating the role of exogenous iron (Fe) in regulation of hydrogen sulphide (H2S) biosynthesis and its concomitant effect on seedling growth, pigment composition and antioxidative defense in NaCl stressed tomato seedlings.
- Author
-
Subba, Rewaj, Dey, Shreyasi, Mukherjee, Soumya, Roy, Swarnendu, and Mathur, Piyush
- Abstract
There is a paucity of information on the role of iron nutrition in regulating H
2 S-mediated salinity tolerance in plants. The present work implies exogenous Fe and Na2 S (H2 S-donor) for investigating the interactive effects of Fe and H2 S in regulating seedling growth, osmolyte accumulation, chlorophyll accumulation and antioxidative defense under salinity stress. To achieve this, an experiment was set up with seeds of tomato (Solanum lycopersicum L. var. romeo) grown in presence of NaCl concentration (80 mM). Control seedlings were grown using half strength hoagland nutrient solution without NaCl. Exogenous Fe (100 µM) and H2 S was supplied in the form of Na2 S (100 µM) individually and in combination both in presence and absence of NaCl. Growth parameters like shoot length and root lengths were taken along with chlorophyll, osmolyte contents, enzymatic and non-enzymatic antioxidants as well as content of H2 S and L-DES activity were also measured. Results demonstrated that exogenous Fe and H2 S to an extent provide protection to tomato seedlings subjected to salt stress through prevention membrane damage, increased antioxidative defense and there was significant increase in L-DES activity that led to increased H2 S content. Exogenous Fe and Na2 S application in tomato seedlings under salt stress exhibited decrease in malondialdehyde content by 19% and 50% respectively and H2 O2 by 13.7% and 16.8% respectively. Combined application of Fe and Na2 S increased the levels of antioxidative enzyme activities including CAT (53.8%), POX (14%), SOD (58%) and APX (11.7%) was observed under salt stress. However, tomato seedlings supplemented with combined application of Fe and H2 S showed decreased H2 S content as well as lower L-DES activity. Simultaneously, combined application of Fe and H2 S to salt stressed tomato seedlings however showed increased activity of some of the antioxidative enzymes deciphering positive role of this interaction of Fe and Na2 S under the influence of salt stress. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
28. Status of Vitamin B12, Zinc, Copper, Selenium, Manganese, Molybdenum and Cobalt in Severe Acute Malnutrition.
- Author
-
Kamath, Laxmi, Ratageri, Vinod H., Kanthi, Apurva S., Fattepur, S. R., and Desai, R. H.
- Abstract
Objectives: To define the vitamin B12 levels and other micronutrients status in severe acute malnutrition (SAM) children. Methods: This was a prospective hospital based cross-sectional study. Inclusion criteria: Children with severe acute malnutrition as per WHO criteria. Exclusion criteria: (i) Pernicious anemia (ii) Autoimmune gastritis (iii) SAM children on exclusive vitamin B12 supplementation. All enrolled children underwent a detailed clinical history, general physical examination with more emphasis on clinical features of vitamin B12 and other micronutrients deficiencies. Three ml of venous blood was collected to estimate vitamin B12 and other micronutrients. Primary outcome was percentage of deficiency of serum vitamin B12, zinc, copper, selenium, manganese, molybdenum and cobalt in SAM children. Results: Fifty children were included in the study. The mean age of children was 15.60±12.90 mo with male to female ratio 0.85:1. The common clinical presentation in order of frequency were upper respiratory infection (URI) symptoms 35 (70%), hepatomegaly 24 (48%), Hyperpigmentation 17 (34%), angular cheilitis 14 (28%), tremors 11 (22%), edema 07 (14%), and hypotonia 05 (10%). Anemia was found in 44 (88%) children. Prevalence of vitamin B12 deficiency was 34%. Other micronutrient deficiencies observed were cobalt 24 (100%), copper 05 (12%), zinc 04 (9.5%), and molybdenum 03 (12.5%). No statistical significance was found between clinical symptoms and levels of vitamin B12 with different age and sex. Conclusions: Prevalence of low vitamin B12 and cobalt were more common than other micronutrients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
29. The Effects of Cobalt on the Development, Oxidative Stress, and Apoptosis in Zebrafish Embryos.
- Author
-
Cai, Guiquan, Zhu, Junfeng, Shen, Chao, Cui, Yimin, Du, Jiulin, and Chen, Xiaodong
- Abstract
Metal-on-metal hip arthroplasty has been performed with increasing frequency throughout the world, particularly in younger and more active patients, including women of childbearing age. The potential toxicity of cobalt exposure on fetus is concerned since cobalt ions generated by metal-on-metal bearings can traverse the placenta and be detected in fetal blood and amniotic fluid. This study examined the effects of cobalt exposure on early embryonic development and the mechanisms underlying its toxicity. Zebrafish embryos were exposed to a range of cobalt concentrations (0-100 mg/L) between 1 and 144 h postfertilization. The survival and early development of embryos were not significantly affected by cobalt at concentrations <100 μg/L. However, embryos exposed to higher concentrations (>100 μg/L) displayed reduced survival rates and abnormal development, including delayed hatching, aberrant morphology, retarded growth, and bradycardia. Furthermore, this study examined oxidative stress and apoptosis in embryos exposed to cobalt at concentrations of 0-500 μg/L. Lipid peroxidation levels were increased in cobalt-treated embryos at concentrations of 100 and 500 μg/L. The mRNA levels of catalase, superoxide dismutase 2, p53, caspase-3, and caspase-9 genes were upregulated in a dose-dependent manner. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assays also revealed abnormal apoptotic signals in the brain, trunk, and tail when treated with 500 μg/L cobalt. These data suggest that oxidative stress and apoptosis are associated with cobalt toxicity in zebrafish embryos. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
30. Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review.
- Author
-
Migliorini, Filippo, Maffulli, Nicola, Pilone, Marco, Bell, Andreas, Hildebrand, Frank, and Konrads, Christian
- Subjects
TOTAL hip replacement ,PEARSON correlation (Statistics) - Abstract
Total hip arthroplasty (THA) is a successful orthopaedic surgical procedure, and its longevity depends on bearing components and implant fixation. Optimizing polyethylene and ceramics has led to improved wear parameters and contributed to improved long-term outcomes. The present systematic review investigated whether time span from implantation, patient characteristics and performance status exert an influence on liner wear and head migration in THA. This study was conducted in conformity to the 2020 PRISMA guidelines. All the clinical investigations which reported quantitative data on the amount of liner wear and head migration in THA were considered. Only studies which reported quantitative data at least on one of the following patient characteristics were suitable: mean age, mean BMI (kg/m
2 ), sex, side, time span between the index THA and the last follow-up (months) were eligible. A multiple linear model regression analysis was employed to verify the association between patient characteristics and the amount of liner wear and/or head migration. The Pearson Product-Moment Correlation Coefficient was used to assess the association between variables. Data from 12,629 patients were considered. The mean length of the follow-up was 90.5 ± 50.9 months. The mean age of patients at surgery was 58.4 ± 9.4 years, and the mean BMI was 27.2 ± 2.5 kg/m2 . 57% (7199 of 12,629 patients) were women, and in 44% (5557 of 12,629 patients) THAs were performed on the left. The mean pre-operative Harris hip score was 46.5 ± 6.0 points. There was evidence of a moderate positive association between the amount of liner wear and the time elapsed between the index surgery to the follow-up (P = 0.02). There was evidence of a moderate positive association between the amount of head migration and the time elapsed between the index surgery to the follow-up (P = 0.01). No further statistically significant association was found. The time elapsed between the index surgery to the follow-up was the most important factor which influence the head migration and liner wear in THA. Patients' characteristics and preoperative physical activity did not influence the amount of head migration and liner wear. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
31. Heavy Metal Concentrations of Beeswax (Apis mellifera L.) at Different Ages.
- Author
-
Hassona, Nadia M. and El-Wahed, Aida A. Abd
- Subjects
HEAVY metals ,HONEYBEES ,BEESWAX ,PROPOLIS ,BEEHIVES ,PESTICIDE residues in food ,LEAD ,BEEKEEPING - Abstract
Beeswax is a naturally occurring product that worker bees produce. Beeswax is used in a variety of industries and pharmaceuticals. Humans utilize it extensively in cosmetics, medicinal formulations, and food manufacturing. Beeswax is an essential component of advanced contemporary beekeeping. Beekeepers, in particular, utilize significant amounts of beeswax to make beeswax comb foundation. In its natural condition, beeswax is white, but it becomes yellow then dark in color when it comes into touch with honey and pollen. The ongoing use of wax comb in bee activities (such as brood rearing, storage honey and bee bread), combined with environmental factors such as heavy metal and pesticide residues, resulted in a black color. Because of heavy metals can accumulate in wax for decades, beeswax can be a helpful tool for gathering data on hazardous contaminants in the environment. Because of their lipid-based chemical composition, beeswax combs act as a sink for numerous ambient pollutants as well as poisons when in the hive. The current study aims to measure nine heavy metals and important elements, including iron (Fe), chromium (Cr), zinc (Zn), copper (Cu), nickel (Ni), manganese (Mn), lead (Pb), cadmium (Cd), and cobalt (Co) in beeswax collected in the Behaira governorate region of Egypt between 2018 and 2022. Sample collection was conducted each year in triplicate. The samples were analyzed using an atomic absorption spectrophotometer. The quantity of metals in beeswax at different ages differed significantly. Depending on the wax age, Fe has the highest concentration in the range of 2.068 to 5.041 ppm, while Cd has the lowest ratio at 0.024 to 0.054 ppm from the first to fifth years old of comb age. The findings showed that as beeswax combs aged, the concentration of heavy metals rose. According to the study, it should gradually recycle beeswax combs each year and also adding new foundations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
32. Arbuscular mycorrhizal fungi and nitric oxide alleviate cadmium phytotoxicity by improving internal detoxification mechanisms of corn plants.
- Author
-
Zare, Leila, Ronaghi, Abdolmajid, Ghasemi-Fasaei, Reza, Zarei, Mehdi, and Sepehri, Mozhgan
- Subjects
VESICULAR-arbuscular mycorrhizas ,CADMIUM oxide ,NITRIC oxide ,CORN growth ,ROOT-tubercles ,PHYTOTOXICITY ,CALCAREOUS soils - Abstract
Plants develop several external and internal mechanisms to increase their tolerance to heavy metals (HMs) toxicity including cadmium (Cd). Symbiosis with arbuscular mycorrhizae fungi (AMF) is one of the plants' strategies to tolerate HMs toxicity. Nitric oxide (NO), as a signaling molecule, is also involved in physiological responses of plants to various stresses. The present work was conducted as a factorial completely randomized design with three replications to study the effects of Funneliformis mosseae fungi and Sodium nitroprusside (SNP, 100 mM) as a donor of NO alone, in combination (AMF + SNP) on corn plant growth, and internal detoxification mechanisms of Cd toxicity in a Cd-contaminated calcareous soil (0, 25, 50, and 100 mg Cd kg
−1 ). The results showed that under Cd stress, AMF inoculation and/or foliar application of SNP significantly increased plant growth (32% to 103% for shoot and 44% to 84% for root) by decreasing Cd concentration in corn plant tissues (23% to 46% for shoot and 19% to 40% for root). Cd-induced oxidative stress was mitigated by AMF and/or SNP by enhancing the activities of antioxidant enzymes, including superoxide dismutase (SOD) and catalase (CAT), and concentration of non-enzymatic antioxidants such as glutathione (GSH) and phytochelatin (PC). Increasing the tolerance index (TI) and decreasing the transfer factor (TF) in the corn plants treated with AMF and/or SNP, confirm the efficient role of SNP and AMF in stimulating the detoxification mechanisms of Cd within the plant cells, which was more pronounced at the lowest Cd level (25 mg Cd kg−1 ). In conclusion, symbiotic associations of corn plants with AMF alone or in combination with SNP mitigated the detrimental effect of Cd toxicity in corn grown in Cd-contaminated calcareous soil. The corn's internal detoxification mechanisms lowered the Cd concentration in plant tissue which resulted in the improvement of the corn's growth parameters. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
33. Modulation in the enzymatic antioxidants, MDA level and elicitation in conessine biomolecule in Holarrhena pubescens (medicinal tree) cultures exposed to different heavy metals: Ni, Co, Cr and As.
- Author
-
Kumar, Dinesh, Kumar, Ravindra, Singh, Bharat, and Agrawal, Veena
- Subjects
GLUTATHIONE peroxidase ,HEAVY metals ,BIOACTIVE compounds ,SUPEROXIDE dismutase - Abstract
Nodal explants of Holarrhena pubescens, an important medicinal tree, were cultured on Murashige and Skoog's medium (MS) containing 15 µM BA (control) alone and on medium supplemented with different concentrations (0, 1, 5, 25, 50, 100 and 200 mg/L) of heavy metals such as NiCl
2 , CoCl2 , As2 O3 and CrO3 to study their toxic effect. After 28 days of treatments, the nodal segments were harvested to assess the average number of shoots per explants, average shoot length, malondialdehyde content, proline content, conessine accumulation and antioxidant enzymatic activity. Among all the metals tried, best morphogenic response was achieved at 5 mg/L CrO3 where 80% culture differentiated an average of 3.21 ± 0.08 shoots per explant having 0.95 ± 0.018 cm average shoot length. Highest concentration (200 mg/L) of all the heavy metals proved lethal for morphogenesis. Maximum inhibition in average shoot number and average shoot length was observed in nodal explants treated with 25 mg/L As2 O3 where an average of 0.49 ± 0.047 shoots having an average shoot length of 0.3 ± 0.02 cm. Contrarily, addition of heavy metals in culture medium proved strong elicitors, exhibiting significant enhancement in the biosynthesis of conessine, an important bioactive compound. HPLC analysis of the crude extract of in vitro grown untreated nodal cultures revealed an average of 117.06 ± 2.59 µg/g d. w. of conessine, whereas those treated with 100 mg/L of CoCl2 accounted for 297.1 ± 7.76 µg/g d. w. (an increase of 156% over control). Among the heavy metals tried, CoCl2 proved to be the best for conessine enhancement which was in the order of CoCl2 > Cr2 O3 > NiCl2 > As2 O3 in the nodal explants. Concomitantly, MDA content, the antioxidant enzymes activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GR) and ascorbate peroxidase (APX) were also observed to be differentially expressed with the increase in the heavy metals concentration from 1 to 200 mg/L. Free proline, too, increased up to 3.5-fold over control. The results obtained during the present investigation revealed that the overall response of the nodal explants in terms of morphogenesis, conessine content and antioxidant enzyme activities was metal specific as well as dose dependent. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
34. Geochemical composition and potential health risks of geophagic materials: an example from a rural area in the Limpopo Province of South Africa.
- Author
-
Mouri, Hassina, Malepe, Retshepile Evelyn, and Candeias, Carla
- Subjects
HEALTH risk assessment ,RURAL geography ,X-ray fluorescence ,RURAL population ,ANALYTICAL geochemistry ,PATHOGENIC microorganisms ,TRACE elements - Abstract
Geophagy is a common practice among rural population of the Fetakgomo Tubatse Local Municipality area in the Limpopo Province of South Africa. Although, the practice might be beneficial to the health of the consumers, its negative effects could overshadow the positive effects and might lead to detrimental health issues. The present work sought to investigate the geochemical composition as well as pH and organic matter (OM) content of geophagic materials commonly consumed in the study area. Furthermore, assessment of the potential health risk of the materials on geophagic individuals was also considered. Twelve samples were collected in the study area and analysed by X-ray Fluorescence (XRF) and Inductively Coupled Plasma—Mass Spectrometry (ICP-MS) for major and trace elements composition. The results showed higher concentrations of non-essential elements (e.g., As, Cr, Pb) than the proposed recommended daily standards intake, suggesting a potential health risk. The alkaline nature (pH 6.80 to 9.22) of the studied samples might affect the bioacessibility of some essential elements. Furthermore, the OM content (> 0.7%) observed in some of the studied samples may retain pathogenic micro-organisms detrimental to health. Although As and Cr presented a low bioaccessible fraction (< 16.0%), health risk assessment revealed that their concentrations represented a hazard (HQ > 1) and might induce non-carcinogenic health threats to geophagic individuals. Based on the geochemical analysis, pH and OM content as well as health risk assessment findings, the studied geophagic materials are not considered suitable for human consumption. The practice should therefore be discouraged amongst the population in the study area to avoid possible detrimental health issues. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
35. A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity.
- Author
-
Yang, Zhiyu, Guo, Xiaoya, Meng, Meng, Li, Tong, Fang, Huapan, Tang, Zhaohui, Tian, Huayu, and Chen, Xuesi
- Abstract
As a revolutionary cancer treatment strategy, immunotherapy has attracted great attention. However, the effect of immunotherapy such as immune checkpoint blockade (ICB) is usually limited by insufficient immune response in the body. Herein, a polycation-based magnetic nanocluster platform was developed to load therapeutic nucleic acids, which could achieve gene therapy-mediated ICB and efficient magnetic hyperthermia therapy (MHT). The silencing of immune checkpoints together with MHT-induced immunogenic cell death (ICD) effectively alleviated the immune escape of cancer cells and significantly enhanced the visibility of cancer cells to the immune system. This combined treatment strategy activated a strong adaptive anticancer immune response in vivo, greatly inhibiting tumor growth, metastasis and recurrence. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
36. Effects of the Impact of Water-Soluble Forms of Fullerenes and Their Derivatives on Metabolism of Plants and Yield of Agricultural Crops.
- Author
-
Yamskova, O. V., Kurilov, D. V., Zavarzin, I. V., Krasnov, M. S., and Voronkova, T. V.
- Abstract
The search for effective and environmentally friendly plant growth regulators in modern conditions makes it possible to identify and reduce the impact on plant development, its metabolic processes, the biomass of its various parts, and crops. Substances with the least toxicity to living organisms are of particular interest in this field; in particular, these include C
60 and C70 fullerenes and their derivatives. This paper describes the impact of both fullerenes themselves and their derivatives on plant growth, yield, and metabolic and morphological changes observed depending on the processing methods, the chemical structure of the derivative, and the amount of substance used for processing. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
37. Polyoxometalate-based materials for the effluent treatment of removing heavy metals in the water pollutants: mini review.
- Author
-
Madhusree, J. E. and Mal, Sib Sankar
- Subjects
HEAVY metals ,WATER purification ,WATER pollution ,HEAVY metal toxicology ,ELECTROCHEMICAL sensors - Abstract
Water contamination is a big concern nowadays due to increased human activity and the quick expansion of modern industry and agriculture. In our current environment, heavy metal pollution has become a primary concern. Treatment of heavy metals is especially significant, because these metals absorb into biological cells and can lead to severe illness and disorders. Several studies have been conducted over the last several years to remove heavy metals from wastewater using various strategies and materials. Among those strategies, complexation's reaction and the electrochemical sensor are attractive because of their excellent metal selectivity, cost-effectiveness, short analytical time, and high removal efficiency. Polyoxometalates (POMs) are a group of metal–oxygen cluster compounds with extremely electronegative and oxo-enriched surfaces and variable structure and size. POMs have drawn much interest in removing toxins from wastewater due to their electrical and physical characteristics. The removal of heavy metals from wastewater is covered in this review using POM and POM-based MOF nanocomposites in various treatment methods like complexation and electrochemical sensor, which have the advantages of high removal efficiency, excellent metal selectivity, in-expansive, and rapid analytical times. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
38. Uptake, accumulation, toxicity, and interaction of metallic-based nanoparticles with plants: current challenges and future perspectives.
- Author
-
Basit, Farwa, He, Xiang, Zhu, Xiaobo, Sheteiwy, Mohamed Salah, Minkina, Tatiana, Sushkova, Svetlana, Josko, Izabela, Hu, Jin, Hu, Weimin, and Guan, Yajing
- Subjects
PLANT translocation ,SCIENTIFIC knowledge ,POISONS ,PLANT anatomy ,NANOPARTICLES ,METABOLIC detoxification ,PLANT roots - Abstract
The rapid development of industrialization is causing several fundamental problems in plants due to the interaction between plants and soil contaminated with metallic nanoparticles (NPs). Numerous investigations have been conducted to address the severe toxic effects caused by nanoparticles in the past few decades. Based on the composition, size, concentration, physical and chemical characteristics of metallic NPs, and plant types, it enhances or lessens the plant growth at various developmental stages. Metallic NPs are uptaken by plant roots and translocated toward shoots via vascular system based on composition, size, shape as well as plant anatomy and cause austere phytotoxicity. Herein, we tried to summarize the toxicity induced by the uptake and accumulation of NPs in plants and also we explored the detoxification mechanism of metallic NPs adopted by plants via using different phytohormones, signaling molecules, and phytochelatins. This study was intended to be an unambiguous assessment including current knowledge on NPs uptake, accumulation, and translocation in higher plants. Furthermore, it will also provide sufficient knowledge to the scientific community to understand the metallic NPs-induced inhibitory effects and mechanisms involved within plants. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
39. Heavy metal contamination levels, source distribution, and risk assessment in fine sand of urban surface deposited sediments of Ekaterinburg, Russia.
- Author
-
Hanfi, Mohamed Y., Seleznev, Andrian A., Yarmoshenko, Ilia V., Malinovsky, Georgy, Konstantinova, Elizaveta Yu., Alqahtani, Mohammed S., and Sakr, Ahmed K.
- Subjects
HEAVY metals ,INDUCTIVELY coupled plasma mass spectrometry ,RISK assessment ,SAND ,COPPER - Abstract
Urban surface deposited sediments (USDS) are unique indicators of local pollution that pose a potential threat to the living environment and human health. Ekaterinburg is a highly populated metropolitan area in Russia with rapid urbanization and industrialization activities. In Ekaterinburg's residential areas, about 35, 12, and 16 samples are represented by green zones, roads, driveways, and sidewalks, respectively. The total concentrations of heavy metals was detected using a chemical analyzer inductively coupled plasma mass spectrometry (ICP-MS). Zn, Sn, Sb, and Pb have the highest concentrations in the green zone, while V, Fe, Co, and Cu represent the utmost values on roads. Moreover, Mn and Ni are the prevailing metals in the fine sand fraction of driveways along with sidewalks. Broadly, the high pollution in the studied zones is generated by anthropogenic activities and traffic emissions. The potential ecological risk (RI) was observed in high risk (IR > 600), even though the results of all heavy metals reveal no adverse health effects from the considered noncarcinogenic metal for adults and children by different exposure pathways except the children's exposure to Co in case of the dermal contact, where the HI values of Co for children in the studied zones are higher than the proposed level (> 1). In all urban zones, the total carcinogenic risk (TLCR) values are predicted as a high potential inhalation exposure. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
40. Coordination of Distal Carboxylate Anion Alters Metal Ion Specific Binding in Imidazo[1,2-a]pyridine Congeners.
- Author
-
Divya, Dhakshinamurthy, Mala, Ramanjaneyulu, Nandhagopal, Manivannan, Narayanasamy, Mathivanan, and Thennarasu, Sathiah
- Subjects
IMIDAZOPYRIDINES ,METAL ions ,CHEMORECEPTORS ,TRANSITION metal ions ,ANIONS ,GROUNDWATER ,METAL detectors - Abstract
Imidazo[1,2-a]pyridine derivatives have excellent potential for chelation with transition metal ions. Two new imidazo[1,2-a]pyridine-8-carboxylates were synthesized and characterized by
1 H NMR,13 C NMR, HRMS, and single crystal-XRD techniques. Methyl carboxylate (probe 1) turns on fluorescence upon coordination with Zn2+ , while sodium carboxylate (probe 2) turns off its fluorescence upon coordination with Co2+ or Cu2+ ions present in aqueous acetonitrile medium.13 C NMR study revealed that the change in metal ion specific binding was due to the involvement of carboxylate anion in complex formation with Co2+ or Cu2+ ions. The carboxylate anion at 8-position also enhanced the sensitivity of detection of probe 2 by an order of magnitude (detection limits: 3.804 × 10–7 M, probe 1/Zn2+ ; 0.420 × 10–7 M, probe 2/Co2+ and 0.304 × 10–7 M, probe 2/Cu2+ ). The detection limits of probes 1 and 2 comply well with the World Health Organization (WHO) and US Environmental Protection Agency (US-EPA) guidelines for detection of heavy metal ions present in drinking water and ground water. Both the probes form a 1:1 complex with Zn2+ , Co2+ or Cu2+ , and the stoichiometry was verified by Job plot and ESI-mass analysis. The sensing mechanism is explained using13 C NMR experiments, ESI-mass analytical data and theoretical DFT calculations. The suitability of probes 1 and 2 for on-site detection and quantitative determination of Zn2+ , Co2+ and Cu2+ ions present in biological, environmental and industrial samples is demonstrated. In addition, both 1 and 2 are used for detection of intracellular contamination of Zn2+ , Co2+ or Cu2+ ions in onion epidermal cells. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
41. Abstracts from the 2023 Annual Meeting of the Society of General Internal Medicine.
- Subjects
HYPERGLYCEMIA ,HEART failure ,ANNUAL meetings ,INTERNAL medicine ,MEDICAL libraries ,MEDICAL personnel ,MEDICAL students - Abstract
B DESCRIPTION: b Project topics, selected by residents, included improving patient safety (e.g., enhancing treatment of patients admitted with diabetic ketoacidosis) as well as improving resident workflow (e.g., updating patient guidance on how to use the after hours resident clinic phone coverage line). B CONCLUSIONS: b In our study, COVID-19 outcomes among female patients were significantly better than male patients; and race or a race-related confounder plays a role in disease severity in COVID-19. 47,762 patients had either DKA or HHS with sepsis, and thus the sepsis control group will refer here to patients with sepsis bu without DKA or HHS. The distribution of the underlying anemia etiologies in hospitalized patients differs from the outpatient setting, and this data can be used to develop an optimal standardized approach to anemia diagnosis and treatment in hospitalized patients. Chronic anemia was the most common etiology (532 patients, 56%), followed by undiagnosed anemia (250 patients, 26%), acute blood loss anemia (141 patients, 15%), anemia due to nutritional deficiency (83 patients, 9%), and sickle cell anemia (74 patients, 8%). [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
42. Application of silicon and sodium hydrosulfide alleviates arsenic toxicity by regulating the physio-biochemical and molecular mechanisms of Zea mays.
- Author
-
Alatawi, Aishah, Mfarrej, Manar Fawzi Bani, Alshegaihi, Rana M., Asghar, Muhammad Ahsan, Mumtaz, Sahar, Yasin, Ghulam, Marc, Romina Alina, Fahad, Shah, Elsharkawy, Mohsen Mohamed, Javed, Sadia, and Ali, Shafaqat
- Subjects
ARSENIC ,CORN ,ARSENIC poisoning ,PLANT shoots ,PLANT biomass ,PHOTOSYNTHETIC pigments - Abstract
Soil contamination with toxic heavy metals (such as arsenic (As)) is becoming a serious global problem due to rapid development of social economy, although the use of silicon (Si) and sodium hydrosulfide (NaHS) has been found effective in enhancing plant tolerance against biotic and abiotic stresses including the As toxicity. For this purpose, a pot experiment was conducted using the different levels of As toxicity in the soil, i.e., (0 mM (no As), 50, and 100 µM) which were also supplied with the different exogenous levels of Si, i.e., (0 (no Si), 1.5, and 3 mM) and also with the NaHS, i.e., (0 (no NaHS), 1, and 2 mM) on growth, photosynthetic pigments, gas exchange characteristics, oxidative stress biomarkers, antioxidant machinery (enzymatic and non-enzymatic antioxidants), and their gene expression, ion uptake, organic acid exudation, and As uptake of maize (Zea mays L.). Results from the present study showed that the increasing levels of As in the soil significantly (P < 0.05) decreased plant growth and biomass, photosynthetic pigments, gas exchange attributes, sugars, and nutritional contents from the roots and shoots of the plants. In contrast, increasing levels of As in the soil significantly (P < 0.05) increased oxidative stress indicators in terms of malondialdehyde, hydrogen peroxide, and electrolyte leakage and also increased organic acid exudation patter in the roots of Z. mays, although the activities of enzymatic antioxidants and the response of their gene expressions in the roots and shoots of the plants and non-enzymatic such as phenolic, flavonoid, ascorbic acid, and anthocyanin contents were initially increased with the exposure of 50 µM As, but decreased by the increasing the As concentration 100 µM in the soil. The negative impact of As toxicity can overcome the application of Si and NaHS, which ultimately increased plant growth and biomass by capturing the reactive oxygen species and decreased oxidative stress in Z. mays by decreasing the As contents in the roots and shoots of the plants. Our results also showed that the Si was more sever and showed better results when we compared with NaHS under the same treatment of As in the soil. Research findings, therefore, suggest that the combined application of Si and NaHS can ameliorate As toxicity in Z. mays, resulting in improved plant growth and composition under metal stress, as depicted by balanced exudation of organic acids. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. Comparison of bio-based epoxide-diamine coatings prepared with acyclic and cyclic aliphatic diamines.
- Author
-
Babahan-Bircan, Ilknur, Thomas, Jomin, and Soucek, Mark D.
- Subjects
CHEMICAL testing ,GLYCIDYL methacrylate ,DIAMINES ,EPOXY coatings ,SURFACE coatings ,DIELS-Alder reaction ,CHEMICAL resistance - Abstract
As replacements for bisphenol-A, new bio-based and reactive epoxy-amine coatings have been investigated in this study. Bio-based precursor, epoxy-functionalized tung oil (ETO) was synthesized using glycidyl methacrylate (GMA) and tung oil via a Diels–Alder reaction according to our previous work. The new ETO-diamine-cured systems were prepared with the equivalent molar ratio at room temperature. ETO was cured with acyclic aliphatic (Jeffamine D400) and cyclic aliphatic (Epicure 3300) amines, at four temperatures ranging from 25 to 150°C. The coatings were then compared in terms of their thermal and mechanical properties. The cured coatings were analyzed by IR, thermogravimetric analysis (TGA), and gel content tests. TGA analysis showed that the epoxide-diamine polymers demonstrated thermal stability up to 170°C. The mechanical properties of the films were investigated by pendulum hardness, pencil hardness, cross-hatch adhesion, pull-off adhesion, impact resistance, reverse resistance, and chemical resistance testing. While all the cured systems exhibited good pencil hardness, cross-hatch adhesion, impact resistance, and reverse resistance properties, the epoxide-acyclic diamine system demonstrated greater pendulum hardness and notable pull-off adhesion at 150°C. The research demonstrates the potential for greener and more reactive tung oil-based epoxide coatings with enhanced properties. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
44. Concentration urinaire du cobalt et du chrome chez les patients porteurs d'une prothèse totale de hanche non cimentée.
- Author
-
Braun, E., Schmitt, D., Nabet, F., Legras, B., Coudane, H., and Molé, D.
- Abstract
Copyright of International Orthopaedics is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1986
- Full Text
- View/download PDF
45. Sequestration of cobalt and nickel by biofilm forming bacteria isolated from spent nuclear fuel pool water.
- Author
-
Karley, Dugeshwar, Shukla, Sudhir Kumar, and Rao, Toleti Subba
- Subjects
SPENT reactor fuels ,COBALT ,HEAVY metals ,BIOFILMS ,NICKEL ,NUCLEAR fuels ,MICROBIAL contamination ,URANIUM oxides - Abstract
In the current study, six bacterial types, isolated from spent nuclear fuel (SNF) pool facility, were investigated for their ability to sequester heavy metals (cobalt and nickel). Biofilm formation by the six bacterial isolates, viz., Bacillus subtilis, Staphylococcus species, Staphylococcus arlettae, Staphylococcus epidermidis, Staphylococcus auricularis, and Chryseobacterium gleum, were assayed, and they were found to have significant biofilm forming property. Their biofilms were characterised using confocal scanning laser microscopy, and their potential to accumulate Co
2+ and Ni2+ from bulk solutions was analysed with respect to time. A comparative assessment of bioaccumulation capacity was done using biofilms, planktonic cells, and live vs dead cells. The strains accumulated Co2+ and Ni2+ in the range of 4 × 10−4 to 1 × 10−5 g/mg of cell biomass. It is interesting to note that dead biomass also showed significant removal of the two metal ions, suggesting an alternative process for metal removal. This study suggests that hostile environments can be a repertoire of putative bacterial species with potential heavy metals and other contaminants remediation properties. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
46. Deciphering the melatonin-mediated response and signalling in the regulation of heavy metal stress in plants.
- Author
-
Altaf, Muhammad Ahsan, Sharma, Nitin, Srivastava, Dipali, Mandal, Sayanti, Adavi, Sandeep, Jena, Rupak, Bairwa, Rakesh Kumar, Gopalakrishnan, Abilash Valsala, Kumar, Awadhesh, Dey, Abhijit, Lal, Milan Kumar, Tiwari, Rahul Kumar, Kumar, Ravinder, and Ahmed, Parvaiz
- Abstract
Main conclusion: Melatonin has a protective effect against heavy metal stress in plants by immobilizing HM in cell walls and sequestering them in root cell vacuoles, reducing HM's translocation from roots to shoots. It enhances osmolyte production, increases antioxidant enzyme activity, and improves photosynthesis, thereby improving cellular functions. Understanding the melatonin-mediated response and signalling can sustain crop production in heavy metal-stressed soils. Melatonin is a pleiotropic signal molecule that plays a critical role in plant growth and stress tolerance, particularly against heavy metals in soil. Heavy metals (HMs) are ubiquitously found in the soil–water environment and readily taken up by plants, thereby disrupting mineral nutrient homeostasis, osmotic balance, oxidative stress, and altered primary and secondary metabolism. Plants combat HM stress through inbuilt defensive mechanisms, such as metal exclusion, restricted foliar translocation, metal sequestration and compartmentalization, chelation, and scavenging of free radicals by antioxidant enzymes. Melatonin has a protective effect against the damaging effects of HM stress in plants. It achieves this by immobilizing HM in cell walls and sequestering them in root cell vacuoles, reducing HM's translocation from roots to shoots. This mechanism improves the uptake of macronutrients and micronutrients in plants. Additionally, melatonin enhances osmolyte production, improving the plant's water relations, and increasing the activity of antioxidant enzymes to limit lipid peroxidation and reactive oxygen species (ROS) levels. Melatonin also decreases chlorophyll degradation while increasing its synthesis, and enhances RuBisCO activity for better photosynthesis. All these functions contribute to improving the cellular functions of plants exposed to HM stress. This review aims to gain better insight into the melatonin-mediated response and signalling under HM stress in plants, which may be useful in sustaining crop production in heavy metal-stressed soils. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. Influence of Cobalt, Cesium, and Combined Stresses on Physiological Parameters and Gene Expression of Two Hullless Barley Varieties.
- Author
-
Qiao, F., Geng, G. G., Xie, H. C., and Jiang, L. L.
- Subjects
GENE expression ,PHYSIOLOGICAL stress ,BARLEY ,PLANT defenses ,COBALT ,CESIUM ,HEAVY metals ,POWDERY mildew diseases - Abstract
This study investigated the impact of cobalt and cesium stresses on two hulless barley varieties through a hydroponic experiment. The plants were exposed to 200 μM cobalt chloride (Co), 200 μM cesium chloride (Cs), or with concurrent exposure to 100 μM Co + 100 μM Cs. The findings revealed that exposure to Co and Cs, either alone or in combination, caused a substantial reduction in plant growth and weight. Interestingly, the hulless barley seedlings were found to be more resilient to Cs stress, attributed to its lower Cs enrichment factor. The stressed seedlings demonstrated increased oxidative stress levels (malondialdehyde, proline, and content), but also displayed increased activity of antioxidant enzymes (POD and SOD), active oxygen scavenging capacity (GSH and GSSG content), and gene expression (GSH2, POD and SOD), reflecting a plant defense mechanism. Moreover, the expression of PAL and P5CS genes was significantly enhanced in seedlings under Co, Cs, and (Co + Cs) treatments, providing a basis for the physiological mechanism of heavy metal resistance in hulless barley. The results of this study provide valuable insights into the mechanisms of heavy metal resistance in hulless barley, indicating the plant's potential for phytoremediation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
48. Dietary exposure to potentially harmful elements in edible plants in Poland and the health risk dynamics related to their geochemical differentiation.
- Author
-
Wódkowska, Agata and Gruszecka-Kosowska, Agnieszka
- Subjects
EDIBLE plants ,PLANT health ,SCHOOL children ,HEALTH risk assessment ,COPPER ,CONSUMERS ,TRACE metals ,COPPER-zinc alloys - Abstract
Differences in the health risk values calculated for consumers of potentially harmful elements (PHEs) present in edible plants were investigated. Based on a comprehensive literature search, the highest PHE contents in plants were identified in the southern and western regions of Poland, that also revealed the highest geochemical enrichment with Zn, Pb, Cu, As, Cd, and Tl. The highest unacceptable non-carcinogenic risk (HQ) values for mean PHE contents in Poland were found for Pb: toddlers (2.80), pre-schoolers (1.80), and school-aged children (1.45) and for Cd for toddlers (1.42). The highest unacceptable carcinogenic risk (CR) values for mean As content was observed for adults (5.9 × 10
–5 ). The highest non-carcinogenic risk values for consumers were reported in Silesia, Lower Silesia, Lublin, Lesser Poland, and Opole Provinces, indicating the impact of geochemical variability on risk values. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
49. Revision total hip arthroplasty by a ceramic bearing surface after a third- and fourth-generation ceramic head or liner fracture.
- Author
-
Marmor, Simon, Yaacoub, Jean-Jacques, Aubert, Thomas, Graff, Wilfrid, Mouton, Antoine, Le Strat, Vincent, and Lhotellier, Luc
- Subjects
ACETABULUM surgery ,TOTAL hip replacement ,CERAMICS ,HIP joint dislocation ,PATIENT satisfaction ,JOINT infections - Abstract
Purpose: Although rare, fractures of ceramic components are difficult to revise, mainly due to the presence of residual ceramic debris that can cause catastrophic wear of the replacement components. Modern ceramic-on-ceramic bearings are suggested to improve outcomes of revision total hip arthroplasty (THA) for ceramic fractures. However, there are few published reports of mid-term outcomes of revision THA using ceramic-on-ceramic bearings. We evaluated clinical and radiographic outcomes of 10 patients who received ceramic-on-ceramic bearings during revision THA for ceramic fractures. Methods: All patients but one received fourth-generation Biolox Delta bearings. Clinical evaluation was performed using the Harris hip score at latest follow-up, and all patients received a radiographic evaluation to analyze the fixation of the acetabular cup and of the femoral stem. Osteolytic lesions and the presence of ceramic debris were noted. Results: After a mean follow-up of 8.0 years, there were no complications or implant failures, and all patients reported satisfaction with their implant. The average Harris hip score was 90.6. There was neither osteolysis nor loosening, but despite our extensive synovial debridement, ceramic debris was noted in the radiographs of five patients (50%). Conclusion: We report excellent mid-term outcomes, with no implant failures after eight years despite ceramic debris being found in a significant proportion of patients. We conclude that modern ceramic-on-ceramic bearings are an advantageous option for the revision of THA due to the fracture of initial ceramic components. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
50. Environmental and health impacts of mining: a case study in Kenyasi-Ahafo Region, Ghana.
- Author
-
Addo, Albert Martey, Nyantakyi, Emmanuel Kwesi, Appiah-Adjei, Emmanuel, Ackerson, Nana Osei Bonsu, Yeboah, Saeed Ibn Idris Kofi, Borkloe, Julius Kwame, Domfeh, Martin Kyereh, Siabi, Ebenezer K., Wezenamo, Clement Apuri, and Owusu, Michael
- Subjects
DRINKING water quality ,ENVIRONMENTAL management ,RESPIRATORY infections ,NOISE pollution ,COMMUNITIES ,LAND degradation ,CITIES & towns ,SOIL degradation - Abstract
Mining is regarded as one of the major economic activities with the ability to contribute to economic development. However, governments, the general public, stakeholder organizations and individuals have been concerned about the environmental and health implications of mining on surrounding communities. This paper investigated the environmental and health impacts of the Kenyasi-Ahafo mining activities on the local population and other nearby areas. The study employed a cross-sectional, observational and community-based study involving 150 respondents from three different communities through questionnaires and interview data collection. The study also made use of secondary data which included data on water quality from 2017 to 2021, air pollution dataset from blasting (August 2021-July 2022), and health facility record dataset from 2018 to 2021. The study revealed that mining activities have resulted in major environmental impacts, including land degradation. In addition, there is pollution which has affected mainly water resources in the municipality. Air and noise pollution were also evident in the area. The combined effects of environmental problems have ended in health implications with an associated high prevalence of diseases such as malaria, respiratory tract infections and skin diseases. The study found the effects of mining on the health of the local population are dependent on their proximity to the actively mined area. It also found that efforts by authorities to manage the mining impact on air, water and land were unsatisfactory. Lead (Pb) concentration in water sources was above the WHO guidelines for drinking water for most communities. About 92% of respondents agree that the mining activities were to blame for the disease prevalent in their area, with only 4.7% disagreeing. Interestingly, the study established that respondents' years of staying in the community influenced their knowledge of the effect of mining on the environment (p = 0.00132). The study recommends a review of the environmental management policy of Kenyasi-Ahafo Mines restoration efforts and intervention measures, which include afforestation, a review of operational procedures and the provision of alternative drinking water quality to the affected communities. The outcomes of this study are useful to relevant stakeholders and local authorities towards initiating plans to ensure that the environmental and health impact of the mining activities is kept to a minimum. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.