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Objective: To investigate the influencing factors of the effect of dydrogesterone in the treatment of early threatened abortion, and follow up the pregnancy outcome of patients with continued pregnancy. Methods: 300 patients with early threatened abortion who were admitted to our hospital from January 2017 to January 2019 were selected. All patients were given the first dose of dydrogesterone 40 mg/time orally, then changed to 30 mg/time, twice a day. They were divided into effective group and ineffective group according to whether the treatment was effective or not, basic clinical dataes of the two groups were collected. Multivariate Logistic regression was used to analyze the influencing factors of the effect of dydrogesterone on early threatened abortion, and the pregnancy outcome was followed up. Results: Among the 300 patients, 245 cases (81.67%) were effective, and 55 cases (18.33%) were ineffective. Univariate analysis showed that compared with the ineffective group, the age, gestational times, abortion times, birth times and anti-endometrial antibody(EMAb) positive rate in the effective group were lower, and the serum levels of β-human chorionic gonadotropin (β-HCG), progesterone (P) and estradiol (E2) were higher, and the differences were statistically significant (P＜0.05). Multivariate Logistic regression analysis showed that: Age (older), gestational times (more), birth times (more), abortion times (more) and EMAb positive were the risk factors affecting the effect of dydrogesterone treatment (P＜0.05). Serum β-HCG (higher), P (higher) and E2 (higher) were the protective factors affecting the effect of dydrogesterone treatment (P＜0.05). Follow-up results showed that the average gestational age of the 245 patients with continued pregnancy was (39.43± 1.06) weeks. The maternal outcomes were as follows: 6 cases had postpartum hemorrhage, and 17 cases had postpartum placental adhesion. Neonatal outcome: Apgar score was (9.43 ± 0.20) score, preterm delivery occurred in 2 cases, malformation occurred in 1 case, and right umbilical vein was permanent in 1 case. Conclusions: Age, pregnancies times, abortion times, EMAB positive, serum β-HCG, P and E2 are the influencing factors for the efficacy of dydrogesterone in the treatment of early threatened abortion, whether the treatment of Early Threatened Abortion with didroxyprogesterone can increase the risk of adverse maternal and neonatal outcomes remains to be further studied. [ABSTRACT FROM AUTHOR]