1. Chemical Synthesis and Characterization of Poly(poly(ethylene glycol) methacrylate)-Grafted CdTe Nanocrystals via RAFT Polymerization for Covalent Immobilization of Adenosine.
- Author
-
Nguyen, Trinh Duy, Vu-Quang, Hieu, Vo, Thanh Sang, Nguyen, Duy Chinh, Vo, Dai-Viet N., Nguyen, Dai Hai, Lim, Kwon Taek, Tran, Dai Lam, and Bach, Long Giang
- Subjects
- *
POLYMERIZATION , *NANOCRYSTALS , *ETHYLENE glycol , *METHACRYLATES , *CHEMICAL synthesis , *ADENOSINES - Abstract
This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S′-trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2′-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF