1. 513 با خطر ابتلا به عفونت (T/C) همراهی پلی مورفيسم ژن اينترلوکين 19 در موقعيت H.pylori باکتری
- Author
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محمدرضا هادی پورفرد and سيروس نعيمی
- Subjects
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ALLELES , *CHI-squared test , *GENETIC polymorphisms , *HELICOBACTER diseases , *INTERLEUKINS , *POLYMERASE chain reaction , *STATISTICS , *GENOMICS , *DATA analysis , *CASE-control method , *GENOTYPES , *DISEASE risk factors - Abstract
Introduction: Helicobacter Pylori (H. pylori) is a flagellated, spiral-shaped, microaerophilic gram-negative bacterium that colonizes stomach mucosa and causes upper gastrointestinal diseases, such as gastritis, chronic gastric ulcers and gastric carcinoma. IL-19, as an inflammatory cytokine, has been studied in different diseases including skin diseases, liver diseases, autoimmune diseases and infections. IL-19 gene at rs1028181,-513 T/C position is a polymorphic gene, which affects its expression. Materials and Methods: In this case-control study, blood samples of 100 patients and 100 healthy individuals were examined for gene polymorphism of IL-19 at rs1028181-513T/C position in patients with H. pylori infection. Genotypes of this polymorphism were determined by RFLP PCR method. Statistical data analysis of genomic and serum studies of patients was carried out by Chi-square test. Results: The relationship between T and C alleles at rs1028181-513T/C position revealed a significant relationship between allele C and H. pylori infection (p = 0.04 OR = 0.66 (CI; 0.45-0.96)). Conclusion: It appears that a direct relationship exists between H. Pylori infection and C allele at rs1028181-513T/C position. [ABSTRACT FROM AUTHOR]
- Published
- 2018