1. Novel seco-phenanthroquinolizidine alkaloids from Indonesian Boehmeria virgata.
- Author
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Rahim, Abdul, Saito, Yohei, Miyake, Katsunori, Goto, Masuo, and Nakagawa-Goto, Kyoko
- Abstract
[Display omitted] • Two new seco -phenanthroquinolizidine alkaloids and eleven known compounds isolated from the Boehmeria virgata leaves. • The absolute configurations of new seco -phenanthroquinolizidines were established by CD spectra. • Compound 3 exhibited potent cytotoxic activity against A549, MDA-MB-231, MCF-7, KB and MDR (KB-VIN) cell lines. Two novel seco -phenanthroquinolizidine alkaloids, (−)-(14a R ,15 R)-hydroxyjulandine (1) and (+)-(S)-3- O -desmethyljulandine (2), together with eleven known compounds (3 – 13) were isolated from the leaves of Indonesian Boehmeria virgata. The structures of these compounds were assigned based on the interpretation of 1D/2D NMR and HRMS data. The absolute configurations of seco -phenanthroquinolizidines 1 and 2 were determined from their ECD spectra by comparison with the known phenanthroquinolizidine 3. The isolated seco -phenathroquinolizidines 1 – 3 were evaluated for antiproliferative activity against five tumor cell lines. Compound 3 exhibited potent cytotoxic activity, while 1 and 2 were not active against all tested cell lines. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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