1. Poly(β-cyclodextrin)/platinum prodrug supramolecular nano system for enhanced cancer therapy: Synthesis and in vivo study.
- Author
-
Zhang, Ruhe, You, Xinru, Luo, Moucheng, Zhang, Xinyu, Fang, Yifen, Huang, Hai, Kang, Yang, and Wu, Jun
- Subjects
- *
CYCLODEXTRINS , *CYCLODEXTRIN derivatives , *CANCER treatment , *IN vivo studies , *BLOOD circulation , *DRUG delivery systems , *ORGANOPLATINUM compounds , *ADAMANTANE derivatives - Abstract
The use of cisplatin is restricted by systemic toxicity and drug resistance. Supramolecular nano-drug delivery systems involving drugs as building blocks circumvent these limitations promisingly. Herein, we describe a novel supramolecular system [Pt(IV)-SSNPs] based on poly(β-cyclodextrin), which was synthesized for efficient loading of adamantly-functionalized platinum(IV) prodrug [Pt(IV)-ADA 2 ] via the host-guest interaction between β-cyclodextrin and adamantyl. Pt(IV)-ADA 2 can be converted to active cisplatin in reducing environment in cancer cells, which further reduces systemic toxicity. The introduction of the adamantane group-tethered mPEG 2k endowed the Pt(IV)-SSNPs with a longer blood circulation time. In vitro assays exhibited that the Pt(IV)-SSNPs could be uptaken by CT26 cells, resulting in cell cycle arrest in the G2/M and S phases, together with apoptosis. Furthermore, the Pt(IV)-SSNPs showed effective tumor accumulation, better antitumor effect, and negligible cytotoxicity to major organs. These results indicate that supramolecular nanoparticles are a promising platform for efficient cisplatin delivery and cancer treatment. Composition and preparation of Pt(IV)-SSNPs and the possible mechanism of the in vivo drug release and anticancer treatment: accumulation in tumor cell; cell uptake; GSH-activated drug release; DNA binding inducing cell apoptosis. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF