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• Magnesium oxyhydroxide colloid was obtained by pulsed laser ablation of Mg in water. • Magnesium oxyhydroxide lamellas effectively bind to the surface of the paper fibers. • Magnesium oxyhydroxide colloid treatment bleaches, hardens and stabilizes the paper. • The treatment proposed is highly effective and surpasses the conventional techniques. Magnesium-containing nanocolloids were synthesized by nanosecond pulsed laser ablation (PLAL) of a Mg target in water. As-prepared colloids contained 2-D lamellar nanostructures of magnesium oxyhydroxide Mg 5 O(OH) 8 (Mg-NSs) with a thickness of 5–10 nm and a length/width up to one micron. The colloids obtained were used for the first time to restore old, low-quality paper (a Russian book from the beginning of the 20th century). All results were compared to conventional treatment with basic magnesium carbonate. It was found that Mg-NSs facilitated effective deacidification and conservation treatment of the paper. Paper pH increased after treatment and remained stable upon artificial aging. Moreover, treatment led to an increase in paper whiteness of up to 10% and paper strengthening up to 25%. In general, the treated paper became more resistant to the deterioration processes during aging. Thus, colloid of Mg 5 O(OH) 8 lamellar nanostructures obtained by PLAL in water is a promising agent for paper restoration and conservation. [ABSTRACT FROM AUTHOR]

• Latino adults are disproportionately impacted by dementia due to high exposure to adverse social determinants of health (SDOH). • "Brain health literacy" in middle adulthood may be a modifiable factor that could help mitigate later life risk of cognitive decline. • The proposed Brain Health Literacy framework can guide health promotion efforts, with the ultimate goal of increasing brain health equity. [ABSTRACT FROM AUTHOR]

Bacterial cellulose (BC) synthesized by Gluconacetobacter sucrofermentans CECT 7291 seems to be a good option for the restoration of degraded paper. In this work BC layers are cultivated and purified by two different methods: an alkaline treatment when the culture media contains ethanol and a thermal treatment if the media is free from ethanol. The main goal of these tests was the characterization of BC layers measured in terms of tear and burst indexes, optical properties, SEM, X-ray diffraction, FTIR, degree of polymerization, static and dynamic contact angles, and mercury intrusion porosimetry. The BC layers were also evaluated in the same terms after an aging treatment. Results showed that BC has got high crystallinity index, low internal porosity, good mechanical properties and high stability over time, especially when purified by the alkaline treatment. These features make BC an adequate candidate for degraded paper reinforcement. [ABSTRACT FROM AUTHOR]

Xuan paper, also named rice paper, was invented in the Tang Dynasty around 700 AD. Due to its softness, flexibility, fine texture and excellent durability, Xuan paper has been one of the most carriers for a large number of extraordinary artworks since its invention. The mechanical properties of Xuan paper will be varied over time, which has a significant impact on its application and preservation. In this study, for the first time, we employed atomic force microscopy nanoindentation measurement, a simple and nondestructive technique to quantitatively analyze the nanomechanical properties of Xuan paper. Combined with other characterizations, the property of Xuan paper under different aging times was investigated. It is expected that our results should lead to a better understanding of Xuan Paper as ancient materials with superior properties. The current results should provide useful information on the identification and protection of paper-based artifacts. [ABSTRACT FROM AUTHOR]

Abstract: This work focused on studying the dependence of paper sheet strength properties on the composition of additives, namely chitosan, cyanoethyl and carboxymethyl chitosan. Chitosan and its derivatives enhanced the strength properties of unagged and aged paper sheets. Also, cyanoethyl chitosan improved the dielectric properties of the treated paper sheets. The dielectric study was carried out over a frequency range from 100Hz to 100kHz at temperature range from 20 to 140°C. The variations of permittivity ε′ versus the cyanoethyl chitosan content at three different temperatures show the highest dielectric properties at cyanoethyl chitosan of 0.3%. The variation of ε″ versus the applied frequency was fitted by a superposition of Fröhlich and Havriliak–Negami functions in addition to the conductivity term. These functions could be ascribed by the Maxwell–Wagner effect and the orientation of the large aggregates formed by the addition of chitosan to the paper sheet. [Copyright &y& Elsevier]

Abstract: A set of inks was analyzed using Py/GC/MS technique. They were prepared following some ancient Armenian recipes and then analyzed after being dried in air to obtain solid samples. A simple analytical procedure was adopted which excludes any treatment of the samples and consists in introducing the solid sample directly into the injector of the furnace pyrolyzer. Inks were also written on whatman paper by calamum and analyses of papers containing ink were carried out. A real sample analysis was reported. Comparing the pyrograms it was possible to discriminate fragments derived from ink, from that formed by the decomposition of paper by the influence of ink. In order to understand the origin of the fragments formed during the pyrolysis of inks the standard compounds used to prepare them were carried out, too. [Copyright &y& Elsevier]

Natural esters have emerged as a viable and sustainable alternate for liquid insulation in power transformers. However, the natural esters currently used for transformer applications are extracted from edible sources, leading to concerns about their impact on the food supply. In order to overcome this issue, studies on the dielectric properties of non-edible natural esters have received a lot of attention in industries as alternative dielectric liquids for power transformers. In this research work, non-edible natural esters, namely Jatropha oil, Karanja oil, and Mahua oil are taken for analysis. Cellulose materials are impregnated with these oil samples, further, the samples are aged at 130 °C up to 28 days. Different dielectric, mechanical, physical and chemical parameters are measured and analyzed after every 7 days of aging. When comparing the results, karanja oil performed better than others. • Feasibility study on non-edible oils as alternative to existing mineral oil. • Accelerated aging study on non-edible oils. • Non-edible esters performed well after aging. [ABSTRACT FROM AUTHOR]

In order to improve the hydrogen sensing of transition metal oxide nanomaterials at room temperature, MoO 3 nanowire paper was prepared and used as a hydrogen sensing materials on substrate. In this paper, orthorhombic phase, ultra-long (∼1 mm) MoO 3 nanowires were synthesized through conventional hydrothermal method at 260 °C for 96 h. A flexible nanowires paper with size of 200 mm × 300 mm was obtained by further self-assembly formation process of pure α-MoO 3 nanowires in aqueous solution on hydrophobic substrate, and the thickness of paper can be controlled depend on the concentration of disperse nanowires. A novel hydrogen sensor with sensing area of 10 mm × 10 mm was obtained after Pt interdigital electrodes (IDE) deposited on the surface of α-MoO 3 nanowires paper and transferred into ceramic circuit board (CCB) without any surface modification. The response and recovery time are about 3.0 and 2.7 s toward 1.5% H 2 , respectively. The sensors also show good selectivity toward H 2 against other reduce gas, such as C 2 H 5 OH, CO and CH 4 . Large amounts of the porous structures and high specific surface of nanowires paper is beneficial to the absorption of oxygen molecules, which would lead to the high sensitivity, fast response and recovery speed of sensor at room temperature. MoO 3 nanowires paper sensors have excellent stability and reliability, which could work for 5.56 years at room temperature. [ABSTRACT FROM AUTHOR]

Abstract: Zinc oxide nanoparticles were prepared and used for surface treatment of oil paintings painted on paper supports. The prepared coating mixture containing 2% of ZnO nanoparticles showed excellent transparency. The effect of coating on protecting the paper support and paintings against microbial attack by Trichoderma reesei and Aspergillus niger, dirt accumulation, and UV aging was studied. Coatings containing ZnO nanoparticles enhanced the durability of linseed oil-based paintings toward UV aging regarding the change in color. Coatings containing ZnO nanoparticles improved resistance to microbial attack when subjected to inoculums containing T. reesei or A. niger fungi. In addition, coatings containing ZnO nanoparticles reduced accumulation of dirt on oil paintings when left in open air for 6 months; cleaning of paintings was quite easy compared to the non-coated paintings or those coated with the varnish without ZnO nanoparticles. [Copyright &y& Elsevier]

Ageing comes with an increased propensity in the alteration of human organ and body functions, which can e.g. result in multi-morbidity, frailty, polypharmacy, altered medication safety and/or efficacy, and problems with the practical use of medicines in a real world setting. Such problems may e.g. involve difficulties opening containers, swallowing large tablets, breaking tablets by hand, or correctly understanding the user instruction. This review aims to summarize the European regulatory activities towards better medicines for older people, with a main focus on formulation development and the overall drug product design. It addresses the ICH E7 guideline “Studies in support of special populations, geriatrics”, the ICH Q8 guideline “Pharmaceutical development”, the EMA good practice guide on “Risk minimisation and prevention of medication errors” and the forthcoming EMA CHMP QWP reflection paper on the “Quality aspects (pharmaceutical development) of medicines for older people”. In addition, three key aspects to the practical use of medicines by older people are discussed in a wider context: multi-particulates including small tablets (also referred to as mini-tablets), ease of opening and storage conditions. Furthermore, attention is paid to work in progress e.g. incentives by the European national drug regulatory authorities, and patient centric drug product development. [ABSTRACT FROM AUTHOR]

The present studies are focused on the effect of different polymer solutions, e.g. chitosan and polyvinyl alcohol (PVA) on the mechanical properties of the paper sheets. The improvement in the mechanical properties of the treated paper sheets with chitosan is higher than that in the other polymer solution. Moreover, the heat resistance of treated paper sheet with chitosan is more improved than with other polymer. The activation energy of the thermal treatment of untreated and treated paper sheets with mixed polymers solution is also calculated. [Copyright &y& Elsevier]

In this study, several deteriorated pressure sensitive adhesive tapes (PSATs) applied in the past for repairing ripped paper documents of 19th century and books of 20th century were analyzed by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy technique. The comparison of FTIR spectra of the old tapes with those of some commercially available tapes subjected to accelerated aging allowed us to identify, in a fast and nondestructive way, the main classes of old tapes on the basis of their backing (cellophane, cellulose acetate, polyvinyl chloride and polypropylene) and adhesive (natural rubber, synthetic rubber and acrylic polymer) compositions. This procedure's results were very useful to the paper restorers and conservators, who will have the possibility of choosing the most appropriate conservation treatment for the removal of pressure sensitive adhesive tapes that can be found on many paper documents. [ABSTRACT FROM AUTHOR]

Abstract: The effect of polymer on the retention and the thermal stability of bioactive enzymatic papers was measured using a colorimetric technique quantifying the intensity of the enzyme–substrate product complex. Alkaline phosphatase (ALP) was used as model enzyme. Three water soluble polymers: a cationic polyacrylamide (CPAM), an anionic polyacrylic acid (PAA) and a neutral polyethylene oxide (PEO) were selected as retention aids. The model polymers increased the enzyme adsorption on paper by around 50% and prevented enzyme desorption upon rewetting of the papers. The thermal deactivation of ALP retained on paper with polymers follows two sequential first order reactions. This was also observed for ALP simply physisorbed on paper. The retention aid polymers instigated a rapid initial deactivation which significantly decreased the longevity of the enzymatic papers. This suggests some enzyme–polymer interaction probably affecting the enzyme tertiary structure. A deactivation mathematical model predicting the enzymatic paper half-life was developed. [Copyright &y& Elsevier]

Gaseous acetic acid is formed under conditions of storage of historic paper objects. Its presence not only promotes hydrolytic cleavage of cellulose, but also causes acetylation of the cellulosic material to very small degree. The acetylation reaction proceeds under ambient conditions and without catalyst. Different analytical methods were used to prove the presence of organic acetates on cellulosic paper matrices. DESI-MS in combination with 2H-isotopic labeling showed the presence of sugar fragments with different acetylation patterns. A method based on Zemplen saponification was applied and worked also in the presence of a large excess of acetic acid and/or inorganic acetates. The acetylation effect was quantified for model papers and original, naturally aged paper samples. While cellulose acetylation was clearly proven to be another general pathway of paper aging, further studies of this acetylation phenomenon are needed with regard to conservational aspects and suitable paper storage conditions. [Display omitted] [ABSTRACT FROM AUTHOR]

Abstract: High-yield bagasse pulp was prepared by mechanical treatment after soaking in cold 10% sodium hydroxide. One-, two- and three-stage bleaching of the pulp were investigated by using hydrogen peroxide (P) and/or sodium dithionite (D), in different sequences. Paper sheets were prepared and tested for the strength properties and brightness value. The effect of ageing on paper properties and brightness was investigated. It was found that three-stage bleaching by using two steps with hydrogen peroxide and one step with sodium dithionite provides the optimum bleaching results with regard to the strength properties and the brightness values. Comparable results were also obtained after paper ageing. The best bleaching sequence is PPD followed by DPP and then PDP. [Copyright &y& Elsevier]

Abstract: The ASTM D6819-02e3 standard for testing the accelerated ageing of paper, published in 2002, recommends using closed glass vials in order to keep the degradation products in contact with the paper and thus permitting a better simulation of the natural ageing conditions inside closed books. In the present study, the actual conditions and their stability inside closed vessels have been evaluated. The necessity of assuring a very high sealing performance (tightness) of the systems in order to avoid leakage of water vapour is the main drawback of this ageing method. Systematic studies presented in this publication tried to monitor this tightness and have provided data that helped to answer the question of what circumstances could lead to achieving its improvement. Both gravimetric monitoring of water content in vials and “in situ” IR measurements of the aged paper humidity have been applied for this purpose. As a result, better sealing materials (gaskets and caps) than those recommended by the ASTM standard, have been found. Additionally, application of a dynamometric spanner for closing the vials is recommended, as this is a guarantee of reasonably high and recurring tightness of the systems used in tests. Nevertheless, the systematic, linear with time, loss of moisture for all used vials was observed. A 9% loss of the initial moisture content in samples of the aged paper was observed for the tested conditions (14 days at 90°C). Therefore, it seems that including some kind of gravimetric control for ageing tests performed in closed vessels is of essential importance. Kinetic studies of accelerated ageing in both closed and open systems, as monitored by DP and breaking length measurements, unexpectedly show that no statistically meaningful difference of degradation rates can be observed. On the other hand, the pH and whiteness index values reveal a meaningful difference between the rates of ageing in these systems, thus confirming the basic assumption of the ASTM test concerning the interaction of paper degradation products with the paper itself. [Copyright &y& Elsevier]

Abstract: Atomic force microscopy was used to characterize the effects of chemical reactions induced by accelerated ageing in a climatic chamber (80°C, R.H. 65%) on Whatman no. 1 chromatography paper surface, in order to study ageing consequences on sub-micron structures in cellulose. Evaluation was carried out by means of a comparison of topographic data with chemical characterization, in addition to spectrophotometric measurement in the UV–vis–NIR range. Imaging of samples at several treatment stages showed a non-homogeneous decomposition of the fibre surface into fibril bunches. Over paper sheet surfaces, occurrence of this phenomenon increases with ageing. Spectrophotometry measurements showed a strong variation of contributions in the UV–vis bands, both in the yellow chromophores region and in the carbonyl formation region, which was consistent with the hypothesis that a predominant oxidation mechanism is involved. [Copyright &y& Elsevier]

Abstract: New evidence shows that older adults need more dietary protein than do younger adults to support good health, promote recovery from illness, and maintain functionality. Older people need to make up for age-related changes in protein metabolism, such as high splanchnic extraction and declining anabolic responses to ingested protein. They also need more protein to offset inflammatory and catabolic conditions associated with chronic and acute diseases that occur commonly with aging. With the goal of developing updated, evidence-based recommendations for optimal protein intake by older people, the European Union Geriatric Medicine Society (EUGMS), in cooperation with other scientific organizations, appointed an international study group to review dietary protein needs with aging (PROT-AGE Study Group). To help older people (>65 years) maintain and regain lean body mass and function, the PROT-AGE study group recommends average daily intake at least in the range of 1.0 to 1.2 g protein per kilogram of body weight per day. Both endurance- and resistance-type exercises are recommended at individualized levels that are safe and tolerated, and higher protein intake (ie, ≥1.2 g/kg body weight/d) is advised for those who are exercising and otherwise active. Most older adults who have acute or chronic diseases need even more dietary protein (ie, 1.2–1.5 g/kg body weight/d). Older people with severe kidney disease (ie, estimated GFR <30 mL/min/1.73m2), but who are not on dialysis, are an exception to this rule; these individuals may need to limit protein intake. Protein quality, timing of ingestion, and intake of other nutritional supplements may be relevant, but evidence is not yet sufficient to support specific recommendations. Older people are vulnerable to losses in physical function capacity, and such losses predict loss of independence, falls, and even mortality. Thus, future studies aimed at pinpointing optimal protein intake in specific populations of older people need to include measures of physical function. [Copyright &y& Elsevier]

Lipid peroxidation is one of the major outcomes of free radical-mediated injury that directly damages membranes and generates a number of secondary products, both from fission and endocyclization of oxygenated fatty acids that possess neurotoxic activity. Numerous studies have demonstrated increased lipid peroxidation in brain of patients with Alzheimer’s disease (AD) compared with age-matched controls. These data include quantification of fission and endocyclized products such as 4-hydroxy-2-nonenal, acrolein, isoprostanes, and neuroprostanes. Immunohistochemical and biochemical studies have localized the majority of lipid peroxidation products to neurons. A few studies have consistently demonstrated increased cerebrospinal fluid (CSF) levels of isoprostanes in AD patients early in the course of their dementia, and one study has suggested that CSF isoprostanes may improve the laboratory diagnostic accuracy for AD. Similar analyses of control individuals over a wide range of ages indicate that brain lipid peroxidation is not a significant feature of usual aging. Quantification of isoprostanes in plasma and urine of AD patients has yielded inconsistent results. These results indicate that brain lipid peroxidation is a potential therapeutic target in probable AD patients, and that CSF isoprostanes may aid in the assessment of antioxidant experimental therapeutics and the laboratory diagnosis of AD. [Copyright &y& Elsevier]

Tight linkage between aging and oxidative stress is indicated by the observations that reactive oxygen species generated under various conditions of oxidative stress are able to oxidize nucleic acids, proteins, and lipids and that aging is associated with the accumulation of oxidized forms of cellular constituents, and also by the fact that there is an inverse relationship between the maximum life span of organisms and the age-related accumulation of oxidative damage. Nevertheless, validity of the oxidative stress hypothesis of aging is questioned by (i) the failure to establish a causal relationship between aging and oxidative damage and (ii) lack of a consistent correlation between the accumulation of oxidative damage and aging. The present discussion is focused on the complexity of the aging process and suggests that discrepancies between various studies in this area are likely due to the fact that aging is not a single process and that the lack of consistent experimental results is partly explained by individual variations. Even so, there is overwhelming support for a dominant role of oxidative stress in the aging of some individuals. [Copyright &y& Elsevier]

Research into the causes of aging has greatly increased in recent years. Much of this interest is due to the discovery of genes in a variety of model organisms that appear to modulate aging. Studies of long-lived mutants can potentially provide valuable insights into the fundamental mechanisms of aging. While there are many advantages to the use of model organisms to study aging it is also important to consider the limitations of these systems, particularly because ectothermic (poikilothermic) organisms can survive a far greater metabolic depression than humans. As such, the consideration of only chronological longevity when assaying for long-lived mutants provides a limited perspective on the mechanisms by which longevity is increased. Additional physiological processes, such as metabolic rate, must also be assayed to provide true insight into the aging process. This is especially true in the nematode Caenorhabditis elegans, which has the natural ability to enter into a metabolically reduced state in which it can survive many times longer than its normal lifetime. The extended longevity of at least some long-lived C. elegans mutants may be due to a reduction in metabolic rate, rather than an alteration of a metabolically independent genetic mechanism specific for aging. [Copyright &y& Elsevier]

The main purpose of this article is to provide a critical overview of the currently available evidence bearing on the validity of the oxidative stress hypothesis of aging, which postulates that senescence-associated attenuations in physiological functions are caused by molecular oxidative damage. Several lines of correlative evidence support the predictions of the hypothesis, e.g., macromolecular oxidative damage increases with age and tends to be associated with life expectancy of organisms. Nevertheless, a direct link between oxidative stress and aging has not as yet been established. Single gene mutations have been reported to extend the life spans of lower organisms, such as nematodes and insects; however, such prolongations of chronological clock time survival are usually associated with decreases in the rate of metabolism and reproductive output without affecting the metabolic potential, i.e., the total amount of energy consumed during life. Studies on genetic manipulations of the aging process have often been conducted on relatively short-lived strains that are physiologically weak, whereby life-span extensions can not be unambiguously assigned to a slowing effect on the rate of aging. It is concluded that although there is considerable evidence implicating oxidative stress in the aging process, additional evidence is needed to clearly define the nature of the involvement. [Copyright &y& Elsevier]

Aging is accompanied by declines in cellular proteolytic capacity. Proteolytic processing is an important step in numerous cellular processes required for normal metabolic function. These include regulation of protein turnover, degradation of altered forms of protein, signal transduction, protein sorting/trafficking, receptor-mediated endo- and exocytosis, stress/immune responses, and activation of gene transcription. Thus, loss of cellular proteolytic function is likely to contribute to the enhanced fragility of cells from senescent relative to young and adult organisms. Free radicals have been implicated as contributing factors to observed age-dependent declines in proteolytic capacity. The current review offers an overview of the evidence linking free radical events to functional alterations in the lysosomal system and the proteasome, two major pathways by which proteins are degraded within cells. Implications for future investigations in the field are discussed in light of these findings. [Copyright &y& Elsevier]

Heme oxygenase (HO) is the rate-limiting enzyme for the degradation of heme, a prooxidant, coming from a multitude of heme-containing proteins/enzymes. With the action of cytochrome P450 reductase, HO cleaves the heme ring into biliverdin which is converted into bilirubin, both have been shown to have intrinsic radical scavenger activities. Iron is also released from the heme core and in its free form can act as a catalyst for oxidative stress damage or can be sequested by several iron-binding proteins. Under physiological conditions, the newly generated iron can be neutralized within the cell. The third product of the opening of the porphyrin ring is carbon monoxide, which role has been puzzling. It has been reported as a potential neuromodulator, it modulates guanylate cyclase activity and has vasodilation, anti-inflammatory and antiapoptotic effects. In the brain, HO2 accounts for the vast majority of HO activity. By decreasing HO2 activity, one would expect more neuronal damage after oxidative stress injury with possible direct implications to acute and chronic neurodegenerative disorders. Pharmacological ways to increase neuronal HO activity is likely to have therapeutic applications. [Copyright &y& Elsevier]

A significant body of evidence supports a key role for free radicals in causing cumulative damage to cellular macromolecules, thereby contributing to senescence/aging, and a number of age-related disorders. Proteins are recognized as major targets for oxidative damage (in addition to DNA and lipids) and the accumulation of oxidized proteins has been reported for many experimental aging models, as measured by several markers for protein oxidation. In young and healthy individuals, moderately oxidized soluble cell proteins are selectively and rapidly degraded by the proteasome. However, severely oxidized, cross-linked proteins are poor substrates for degradation and actually inhibit the proteasome. Considerable evidence now indicates that proteasome activity declines during aging, as the protease is progressively inhibited by binding to ever increasing levels of oxidized and cross-linked protein aggregates. Cellular aging probably involves both an increase in the generation of reactive oxygen species and a progressive decline in proteasome activity, resulting in the progressive accumulation of oxidatively damaged protein aggregates that eventually contribute to cellular dysfunction and senescence. [Copyright &y& Elsevier]

There is a large body of evidence implicating oxidative damage in the pathogenesis of both normal aging and neurodegenerative diseases. Oxidative damage to proteins has been well established. Although there are a large number of potential oxidative modifications only a few have been systematically studied. The most frequently studied marker of oxidative damage to proteins is protein carbonyl groups. 3-Nitrotyrosine is thought to be a relatively specific marker of oxidative damage mediated by peroxynitrite. Increased concentrations of both protein carbonyls and 3-nitrotyrosine have been documented in both normal aging as well as in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). These findings help to provide a rationale for trials of antioxidants in neurodegenerative diseases. [Copyright &y& Elsevier]

This article further investigates the suitability of an inkless method to obtain and maintain exemplar fingerprint recordings on thermal paper; in this case, stored for 1.5 years at different temperatures. Inkless impressions were (re-)examined by optical means via two independent methods. First, an automated metric from the FBI's Universal Latent Workstation (ULW) was adapted (i.e., BlueGreen color-coded maps) to evaluate visual differences among inkless fingerprint sets with respect to storage time, temperature, relative humidity, and biological sex. Additionally, a conventional assessment system was applied, a categorical quality score (QS) metric that ranges on a grading scale from 1 to 4. Results revealed that storage time (72 weeks), as well as a colder temperature (~ 3 ºC) and lower relative humidity (~ 12 %), had little impact on the preservation of ridge clarity when compared to freshly deposited counterparts. A biological sex effect was again detected, but its influence was not significant under certain conditions. Despite minor visual differences, the ridge clarity of the inkless impressions remained stable for the duration of the experiment. The stability and durability of the proposed inkless method were proven, becoming a potential alternative to the conventional black ink method. [ABSTRACT FROM AUTHOR]

Preferential Attachment (PA) models the scientific citation process. In the PA model, a new paper attaches itself to the citation network based only on the popularity of the currently existing papers. This invariably leads to a network whose degree distribution satisfies the Power Law. Yet, empirical results show that paper age should also play a role in the citation process. In other words, when references are chosen for a new paper, the age of an existing paper may also affect the choice for citing. In this paper, we derive a generalized PA model that includes the effect of aging, with analytical solution. Such a model can be used to analyze the competing influence of preferential attachment and aging effect quantitatively in citation process and explain differences in various research domains by the extent of aging. It may also serve as a general model of network formation. [ABSTRACT FROM AUTHOR]

Older adults exhibit increased gait variability that is associated with fall history and predicts future falls. It is not known to what extent this increased variability results from increased physiological noise versus a decreased ability to regulate walking movements. To "walk", a person must move a finite distance in finite time, making stride length (Ln) and time (Tn) the fundamental stride variables to define forward walking. Multiple age-related physiological changes increase neuromotor noise, increasing gait variability. If older adults also alter how they regulate their stride variables, this could further exacerbate that variability. We previously developed a Goal Equivalent Manifold (GEM) computational framework specifically to separate these causes of variability. Here, we apply this framework to identify how both young and high-functioning healthy older adults regulate stepping from each stride to the next. Healthy older adults exhibited increased gait variability, independent of walking speed. However, despite this, these healthy older adults also concurrently exhibited no differences (all p>0.50) from young adults either in how their stride variability was distributed relative to the GEM or in how they regulated, from stride to stride, either their basic stepping variables or deviations relative to the GEM. Using a validated computational model, we found these experimental findings were consistent with increased gait variability arising solely from increased neuromotor noise, and not from changes in stride-to-stride control. Thus, age-related increased gait variability likely precedes impaired stepping control. This suggests these changes may in turn precede increased fall risk. [ABSTRACT FROM AUTHOR]

Background: Due to the aging of the population, cancer has become a health priority worldwide. While the number of elderly cancer patients is rapidly increasing, many barriers still exist to their effective management. Compared with their younger counterparts, the elderly are less likely to receive optimal medical, psychological and spiritual treatment provided in a culturally competent manner. Design: The scanty literature on cultural competence in elderly cancer patients has been reviewed. Additional material has been selected based on the authors' clinical research in medical oncology and psycho-oncology, and on their scholarly work in anthropology and bioethics. Results: The aging process is a synergistic product of biological, behavioral and social issues within a cultural context. Knowledge about how older people understand, perceive and experience their illness trajectory and make choices is essential to the planning and delivering of effective cancer care. Conclusion: This position paper of the SIOG Task Force on Cultural Competence in the Elderly creates awareness of the influence of culture in geriatric oncology. Negotiating cross-cultural issues in geriatric oncology helps managing possible conflicts between patients, families and physicians over differing health care values, beliefs, or practices. Possible areas of future scholarly investigation and clinical research are identified. [ABSTRACT FROM AUTHOR]

Gait changes with aging have been investigated, but few studies have examined a wide range of gait parameters across the adult lifespan. This study aimed to investigate gait differences across age groups stratified by sex. This cross-sectional study included 629 healthy, normal-weight (i.e., BMI < 30 kg/m2) participants from Switzerland of the COmPLETE cohort study, aged 20 to over 90 years. Gait metrics were assessed using an inertial measurement unit (IMU)-based gait analysis system, including speed, cycle duration variability, asymmetry, stride length, cycle duration, cadence, double support, stance (time foot is on the ground during a gait cycle), swing (time foot is in the air during a gait cycle), loading (early part of the stance phase), foot-flat (mid-stance phase when foot is flat), and pushing (late stance phase leading to toe-off) phases. Percentile curves were calculated using generalized additive models for location, scale, and shape. Gait data from 545 participants (273 men and 272 women) were analyzed. Participants were equally distributed across the seven age decades, with an average of 40 men and 40 women representing every decade. Both men and women showed a reduction in gait speed and stride length, and an increase in cycle duration variability and asymmetry with aging. Gait speed and stride length declined across the age groups, with a significant difference found in participants aged 80 to 91 compared to younger age groups. Age-related changes in gait parameters were seen in both men and women. These may be attributed to the typical decline in muscle strength, balance, coordination, and neuromuscular function. The results of this study contribute to the understanding of gait changes throughout the lifespan and can be used for comparison with other populations and as reference values for individual patients. • First paper providing norm values for gait parameters in a European population. • Large sample of healthy adults across the life span (20 to over 90 years of age). • Comprehensive overview of gait parameters across age groups, stratified by sex. • Both men and women displayed lower gait speed and stride length with age. • Gait variability and asymmetry was higher from around 60 years of age. [ABSTRACT FROM AUTHOR]

Recent papers have emphasized the primary role of cellular information management in biological and evolutionary development. In this framework, intelligent cells collectively measure environmental cues to improve informational validity to support natural cellular engineering as collaborative decision-making and problem-solving in confrontation with environmental stresses. These collective actions are crucially dependent on cell-based memories as acquired patterns of response to environmental stressors. Notably, in a cellular self-referential framework, all biological information is ambiguous. This conditional requirement imposes a previously unexplored derivative. All cellular memories are imperfect. From this atypical background, a novel theory of aging and death is proposed. Since cellular decision-making is memory-dependent and biology is a continuous natural learning system, the accumulation of previously acquired imperfect memories eventually overwhelms the flexibility cells require to react adroitly to contemporaneous stresses to support continued cellular homeorhetic balance. The result is a gradual breakdown of the critical ability to efficiently measure environmental information and effect cell-cell communication. This age-dependent accretion governs senescence, ultimately ending in death as an organism-wide failure of cellular networking. This approach to aging and death is compatible with all prior theories. Each earlier approach illuminates different pertinent cellular signatures of this ongoing, obliged, living process. [ABSTRACT FROM AUTHOR]

What is already known about the topic?. • Quality of life is an essential factor in later life, exploring predictors of quality of life thereby conducting targeted interventions in old age is important for healthy aging. • On the basis of future demographic changes and technology development, investing in digital competences, especially eHealth literacy is significant for the aging population. What this paper adds. • This study provides experimental evidence for the integrative model of eHealth use model from the specific health personality perspective. • Lower levels of health neuroticism, higher levels of health openness and health conscientiousness are correlated with higher quality of life. • eHealth can significantly mediate the relationship between health personality factors and quality of life among older adults. To explore the relationship between health personality and quality of life among community-dwelling older adults and to examine the mediating effect of eHealth literacy on this relationship. A total of 413 community-dwelling older adults from central China were recruited from September 2022 to January 2023. A cross-sectional investigation was conducted using the Chinese versions of the Health Personality Assessment (HPA), eHealth Literacy Scale (eHEALS), and 12-item Short Form Health Survey (SF-12). Correlations between the three variables were examined by Pearson analysis, and mediation analysis was conducted to explore the direct, indirect, and total effects of the health personality on quality of life vis-à-vis eHealth literacy. Health personality factors (including health neuroticism, health openness, and health conscientiousness), eHealth literacy, and quality of life are significantly correlated (P <0.05); eHealth literacy can play a significant mediating role in the relationship between health neuroticism (β= -0.256, 95 %CI: [-0.405, -0.119]), health openness (β = 0.488, 95 % CI: [0.343,0.652]), health conscientiousness (β= 0.489, 95 % CI: [0.354, 0.634]) and quality of life. This study revealed that the effect of health personality factors (including health neuroticism, health openness, and health conscientiousness) on quality of life in older adults was mediated through eHealth literacy. Individual personality is essential to understanding eHealth literacy and quality of life among community-dwelling older adults. It may be helpful to identify the health personality traits of older adults first, then implement targeted interventions accordingly to enhance eHealth literacy and ultimately improve quality of life. [ABSTRACT FROM AUTHOR]

This systematic review aimed to evaluate the literature and answer the question: "Do surface-treated zirconia implants exhibit higher fracture resistance when subjected to aging than untreated ones?" This systematic review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols (PRISMA) guidelines and was registered in the Open Science Framework (osf.io/ukhdz). A personalized search strategy was applied in the Embase, PubMed, Scopus, Science Direct, and Web of Science databases. The article's selection was independently conducted in two steps by the reviewers. The risk of bias analysis was performed by adapting the Joanna Briggs Institute's quasi-experimental studies tool. A total of 648 articles were found in the initial search. After excluding the duplicates, 601 were evaluated according to the title and abstract. Of these, 29 papers were selected for full-text reading, and 15 met the eligibility criteria. Concerning the risk of bias, 12 had a low risk of bias, and 3 had a moderate risk of bias. The articles included in this review were heterogeneous regarding the influence of surface treatment on the fracture resistance of zirconia implants. The literature reviewed allowed inferring that there is a need for care in the zirconia implant development to have fracture resistance according to the parameters defined in ABNT, ASTM, or ISO standards, ensuring the survival of the rehabilitation. [ABSTRACT FROM AUTHOR]

Social gradients in health and aging have been reported in studies across many human populations, and - as the papers included in this special collection highlight – also occur across species. This paper serves as a general introduction to the special collection of Neuroscience and Biobehavioral Reviews entitled "Social dimensions of health and aging: population studies, preclinical research, and comparative research using animal models". Authors of the fourteen reviews are primarily members of a National Institute of Aging-supported High Priority Research Network on "Animal Models for the Social Dimensions of Health and Aging". The collection is introduced by a foreword, commentaries, and opinion pieces by leading experts in related fields. The fourteen reviews are divided into four sections: Section 1: Biodemography and life course studies; Section 2: Social behavior and healthy aging in nonhuman primates; Section 3: Social factors, stress, and hallmarks of aging; Section 4: Neuroscience and social behavior. [ABSTRACT FROM AUTHOR]

The village is important as a residential environment for rural older people. Village populations in The Netherlands have a higher proportion of older people than cities and are facing higher rates of greying. The aim to create 'age-friendly communities' which enable people to 'age in place' is therefore even more relevant for villages than for urban places. However, the age-friendly community concept does not take into account the diversity of both older people and rural places. Rural places which are a 'paradise' for certain groups of older adults might feel like a 'prison' to others. Moreover, rural older people are changing, just as villages are changing. A situation characterised as a good 'person-environment fit' may transform into a poor fit through changes in both the characteristics of the older people and the local environment. This paper aims to investigate changes in person-environment fit for older people in East Gelderland, a peripheral rural area in the east of The Netherlands. By distinguishing between different types of villages in one rural area, we are able to explore which types of villages demonstrate the best person-environment fit, and for which categories of older adults. The multivariate analysis (UNIANOVA) is based on a secondary analysis of two datasets derived from two surveys conducted in 17 villages in East Gelderland in two different years, 1995 and 2009. The analysis includes data on 515 persons aged 55 years and older from the 1995 survey, and 463 persons in the same age group from the 2009 survey. Person-environment fit is measured in terms of satisfaction, feeling unsafe, feeling at home, village attachment and participation. The analysis demonstrates the growing importance of certain differentiations, whereby specific village types match the needs and preferences of specific groups of older adults. Income, migration history and age appear to be the core characteristics. The paper concludes that the villages in East Gelderland form a fitting 'coat' for most older people, but certain categories of older people face a lower person-environment fit and fewer possibilities to 'age in place' in specific types of villages. Relatively poor villages seem to be more at risk with respect to person-environment fit for the older population in the transition from the 'third age' to the 'fourth age'. But even for specific subgroups of older people in rich villages, such as older people with a low income and retired migrants, ageing-in-place is not self-evident. • The 'age-friendly community' concept does not take into account the changing diversity of rural people and rural places. • Certain older people face a lower person-environment fit and fewer possibilities to 'age in place' in certain villages. • The 'life-cycle robust neighbourhood' as a policy goal is a utopia. It ignores the growing importance of differentiation. • Poor peripheral small villages are at risk when it comes to 'ageing in place'. [ABSTRACT FROM AUTHOR]

• Aerogel-based cool roof compared with ceramic paint and bituminous membrane. • Summer and autumn campaign in a full-scale test-room in a Mediterranean climate. • Aerogel paint determines a surface temperature reduction of 9.7 °C during the day. • During extremely hot day the maximum surface temperature decreases of −36%. • After one year of aging Aerogel shows a solar reflectance 47% greater than traditional cool roof. Passive radiative cooling material for building application show consolidated energy environmental and economic benefit, both to the users than community. Technological progress allows to develop new types of cool materials able, for instance, to emit infrared radiation into the space or to have a dynamic behaviour. There are also some paints based on Aerogel, marketed as insulating paints, which however, achieve a limited insulation, due to the extremely reduced thickness. The study of their spectral characteristics and behavior is limited in scientific literature and, their commercialization lacks independent scientific evidence and relies on non-standard detection methods. This paper aims to investigate, under real climatic conditions, the thermal performance of Aerogel-based cool roof, with a solar reflectance of 84% and a thermal emissivity of 90%. It is compared with a ceramic-based paint and a common finishing roof material of bituminous membrane. Since in literature there are mainly numerical/simulative studies or in-lab based, the analysis covers a whole summer and autumn season of continuous experimental campaign in a full-scale test-room, placed in Mediterranean climate. The application of ceramic paint determines an average surface temperature reduction of 9.0 °C during the day and 2.1 °C at night; while the Aerogel one 9.7 °C and 2.2 °C respectively. During the sunniest day the maximum surface temperature decreases of 25% and 28% for the ceramic and Aerogel coating respectively. This percentage increases on extremely hot day (-36% for both coatings) and decreases on windiest day (-20% for Ceramic coating and −24% for Aerogel coating). [ABSTRACT FROM AUTHOR]

Chronic disease has profound impacts on the structural features of individuals' interpersonal connections such as bridging — ties to people who are otherwise poorly connected to each other. Prior research has documented competing arguments regarding the benefits of network bridging, but less is known about how chronic illness influences bridging and its underlying mechanisms. Using data on 1555 older adults from the National Social Life, Health, and Aging Project (NSHAP), I find that older adults diagnosed with chronic illness tend to have lower bridging potential in their networks, particularly between kin and non-kin members. They also report more frequent interactions with close ties but fewer neighbors, friends, and colleagues in their networks, which mediates the association between chronic illness and social network bridging. These findings illuminate both direct and indirect pathways through which chronic illness affects network bridging and highlight the context-specific implications for social networks in later life. • The paper discusses context-specific implications for social network bridging potential in a novel context of chronic health. • Older adults' bridging potential in personal networks are classified into three distinct types. • Chronic illnesses directly and only reduce the likelihood of bridging kin and non-kin members. • The declining non-kin informal ties accelerate the adverse association between chronic illnesses and social network bridging. [ABSTRACT FROM AUTHOR]

This paper, based on a qualitative study, explores the home-making activities of older adults living in a non-profit, welfare-based institutional care home in Kerala, India. We employed in-depth interviews and observation to obtain rich data on various home-making practices of older adults. Contrary to the stigmatization in India of care homes as places of abandonment and desertion, this study illustrates: (1) the important role of non-profit care homes in protecting neglected older adults especially in non-western contexts; and (2) the performative roles of older adults who utilize, modify, and recreate home in formal care spaces. Our empirical results show that daily rhythmic activities, gender roles, kinning, and cultural practices in a formal care setting contribute to establishing new familial ties and continuity in life as well as a sense of insideness in a formal care home. This paper contributes to the emerging dialogue on the role of rhythm, kinning, and culture in home-making practices in formal care spaces in a non-western context. [ABSTRACT FROM AUTHOR]

Existing research has documented various determinants of mental health related to individuals' social connections, but less is known about the role of the structural features of interpersonal networks. This is especially true in the case of bridging , which refers to ties to people who are otherwise disconnected from each other. By intersecting theories of social networks and gerontology, this study employs within- and between-person analysis with data from the National Social Life, Health, and Aging Project (NSHAP) to examine the association between social network bridging and depression in later life. The study finds that bridging, particularly between kin and non-kin members in the network, is associated with increased depressive symptoms in later life. This association is contingent on social support and strain respondents experienced, and it exhibits variations within individuals over time, especially among older adults in the youngest age cohort (57–64 years old included in NSHAP in 2005). In closing, the paper discusses the extent to which heterogeneous network structures may be one mechanism that shapes mental health trajectories in the context of later life-course experiences. • The paper discusses how bridging disparate network members produces strain that elevates depression risks in later life. • Older adults' bridging potential in personal networks is classified into three distinct types. • The association between bridging and elevated depressive symptoms is unique to bridging unconnected kin and non-kin. • The effect of bridging is more so for the youngest age cohort than older cohorts. [ABSTRACT FROM AUTHOR]

This paper takes the co-construction of age and gender over the course of a life as a starting point and expands this perspective by looking at the intersectional interplay of institutional, spatial, and bodily materiality in the setting of a nursing home. Nursing homes are often perceived as a female space, both socially and physically. Moreover, they are institutional spaces that are primarily oriented towards the deficits of aging and bodies in need of care so that age and aging are reproduced in a narrative of decline, and gender hardly has space to be constructed. This interweaving of institutional spaces, bodies in need of care, and gender poses the question: How are age and gender produced through the space(s) of the nursing home and its materiality, and vice versa? On this basis, the influence on the construction of masculinities in the context of materialism is discussed. This paper draws on two case studies, Walter Probst (age 93) and Günther Schiffke (age 78), based on biographical interviews, to focus on the perspective of very old men in need of care and work out the interplay between the material nature of the institutional space and the body in need of care. It will be shown how closely the performance of age, gender, and masculinities is determined by spatial materiality in the nursing home and the increasing dependence of bodies in need of care, as well as how these bodies produce the spaces in turn. On the basis of the case studies, three aspects of materiality of care home spaces are highlighted. The first aspect of this materiality shows how the body can be increasingly perceived and treated as a material object. The second aspect is defined by the body situated in space, and its relationship to objects and aids. As a third aspect, the possibilities of interacting in communal and private spaces of the nursing home are explored. The article thus contributes to linking the (re-) construction of biographic narratives more strongly to spatial materiality and to embedding the construction and performance of age and gender in spatial and institutional structures, thus demonstrating that spaces and environments shape age, gender, and masculinities in a reciprocal way. • The intersectional perspective show how institutional spaces shape both age and gender in a reciprocal way. • Two case studies show the limits and options materialities of nursing homes provide for the presentations of residents. • The materialities of the care setting play a strong role by replicating the deficit perspective on nursing home residents [ABSTRACT FROM AUTHOR]

This paper discusses an overarching framework that integrates latent variable models and prediction success with receiver operator characteristics (ROC) curves. In three illustrative examples that focus on trip purpose, health market indicators, and resources, the paper employs binary logit models and ROC methodology to identify factors that best discriminate individuals' trips to out-patient health care facilities. Data for the examples are a three-year longitudinal survey of persons 45 years and older in China. The study contributes to the sparse empirical economics literature using ROC methodologies and more broadly to the transportation and health literatures. The ROC applications provide new insights on health care trips, finding that out-patient trips for treatment, paying out-of-pocket costs, and lack of monetary resources are salient discriminators in one's trip choice decisions. [ABSTRACT FROM AUTHOR]

In order to achieve the goal of reducing the environmental footprint of the transport sector, new low-carbon energy systems including fuel cells and power converters are proposed. The sizing and operation of such systems have to take into account the aging of the fuel cell. This paper focuses on the study of a potential impact of high frequency current ripples (HFCR) on the degradation of a high-temperature proton exchange membrane fuel cell (HT-PEMFC). A 2600 h long endurance test was carried out on 4 HT-PEMFC single cells with and without HFCR. The degradation of two cells operated with a triangular current waveform of frequency 20 kHz and amplitude 20 % pp of the mean current density (0.2 A/cm2) is compared to the degradation of two cells operated at the same constant mean current density. In addition to endurance phase, several characterization phases (polarization curves, electrochemical impedance spectroscopy and cyclic voltammetry) are used to analyse the impact of the current harmonics. The obtained results show that the high frequency current ripples do not seem to accelerate the degradation of the HT-PEMFC single cells. • Two HT-PEMFC single cells are operated for 2600 h at 0.2 A/cm2 with 20 kHz 20 % pp triangular current waveform. • Ageing is compared with two HT-PEMFC single cells operated simultaneously at the same constant mean current density. • Evolution of cell voltages during endurance and characterization phases is similar with and without HF current ripples. • Reduction of ECSA leading to an increase in activation losses is found for all tested fuel cells. [ABSTRACT FROM AUTHOR]

• Gut-brain axis is involve in aged-related neurological disorders like Alzheimer. • Oral and gut dysbiosis has been associated to biomarkers of cognitive decline. • Microbial-derived metabolites could modulate tau and β-amyloid deposition. • Gut microbiome could affect brain activity via epigenetic changes. • Oral and gut dysbiosis as additional hallmark of human aging and neurodegeneration. Gut microbiota represents a diverse and dynamic population of microorganisms harbouring the gastrointestinal tract, which influences host health and disease. Bacterial colonization of the gastrointestinal tract begins at birth and changes throughout life, with age being one of the conditioning factors for its vitality. Aging is also a primary risk factor for most neurodegenerative diseases. Among them, Alzheimeŕs disease (AD) is probably the one where its association with a state of dysbiosis of the gut microbiota has been most studied. In particular, intestinal microbial-derived metabolites have been associated with β-amyloid formation and brain amyloid deposition, tau phosphorylation, as well as neuroinflammation in AD patients. Moreover, it has been suggested that some oral bacteria increase the risk of developing AD. However, the causal connections among microbiome, amyloid-tau interaction, and neurodegeneration need to be addressed. This paper summarizes the emerging evidence in the literature regarding the link between the oral and gut microbiome and neurodegeneration with a focus on AD. Taxonomic features of bacteria as well as microbial functional alterations associated with AD biomarkers are the main points reviewed. Data from clinical studies as well as the link between microbiome and clinical determinants of AD are particularly emphasized. Further, relationships between gut microbiota and age-dependent epigenetic changes and other neurological disorders are also described. Together, all this evidence suggests that, in some sense, gut microbiota can be seen as an additional hallmark of human aging and neurodegeneration. [ABSTRACT FROM AUTHOR]

Increasing research highlights heterogeneity in patterns of social network change, with growing evidence that these patterns are shaped in part by social structure. The role of social and structural neighborhood conditions in the addition and loss of kin and non-kin network members, however, has not been fully considered. In this paper, we argue that the residential neighborhood context can either facilitate or prevent the turnover of core network relationships in later life – a period of the life course characterized by heightened reliance on network ties and vulnerability to neighborhood conditions. Using longitudinal data from the National Social Life, Health, and Aging Project linked with data from the American Community Survey, we find that higher levels of neighborhood concentrated disadvantage are associated with the loss of older adults' kin and non-kin network members over time. Higher levels of perceived neighborhood social interaction, however, are associated with higher rates of adding non-kin network members and lower rates of adding kin network members over time. We suggest that neighborhood conditions, including older adults' perceptions of neighborhood social life, represent an underexplored influence on kin and non-kin social network dynamics, which could have implications for access to social resources later in the life course. • Neighborhood conditions influence the addition and loss of older adults' personal network members over time. • These associations emerge even when accounting for life-course transitions, health, and social position. • Older adults living in higher levels of local concentrated disadvantage lose kin and non-kin network ties at higher rates. • Greater perceived neighborhood social ties are associated with higher rates of non-kin additions and lower rates of kin additions. [ABSTRACT FROM AUTHOR]

This paper presents a number of power grid network design and optimization techniques that consider the electromigration (EM) effects for multi-segment interconnect wires. First, we consider a new EM immortality constraint due to EM void saturation volume for multi-segment interconnects. It helps reduce conservativeness in the EM-aware on-chip power grid design. Along with the EM nucleation phase immortality constraint, we show that both EM immortality constraints can be naturally integrated into the existing programming based power grid optimization framework. Second, to mitigate the overly conservativeness of the immortality constrained optimization methods, we further explore three strategies: we first size up failed wires to meet one of the immortality conditions subject to the design rules; second, we consider the EM-induced aging effects on power supply networks for a target lifetime, which allows some short-lived wires to fail and optimizes the remaining wires; third, we propose a large change sensitivity-based optimization scheme to perform localized fixing based on recently proposed coupled EM-IR drop analysis method. Numerical results on a number of IBM-format power grid networks demonstrate that the new method can reduce more power grid area compared to the existing EM immortality constrained optimizations. Moreover, the new method is able to optimize power grids with nucleated wires, which would not be possible with the existing methods. Results also show the sensitivity-based localized power girds fixing can fix EM-induced IR drop violations in a few minutes for synthesized power grid networks from ARM core designs. • This paper introduces new power grid design and optimization techniques considering EM aging effects for a target lifetime. • A new EM immortality constraint due to EM void saturation volume is integrated into the framework • Three strategies are explored to further mitigate the conservativeness of the immortality constrained optimization method. • Experimental results validated the soundness of the proposed methods. [ABSTRACT FROM AUTHOR]

Selective catalytic reduction (SCR) is one of the main methods used to reduce NO x emissions from diesel engines. Vanadium-based catalysts are widely used in SCR because of their good sulfur resistances and low costs. In this paper, for improving the catalytic performance of aged SCR, experimental and simulation methods were used to study the effects of the aged SCR state, space velocity, and ammonia-to-nitrogen ratio on the NO x conversion efficiency. The experimental results showed that the catalytic performances of the aged SCR state in the low- and medium-temperature regions were not significantly different from that of the fresh SCR, and the degradation in the high-temperature region was significant. In the low- and high-temperature regions, space velocity was an important factor affecting the aged SCR. Increasing the ammonia-to-nitrogen ratio could compensate for the effect of the SCR aging in the low- and medium-temperature regions to some extent. Image 1 • The catalytic performance of the aged SCR decreases more at high temperature. • Change of NO x conversion efficiency during cold start phase was studied. • The effect of space velocity on SCR in low and high temperature regions is greater. • Ammonia-to-nitrogen ratio has more influence on SCR at low and medium temperatures. [ABSTRACT FROM AUTHOR]

Chronic alcohol consumption, Alzheimer's disease (AD), and vascular dementia are all associated with cognitive decline later in life, raising questions about whether their underlying neuropathology may share some common features. Indeed, recent evidence suggests that ethanol exposure during adolescence or intermittent drinking in young adulthood increased neuropathological markers of AD, including both tau phosphorylation and beta-amyloid (Aβ) accumulation. The goal of the present study was to determine whether alcohol consumption later in life, a time when microglia and other neuroimmune processes tend to become overactive, would influence microglial clearance of Aβ (1-42) , focusing specifically on microglia in close proximity to the neurovasculature. To do this, male and female Fischer 344 rats were exposed to a combination of voluntary and involuntary ethanol consumption from ∼10 months of age through ∼14 months of age. Immunofluorescence revealed profound sex differences in microglial co-localization, with Aβ (1-42) showing that aged female rats with a history of ethanol consumption had a higher number of iba1+ cells and marginally reduced expression of Aβ (1-42) , suggesting greater phagocytic activity of Aβ (1-42) among females after chronic ethanol consumption later in life. Interestingly, these effects were most prominent in Iba1+ cells near neurovasculature that was stained with tomato lectin. In contrast, no significant effects of ethanol consumption were observed on any markers in males. These findings are among the first reports of a sex-specific increase in microglia-mediated phagocytosis of Aβ (1-42) by perivascular microglia in aged, ethanol-consuming rats, and may have important implications for understanding mechanisms of cognitive decline associated with chronic drinking. • The present experiment used a novel, moderate intermittent ethanol consumption procedure across middle to late aging. • Aged females with a history of ethanol consumption have increased co-localization of microglia and Aβ (1-42) in the dorsal hippocampus. • This paper offers insight into microglia-Aβ (1-42) co-localization around neurovasculature after moderate chronic ethanol exposure. [ABSTRACT FROM AUTHOR]

Fractals are everywhere in nature, particularly at the interfaces where matter or energy must be transferred, since they maximize surface area while minimizing energy losses. Temporal fractals have been well studied at micro scales in human biology, but have received comparatively little attention at broader macro scales. In this paper, we describe a fractal time series model of human aging from a systems biology perspective. This model examines how intrinsic aging rates are shaped by entropy and Fibonacci fractal dynamics, with implications for the emergence of key life cycle traits. This proposition is supported by research findings. The finding of an intrinsic aging rate rooted in Fibonacci fractal dynamics represents a new predictive paradigm in evolutionary biology. [ABSTRACT FROM AUTHOR]

The paper analyses lifestyle migrants' choice of relocation and experiences of growing older in the Azores islands, drawing on Bourdieu's concept of 'distinction'. The paper weaves together two main contributions: it develops empirical research on a 'new frontier' for lifestyle migration in Europe, operationalising the concepts of social and spatial distinction in this rather unique rural insular context; and it unpicks the complex relationship between lifestyle migrants and local Azoreans. The article draws on extensive field research in the Azores archipelago, including 66 life narrative interviews with older foreign lifestyle migrants and local people. A quest for social and spatial distinction is found to be deeply embedded in the migrants' decision to relocate to and grow older in these rural islands, and this distinction is discursively co-produced by both migrants and locals. Lifestyle migrants to the Azores are shown to construct their 'difference' mainly in relation to lifestyle migrants in other, so-called 'mainstream' destinations and to validate this narrative by displaying their pursuit for alternative lifestyles, where rurality, closeness to nature, place attachment, and a 'true' belonging to the islander community feature as centrepieces in their narratives. • Research on an insular rural-space and 'new frontier' for lifestyle migration in Europe. • Desire for social and spatial distinction as part of migrants' decision to relocate. • Distinction discursively co-produced by migrants and local islanders. • Pursuit of alternative lifestyles, rurality, and belonging to an islander community. [ABSTRACT FROM AUTHOR]