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The world needs to rapidly reduce emissions of carbon dioxide (CO 2) emission to stave off the risks of disastrous climate change. In particular, decarbonizing U.S. manufacturing industries is particularly challenging due to the specific process requirements. This study estimates the potential for future CO 2 emission reductions in this important sector. The analysis is a detailed accounting exercise that relies on estimates of emission-reduction potential from other studies and applies those potentials to the manufacturing sector using a bottom-up approach. The actions are grouped into four "pillars" that support deep decarbonization of manufacturing (DDM): Energy Efficiency, Material Efficiency, Industry-Specific, and Power Grid. Based on this bottom-up approach, the analysis shows that an 86% reduction in carbon dioxide emissions from the Reference Case is feasible. No single pillar dominates DDM, although opportunities vary widely by sub-sector. The analysis shows that a strategy incorporating a broad set of elements from each pillar can be effective instead of relying on any single pillar. Some pillars, such as Energy Efficiency and Material Efficiency, have wide applicability; others have key niche roles that are Industry-Specific; the Power Grid pillar requires interaction between grid decarbonization and industry action to switch from fossil fuels to zero-carbon electricity where appropriate. [Display omitted] • Four technological strategies ("pillars") for deep decarbonization of U.S. manufacturing are investigated. • Seven energy-intensive and one non-energy-intensive industries are examined separately. • An 86% reduction in energy related CO 2 emissions is feasible in U.S. manufacturing by 2050. • No single pillar dominates implying a diversified approach to decarbonization is needed. • Some emissions remain in select industries, in particular chemicals. [ABSTRACT FROM AUTHOR]