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Based on the new energy power prediction data with the highest probability of occurrence to check the security and stability of the deterministic dispatching plan, the conclusion is quite different from the actual situation of the power grid. In order to improve the adaptability of the results, a security and stability checking method of dispatching plan considering uncertainty of new energy is proposed. Based on the quantitative assessment results of the safety and stability of traditional deterministic dispatching plan, a safety and stability margin minimization model with confidence interval constraints on the predicted power of new energy stations is constructed to realize effective identification of high-risk planning modes. Based on the active power sensitivity, the equivalence aggregation and uncertainty variable dimensionality reduction of new energy stations are carried out to improve the efficiency of the security and stability margin minimization model. Based on the parallel processing platform, the multi-mode grouping parallel security check of the dispatching plan is carried out. The results of security and stability check considering the uncertainty of new energy power prediction are obtained. The proposed method can effectively improve the accuracy and timeliness of the security and stability check of the high-proportion new energy grid dispatching plan. The effectiveness of the proposed method is verified by an actual grid case.

Coal mining in the Loess Plateau can very easily generate ground cracks, and these cracks can immediately result in ventilation trouble under the mine shaft, runoff disturbance, and vegetation destruction. Advanced UAV (Unmanned Aerial Vehicle) high-resolution mapping and DL (Deep Learning) are introduced as the key methods to quickly delineate coal mining ground surface cracks for disaster prevention. Firstly, the dataset named the Ground Cracks of Coal Mining Area Unmanned Aerial Vehicle (GCCMA-UAV) is built, with a ground resolution of 3 cm, which is suitable to make a 1:500 thematic map of the ground crack. This GCCMA-UAV dataset includes 6280 images of ground cracks, and the size of the imagery is 256 × 256 pixels. Secondly, the DRA-UNet model is built effectively for coal mining ground surface crack delineation. This DRA-UNet model is an improved UNet DL model, which mainly includes the DAM (Dual Dttention Dechanism) module, the RN (residual network) module, and the ASPP (Atrous Spatial Pyramid Pooling) module. The DRA-UNet model shows the highest recall rate of 77.29% when the DRA-UNet was compared with other similar DL models, such as DeepLabV3+, SegNet, PSPNet, and so on. DRA-UNet also has other relatively reliable indicators; the precision rate is 84.92% and the F1 score is 78.87%. Finally, DRA-UNet is applied to delineate cracks on a DOM (Digital Orthophoto Map) of 3 km2 in the mining workface area, with a ground resolution of 3 cm. There were 4903 cracks that were delineated from the DOM in the Huojitu Coal Mine Shaft. This DRA-UNet model effectively improves the efficiency of crack delineation. [ABSTRACT FROM AUTHOR]

Aloperine (ALO), a quinolizidine‐type alkaloid isolated from a natural Chinese herb, has shown promising antitumor effects. Nevertheless, its common mechanism of action and specific target remain elusive. Here, it is demonstrated that ALO inhibits the proliferation and migration of non‐small cell lung cancer cell lines in vitro and the tumor development in several mouse tumor models in vivo. Mechanistically, ALO inhibits the fusion of autophagosomes with lysosomes and the autophagic flux, leading to the accumulation of sequestosome‐1 (SQSTM1) and production of reactive oxygen species (ROS), thereby inducing tumor cell apoptosis and preventing tumor growth. Knockdown of SQSTM1 in cells inhibits ROS production and reverses ALO‐induced cell apoptosis. Furthermore, VPS4A is identified as a direct target of ALO, and the amino acids F153 and D263 of VPS4A are confirmed as the binding sites for ALO. Knockout of VPS4A in H1299 cells demonstrates a similar biological effect as ALO treatment. Additionally, ALO enhances the efficacy of the anti‐PD‐L1/TGF‐β bispecific antibody in inhibiting LLC‐derived subcutaneous tumor models. Thus, ALO is first identified as a novel late‐stage autophagy inhibitor that triggers tumor cell death by targeting VPS4A. [ABSTRACT FROM AUTHOR]

Hydrogels are widely used as wound healing dressings to repair wound tissues because of their good biocompatibility. However, issues of excessive swelling and the disordered release of loaded drugs remain to be addressed in practical wound-healing applications. In this study, we designed a near-infrared- (NIR-) responsive composite nanofiber-based hydrogel patch (NIR-NFHP). The nanofibers embedded in the hydrogel inhibited its swelling, such that the swelling rate of the composite was only 1.3. Meanwhile, during the proliferative phase of wound healing, the orderly and stable release of deferoxamine through the on/off NIR response achieved a controlled and hierarchical release of drugs. During the acute inflammatory phase of wound healing, the fast release of valsartan provided a strong anti-inflammatory environment. The synergistic effects of anti-inflammatory and vascularization responses achieved improved the wound healing rate up to 95%. Based on its antiswelling effects as well as the controlled and hierarchical release of drugs, we believed that this NIR-responsive nanofiber hydrogel patch has broad prospects for applications as a dressing in the field of wound healing. [ABSTRACT FROM AUTHOR]

In multi-seam mining, as mining ranges expand and depths increase, the strong ground pressure exerted on the lower coal-seam working faces (WFs) or roadways by coal pillars (CPs) and the hard roof between the interburdens becomes increasingly severe, leading to periodic roof-fall accidents. This study focused on the 42108 WF of the 4-2 coal seam in the Buertai Coal Mine of Shandong mining. It combined field tests, theoretical research, and numerical calculations to investigate the superposition or amplification of ground pressure as WF traversed the CP with the hard roof between interburdens. The ground pressure behavior of WF entering and exiting the CP stage progressed from strong to weak: exiting the CP > under the CP > entering the CP, with the CP stage being prone to a strong ground pressure occurrence. We proposed the influence mechanism of strong ground pressure and a seesaw structural mechanics model under the mining conditions with parallel CPs and hard roofs. The relationship between the geometric structure movement and stress evolution of the seesaw space of the overlying hard roof was analyzed, revealing the mechanism behind stress increase, evident damage, and the likelihood of dynamic disasters within 5-10 m from the CP boundary of the WF. The stress concentration factor (SCF) of the advance abutment pressure in the coal wall was the primary controlling factor determining seesaw instability, effectively ensuring safe and efficient mining practices. This research holds significant theoretical importance and practical engineering value for controlling strong mine pressure under the overlying CPs and hard roofs. [ABSTRACT FROM AUTHOR]

Background: Few studies have compared the correlation between visceral fat area (VFA) and abdominal subcutaneous fat area (SFA) with arterial stiffness (AS) in patients with type 2 diabetes (T2D). In addition, there is currently controversy regarding the correlation between VFA and SFA with AS. We aimed to investigate the relationship between VFA and SFA with AS in patients with T2D. Methods: In this cross-sectional study, 1475 Chinese T2D patients with an average age of 52.32 ± 10.96 years were included. VFA and SFA were determined by a dual bioelectrical impedance analyzer, and AS was determined by measurement of brachial-ankle pulse wave conduction velocity (baPWV). Atherosclerosis was deemed present in study participants with baPWV values higher than 75th percentile (1781 cm/s). Independent correlations of logVFA and logSFA with AS were assessed using multiple linear regression and multivariate logistic regression. Results: The baPWV was linked with VFA, waist circumference, and women's SFA in a general linear correlation study (P < 0.05), but not with body mass index (P = 0.3783) or men's SFA (P = 0.1899). In both men and women, VFA and SFA were positively correlated with AS, according to the generalized additive model (GAM). After fully adjusting for confounders, multiple linear regression analyses showed that for every 1-unit increase in logVFA, the beta coefficient of baPWV increased by 63.1 cm/s (95% CI: 18.4, 107.8) (P < 0.05). logSFA did not correlate significantly with baPWV (P = 0.125). In the multiple logistic regression analysis, the odds ratio (OR) of elevated baPWV was 1.8 (95% CI: 1.1, 3.1) (P = 0.019) per 1-unit increase in logVFA. logSFA did not correlate significantly with AS (P = 0.091). In the subgroup analysis, the correlation between logVFA and baPWV did not interact across subgroups (P-interaction > 0.05). Conclusions: Compared with SFA, VFA had a stronger independent positive correlation with AS in Chinese T2D patients. Patients with T2D should pay more attention to monitoring VFA and lowering it to minimize cardiovascular events. [ABSTRACT FROM AUTHOR]

This study investigates the performance of two types of multi-encapsulated electrode (MEE) plasma actuators, compared to typical dielectric barrier discharge (DBD) plasma actuators, in quiescent air. The objective is to determine whether the multiple encapsulated structure can enhance the performance of the plasma actuator. In the present paper, flow characteristics are investigated by using particle image velocimetry (PIV) and Schlieren visualisation. In addition, the distribution of body force over the gas volume based on the Navier–Stokes equations is calculated from velocity measurements. The obtained results demonstrate that the starting vortex behavior is influenced by electrode arrangement. Specifically, it can be observed that when the first encapsulated electrode is positioned closer to the exposed electrode, then a significantly higher induced velocity can be obtained compared to the baseline condition. In fact, the induced velocity can be increased by up to 1.5 times under this optimize configuration. These results highlight the importance of electrode arrangement in the plasma actuator design. Based on body force estimation, MEE plasma actuators exhibit a significantly higher momentum transfer, particularly in the wall normal direction. The investigation on the mechanical efficiency also reveals that the optimized configuration proposed in the present study can significantly enhance the efficiency. In fact, a four-fold increase in maximum efficiency compared to the typical configuration is observed. These results suggest that the proposed configuration could be considered a promising solution for improving the mechanical efficiency of plasma actuators. [ABSTRACT FROM AUTHOR]

BACKGROUND: Isopropyl 4‐(2‐chloro‐6‐(1H‐1,2,4‐triazol‐1‐yl)benzamido)benzoate (TPB) was a 1,2,4‐triazole benzoyl arylamine derivative with excellent antifungal activity, especially against Gaeumannomyces graminis var. tritici (Ggt). Its mechanism of action was investigated by transmission electron microscopy (TEM) observation, assays of sterol composition, cell membrane permeability, intracellular ATP and mitochondrial membrane potential, and mPTP permeability, ROS measurement, RNA sequencing (RNA‐seq) analysis. RESULTS: TPB interfered with ergosterol synthesis, reducing ergosterol content, increasing toxic intermediates, and finally causing biomembrane disruption such as increasing cell membrane permeability and content leakage, and destruction of organelle membranes such as coarse endoplasmic reticulum and vacuole. Moreover, TPB destroyed the function of adenine nucleotide transferase (ANT), leading to ATP transport obstruction in mitochondria, inhibiting mPTP opening, inducing intracellular ROS accumulation and mitochondrial membrane potential loss, finally resulting in mitochondrial damage including mitochondria swelled, mitochondrial membrane dissolved, and cristae destroyed and reduced. RNA‐seq analyses showed that TPB increased the expression of ERG11, ERG24, ERG6, ERG5, ERG3 and ERG2 genes in ergosterol synthesis pathway, interfered with the expression of genes (NDUFS5, ATPeV0E, NCA2 and Pam17) related to mitochondrial structure, and inhibited the expression of genes (WrbA and GST) related to anti‐oxidative stress. CONCLUSIONS: TPB exhibited excellent antifungal activity against Ggt by inhibiting ergosterol synthesis and destroying ANT function. So, TPB was a novel compound with dual‐target mechanism of action and can be considered a promising novel fungicide for the control of wheat Take‐all. The results provided new guides for the structural design of active compounds and powerful tools for pathogen resistance management. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

In this paper, berberine hydrochloride-loaded liposomes-in-gel were designed and developed to investigate their antioxidant properties and therapeutic effects on the eczema model of the mouse. Berberine hydrochloride-liposomes (BBH-L) as the nanoparticles were prepared by the thin-film hydration method and then dispersed BBH-L evenly in the gel matrix to prepare the berberine hydrochloride liposomes-gel (BBH-L-Gel) by the natural swelling method. Their antioxidant capacity was investigated by the free radical scavenging ability on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and H2O2 and the inhibition of lipid peroxides malondialdehyde (MDA). An eczema model was established, and the efficacy of the eczema treatment was preliminarily evaluated using ear swelling, the spleen index, and pathological sections as indicators. The results indicate that the entrapment efficiency of BBH-L prepared by the thin-film hydration method was 78.56% ± 0.7%, with a particle size of 155.4 ± 9.3 nm. For BBH-L-Gel, the viscosity and pH were 18.16 ± 6.34 m Pas and 7.32 ± 0.08, respectively. The cumulative release in the unit area of the in vitro transdermal study was 85.01 ± 4.53 μg/cm2. BBH-L-Gel had a good scavenging capacity on DPPH and H2O2, and it could effectively inhibit the production of hepatic lipid peroxides MDA in the concentration range of 0.4–2.0 mg/mL. The topical application of BBH-L-Gel could effectively alleviate eczema symptoms and reduce oxidative stress injury in mice. This study demonstrates that BBH-L-Gel has good skin permeability, excellent sustained release, and antioxidant capabilities. They can effectively alleviate the itching, inflammation, and allergic symptoms caused by eczema, providing a new strategy for clinical applications in eczema treatment. [ABSTRACT FROM AUTHOR]

An asymmetric transfer hydrogenation of 2‐oxazolones in the presence of a chiral diamine ruthenium catalyst with potassium formate as a hydrogen source and potassium carbonate as an additive in 2,2,2‐trifluoroethanol is described. A series of chiral 2‐oxazolidinones were obtained with 29%–95% yields and 86%–>99% ee's. Furthermore, gram‐scale synthesis of chiral 2‐oxazolidinone and its downstream derivatizations demonstrate the practicality of this method. [ABSTRACT FROM AUTHOR]

A straightforward asymmetric transfer hydrogenation for accessing enantiomerically enriched secondary benzyl alcohols involving free phenolic hydroxyl group(s) under mild conditions was developed. Various of optical pure aryl alcohols with a remarkable functional group compatibility were achieved with 78%-97% yields, 84%->99% ee's and up to 10 000 TON. This rhodium-catalyzed reaction could be performed in a gram-scale without loss of the efficiency. Furthermore, the synthetic utility has also been demonstrated in the asymmetric synthesis of (S)-adrenaline and (S)-phenylephrine., (© 2024 Wiley‐VCH GmbH.)

Objective: Non-cirrhotic porto-mesenteric vein thrombosis (NC-PMVT) is a rare but severe clinical condition. The study aims to assess the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) coupled with dual-access thrombolysis in patients with acute severe NC-PMVT., Methods: From January 2018 to February 2023, a total of 25 patients with acute severe NC-PMVT who were treated with TIPS in conjunction with mechanical thrombectomy and dual-access thrombolysis. The period of thrombolysis was determined by the improvement of clinical symptoms and vascular recanalization. The technical success, recanalization rate, clinical success, and procedure-related complications were analyzed., Results: The technical success rate was 100 %. The median duration for thrombolytic catheter removal was 5 (IQR 3.5 - 7) days. Full and partial recanalization were accomplished in 10 (40 %) and 15 (60 %) patients respectively before discharge. No significant procedure-related complications were reported. The clinical success rate was 88 %, with a mortality rate of 12 %. Over a median follow-up of 8 months, 3/22 (13.64 %) patients had a recurrence of thrombosis; 1/22 (4.54 %) patients underwent partial intestinal resection one and a half months post-discharge; the remaining patients did not experience any portal hypertensive complications., Conclusion: The combination of TIPS and dual-access thrombolysis appears to be safe and effective for patients with acute severe NC-PMVT., Competing Interests: Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024. Published by Elsevier Ltd.)

High-performance ion-conducting hydrogels (ICHs) are vital for developing flexible electronic devices. However, the robustness and ion-conducting behavior of ICHs deteriorate at extreme temperatures, hampering their use in soft electronics. To resolve these issues, a method involving freeze-thawing and ionizing radiation technology is reported herein for synthesizing a novel double-network (DN) ICH based on a poly(ionic liquid)/MXene/poly(vinyl alcohol) (PMP DN ICH) system. The well-designed ICH exhibits outstanding ionic conductivity (63.89 mS cm -1 at 25 °C), excellent temperature resistance (- 60-80 °C), prolonged stability (30 d at ambient temperature), high oxidation resistance, remarkable antibacterial activity, decent mechanical performance, and adhesion. Additionally, the ICH performs effectively in a flexible wireless strain sensor, thermal sensor, all-solid-state supercapacitor, and single-electrode triboelectric nanogenerator, thereby highlighting its viability in constructing soft electronic devices. The highly integrated gel structure endows these flexible electronic devices with stable, reliable signal output performance. In particular, the all-solid-state supercapacitor containing the PMP DN ICH electrolyte exhibits a high areal specific capacitance of 253.38 mF cm -2 (current density, 1 mA cm -2 ) and excellent environmental adaptability. This study paves the way for the design and fabrication of high-performance multifunctional/flexible ICHs for wearable sensing, energy-storage, and energy-harvesting applications., (© 2024. The Author(s).)