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Start Over Search Limiters Academic (Peer-Reviewed) Journals Topic chemical reactions Topic imidazoles Publication Year Range More than 50 years ago Publication Type Academic Journals

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1. Induction of Salt Sensitivity in Ophiostoma and Its Reversal by Imidazole Derivatives.

Author

Fries, Nils

Subjects
OPHIOSTOMA, IMIDAZOLES, INTERMEDIATES (Chemistry), CARBON compounds, CHEMICAL reactions, SOLUTION (Chemistry)
Abstract

Cells of the ascomycete Ophiostoma multiannulattum became sensitive to inorganic salts after a heat shock or a treatment with 2,4-dinitrophenol. The induced sensitivity to chloride and bromide ions could be largely reversed by histidine and certain other imidazole derivatives. No other organic compounds tested except imidazoles possessed this ability. The sensitization is interpreted as a consequence of an injury to cellular membranes, in particular those of the mitochondria, and to an impaired oxidative phosphorylation. [ABSTRACT FROM AUTHOR]

Published
1972
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