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239 results on '"Romano, Marta"'

4. Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas

Author

Carrasco-Nunes, Nayely, Romano, Marta, and Cabeza, Marisa

Subjects
Brain -- Health aspects, Biosynthesis -- Health aspects, Hormones, Sex -- Health aspects, GABA -- Health aspects, Sleep -- Health aspects, Biological sciences
Abstract

No data in the literature have evaluated sex hormone dose escalation for treating abnormal sleep of ovariectomized rats--nor studies on the role of sex hormones in GABA synthesis of rats' sleep-related areas. The main aim of this study was to determine the maximum tolerated dose (MTD) of estradiol (ET), progesterone (PT), and the mixture of both (EPT) to restore normal sleep in a model of menopause in rats. The second purpose was to describe the in vitro activity of glutamate decarboxylase (GAD) in sleep-related brain areas in the presence or absence of sex hormones. A weekly dose-escalation design of ET, PT, or EPT was implemented in ovariectomized rats (six per group). Dose escalation continued until the dose at which 100% of the rats exhibited a state of 'complete somnolence.' Doses that were not toxic or did not show side effects were considered. For in vitro experiments, sleep-related brain areas were separated and incubated with radiolabeled glutamate. Estradiol (17[beta]-[E.sub.2]), progesterone (P), and pyridoxal phosphate (PLP) were added to this assay, and GAD activity was determined. Under the same conditions, a second test was carried out, but the P antagonist RU486 was added to assess the role of P in GAD activity. Ovariectomy increased periodic awakenings compared to those determined for the SHAM group. The EPT for ovariectomized rats was very effective by the fifth week in decreasing arousal and achieving a similar sleep behavior to the SHAM-control group. Rats tolerated the ET, PT, and EPT well to the maximum planned dose (0.66 mg/kg and 4.4 mg/kg, respectively). No lethal events occurred; the MTD was reached. The in vitro studies indicated that the presence of 17[beta]-[E.sub.2] plus P in the assay triggered the activity of isotype 65 GAD in all the studied brain areas. RU486 in the incubation medium blocked such activity; however, the action of isotype 67 GAD was not blocked by RU486. A dose-escalation model was determined; the MTD coincided with the maximum dose of ET and PT used. However, the EPT combination restored normal sleep in the menopause model compared to the SHAMs without toxic effects. The in vitro model demonstrated that 17[beta]-[E.sub.2] plus P presence in the assay increased the activity of [GAD.sub.65] in the studied brain tissues. Keywords: menopause, intermittent awakenings, glutamate decarboxylase activity, GABAergic brain regions, disturbed sleeping, female sex hormone., 1. Introduction Menopause marks the cessation of menstruation due to the loss of follicular function (Santoro 2005; Brown and Gervais 2020) Some women in this stage report symptoms that prevent [...]

Published
2023
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5. Intranasal Versus Intravenous Dexamethasone to Treat Hospitalized COVID-19 Patients: A Randomized Multicenter Clinical Trial

Author

Cárdenas, Graciela, Chávez-Canales, María, Espinosa, Ana María, Jordán-Ríos, Antonio, Malagon, Daniel Anica, Murillo, Manlio Fabio Márquez, Araujo, Laura Victoria Torres, Campos, Ricardo Leopoldo Barajas, Wong-Chew, Rosa María, González, Luis Esteban Ramirez, Cresencio, Karent Ibet, Velázquez, Enrique García, de la Cerda, Mariana Rodriguez, Leyva, Yoana, Hernández-Ruiz, Joselin, Hernández-Medel, María Luisa, León-Hernández, Mireya, Quero, Karen Medina, Monciváis, Anahí Sánchez, Sarmiento, Eduardo Beltrán, Reynoso, Rafael Ignacio Aguilar, Reyes, Daniela Murillo, del Río Ambriz, Luis Rodrigo, Hernández, Juan Salvador García, Cruz, Jocelyn, Ferrer, Sergio Iván Valdés, Huerta, Leonor, Fierro, Nora Alma, Hernández, Marisela, Pérez-Tapia, Mayra, Meneses, Gabriela, Rosas, Gabriela, Hernández-Aceves, Juan Alberto, Cervantes-Torres, Jaquelynne, Valdez, Ricardo A., Rodríguez, Anai Fuentes, Espíndola-Arriaga, Erick, Ortiz, Mauricio, Salazar, Evelyn Alvarez, Barba, Carlos Castellanos, Besedovsky, Hugo, Romano, Marta C., Jung, Helgi, Bobes, Raúl J., Soldevila, Gloria, López-Alvarenga, Juan C., Fragoso, Gladis, Laclette, Juan Pedro, and Sciutto, Edda

Published
2024
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10. The global response to the COVID-19 pandemic: how have immunology societies contributed?

Author

Osier, Faith, Ting, Jenny, Fraser, John, Lambrecht, Bart, Romano, Marta, Gazzinelli, Ricardo, Bortoluci, Karina, Zamboni, Dario, Akbar, Arne, Evans, Jennie, Brown, Doug, Patel, Kamala, Wu, Yuzhang, Perez, Ana, Pérez, Oliver, Kamradt, Thomas, Falk, Christine, Barda-Saad, Mira, Ariel, Amiram, Santoni, Angela, Annunziato, Francesco, Cassatella, Marco, Kiyono, Hiroshi, Chereshnev, Valeriy, Dieye, Alioune, Mbow, Moustapha, Mbengue, Babacar, Niang, Maguette, and Suchard, Melinda

Subjects
Antiviral Agents, Betacoronavirus, COVID-19, COVID-19 Vaccines, Community-Institutional Relations, Coronavirus Infections, Global Health, Humans, International Cooperation, Pandemics, Patient Education as Topic, Personal Protective Equipment, Pneumonia, Viral, SARS-CoV-2, Severe Acute Respiratory Syndrome, Societies, Scientific, Viral Vaccines
Abstract

The COVID-19 pandemic is shining a spotlight on the field of immunology like never before. To appreciate the diverse ways in which immunologists have contributed, Nature Reviews Immunology invited the president of the International Union of Immunological Societies and the presidents of 15 other national immunology societies to discuss how they and their members responded following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Published
2020

19. Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients

Author

Cárdenas, Graciela, Chávez-Canales, María, Espinosa, Ana María, Jordán-Ríos, Antonio, Malagon, Daniel Anica, Murillo, Manlio Fabio Márquez, Araujo, Laura Victoria Torres, Campos, Ricardo Leopoldo Barajas, Wong-Chew, Rosa María, González, Luis Esteban Ramirez, Cresencio, Karent Ibet, Velázquez, Enrique García, de la Cerda, Mariana Rodriguez, Leyva, Yoana, Hernández-Ruiz, Joselin, Hernández-Medel, María Luisa, León-Hernández, Mireya, Quero, Karen Medina, Monciváis, Anahí Sánchez, Díaz, Sergio Hernández, Martínez, Ignacia Rosalia Zeron, Martínez-Cuazitl, Adriana, Salazar, Iván Noé Martínez, Sarmiento, Eduardo Beltrán, Peña, Aldo Figueroa, Hernández, Patricia Saraí, Reynoso, Rafel Ignacio Aguilar, Reyes, Daniela Murillo, del Río Ambriz, Luis Rodrigo, Bonilla, Rogelio Antonio Alfaro, Cruz, Jocelyn, Huerta, Leonor, Fierro, Nora Alma, Hernández, Marisela, Pérez-Tapia, Mayra, Meneses, Gabriela, Espíndola-Arriaga, Erick, Rosas, Gabriela, Chinney, Alberto, Mendoza, Sergio Rosales, Hernández-Aceves, Juan Alberto, Cervantes-Torres, Jaquelynne, Rodríguez, Anai Fuentes, Alor, Roxana Olguin, Francisco, Sandra Ortega, Salazar, Evelyn Alvarez, Besedovsky, Hugo, Romano, Marta C., Bobes, Raúl J., Jung, Helgi, Soldevila, Gloria, López-Alvarenga, Juan, Fragoso, Gladis, Laclette, Juan Pedro, and Sciutto, Edda

Published
2022
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20. Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease

Author

Fernandez-Cooke, Elisa, Calvo, Cristina, Sánchez-Manubens, Judith, Antón, Jordi, Santos, Javier Aracil, Cuadros, Esmeralda Nuñez, Navarro Gómez, Maria Luisa, Pérez, David Moreno, Cantero Pérez, María Martín, Cuadros Pérez, Esmeralda Nuñez, Gallego Pérez, Begoña Carazo, García, Fernando Sánchez, Lovillo, Marisol Camacho, Marqués, Renata, Laura, Olaf Neth, Silveira, Fernández, Forte, Miguel Sánchez, Montes, Ángeles Ortega, Martínez Campos, Leticia Isabel, Mancheño, Beatriz Bravo, Camacho, Margarita, Medina Claros, Antonio F., Salido, Carlos, Rico, María Torres, Saez, Beatriz Ruiz, de la Puebla Lechuga, Elena Fernadez, Cruz, M<ce:sup loc='post">a</ce:sup> José Lirola, Carrasco, Kety Maya, González, Moisés Rodríguez, Jover, Enrique Blanca, Fernández, José Uberos, Ibáñez Alcalde, María Mercedes, Hidalgo, Miguel Lafuente, Montañés, Lorenzo Jiménez, Alonso, Matilde Bustillo, Casas, Ariadna Ayerza, Zapico, Bárbara Montes, Méndez, Carlos Pérez, Aracama, Javier Fernández, Rodríguez, Lucía, Ibáñez Fernández, María Aleida, Campo, Sandra Navarro, Bori, Silvia Escribà, Mir Perelló, María Concepción, Sánchez, M<ce:sup loc='post">a</ce:sup> Ángeles de la Fuente, García, Patricia Aparicio, Briales, Carlos, Crespí, Joaquín Castilla, Colino Gil, María Elena, Cabrera, Nerea Delgado, Naranjo, Ana Bello, Páez, Jesús Poch, Yáñez, Moneyba García, García, Montse González, Viadero, Maite, Montero, Beatriz Jiménez, García, Olga Domínguez, Pinedo, Begoña Losada, Martín, Gema Iñigo, Escribano Gómez, Lucía María, Cepillo, Antonio, Lillo, Miguel Lillo, Buedo, María Isabel, Rey, Laura del, Rodríguez, Elena Urbaneja, Rodríguez, Sara Rellán, Cantero, Teresa, Izquierdo, Beatriz Plata, García-Cuenllas Álvarez, Luisa, Erroz, Ignacio Oulego, Santaolalla, Elena Pérez, Martín, Carlos Alcalde, Malfaz, Fernando Centeno, Gutiérrez, Elena Pérez, Casso, M<ce:sup loc='post">a</ce:sup> Soledad Jiménez, Prada, Fredy, Bou, Rosa, Iglesias, Estibaliz, Calzada, Joan, Garsaball, Olga Calavia, Rue, Marc Tobeña, García, Gemma Giralt, Lobato, Zulema, Gordillo, Neus Rius, Torres, Montserrat Pascual, Hernández, María Méndez, García, Lourdes, Villar, Sergio Flores, Ruiz, Silvia Yevenes, Domingo, Laura Minguell, Ballester, Anna, Miralles, Ana, Soler, Berta Pujol, Vidal, Anton Foguet, Castellví, Pere Sala, Aguiar, Angelita Serrano, Siurana Rodríguez, José Manuel, Iranzo, Anna Sangorrin, Pérez, Roser Álvarez, Cajas, Paula Ribes, Genaró i Jornet, Pere, Tejada, Ana Grande, Zarallo, Cristina, Martinón-Torres, Federico, Calle, Irene Rivero, Grande, Antonio Justicia, Sousa, María López, Vilas, Alejandro Souto, Abel, Bernardo López, de Miguel Esteban, Elisa, Méndez, Bibiana Riaño, Blázquez, Daniel, Conejo, Pablo Rojo, Lozano, Carlos Grasa, Toral, Belén, De la Torre, Leticia Albert, de Inocencio, Jaime, Santos, Mar, Díaz-Delgado de la Peña, Rafael, Ramos, Paz Collado, Raga, Teresa, Latorre, Libertad, Guillén, Sara, Caballero, Ignacio Callejas, Prieto Tato, Luis Manuel, Guzmán Monagas, María Fernanda, López, Isabel Jiménez, Villagrá, Sandra, Arreo, Viviana, Pérez, Roi Piñeiro, Parte, María de la, Tamariz-Martes, Amalia, Romano, Marta Llorente, Hernández Rupérez, Maria Belén, Sombrero, Henar Rojo, Cerro, Estefanía García, Cano, Irene Maté, Alonso, Marta Villares, Osuna Marco, Marta Pilar, Veron, Julia Jensen, Reales, Cristina Zarallo, Rodríguez Mesa, María Dolores, Esteban, Santiago Rueda, Ramos Amador, José Tomás, Menchén, Cristina González, Jiménez Jiménez, Ana Belén, Galán, Pilar, Campos, Dolores Pérez, Bueno, M<ce:sup loc='post">a</ce:sup> Mercedes, Marcos, David Crespo, Otheo de Tejada Barásoain, Enrique, Sifuentes Giraldo, Walter Alberto, Gámir Gámir, María Luz, José Cilleruelo Ortega, María, López, Agustín López, Vaquerizo, Cristina Sánchez, Usano Carrasco, Ana Isabel, Gómez, Ester Moreno, Carvajal del Castillo, Olga, Del Pozo Menéndez, Beatriz, Navarro, Katie Badillo, Baquero, Fernando, Bronte, Lucía Deiros, Fraga, Pablo Fernández, Domínguez, Nieves, Rodríguez, Beatriz Mercader, García, Francisco Castro, Chamorro, Águeda Herrera, Rodríguez, Paula Alcañiz, García, Moisés Sorlí, Rex Nicolás, María Concepción, Romero, Elena Vera, Olorón, Patricia Martínez, Cilveti, Beatriz Rocandio, Berridi, Amaia, Santos-Díez Vázquez, Laura, Fernández, Olaia, Calvo, Inmaculada, Tudela, Belén Fernández, Benavent, Manuel Oltra, Archilés, Marta Dapena, Ferrer, Franciasco Sanchez, Gavilán, César, Fos, Ignacio Izquierdo, Serrano Robles, María Isabel, Sánchez, Yolanda Herranz, Pinto, Enrique Villalobos, Garulo, Daniel Clemente, Pie, Stella, Calvo, Manuel Marrero, Olmos García, José María, Barrios-Tascón, Ana, Miura, Masaru, Domínguez-Rodríguez, Sara, Fernández-Cooke, Elisa, Sarquella-Brugada, Georgia, and Tagarro, Alfredo

Published
2021
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36. A randomized, multicentre, open-label phase II proof-of-concept trial investigating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients hospitalized with COVID-19: the Donated Antibodies Working against nCoV (DAWn-Plasma) trial

Author

Devos, Timothy, Geukens, Tatjana, Schauwvlieghe, Alexander, Ariën, Kevin K., Barbezange, Cyril, Cleeren, Myriam, Compernolle, Veerle, Dauby, Nicolas, Desmecht, Daniël, Grimaldi, David, Lambrecht, Bart N., Luyten, Anne, Maes, Piet, Moutschen, Michel, Romano, Marta, Seyler, Lucie, Nevessignsky, Michel Toungouz, Vandenberghe, Katleen, van Griensven, Johan, Verbeke, Geert, Vlieghe, Erika, Yombi, Jean Cyr, Liesenborghs, Laurens, Verhamme, Peter, and Meyfroidt, Geert

Published
2020
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37. Correction to: A randomized, multicentre, open-label phase II proof-of-concept trial investigating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients hospitalized with COVID-19: the Donated Antibodies Working against nCoV (DAWn-Plasma) trial

Author

Devos, Timothy, Geukens, Tatjana, Schauwvlieghe, Alexander, Ariën, Kevin K., Barbezange, Cyril, Cleeren, Myriam, Compernolle, Veerle, Dauby, Nicolas, Desmecht, Daniël, Grimaldi, David, Lambrecht, Bart N., Luyten, Anne, Maes, Piet, Moutschen, Michel, Romano, Marta, Seyler, Lucie, Nevessignsky, Michel Toungouz, Vandenberghe, Katleen, van Griensven, Johan, Verbeke, Geert, Vlieghe, Erika, Yombi, Jean Cyr, Liesenborghs, Laurens, Verhamme, Peter, and Meyfroidt, Geert

Published
2020
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40. Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial

Author

Ndiaye, Birahim Pierre, Thienemann, Friedrich, Ota, Martin, Landry, Bernard S, Camara, Makhtar, Dièye, Siry, Dieye, Tandakha Ndiaye, Esmail, Hanif, Goliath, Rene, Huygen, Kris, January, Vanessa, Ndiaye, Ibrahima, Oni, Tolu, Raine, Michael, Romano, Marta, Satti, Iman, Sutton, Sharon, Thiam, Aminata, Wilkinson, Katalin A, Mboup, Souleymane, Wilkinson, Robert J, and McShane, Helen

Published
2015
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48. Low responsiveness of peripheral lymphocytes in extraparenchymal neurocysticercosis.

Author

Romo, Matthew L., Osorio, Rocio, Toledo, Andrea, Carrillo-Mezo, Roger, Valdez, Ricardo, Romano, Marta C., Sciutto, Edda, Fragoso, Gladis, and Fleury, Agnès

Subjects
CENTRAL nervous system infections, NEUROCYSTICERCOSIS, ESTRADIOL, KILLER cells, LYMPHOCYTES, TAENIA solium
Abstract

Background: The morbidity and mortality of extraparenchymal neurocysticercosis (EP-NC) remain high and effectiveness of current medical treatment is suboptimal. Various factors have been implicated in the severity of EP-NC and in the poor response to treatment, but the possible role of host immune and endocrine systems has not yet been examined thoroughly. Methodology/Principal findings: 42 participants with EP-NC before receiving standard treatment and 25 healthy controls were included in the study. Treatment response was assessed by comparing pre/post treatment parasite volumes from 3D MRI. Prior to treatment among participants with EP-NC, specific stimulation induced an increased specific proliferative response accompanied by a significant increase in IL-4, NK, NKT, Bregs and Tregs cells, whereas in healthy controls, specific stimulation induced a significant increase in IL-1β, IL-5, CCL5, IL-6, TNF-α, NK and Bregs cells. Significant differences between participants with EP-NC and healthy controls in the specific inflammatory response were observed. Participants with EP-NC prior to treatment had significantly weaker responses of proinflammatory cytokines (IL-6, TNF-α) and NK cells, and stronger IL-4 response. Anthelmintic treatment did not promote significant peripheral immunological changes at any time, although inflammation was sustained in the cerebrospinal fluid. Serum estradiol concentration significantly decreased after anthelmintic treatment among males, and cortisol correlated negatively with IL-6 and positively with IFN-γ levels. No pre-treatment immunologic or endocrinologic parameters were significantly associated with response to treatment. Conclusion/Significance: Prior to anthelmintic treatment, EP-NC was characterized by low lymphocyte reactivity accompanied by a regulatory response, which may be involved in the lack of peripheral immunological changes during and after treatment, although a central inflammatory response was present. This weak specific peripheral response could favor the chronicity of the infection and the poor response to treatment. Our findings highlight the need for new anti-inflammatory treatment focused on the central nervous system with less systemic immunosuppressive effects. Author summary: Neurocysticercosis is a central nervous system infection with the helminth Taenia solium in its larval stage. It is a marker of poverty and remains endemic in countries of Latin America, Africa, and Asia. The severity of neurocysticercosis and the prognosis of patients depend on the location of the parasites. Extraparenchymal infection involving the subarachnoid and/or ventricular space is associated with high morbidity and mortality and a suboptimal response to current anthelminthic treatment regimens. We examined peripheral immunological parameters and hormones of 42 participants with extraparenchymal neurocysticercosis before and after treatment, and their associations with subsequent treatment response. Prior to treatment, compared with healthy controls, there was low lymphocyte reactivity with a regulatory response, which may explain the lack of peripheral immunological changes during and after treatment. This weak specific peripheral response could favor the chronicity of the infection and the poor response to treatment and should be considered in research to improve patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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