Search

Recent studies have reported altered methylation levels at disorder-relevant DNA sites in people who are ill with Anorexia Nervosa (AN) compared to findings in people with no eating disorder (ED) or in whom AN has remitted. The preceding implies state-related influences upon gene expression in people with AN. This study further examined this notion. We measured genome-wide DNA methylation in 145 women with active AN, 49 showing stable one-year remission of AN, and 64 with no ED. Comparisons revealed 205 differentially methylated sites between active and no ED groups, and 162 differentially methylated sites between active and remitted groups (Q < 0.01). Probes tended to map onto genes relevant to psychiatric, metabolic and immune functions. Notably, several of the genes identified here as being differentially methylated in people with AN (e.g. SYNJ2, PRKAG2, STAT3, CSGALNACT1, NEGR1, NR1H3) have figured in previous studies on AN. Effects also associated illness chronicity and lower BMI with more pronounced DNA methylation alterations, and remission of AN with normalisation of DNA methylation. Findings corroborate earlier results suggesting reversible DNA methylation alterations in AN, and point to particular genes at which epigenetic mechanisms may act to shape AN phenomenology. [ABSTRACT FROM AUTHOR]

Anhedonia is a negative prognostic indicator in schizophrenia. However, the underlying nature of this emotional deficit is unclear. Laboratory studies examining patients' emotional reactions under controlled circumstances have failed to find evidence for a diminished hedonic response, instead finding that patients' reactions to laboratory stimuli are characterised by high levels of negative emotion. The present study employed lexical analysis of natural speech in 52 patients and 49 non-patient controls while they discussed separate neutral, pleasant and unpleasant autobiographical memories. Patients with clinically rated anhedonia, versus other patients and controls, showed a dramatic increase in negative emotion expression when discussing pleasurable memories, but they showed no corresponding decrease in positive emotion. These findings provide further evidence that “anhedonia” is more reflective of negative emotional states than the absence of positive ones. These findings also raise questions about how positive and negative emotions can be simultaneously co-activated in patients with schizophrenia. [ABSTRACT FROM AUTHOR]

Introduction. Many recent studies have found that, although schizophrenia patients tend to display diminished facial expressions of emotion, they report levels of emotional experiences that are similar to those of controls. Although these findings are very informative, it is unknown whether such dissociation exits for other modalities such as verbal expression of emotion. The purpose of this study was to investigate the association between the use of emotion words during a free speech task and subjective experience of emotion in schizophrenia patients and controls. Methods. Speech samples of 48 schizophrenia patients and 48 nonpsychiatric control individuals were compared on the type and amount of emotional words used, as well as on the level of self-reported stress experienced while providing descriptions of themselves. Results. Groups did not differ in the amount or type of emotion words uttered during the free speech task. Patients, however, found the task more stressful than controls. Emotion word use and subjective emotional experience were not related in either group. Conclusions. Results do not fully support prior findings, but are consistent with the notion of a lack of correspondence between the expression and experience of emotion. [ABSTRACT FROM AUTHOR]