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Your search keyword '"Clarke, Michael"' showing total 1 results
Start Over Author "Clarke, Michael" Topic breast cancer Publication Year Range Last 3 years Publication Type Academic Journals

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1 results on '"Clarke, Michael"'

1. Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis.

Author

Sikandar, Shaheen S., Gulati, Gunsagar S., Antony, Jane, Fetter, Isobel, Kuo, Angera H., Hai Dang Ho, William, Haro-Acosta, Veronica, Das, Soumyashree, Steen, Chloé B., Pereira, Thiago Almeida, Qian, Dalong, Beachy, Philip A., Dirbas, Fredrick, Red-Horse, Kristy, Rabbitts, Terence H., Thiery, Jean Paul, Newman, Aaron M., and Clarke, Michael F.

Subjects
*BREAST, *CANCER cells, *BREAST cancer, *MEDICAL sciences, *STAT proteins, *FATE mapping (Genetics), *KERATIN
Abstract

The article discusses a 2022 study on a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis. Topics covered include the reduction of lung metastasis by LMO2 knockdown in human breast tumors, and the binding of LMO2 to STAT3 that is required for the latter's activation. Also noted is the identification of cells with angiogenic features that establishes the LMO2-STAT3 signaling axis as a therapeutic target in breast cancer metastasis.

Published
2022
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