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Taking advantage of thermo-sensitive, fast responsive rates and self-assemble into ordered structure ability of the soft P(NIPAM- co -AA) nanoparticles, and inspired by the excellent mechanical properties of polyurethane, a novel composite materials is presented, which combines the highly ordered structure of soft particles and polyacrylamide- co -polyurethane acrylate for the first time. As proof-of-concept, BSA was selected as model of protein-based drugs, the smart materials exhibit different optical properties during the release of BSA. Stimuli-responsive microgel have shown great promise in drug delivery material applications. However, it still remains an unresolved problem to establish method that can monitor the degree of drug release in situ and real-time. Here, taking advantage of thermo-sensitive and fast responsive ability of the soft nanoparticles, and inspired by the excellent mechanical properties of polyurethane, a novel materials is presented, which combines the soft particles and polyacrylamide- co -polyurethane acrylate for the first time, the generation of multifunctional material based on soft photonic crystals with tunable structure color and drug delivery capability is reported. As proof-of-concept, BSA was selected as model of protein-based drug, the smart materials exhibit different optical properties during the release of BSA. Consequently, the cumulative release amount of the BSA can be sensitively evaluated by measuring the reflection peak position, and shows a property of self-monitoring. Our strategy is a straightforward way to propose simple smart drug delivery materials whose cumulative release of drug and reflection peak can be tuned through the judicious choice of the temperature, and it has been proved that this is a promising way to construct visualized self-monitoring drug delivery systems using soft colloidal crystal films as stimuli-responsive and drug carrier substrates. [ABSTRACT FROM AUTHOR]

Excessive friction between hydrogels and biological tissue is a major risk factor that can lead to tissue damage and inflammation, limiting their application as biomaterials. Herein, we designed a photonic hydrogel film with an extremely low friction coefficient (COF∼1.71 × 10−3) by embedding free linear polyacrylamide (PAAm) polymer chains within a thermosensitive hydrogel matrix. This photonic hydrogel with brush structure possesses elastic deformation and reversible color change due to its excellent mechanical property. As proof-of-concept, gentamicin sulfate (GS) was selected as model of antibiotic drug, the structural color of material changes during the release of GS. Consequently, the cumulative release amount of the GS can be evaluated by measuring the reflection wavelength. These features make our strategy potentially useful in preparation of materials with low COF and extending the application of photonic hydrogels, including ocular drug delivery and monitoring systems, as well as articular tissue-mechanical sensors. Drawing inspiration from natural systems, we propose a novel method to create biomimetic photonic hydrogels with an exceptionally low surface friction coefficient. These hydrogels can be utilized in the development of ocular drug delivery systems and for real-time monitoring of drug release efficiency. Compared to traditional eye drops or ointments, this dressing with local sustained-release characteristics can better maintain the concentration and efficacy of the drug. These extremely low surface friction photonic hydrogels have the potential to be a promising candidate for novel drug carriers for eye diseases and other situations that require materials with extremely low friction coefficient. [Display omitted] • The photonic crystal prepared exhibits an extremely low friction coefficient (1.71 × 10−3). • The hydrogel possesses excellent mechanochromic and thermochromism properties. • The GS was released from the hydrogel followed a Korsmeyer-peppas model. • The material has the potential to serve as an ocular drug carrier and enable visualization of drug release efficiency. [ABSTRACT FROM AUTHOR]