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Ultrafast X-ray computed tomography is an advanced imaging technique for multiphase flows. It has been used with great success for studying gas–liquid as well as gas–solid flows. Here, we apply this technique to analyze density-driven particle segregation in a rotating drum as an exemplary use case for analyzing industrial particle mixing systems. As glass particles are used as the denser of two granular species to be mixed, beam hardening artefacts occur and hamper the data analysis. In the general case of a distribution of arbitrary materials, the inverse problem of image reconstruction with energy-dependent attenuation is often ill-posed. Consequently, commonly known beam hardening correction algorithms are often quite complex. In our case, however, the number of materials is limited. We therefore propose a correction algorithm simplified by taking advantage of the known material properties, and demonstrate its ability to improve image quality and subsequent analyses significantly. [ABSTRACT FROM AUTHOR]

Dental CBCT and panoramic imaging play a pivotal role in dental diagnosis and treatment planning, alongside the indispensable use of computed tomography (CT) and X-ray imaging in dentistry, particularly for surgical planning. Given the widespread adoption of dental cone beam CT in clinics today, we explore a novel approach in this study—utilizing CT's three-dimensional (3D) data to reconstruct a two-dimensional (2D) panoramic dental image. This method eliminates the requirement for an extra panoramic scan. In this work, we propose a novel framework to generate an enhanced and extended 2D panoramic view by using the dental arch extracted from 3D CBCT. Our method involves segmenting the patient's dental arch from their 3D CBCT image by identifying horizontal slices with above-average intensity, followed by morphological operations, including dilation, Gaussian filtering, and skeletonization, to delineate the dental arch line. Additionally, we extend the dental arch beyond the wisdom teeth using quadratic curve fitting. Finally, we employ Maximum Intensity Projection on rotated cubic segments aligned with the dental arch curve to produce captivating panoramic images. The panoramic view produced using our proposed method, when compared to the results obtained from BlueSky and OpenInventor, exhibited superior enhancements and greater accuracy in panoramic visualization. [ABSTRACT FROM AUTHOR]

Simple Summary: Cone-beam computed tomography (CBCT) not only plays an important role in image-guided radiation therapy (IGRT) but also has the potential for dose calculation. Because CBCT suffers from poor image quality and uncertainties in the Hounsfield unit (HU) values, the accuracy of dose calculation with CBCT is insufficient for clinical use. This study investigated deep learning approaches that utilize a generative adversarial network (GAN) with an additional registration network (RegNet) to generate synthetic CT (sCT) from CBCT. Our study addressed the limitation of having paired CT and CBCT with their anatomy perfectly aligned for supervised training. RegNet can dynamically estimate the correct labels, enabling supervised learning with noisy labels, whereas GAN learns the bidirectional mapping from CBCT to CT. The HU values for sCT were sufficiently accurate for dose calculation, while preserving the anatomy of CBCT with clear structural boundaries. Recently, deep learning with generative adversarial networks (GANs) has been applied in multi-domain image-to-image translation. This study aims to improve the image quality of cone-beam computed tomography (CBCT) by generating synthetic CT (sCT) that maintains the patient's anatomy as in CBCT, while having the image quality of CT. As CBCT and CT are acquired at different time points, it is challenging to obtain paired images with aligned anatomy for supervised training. To address this limitation, the study incorporated a registration network (RegNet) into GAN during training. RegNet can dynamically estimate the correct labels, allowing supervised learning with noisy labels. The study developed and evaluated the approach using imaging data from 146 patients with head and neck cancer. The results showed that GAN trained with RegNet performed better than those trained without RegNet. Specifically, in the UNIT model trained with RegNet, the mean absolute error (MAE) was reduced from 40.46 to 37.21, the root mean-square error (RMSE) was reduced from 119.45 to 108.86, the peak signal-to-noise ratio (PSNR) was increased from 28.67 to 29.55, and the structural similarity index (SSIM) was increased from 0.8630 to 0.8791. The sCT generated from the model had fewer artifacts and retained the anatomical information as in CBCT. [ABSTRACT FROM AUTHOR]

In-house fabrication of three-dimensional (3D) models for medical use has become easier in recent years. Cone beam computed tomography (CBCT) images are increasingly used as source data for fabricating osseous 3D models. The creation of a 3D CAD model begins with the segmentation of hard and soft tissues of the DICOM images and the creation of an STL model; however, it can be difficult to determine the binarization threshold in CBCT images. In this study, how the different CBCT scanning and imaging conditions of two different CBCT scanners affect the determination of the binarization threshold was evaluated. The key to efficient STL creation through voxel intensity distribution analysis was then explored. It was found that determination of the binarization threshold is easy for image datasets with a large number of voxels, sharp peak shapes, and narrow intensity distributions. Although the intensity distribution of voxels varied greatly among the image datasets, it was difficult to find correlations between different X-ray tube currents or image reconstruction filters that explained the differences. The objective observation of voxel intensity distribution may contribute to the determination of the binarization threshold for 3D model creation. [ABSTRACT FROM AUTHOR]

Background: Children have a potential risk from radiation exposure because they are more sensitive to radiation than adults. Objective: The purpose of this work is to estimate image quality according to tube voltage (kV) and radiation dose in pediatric computed tomography (CT) using deep learning reconstruction (DLR). Methods: Phantom images of children and adults were obtained for kV, radiation dose, and image reconstruction methods. The CT emits a fan beam to the opposite detector, and the geometry of the detector was symmetrical. Phantom images of children and adults were acquired at a volume CT dose index (CTDIvol) from 0.5 to 10.0 mGy for tube voltages at 80, 100, and 120 kV. A DLR was used to reconstruct the phantom image, and filtered back projection (FBP) and iterative reconstruction (IR) were also performed for comparison with the DLR. Image quality was evaluated by measuring the contrast-to-noise ratio (CNR) and noise. Results: Under the same imaging conditions, the DLR images of pediatric and adult phantoms generally provided improved CNR and noise compared with the FBP and IR images. At a similar CNR and noise, the FBP, IR, and DLR of the pediatric images showed a dose reduction compared with the FBP, IR, and DLR of the adult images, respectively. In terms of the effect of tube voltage, the CNR of the 100 kV DLR images was higher than that of the 120 kV DLR images. Conclusion: According to the results, since pediatric CT images maintain the same image quality at lower doses compared with adult CT images, DLR can improve image quality while reducing the radiation dose in children's abdominal CT scans. [ABSTRACT FROM AUTHOR]

Featured Application: The development of this co-registration method that combines CBCT with photographic images and subsequent realistic image reconstruction can be used during the orthognathic surgical planning stage. Therefore, both orthodontists and maxillofacial surgeons will obtain more realistic and precise result predictions, allowing them to better clarify the patient's surgical prognosis. Orthognathic surgery is a procedure used to correct intermaxillary discrepancies, thus promoting significant improvements in chewing and breathing. During the surgical planning stage, orthodontists often use two-dimensional imaging techniques. The assessment is based on CBCT images and dental cast models to overcome these limitations; however, the evaluation of soft tissues remains complex. The aim of the present study was to develop a co-registration method of CBCT and photo images that would result in realistic facial image reconstruction. CBCT images were three-dimensionally rendered, and the soft tissues were subsequently segmented resulting in the cranial external surface. A co-registration between the obtained surface and a frontal photo of the subject was then carried out. From this mapping, a photorealistic model capable of replicating the features of the face was generated. To assess the quality of this procedure, seven orthodontists were asked to fill in a survey on the models obtained. The survey results showed that orthodontists consider the three-dimensional model obtained to be realistic and of high quality. This process can automatically obtain a three-dimensional model from CBCT images, which in turn may enhance the predictability of surgical-orthognathic planning. [ABSTRACT FROM AUTHOR]

Panoramic images have been widely used in the diagnosis of dental diseases. In the process of panoramic image reconstruction, the position of the dental arch curve usually affects the quality of display content, especially the completion level of the panoramic image. In addition, the metal implants in the patient's mouth often lead the contrast of the panoramic image to decrease. This paper describes a method to automatically synthesize panoramic images from dental cone beam computed tomography (CBCT) data. The proposed method has two essential features: the first feature is that the method can detect the dental arch curve through axial maximum intensity projection images over different ranges, and the second feature is that our method is able to adjust the intensity distribution of the implant in critical areas, to reduce the impact of the implant on the contrast of the panoramic image. The proposed method was tested on 50 CBCT datasets; the panoramic images generated by this method were compared with images attained from three other commonly used approaches and then subjectively scored by three experienced dentists. In the comprehensive image contrast score, the method in this paper has the highest score of 11.16 ± 2.64 points. The results show that the panoramic images generated by this method have better image contrast. [ABSTRACT FROM AUTHOR]

Compared to single source systems, stereo X-ray CT systems allow acquiring projection data within a reduced amount of time, for an extended field-of-view, or for dual X-ray energies. To exploit the benefit of a dual X-ray system, its acquisition geometry needs to be calibrated. Unfortunately, in modular stereo X-ray CT setups, geometry misalignment occurs each time the setup is changed, which calls for an efficient calibration procedure. Although many studies have been dealing with geometry calibration of an X-ray CT system, little research targets the calibration of a dual cone-beam X-ray CT system. In this work, we present a phantom-based calibration procedure to accurately estimate the geometry of a stereo cone-beam X-ray CT system. With simulated as well as real experiments, it is shown that the calibration procedure can be used to accurately estimate the geometry of a modular stereo X-ray CT system thereby reducing the misalignment artifacts in the reconstruction volumes. [ABSTRACT FROM AUTHOR]

Circular cone-beam (CCB) Computed Tomography (CT) has become an integral part of industrial quality control, materials science and medical imaging. The need to acquire and process each scan in a short time naturally leads to trade-offs between speed and reconstruction quality, creating a need for fast reconstruction algorithms capable of creating accurate reconstructions from limited data. In this paper, we introduce the Neural Network Feldkamp-Davis-Kress (NN-FDK) algorithm. This algorithm adds a machine learning component to the FDK algorithm to improve its reconstruction accuracy while maintaining its computational efficiency. Moreover, the NN-FDK algorithm is designed such that it has low training data requirements and is fast to train. This ensures that the proposed algorithm can be used to improve image quality in high-throughput CT scanning settings, where FDK is currently used to keep pace with the acquisition speed using readily available computational resources. We compare the NN-FDK algorithm to two standard CT reconstruction algorithms and to two popular deep neural networks trained to remove reconstruction artifacts from the 2D slices of an FDK reconstruction. We show that the NN-FDK reconstruction algorithm is substantially faster in computing a reconstruction than all the tested alternative methods except for the standard FDK algorithm and we show it can compute accurate CCB CT reconstructions in cases of high noise, a low number of projection angles or large cone angles. Moreover, we show that the training time of an NN-FDK network is orders of magnitude lower than the considered deep neural networks, with only a slight reduction in reconstruction accuracy. [ABSTRACT FROM AUTHOR]

Cone-beam dental CT can provide high-precision 3D images of the teeth and surrounding bones. From the 3D CT images, 3D models, also called digital impressions, can be computed for CAD/CAM-based fabrication of dental restorations or orthodontic devices. However, the cone-beam angle-dependent artifacts, mostly caused by the incompleteness of the projection data acquired in the circular cone-beam scan geometry, can induce significant errors in the 3D models. Using a micro-CT, we acquired CT projection data of plaster cast models at several different cone-beam angles, and we investigated the dependency of the model errors on the cone-beam angle in comparison with the reference models obtained from the optical scanning of the plaster models. For the 3D CT image reconstruction, we used the conventional Feldkamp algorithm and the combined half-scan image reconstruction algorithm to investigate the dependency of the model errors on the image reconstruction algorithm. We analyzed the mean of positive deviations and the mean of negative deviations of the surface points on the CT-image-derived 3D models from the reference model, and we compared them between the two image reconstruction algorithms. It has been found that the model error increases as the cone-beam angle increases in both algorithms. However, the model errors are smaller in the combined half-scan image reconstruction when the cone-beam angle is as large as 10 degrees. [ABSTRACT FROM AUTHOR]

This paper studies the problem of efficiently tuning the hyper-parameters in penalised least-squares reconstruction for XCT. Discovered through the lens of the Compressed Sensing paradigm, penalisation functionals such as Total Variation types of norms, form an essential tool for enforcing structure in inverse problems, a key feature in the case where the number of projections is small as compared to the size of the object to recover. In this paper, we propose a novel hyper-parameter selection approach for total variation (TV)-based reconstruction algorithms, based on a boosting type machine learning procedure initially proposed by Freund and Shapire and called Hedge. The proposed approach is able to select a set of hyper-parameters producing better reconstruction than the traditional Cross-Validation approach, with reduced computational effort. Traditional reconstruction methods based on penalisation can be made more efficient using boosting type methods from machine learning. [ABSTRACT FROM AUTHOR]

X-ray scattering significantly limits image quality. Conventional strategies for scatter reduction based on physical equipment or measurements inevitably increase the dose to improve the image quality. In addition, scatter reduction based on a computational algorithm could take a large amount of time. We propose a deep learning-based scatter correction method, which adopts a convolutional neural network (CNN) for restoration of degraded images. Because it is hard to obtain real data from an X-ray imaging system for training the network, Monte Carlo (MC) simulation was performed to generate the training data. For simulating X-ray images of a human chest, a cone beam CT (CBCT) was designed and modeled as an example. Then, pairs of simulated images, which correspond to scattered and scatter-free images, respectively, were obtained from the model with different doses. The scatter components, calculated by taking the differences of the pairs, were used as targets to train the weight parameters of the CNN. Compared with the MC-based iterative method, the proposed one shows better results in projected images, with as much as 58.5% reduction in root-mean-square error (RMSE), and 18.1% and 3.4% increases in peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM), on average, respectively. [ABSTRACT FROM AUTHOR]