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1. A Mutation in Af4 Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse.

Author

Isaacs, Adrian M., Oliver, Peter L., Jones, Emma L., Jeans, Alexander, Potter, Allyson, Hovik, Berit H., Nolan, Patrick M., Vizor, Lucie, Glenister, Peter, Simon, A. Katharina, Gray, Ian C., Spurr, Nigel H., Brown, Steve D.M., Hunter, A. Jackie, and Davies, Kay E.

Subjects
*ROBOTICS, *PURKINJE cells, *CEREBELLAR ataxia, *NEURODEGENERATION, *ATAXIA
Abstract

Presents information on a study which demonstrated a mutant mouse model for cerebellar ataxia that develops Purkinje cell loss in a stereotypical region-specific manner. Histology and immunohistochemistry; Identification of robotic mice which develop region-specific Purkinje cell loss; Neurodegenerative changes in the robotic cerebellum.

Published
2003
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