1. Expression and clinical significance of L-plastin in colorectal carcinoma.
- Author
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Li, Jing and Zhao, Ren
- Subjects
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COLON cancer , *MICROFILAMENT proteins , *BLOOD plasma , *ENZYME-linked immunosorbent assay , *IMMUNOHISTOCHEMISTRY , *GENE expression , *PROGNOSIS , *GENE therapy , *ANALYSIS of variance , *CANCER , *COLON tumors , *METASTASIS , *PHARMACOKINETICS , *TUMOR classification , *RECEIVER operating characteristic curves , *MEMBRANE glycoproteins ,RECTUM tumors - Abstract
Introduction: L: -plastin, an actin-binding protein, is upregulated in many tumours, including colorectal carcinoma. This study evaluated the expression of L: -plastin in plasma and colorectal tumour tissue and analysed the correlation between clinicopathological staging and prognosis.Materials and Methods: Enzyme-linked immunosorbent assay was used to detect L: -plastin in the plasma of 120 colorectal carcinoma patients and 40 control subjects. Immunohistochemistry analyses were also used.Results: The rate of positive L: -plastin expression was significantly higher in colorectal carcinoma patients than in control subjects, and was significantly higher in tumour tissues than in the tissues surrounding the tumour. L: -Plastin expression also is correlated with tumour grade and size, and lymph node metastasis. However, there was no correlation with the extent of tumour invasion or distant metastasis.Conclusion: L: -Plastin may be a useful marker for screening colorectal carcinoma and determining the prognosis of patients with colorectal carcinoma, and for genetic therapy and targeted therapy of colorectal carcinoma. [ABSTRACT FROM AUTHOR]- Published
- 2011
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