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Background: One way of quitting addiction is forming narcotics anonymous (NA) groups. Noticing the high rate of reappearance of drug usage in these groups, the researchers decided to obtain a proper method of increasing the duration of abandonment period through the analysis of different factors affecting the reappearance of addiction. Materials and Methods: In a cross-sectional analytical study, all NA members (350 men) in Khomein were evaluated through questionnaire and referral interview. Data related to factors affecting quitting addiction, development of addiction, and reappearance of addiction were analyzed. Results: The most important causes of addiction were enjoyment and curiosity (75.1%), whereas the most important factors in abandonment were weariness and pressure from family (45.4%). Also, 48.9% of individuals had previously relapsed into using narcotic substances. The most important factors in reappearance of addiction in NA groups were unemployment and change in income (12.6%). A significant relationship was found between level of education and place of living and addiction to narcotics (p=0.000), whereas there were no significant relationships between the type of narcotic substance and quitting addiction or the mean age of individuals and trying or not trying to quit. Conclusion: Noticing the high rate of reappearance of narcotics usage in NA groups, it seems that current programs for prevention of addiction have not been successful in this regard. However, based on the findings of this study, it is suggested that provision of employment opportunities after quitting addiction can, to some extent, prevent the reappearance of addiction in NA groups. [ABSTRACT FROM AUTHOR]