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(This paper has been retracted)

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In epidemiological studies, dairy food consumption has been associated with minimal effect or decreased risk of some cardiometabolic diseases (CMD). However, current methods of dietary assessment do not provide objective and accurate measures of food intakes. Thus, the identification of valid and reliable biomarkers of dairy product intake is an important challenge to best determine the relationship between dairy consumption and health status. This review investigated potential biomarkers of dairy fat consumption, such as odd-chain, trans- and branched-chain fatty acids (FA), which may improve the assessment of full-fat dairy product consumption. Overall, the current use of serum/plasma FA as biomarkers of dairy fat consumption is mostly based on observational evidence, with a lack of well-controlled, dose–response intervention studies to accurately assess the strength of the relationship. Circulating odd-chain SFA and trans-palmitoleic acid are increasingly studied in relation to CMD risk and seem to be consistently associated with a reduced risk of type 2 diabetes in prospective cohort studies. However, associations with CVD are less clear. Overall, adding less studied FA such as vaccenic and phytanic acids to the current available evidence may provide a more complete assessment of dairy fat intake and minimise potential confounding from endogenous synthesis. Finally, the current evidence base on the direct effect of dairy fatty acids on established biomarkers of CMD risk (e.g. fasting lipid profiles and markers of glycaemic control) mostly derives from cross-sectional, animal and in vitro studies and should be strengthened by well-controlled human intervention studies.

Biosorption of metal ions by phototrophic microorganisms is regarded as a sustainable and alternative method for bioremediation and metal recovery. In this study, 12 cyanobacterial strains, including 7 terrestrial and 5 aquatic cyanobacteria, covering a broad phylogenetic diversity were investigated for their potential application in the enrichment of rare earth elements through biosorption. A screening for the maximum adsorption capacity of cerium, neodymium, terbium, and lanthanum was conducted in which Nostoc sp. 20.02 showed the highest adsorption capacity with 84.2–91.5 mg g-1. Additionally, Synechococcus elongatus UTEX 2973, Calothrix brevissima SAG 34.79, Desmonostoc muscorum 90.03, and Komarekiella sp. 89.12 were promising candidate strains, with maximum adsorption capacities of 69.5–83.4 mg g-1, 68.6–83.5 mg g-1, 44.7–70.6 mg g-1, and 47.2–67.1 mg g-1 respectively. Experiments with cerium on adsorption properties of the five highest metal adsorbing strains displayed fast adsorption kinetics and a strong influence of the pH value on metal uptake, with an optimum at pH 5 to 6. Studies on binding specificity with mixed-metal solutions strongly indicated an ion-exchange mechanism in which Na+, K+, Mg2+, and Ca2+ ions are replaced by other metal cations during the biosorption process. Depending on the cyanobacterial strain, FT-IR analysis indicated the involvement different functional groups like hydroxyl and carboxyl groups during the adsorption process. Overall, the application of cyanobacteria as biosorbent in bioremediation and recovery of rare earth elements is a promising method for the development of an industrial process and has to be further optimized and adjusted regarding metal-containing wastewater and adsorption efficiency by cyanobacterial biomass.

Intel's software guard extensions (SGX) provide hardware enclaves to guarantee confidentiality and integrity for sensitive code and data. However, systems leveraging such security mechanisms must often pay high performance overheads. A major source of this overhead is SGX enclave transitions which induce expensive cross-enclave context switches. The Intel SGX SDK mitigates this with a switchless call mechanism for transitionless cross-enclave calls using worker threads. Intel's SGX switchless call implementation improves performance but provides limited flexibility: developers need to statically fix the system configuration at build time, which is error-prone and misconfigurations lead to performance degradations and waste of CPU resources. ZC-SWITCHLESS is a configless and efficient technique to drive the execution of SGX switchless calls. Its dynamic approach optimises the total switchless worker threads at runtime to minimise CPU waste. The experimental evaluation shows that ZC-SWITCHLESS obviates the performance penalty of misconfigured switchless systems while minimising CPU waste., Comment: 10 pages, 53rd Annual IEEE/IFIP International Conference on Dependable Systems and Networks (DSN)

The European Medicines Agency (EMA) started operating under its new legal mandate on 1 April 2022. The mandate brings new responsibilities to the Agency in three different areas: • Reinforcement of the role and activities of the EMA pandemic Task Force(which is now known as the Emergency Task Force (ETF)). • A stronger role of EMA in the monitoring of shortages of critical medicines, medical devices and in-vitro diagnostics, both in anticipation of and during a crisis. • A more coordinated mechanism of European Union (EU) experts advice on medical devices classified as high-risk (class IIa and III or class D (1)) and in-vitro diagnostic medical devices. Here we consider the impact of the COVID-19 pandemic on the operations of EMA and the European medicines regulatory network, and how EMA’s new mandate will strengthen the Agency’s and the Network’s ability to face crises. EMA’s extended mandate brings clear benefits in terms of response to public health emergencies at EU level, which ranges from improvements in crisis management to avoiding medicine shortages and improving access to diagnostics and medical devices that are safe and conform to their expected function.

DIS2022 conference presentation

This paper is on a brief interpretation of class P and NP as bounds over the number of jumps between strings in an infinite Hamming cube consisting all the instances of a language on a Turing machine’s tape. It is shown that P and NP are more comparable when defined in Hamming space respecting its cubic structure; while, this results P = NP.

In order to survive and thrive, man has required and utilized energy at an increasing pace ever since he first appeared on the planet a few million years ago. As a result, a significant amount of energy has been depleted and squandered. In nations with large populations, such as India and China, where fitness centres are very popular, the idea of repurposing waste energy generated by gym pulleys is a no-brainer. We're using a non-traditional approach to generate electrical power in this project by just pulling up and pulling down. Our country's reliance on non-traditional sources of energy is more important than ever. The conversion of mechanical energy to electrical energy occurs via non-conventional energy sources such as pull-ups and pull-downs. Force energy is converted into electrical energy in this project. Modern technology has made it feasible to use human power in a more effective method for generating. Pull up pull down power is a great source of energy, with 95 percent of the effort put into it being turned into energy. The business has introduced a human-powered energy producing system for the public to see. To generate electricity, the user of this device must raise and lower gym equipment. &nbsp

Iron reduction and sulfate reduction often occur simultaneously in anoxic systems, and where that is the case, the molar ratio between the reactions (i.e., Fe/SO42- reduced) influences their impact on water quality and carbon storage. Previous research has shown that pH and the supply of electron donors and acceptors affect that ratio, but it is unclear how their influences compare and affect one another. This study examines impacts of pH and the supply of acetate, sulfate, and goethite on the ratio of iron to sulfate reduction in semi-continuous sediment bioreactors. We examined which parameter had the greatest impact on that ratio and whether the parameter influences depended on the state of each other. Results show that pH had a greater influence than acetate supply on the ratio of iron to sulfate reduction, and that the impact of acetate supply on the ratio depended on pH. In acidic reactors (pH 6.0 media), the ratio of iron to sulfate reduction decreased from 3:1 to 2:1 as acetate supply increased (0-1 mM). In alkaline reactors (pH 7.5 media), iron and sulfate were reduced in equal proportions, regardless of acetate supply. Secondly, a comparison of experiments with and without sulfate shows that the extent of iron reduction was greater if sulfate reduction was occurring and that the effect was larger in alkaline reactors than acidic reactors. Thus, the influence of sulfate supply on iron reduction extent also depended on pH and suggests that iron reduction grows more dependent on sulfate reduction as pH increases. Our results compare well to trends in groundwater geochemistry and provide further evidence that pH is a major control on iron and sulfate reduction in systems with crystalline (oxyhydr)oxides. pH not only affects the ratio between the reactions but also the influences of other parameters on that ratio.

In analogy to higher plants, eukaryotic microalgae are thought to be incapable of utilizing green light for growth, due to the "green gap" in the absorbance profiles of their photosynthetic pigments. This study demonstrates, that the marine chlorophyte

In this study water soluble compounds that form complexes with Rare Earth Elements (REE) and other metals were isolated from Calothrix brevissima biomass with chromatographic methods for the first time. Molecular characterization showed that the isolated compounds are most likely polysaccharides comprised of arabinose, xylose, mannose, galactose and glucose. FT-IR analysis revealed functional groups involved in the binding mechanism of Tb are likely sulfate- and to a lesser extend hydroxyl-groups. The binding specificity of the isolated compounds was investigated with different metal solutions. Here, ions of the alkali and alkaline earth metals Na, K, Mg and Ca showed no competition for Tb-binding even at 10-fold excess concentration. Ions of the elements Co and Pb on the other hand replaced Tb at higher concentrations. Addition of the isolated compounds significantly reduced the precipitation of Eu at pH-values between 6.7 and 9.5, indicating that the interaction between the isolated chelators and Rare Earth Metals is stable even at high pH-values.

To assess the cross-sectional association between dietary indexes (DI) that underlie, respectively, the Nutri-score (NS), the proposed Canadian 'High In' Symbol (CHIL) and the Diabetes Canada Clinical Practice Guidelines (DCCP) with food consumption, nutrient intakes and metabolic markers.1836 adults (18-74 years) participating in the representative ESTEBAN study, conducted in mainland France in 2014-2016, were included in the analysis. Food consumption was assessed with three repeated 24 h dietary recalls. Anthropometric measurements and biomarkers of metabolic risk (cholesterol-total, LDL (Low Density Lipoprotein), HDL (High Density Lipoprotein)-triglycerides, glucose) were obtained through a clinical examination and fasting blood draw. The DI were assessed for their association with food consumption, dietary intakes and metabolic biomarkers as quintiles and continuous variables using multi-adjusted linear regression. Heathier diets were assigned to lower scores.Correlations between scores ranged from + 0.62 between CHIL-DI and NS-DI to + 0.75 between NS-DI and DCCP-DI. All DIs discriminated individuals according to the nutritional quality of their diets through food consumption and nutrient intakes (healthier diets were associated with lower intakes of energy, added sugars and saturated fat; and with higher intakes of fiber, vitamins and minerals). NS-DI was associated with blood glucose (adjusted mean in Q1 = 5 vs. Q5 = 5.46 mmol/dl, pThis study provides elements supporting the validity of the nutrient profiling systems underlying front-of-package nutrition labellings (FOPLs) to characterize the healthiness of diets.

Geologic ontology

In this study water soluble compounds that form complexes with Rare Earth Elements (REE) and other metals were isolated from

Chinese named entity recognition in the geoscience domain based on BERT

Original GPM data can download from https://disc.gsfc.nasa.gov/datasets/GPM_3IMERGDF_06/summary?keywords="IMERG final"original SinGAN: https://github.com/tamarott/SinGAN

In analogy to higher plants, eukaryotic microalgae are thought to be incapable of utilizing green light for growth, due to the “green gap” in the absorbance profiles of their photosynthetic pigments. This study demonstrates, that the marine chlorophyte Picochlorum sp. is able to grow efficiently under green light emitting diode (LED) illumination. Picochlorum sp. growth and pigment profiles under blue, red, green and white LED illumination (light intensity: 50–200 μmol m−2 s−1) in bottom-lightened shake flask cultures were evaluated. Green light-treated cultures showed a prolonged initial growth lag phase of one to 2 days, which was subsequently compensated to obtain comparable biomass yields to red and white light controls (approx. 0.8 gDW L−1). Interestingly, growth and final biomass yields of the green light-treated sample were higher than under blue light with equivalent illumination energies. Further, pigment analysis indicated, that during green light illumination, Picochlorum sp. formed unknown pigments (X1-X4). Pigment concentrations increased with illumination intensity and were most abundant during the exponential growth phase. Mass spectrometry and nuclear magnetic resonance data indicated, that pigments X1-X2 and X3-X4 are derivatives of chlorophyll b and a, which harbor C=C bonds in the phytol side chain similar to geranylgeranylated chlorophylls. Thus, for the first time, the natural accumulation of large pools (approx. 12 mg gDW−1) of chlorophyll intermediates with incomplete hydrogenation of their phytyl chains is demonstrated for algae under monochromatic green light (Peak λ 510 nm, full width at half maximum 91 nm). The ability to utilize green light offers competitive advantages for enhancing biomass production, particularly under conditions of dense cultures, long light pathways and high light intensity. Green light acclimation for an eukaryotic microalgae in conjunction with the formation of new aberrant geranylgeranylated chlorophylls and high efficiency of growth rates are novel for eukaryotic microalgae. Illumination with green light could enhance productivity in industrial processes and trigger the formation of new metabolites–thus, underlying mechanisms require further investigation.

Surface-enhanced Raman spectroscopy (SERS) has been increasingly used in the last decade for the identification of organic colourants in works of art. 'Surface-enhancement' is the giant increase in Raman scattering intensity experienced by organic molecules adsorbed on atomically rough metallic surfaces. In the case of organic colourants, which are in general strongly luminescent under laser excitation and therefore cannot usually be identified by conventional Raman microscopy (see AMCTB no. 67), SERS yields a strong and clearly resolved spectrum, allowing for easy identification. Unlike ordinary Raman spectroscopy, SERS often requires sampling, yet the sample size is considerably smaller (from 20 to 100 micrometres) than that required for high-performance liquid chromatography (HPLC), the benchmark technique for organic colourants analysis. For this reason, SERS has seen substantial use in the analysis of works of art such as prints, drawings, paintings, and polychrome sculpture. This technical brief focuses on the practical aspects of SERS and its application to the analysis of cultural heritage material, as well as on its current limitations.

Paper Shredding Services There are basically two distinct strategies utilized for this interaction: on location and off-site. There are likenesses between these alternatives however it is critical to see everyone. Versatile or on location record annihilation is a clear interaction. Organizations utilizing this alternative will have holders that they load up with archives that should be obliterated. When the containers are filled, the organization plans an arrangement for annihilation. A truck outfitted with shred machines comes straightforwardly to the business, and the substance of those holders are filled the machine. The compartments are returned so they can be topped off. Entrepreneurs and supervisors have the alternative of directing the interaction. By and large, the versatile alternative is generally good as it gives almost no chance of bargained data. Off-site paper destroying administrations are utilized in two distinct manners; the business either organizes pickup or brings the documents straightforwardly to the office. https://www.softage.net/data-management/document-shredding, Paper Shredding Services might be identified with business activities, past and current workers, and even private client data

Inference and testing in general point process models such as the Hawkes model is predominantly based on asymptotic approximations for likelihoodbased estimators and tests, as originally developed in Ogata (1978). As an alternative, and to improve finite sample performance, this paper considers bootstrap-based inference for interval estimation and testing. Specifically, for a wide class of point process models we consider a novel bootstrap scheme labeled 'fixed intensity bootstrap' (FIB), where the conditional intensity is kept fixed across bootstrap repetitions. The FIB, which is very simple to implement and fast in practice, naturally extends previous ideas from the bootstrap literature on time series in discrete time, where the so-called 'fixed design' and 'fixed volatility' bootstrap schemes have shown to be particularly useful and effective. We compare the FIB with the classic recursive bootstrap, which is here labeled 'recursive intensity bootstrap' (RIB). In RIB algorithms, the intensity is stochastic in the bootstrap world and implementation of the bootstrap is more involved, due to its sequential structure. For both bootstrap schemes, no asymptotic theory is available; we therefore provide here a new bootstrap (asymptotic) theory, which allows to assess bootstrap validity. We also introduce novel 'nonparametric' FIB and RIB schemes, which are based on resampling time-changed transformations of the original waiting times. We show effectiveness of the different bootstrap schemes in finite samples through a set of detailed Monte Carlo experiments. As far as we are aware, this is the first detailed Monte Carlo study of bootstrap implementations for Hawkes-type processes. Finally, in order to illustrate, we provide applications of the bootstrap to both financial data and social media data.

We introduce the basic concepts of deep learning. We use TensorFlow 2.x, the Google cloud service, and Google Drive interaction to make the concepts come alive with Python coding examples.

This paper investigates the effects of automation and offshoring on the dynamics of the occupational distribution of employment with a focus on Western Europe between 2000 and 2016. I use a general equilibrium model with three regions, three types of workers, ICT capital, trade in final goods and endogenous offshoring. Fed with exogenous measures of ICT-capital prices and trade costs, the model replicates key features of the data. It matches the observed dynamics of offshoring to Eastern Europe and Asian countries. It also reproduces accurately the observed polarization of the labor market: abstract and manual labor increase while routine labor falls. A counterfactual experiment reveals that automation is the main driver of polarization. Since it is also the only factor that drives individuals to become abstract (highskill) workers, it is welfare enhancing. The effects of falling trade costs on labor polarization are smaller, but imply welfare gains.

Neural style transfer (NST) is a computer vision technique that takes two images – a content image and a style reference image – and blends them together so that the resulting output image retains the core elements of the content image but appears to be painted in the style of the style reference image. The output image from a NST network is called a pastiche. A pastiche is a work of visual art, literature, theater or music that imitates the style (or character) of the work of one or more other artists. Unlike a parody, a pastiche celebrates rather than mocks the work it imitates.