2,502 results on '"van Dalen, A."'
Search Results
2. Patient-Reported Symptoms of Late Toxicity in Patients With Breast Cancer Treated With Hypofractionated Radiation Therapy and the Association With Quality of Life
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M.C.T. Batenburg, D.R. Mink van der Molen, F. van der Leij, A. Doeksen, T. van Dalen, E.J.P. Schoenmaeckers, R.M. Bijlsma, A.J. Witkamp, M. Ernst, M.F. Sier, W. Maarse, H.J.G.D. van den Bongard, H.M. Verkooijen, Graduate School, ACS - Atherosclerosis & ischemic syndromes, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiotherapy, and CCA - Imaging and biomarkers
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Cancer Research ,Radiation ,Oncology ,Radiology, Nuclear Medicine and imaging - Abstract
Purpose: Our purpose was to assess the prevalence of patient-reported symptoms of local late toxicity in patients with irradiated breast cancer and determine the association between late toxicity and quality of life. Methods: Within the prospective Utrecht cohort for Multiple BReast cancer intErvention studies and Long-term evaluation cohort, a survey on self-reported late toxicity was sent to all patients with breast cancer with ≥12 months interval since radiation therapy treated with curative intent. Patients were treated with hypofractionated radiation therapy of 40 Gy/15 fractions or 42.5 Gy/16 fractions, with or without a simultaneous integrated boost. Symptoms of late toxicity were evaluated on a 4-point Likert scale. Late toxicity was defined as moderate-severe breast or chest wall pain combined with at least 1 other mild-severe late toxicity symptom, that is, breast or arm/hand lymphedema, firmness of the breast, or impaired arm movement. Physical, role, and social functioning were measured before, during, and after the late toxicity survey using the European Organization for Research and Treatment of Cancer Quality of Life Core questionnaire-C30 and compared with a Dutch normative population. Results: In the study, 1613/2248 patients (72%) were included. Of those, 16% (n = 265) reported late toxicity. The median time interval between radiation therapy and survey was 38 months (interquartile range, 21-55). Moderate/severe firmness of the breast, chest wall pain, and breast pain were reported by, respectively, 18% (n = 295), 14% (n = 225), and 10% (n = 140) of all patients. Physical, role, and social functioning were below the clinical threshold (ie, clinically relevant impairment) in 13% to 52% of patients with late toxicity and 2% to 26% of patients without late toxicity. Patients with late toxicity significantly more often received analgesics, physiotherapy, and lymphedema therapy compared with patients without late toxicity. Conclusions: This study provided insight into the prevalence of patient-reported late toxicity after hypofractionated radiation therapy and the influence of late toxicity on quality of life after breast cancer. These results may help health care professionals to inform their patients about long-term effects of breast cancer treatment including hypofractionated radiation therapy.
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- 2023
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3. Morphodynamic signatures derived from daily surface elevation dynamics can explain the morphodynamic development of tidal flats
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Grandjean, T., de Smit, J.C., van Belzen, J., Fivash, G.S., van Dalen, J., Ysebaert, T., and Bouma, T.J.
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Ocean Engineering ,Civil and Structural Engineering - Abstract
Understanding the sensitivity of tidal flats to environmental changes is challenging. Currently, most studies rely on process-based models to systematically explain the morphodynamic evolution of tidal flats. In this study, we proposed an alternative empirical approach to explore tidal flat dynamics using statistical indices based on long-term time series of daily surface elevation development. Surface elevation dynamic (SED) indices focus on the magnitude and period of surface elevation changes, while morphodynamic signature (MDS) indices relate sediment dynamics to environmental drivers. The statistical analyses were applied to an intervention site in the Netherlands to determine the effect of recently constructed groynes on the tidal flat. Using these analyses, we were able to (1) detect a reduction in the daily SED and (2) determine that the changes in the daily SED were predominantly caused by the reduction in wave impact between the groynes rather than the reduction in tidal currents. Overall, the presented results showed that the combination of novel statistical indices provides new insights into the trajectories of tidal flats, ecosystem functioning, and sensitivity to physical drivers (wind and tides). Finally, we suggested how the SED and MDS indices may help to explore the future trajectories and climate resilience of intertidal habitats.
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- 2023
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4. Migrating to a new country in late life: A review of the literature on international retirement migration
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Esma Betül Savaş, Juul Spaan, Kène Henkens, Matthijs Kalmijn, and Hendrik P. van Dalen
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Europe ,amenities ,NETHERLANDS ,international migration ,pension ,retirement migration ,Demography - Abstract
Background: In the last few decades, a substantial number of older adults have migrated to new countries around the retirement age to raise their quality of life, a phenomenon that has been labeled as international retirement migration. The scattered body of research on this type of migration across disciplines has made it difficult to get an overview of why retirement migrants move and how they fare in their destination countries. Objective: This paper accumulates findings from research on international retirement migration from different disciplines to obtain a comprehensive picture of the field. We do so by (1) evaluating the strengths and weaknesses of methodological approaches, (2) reviewing empirical findings, and (3) discussing future research directions. Methods: We carried out a systematic literature search of peer-reviewed studies in the English language on Web of Science and Google Scholar published between 1998 and 2021 with the keyword search “international retirement migration.” From an initial pool of 148 articles, we excluded articles focusing on the return of retiring labor migrants, internal retirement migrants, and seasonal retirement migrants. We conducted a literature review on the remaining 90 articles about retirement migration. Contribution: Our review shows that the unbalanced nature of methods and samples used in the retirement migration literature offers challenges for future research. In particular, it remains important to assess whether the current accounts are representative of the wider retirement migrant population and to systematically test hypotheses that arise from this basis. We suggest methodological improvements and future research directions.
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- 2023
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5. Risk Prediction Models for Myocardial Dysfunction and Heart Failure in Patients with Current or Prior Cancer
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E. C. van Dalen, J. M. Leerink, L. C. M. Kremer, and E. A. M. Feijen
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Oncology ,Heart failure ,Myocardial dysfunction ,Cancer ,Risk prediction model - Abstract
Purpose of Review: Cancer patients are at risk for treatment-related myocardial dysfunction and heart failure during or after treatment. Risk prediction models have the potential to play an important role in identifying patients at high or low risk in order to take appropriate measures. Here, we review their current role. Recent Findings: More and more risk prediction models are currently being developed. Unfortunately, they vary widely in their ability to identify patients and survivors at risk for myocardial dysfunction or heart failure, from very poor to strong. Part of this variation might be explained by methodological limitations of the models, but due to a lack of reporting it is not possible to completely assess this. Summary: There lies great potential in the improvement of the quality and the use of risk prediction models to inform patients and clinicians on the absolute risk of cardiac events in order to guide care.
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- 2023
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6. Effectiveness of Regulatory Policies on Online/Digital/Internet-Mediated Alcohol Marketing: a Systematic Review
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Sandra Radoš Krnel, Gorazd Levičnik, Wim van Dalen, Giulia Ferrarese, and Sandra Tricas-Sauras
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Background The rapid growth of social networking sites and video sharing platforms has created an opportunity for the alcohol industry to employ advanced advertising and marketing approaches to target their audiences, increasingly blurring the lines between commercial marketing and user-generated content, which poses a challenge for effective regulation. Methods We conducted a systematic search through three peer-reviewed journal databases (WoS, PubMed, Scopus). Studies were included if published in English, after 2004, and assessed statutory regulation or voluntary industry codes, enacted by an EU or nation’s governmental agency or private entity, and with the intent to restrict digital alcohol advertising. In addition, we conducted a manual search of gray literature. Results A total of 4690 records were identified. After duplicate removal and full-text assessment, 14 articles were examined. Our findings indicate that children and adolescents may often be exposed to alcohol advertisements on social media and websites due to industry’s self-regulatory age-affirmation systems being largely ineffective at preventing under-aged access. Cases of self-regulatory violations by the alcohol industry, and increasingly innovative ‘gray-area’ advertising approaches have also been noted. Additionally, research illustrates a lack of developed statutory restrictions of digital alcohol advertising and instead continued reliance on voluntary industry self-regulation. Conclusions There is a substantial need for further research to examine the effectiveness of digital alcohol advertising restrictions in social media, websites and image/video sharing platforms. Moreover, there is a necessity for countries to develop comprehensive statutory frameworks, which would effectively restrict and monitor rapidly advancing digital alcohol advertising practices on new digital media.
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- 2023
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7. Risk Factors for Heart Failure Among Pan-European Childhood Cancer Survivors: A PanCareSurFup and ProCardio Cohort and Nested Case-Control Study
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Esmée C. de Baat, Elizabeth A.M. Feijen, Raoul C. Reulen, Rodrigue S. Allodji, Francesca Bagnasco, Edit Bardi, Fabiën N. Belle, Julianne Byrne, Elvira C. van Dalen, Ghazi Debiche, Ibrahima Diallo, Desiree Grabow, Lars Hjorth, Momcilo Jankovic, Claudia E. Kuehni, Gill Levitt, Damien Llanas, Jacqueline Loonen, Lorna Z. Zaletel, Milena M. Maule, Lucia Miligi, Helena J.H. van der Pal, Cécile M. Ronckers, Carlotta Sacerdote, Roderick Skinner, Zsuzsanna Jakab, Cristina Veres, Nadia Haddy, David L. Winter, Florent de Vathaire, Michael M. Hawkins, and Leontien C.M. Kremer
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Heart Failure ,Cancer Research ,European People ,Antibiotics, Antineoplastic ,360 Soziale Probleme, Sozialdienste ,610 Medicine & health ,Middle Aged ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,All institutes and research themes of the Radboud University Medical Center ,Oncology ,Cancer Survivors ,360 Social problems & social services ,Risk Factors ,Neoplasms ,Case-Control Studies ,Humans ,Anthracyclines ,610 Medizin und Gesundheit ,Child - Abstract
PURPOSE Heart failure (HF) is a potentially life-threatening complication of treatment for childhood cancer. We evaluated the risk and risk factors for HF in a large European study of long-term survivors. Little is known of the effects of low doses of treatment, which is needed to improve current treatment protocols and surveillance guidelines. METHODS This study includes the PanCareSurFup and ProCardio cohort of ≥ 5-year childhood cancer survivors diagnosed between 1940 and 2009 in seven European countries (N = 42,361). We calculated the cumulative incidence of HF and conducted a nested case-control study to evaluate detailed treatment-related risk factors. RESULTS The cumulative incidence of HF was 2% (95% CI, 1.7 to 2.2) by age 50 years. The case-control study (n = 1,000) showed that survivors who received a mean heart radiation therapy (RT) dose of 5 to < 15 Gy have an increased risk of HF (odds ratio, 5.5; 95% CI, 2.5 to 12.3), when compared with no heart RT. The risk associated with doses 5 to < 15 Gy increased with exposure of a larger heart volume. In addition, the HF risk increased in a linear fashion with higher mean heart RT doses. Regarding total cumulative anthracycline dose, survivors who received ≥ 100 mg/m2 had a substantially increased risk of HF and survivors treated with a lower dose showed no significantly increased risk of HF. The dose-response relationship appeared quadratic with higher anthracycline doses. CONCLUSION Survivors who received a mean heart RT dose of ≥ 5 Gy have an increased risk of HF. The risk associated with RT increases with larger volumes exposed. Survivors treated with < 100 mg/m2 total cumulative anthracycline dose have no significantly increased risk of HF. These new findings might have consequences for new treatment protocols for children with cancer and for cardiomyopathy surveillance guidelines.
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- 2023
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8. Effective alcohol policies and lifetime abstinence: An analysis of the International Alcohol Control policy index
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June Leung, Sally Casswell, Karl Parker, Taisia Huckle, Jose Romeo, Thomas Graydon‐Guy, Karimu Byron, Sarah Callinan, Surasak Chaiyasong, Ross Gordon, Nadine Harker, Anne Marie MacKintosh, Petra Meier, Guillermo Paraje, Charles D. Parry, Cuong Pham, Petal Petersen Williams, Stephen Randerson, Karen Schelleman‐Offermans, Gantuya Sengee, Perihan Torun, Wim van Dalen, Section Applied Social Psychology, and RS: FPN WSP II
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Health (social science) ,Abstention ,Abstinence ,Policy index ,Alcohol policy ,Medicine (miscellaneous) ,Alcohol - Abstract
INTRODUCTION: Alcohol abstinence remains common among adults globally, although low and middle-income countries are experiencing declines in abstention. The effect of alcohol policies on lifetime abstinence is poorly understood. The International Alcohol Control (IAC) policy index was developed to benchmark and monitor the uptake of effective alcohol policies and has shown strong associations with alcohol per capita consumption and drinking patterns. Uniquely, the index incorporates both policy 'stringency' and 'impact', reflecting policy implementation and enforcement, across effective policies. Here we assessed the association of the IAC policy index with lifetime abstinence in a diverse sample of jurisdictions.METHODS: We conducted a cross-sectional analysis of the relationship between the IAC policy index score, and its components, and lifetime abstinence among adults (15+ years) in 13 high and middle-income jurisdictions. We examined the correlations for each component of the index and stringency and impact separately.RESULTS: Overall, the total IAC policy index scores were positively correlated with lifetime abstinence (r = 0.76), as were both the stringency (r = 0.62) and impact (r = 0.82) scores. Marketing restrictions showed higher correlations with lifetime abstinence than other policy domains (r = 0.80), including restrictions on physical availability, pricing policies and drink-driving prevention.DISCUSSION AND CONCLUSION: Our findings suggest that restricting alcohol marketing could be an important policy for the protection of alcohol abstention. The IAC policy index may be a useful tool to benchmark the performance of alcohol policy in supporting alcohol abstention in high and middle-income countries.
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- 2022
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9. Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial
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Fleur M Keij, René F Kornelisse, Nico G Hartwig, Jacqueline van der Sluijs-Bens, Ron H T van Beek, Arianne van Driel, Linda G M van Rooij, Ilka van Dalen-Vink, Gertjan J A Driessen, Sandra Kenter, Jeannette S von Lindern, Marianne Eijkemans, Gerda M Stam-Stigter, Hongchao Qi, Maartje M van den Berg, Martin G A Baartmans, Laura H van der Meer-Kappelle, Clemens B Meijssen, Obbe F Norbruis, Jojanneke Heidema, Maaike C van Rossem, Paul C P den Butter, Karel Allegaert, Irwin K M Reiss, Gerdien A Tramper-Stranders, Pediatrics, Epidemiology, and Pharmacy
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Adult ,Adolescent ,Research ,Infant, Newborn ,Amoxicillin ,Infant ,Bacterial Infections ,Amoxicillin-Potassium Clavulanate Combination ,Anti-Bacterial Agents ,Young Adult ,Treatment Outcome ,Child, Preschool ,Reinfection ,Pediatrics, Perinatology and Child Health ,Developmental and Educational Psychology ,Humans ,Child ,Clavulanic Acid - Abstract
Background: Switching from intravenous antibiotic therapy to oral antibiotic therapy among neonates is not yet practised in high-income settings due to uncertainties about exposure and safety. We aimed to assess the efficacy and safety of early intravenous-to-oral antibiotic switch therapy compared with a full course of intravenous antibiotics among neonates with probable bacterial infection. Methods: In this multicentre, randomised, open-label, non-inferiority trial, patients were recruited at 17 hospitals in the Netherlands. Neonates (postmenstrual age ≥35 weeks, postnatal age 0–28 days, bodyweight ≥2 kg) in whom prolonged antibiotic treatment was indicated because of a probable bacterial infection, were randomly assigned (1:1) to switch to an oral suspension of amoxicillin 75 mg/kg plus clavulanic acid 18·75 mg/kg (in a 4:1 dosing ratio, given daily in three doses) or continue on intravenous antibiotics (according to the local protocol). Both groups were treated for 7 days. The primary outcome was cumulative bacterial reinfection rate 28 days after treatment completion. A margin of 3% was deemed to indicate non-inferiority, thus if the reinfection rate in the oral amoxicillin–clavulanic acid group was less than 3% higher than that in the intravenous antibiotic group the null hypothesis would be rejected. The primary outcome was assessed in the intention-to-treat population (ie, all patients who were randomly assigned and completed the final follow-up visit on day 35) and the per protocol population. Safety was analysed in all patients who received at least one administration of the allocated treatment and who completed at least one follow-up visit. Secondary outcomes included clinical deterioration and duration of hospitalisation. This trial was registered with ClinicalTrials.gov, NCT03247920, and EudraCT, 2016-004447-36. Findings: Between Feb 8, 2018 and May 12, 2021, 510 neonates were randomly assigned (n=255 oral amoxicillin–clavulanic group; n=255 intravenous antibiotic group). After excluding those who withdrew consent (n=4), did not fulfil inclusion criteria (n=1), and lost to follow-up (n=1), 252 neonates in each group were included in the intention-to-treat population. The cumulative reinfection rate at day 28 was similar between groups (one [non-inferiority
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- 2022
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10. Trust in pension funds, or the importance of being financially sound
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Hendrik P. van Dalen, Kène Henkens, Netherlands Interdisciplinary Demographic Institute (NIDI), Department of Economics, and Research Group: Economics
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Organizational Behavior and Human Resource Management ,Economics and Econometrics ,buffers ,Funding ratio ,funding ,Strategy and Management ,Mechanical Engineering ,Metals and Alloys ,pension funds ,trust ,Finance ,Industrial and Manufacturing Engineering - Abstract
Is the trust that participants have in their pension fund affected by its funding ratio (i.e., asset/liabilities ratio)? Based on survey, carried out in October 2021, among Dutch pension fund participants we link our survey data to the funding ratio of their pension fund as registered by the pension regulator. First, we show that the level of the funding ratio of their pension fund is positively associated with the trust level of participants. Pension funds with large buffers are associated with a high level of trust. Second, sub-group analyses show that the trust of younger participants is weakly related to the level of the funding ratio and this association is strong and positive for older (55+)/retired participants. It suggests that an interest in or awareness about the financial health of one's pension fund is associated with a higher responsiveness of participants in terms of trust. And third, firm-based pension funds enjoy a higher level of trust compared to sector-based pension funds.
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- 2022
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11. Do We Judge Fiction by the Author’s Gender?
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Chantelle Ivanski, Stacey Humphries, Karina van Dalen-Oskam, Raymond A. Mar, and Computationele Literatuurwetenschap (HI)
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narrative fiction ,Social Psychology ,reading ,evaluations ,Communication ,discourse ,literary quality ,gender stereotypes ,Applied Psychology - Abstract
Abstract. Female authors of fiction often perceive themselves to be undervalued in relation to their male counterparts. What is not clear is whether this preference for male authors comes from readers or publishers. Two pre-registered studies examined how university students evaluated book passages attributed to either male or female authors, and investigated whether negative evaluations of romance novels are based on their association with women. In Study 1, participants read identical passages attributed to either male or female authors and evaluated them. Study 2 extended this work by adding attributions of genre: either romance or literary fiction. Linear mixed-effects modeling and Bayesian analyses were employed to analyze these data. Study 1 demonstrated little preference for books attributed to males over females and Bayesian analyses confirmed support for the null in most cases. The results of Study 2 similarly suggested that author gender and genre attributions do not have a strong influence on evaluations.
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- 2022
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12. Mene y Guachimanes: una lectura desde la escritura geológica
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Raquel Abend van Dalen
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Cultural Studies ,Linguistics and Language ,Literature and Literary Theory - Abstract
This article proposes a new reading of Venezuelan oil novels Mene and Guachimanes from the theoretical framework of geological writing. While literary criticism has focused on anthropocentric aspects of these novels, a geological analysis considers other factors within their narratives (non-human agency, materiality of bodies, and accumulation processes). I argue that reading these novels from this materialist perspective enables us to highlight substantial narrative elements in oil fiction that other readings have not adequately addressed, which has led to the literary devaluation of these petrofictions.
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- 2022
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13. The impact of the multidisciplinary Endocarditis Team on the management of infective endocarditis
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A. R. Wahadat, W. Tanis, T. W. Galema, L. E. Swart, W. J. van Leeuwen, N. J. Verkaik, C. A. M. Schurink, B. van Dalen, S. Zoet-Nugteren, C. Gurlek, R. P. J. Budde, J. W. Roos-Hesselink, Radiology & Nuclear Medicine, Cardiology, Cardiothoracic Surgery, Medical Microbiology & Infectious Diseases, and Internal Medicine
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Cardiology and Cardiovascular Medicine - Abstract
Background In their latest guidelines for infective endocarditis (IE) (2015), the European Society of Cardiology (ESC) introduced the implementation of the Endocarditis Team (ET) to facilitate the management of IE. This study presents our experiences and the diagnostic and therapeutic impact of the ET on the management of IE. Methods From 2016–2020, data of all patients with suspected IE referred to the ET were prospectively collected. The final diagnosis was defined by the ET as either rejected, possible or definite IE. Diagnostic impact was scored as any change in initial diagnosis, the frequency of additional diagnostic tests advised by the ET and any change in diagnosis after these tests. Therapeutic impact was scored as any change in antibiotic therapy or change from conservative to invasive therapy or vice versa. Results A total of 321 patients (median age 67 [55–77] years, 71% male) were enrolled. The final diagnosis was rejected IE in 47 (15%), possible IE in 34 (11%) and definite IE in 240 (75%) patients. A change of initial diagnosis was seen in 53/321(17%) patients. Additional microbiological tests were advised in 69/321 (21%) patients, and additional imaging tests in 136/321 (42%) patients, which resulted in subsequent change in diagnosis in 23/321 (7%) patients. Any change in antibiotic treatment was advised in 135/321 (42%) patients, and change from initial conservative to additional surgical treatment in 15/321 (5%) patients. Conclusion The ET had a clear impact on the therapeutic policy for patients with suspected IE and is useful in the management of this life-threatening disease. Broad implementation is warranted.
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- 2022
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14. Introduction
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Arjen van Dalen
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- 2023
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15. The Mediating Power of Algorithms
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Arjen van Dalen
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- 2023
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16. Algorithm Aversion
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Arjen van Dalen
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- 2023
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17. Structuring Power
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Arjen van Dalen
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- 2023
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18. Algorithmic Power, Trust, and Legitimacy
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Arjen van Dalen
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- 2023
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19. Algorithmic Gatekeeping for Professional Communicators
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Arjen van Dalen
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- 2023
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20. Biogeography of the theileriosis vector, Rhipicephalus appendiculatus under current and future climate scenarios of Zimbabwe
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Tinotenda M. Nemaungwe, Ellie M. S. P. van Dalen, Emily O. Waniwa, Pious V. Makaya, Gerald Chikowore, and Frank Chidawanyika
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Ecology ,Insect Science ,General Medicine - Abstract
Climate directly influences the epidemiology of vector-borne diseases at various spatial and temporal scales. Following the recent increased incidences of theileriosis in Zimbabwe, a disease mainly transmitted by Rhipicephalus appendiculatus, we determined lethal temperatures for the species and current and possible future distribution using the machine learning algorithm ‘Maxent’. Rhipicephalus appendiculatus larvae had an upper lethal temperature (ULT50) of about 44 ± 0.5 °C and this was marginally higher for nymphs and adults at 46 ± 0.5 °C. Environmental temperatures recorded in selected zonal tick microhabitats were below the determined lethal limits, indicating the ability of the tick to survive these regions. The resultant model under current climatic conditions showed areas with high suitability indices to the eastern, northeastern and southeastern parts of the country, mainly in Masvingo, Manicaland and Mashonaland Central provinces. Future predictions as determined by 2050 climatic conditions indicate a reduction in suitable habitats with the tick receding to presently cooler high elevation areas such as the eastern Highlands of Zimbabwe and a few isolated pockets in the interior of the country. Lowveld areas show low suitability under current climatic conditions and are expected to remain unsuitable in future. Overall, the study shows that R. appendiculatus distribution is constrained by climatic factors and helps identify areas of where occurrence of the species and the disease it transmits is highly likely. This will assist in optimizing disease surveillance and vector management strategies targeted at the species.
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- 2023
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21. GRADE concept 4: Rating the certainty of evidence when study interventions or comparators differ from PICO targets
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Marius Goldkuhle, Gordon H. Guyatt, Nina Kreuzberger, Elie A. Akl, Philipp Dahm, Elvira C. van Dalen, Lars G. Hemkens, Miloslav Klugar, Reem A. Mustafa, Francesco Nonino, Holger J. Schünemann, Marialene Trivella, and Nicole Skoetz
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Epidemiology - Published
- 2023
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22. Patient-tailored risk assessment of obstructive coronary artery disease using Rubidium-82 PET-based myocardial flow quantification with visual interpretation
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S. S. Koenders, J. A. van Dalen, P. L. Jager, M. Mouden, C. H. Slump, and J. D. van Dijk
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Abstract
Introduction Our aim was to estimate the probability of obstructive CAD (oCAD) for an individual patient as a function of the myocardial flow reserve (MFR) measured with Rubidium-82 (Rb-82) PET in patients with a visually normal or abnormal scan. Materials and Methods We included 1519 consecutive patients without a prior history of CAD referred for rest-stress Rb-82 PET/CT. All images were visually assessed by two experts and classified as normal or abnormal. We estimated the probability of oCAD for visually normal scans and scans with small (5%–10%) or larger defects (> 10%) as function of MFR. The primary endpoint was oCAD on invasive coronary angiography, when available. Results 1259 scans were classified as normal, 136 with a small defect and 136 with a larger defect. For the normal scans, the probability of oCAD increased exponentially from 1% to 10% when segmental MFR decreased from 2.1 to 1.3. For scans with small defects, the probability increased from 13% to 40% and for larger defects from 45% to > 70% when segmental MFR decreased from 2.1 to 0.7. Conclusion Patients with > 10% risk of oCAD can be distinguished from patients with
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- 2023
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23. Hypertension and Alzheimer's disease pathology at autopsy: A systematic review
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Herrer Abdulrahman, Jan Willem van Dalen, Melina den Brok, Caitlin S. Latimer, Eric B. Larson, and Edo Richard
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neuropathology ,Epidemiology ,Health Policy ,blood pressure ,Brain ,Neurofibrillary Tangles ,Plaque, Amyloid ,Alzheimer's disease ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,neuritic plaques ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,systematic review ,Developmental Neuroscience ,Alzheimer Disease ,Hypertension ,Humans ,Autopsy ,Neurology (clinical) ,Geriatrics and Gerontology ,Antihypertensive Agents - Abstract
Contains fulltext : 287475.pdf (Publisher’s version ) (Open Access) Hypertension is an important risk factor for Alzheimer's disease (AD) and all-cause dementia. The mechanisms underlying this association are unclear. Hypertension may be associated with AD neuropathological changes (ADNC), but reports are sparse and inconsistent. This systematic review included 15 autopsy studies (n = 5879) from observational cohorts. Studies were highly heterogeneous regarding populations, follow-up duration, hypertension operationalization, neuropathological methods, and statistical analyses. Hypertension seems associated with higher plaque and tangle burden, but results are inconsistent. Four studies (n = 3993/5879; 68%), reported clear associations between hypertension and ADNC. Another four suggested that antihypertensive medication may protect against ADNC. Larger studies with longer follow-up reported the strongest relationships. Our findings suggest a positive association between hypertension and ADNC, but effects may be modest, and possibly attenuate with higher hypertension age and antihypertensive medication use. Investigating interactions among plaques, tangles, cerebrovascular pathology, and dementia may be key in better understanding hypertension's role in dementia development.
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- 2022
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24. Performance of digital PET/CT compared with conventional PET/CT in oncologic patients: a prospective comparison study
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Tonke L. de Jong, Daniëlle Koopman, Jorn A. van Dalen, Aline Tegelaar, Joris D. van Dijk, Henk Stevens, and Pieter L. Jager
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Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2022
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25. Dynamic amplification in a periodic structure with a transition zone subject to a moving load: Three different phenomena
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Andrei B Fărăgău, João M de Oliveira Barbosa, Andrei V Metrikine, and Karel N van Dalen
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moving load ,Mechanics of Materials ,General Mathematics ,wave interference ,General Materials Science ,transition radiation ,Periodic structure - Abstract
The study of periodic systems under the action of moving loads is of high practical importance in railway, road, and bridge engineering, among others. Even though plenty of studies focus on periodic systems, few of them are dedicated to the influence of a local inhomogeneous region, a so-called transition zone, on the dynamic response. In railway engineering, these transition zones are prone to significant degradation, leading to more maintenance requirements than the rest of the structure. This study aims to identify and investigate phenomena that arise due to the combination of periodicity and local inhomogeneity in a system acted upon by a moving load. To study such phenomena in their purest form, a one-dimensional model is formulated consisting of a constant moving load acting on an infinite string periodically supported by discrete springs and dashpots, with a finite domain in which the stiffness and damping of the supports is larger than for the rest of the infinite domain; this model is representative of a catenary system (overhead wires in railway tracks). The identified phenomena can be considered as additional constraints for the design parameters at transition zones such that dynamic amplifications are avoided.
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- 2022
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26. A parameter identification technique for traffic speed deflectometer tests of pavements
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Zhaojie Sun, Cor Kasbergen, Karel N. van Dalen, Kumar Anupam, Athanasios Skarpas, and Sandra M. J. G. Erkens
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Parameter identification technique ,Moving load ,Pavement ,Minimisation algorithm ,Traffic Speed Deflectometer ,Civil and Structural Engineering - Abstract
The structural evaluation of existing pavements forms the basis for formulating cost-effective maintenance and rehabilitation strategies. A promising tool for pavement structural evaluation at network level is the Traffic Speed Deflectometer (TSD) test. However, the application of the TSD test is hindered by the lack of a robust and efficient parameter identification technique. To solve this problem, a theoretical model for the TSD test is first formulated. Then, a minimisation algorithm which works best with the theoretical TSD model for parameter identification is selected. Finally, the performance of this combination in processing field TSD measurements is studied. The results show that the modified Levenberg-Marquardt algorithm using all the 9 detection points is most suitable to be combined with the theoretical TSD model for parameter identification, which gives a promising parameter identification technique for TSD tests of pavements. The presented work contributes to the development of technologies for pavement structural evaluation.
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- 2022
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27. Discontinuation of adjuvant endocrine therapy and impact on quality of life and functional status in older patients with breast cancer
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Annelieke A. Lemij, Nienke A. de Glas, Marloes G. M. Derks, Esther Bastiaannet, Jos W. S. Merkus, Titia E. Lans, Carmen C. van der Pol, Thijs van Dalen, Annelie J. E. Vulink, Leander van Gerven, Onno R. Guicherit, Eugenie M. H. Linthorst-Niers, Frederiek van den Bos, Judith R. Kroep, Gerrit Jan Liefers, Johanneke E. A. Portielje, and Obstetrics and Gynaecology
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Endocrine therapy ,Cancer Research ,Antineoplastic Agents, Hormonal ,Breast Neoplasms ,Geriatric assessment ,Functional Status ,Breast cancer ,Oncology ,Chemotherapy, Adjuvant ,Quality of Life ,Older patients ,Humans ,Female ,Aged - Abstract
Purpose Side effects are the main reason for discontinuation of adjuvant endocrine therapy in older adults. The aim of this study was to examine geriatric predictors of treatment discontinuation of adjuvant endocrine therapy within the first 2 years after initiation, and to study the association between early discontinuation and functional status and quality of life (QoL). Methods Patients aged ≥ 70 years with stage I–III breast cancer who received adjuvant endocrine therapy were included. The primary endpoint was discontinuation of endocrine therapy within 2 years. Risk factors for discontinuation were assessed using univariate logistic regression models. Linear mixed models were used to assess QoL and functional status over time. Results Overall, 258 patients were included, of whom 36% discontinued therapy within 2 years after initiation. No geriatric predictive factors for treatment discontinuation were found. Tumour stage was inversely associated with early discontinuation. Patients who discontinued had a worse breast cancer-specific QoL (b = − 4.37; 95% CI − 7.96 to − 0.78; p = 0.017) over the first 2 years, in particular on the future perspective subscale (b = − 11.10; 95% CI − 18.80 to − 3.40; p = 0.005), which did not recover after discontinuation. Treatment discontinuation was not associated with functional improvement. Conclusion A large proportion of older patients discontinue adjuvant endocrine treatment within 2 years after initiation, but geriatric characteristics are not predictive of early discontinuation of treatment. Discontinuation of adjuvant endocrine therapy did not positively affect QoL and functional status, which implies that the observed poorer QoL in this group is probably not caused by adverse effects of endocrine therapy.
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- 2022
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28. Late Toxicity After 3-Dimensional External Beam Radiotherapy Among Children With Cancer: A Systematic Review
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Josien G M, Beijer, Jop C, Teepen, Nina, Streefkerk, Richard M, Heijnen, Geert O, Janssens, Leontien C M, Kremer, Elvira C, van Dalen, and Cécile M, Ronckers
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Radiotherapy Dosage ,Hematology ,2-dimensional conventional radiotherapy ,3-dimensional radiotherapy ,systematic review ,Oncology ,Head and Neck Neoplasms ,Pediatrics, Perinatology and Child Health ,Proton Therapy ,childhood cancer ,Humans ,Radiotherapy, Intensity-Modulated ,Child ,late toxicity - Abstract
Radiotherapy has evolved from 2-dimensional conventional radiotherapy (2D-RT) to 3-dimensional planned radiotherapy (3D-RT). Because 3D-RT improves conformity, an altered late health outcomes risk profile is anticipated. Here, we systematically reviewed the current literature on late toxicity after 3D-RT in children treated for cancer. PubMed was searched for studies describing late toxicity after 3D-RT for childhood cancer (below 21 y). Late toxicity was defined as somatic health outcomes occurring ≥90 days after treatment. We identified 13 eligible studies, describing most frequently head/neck area tumors. Included studies reported on crude frequencies of late toxicities including subsequent tumors and conditions of organ systems. Three studies offered a global assessment of the full spectrum of late toxicity; one study compared toxicities after 2D-RT and 3D-RT. Incidence rates were typically not provided. Heterogeneity in study characteristics, small study sizes and short follow-up times precluded multivariable modeling and pooling of data. In conclusion, among the first pediatric cohorts treated with 3D-RT, a broad variety of late toxicity is reported; precise estimates of incidence, and contributions of risk factors are unclear. Continued systematic evaluation of well-defined health outcomes in survivors treated with 3D-RT, including proton therapy, is needed to optimize evidence-based care for children with cancer and survivors.
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- 2022
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29. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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Ahmed, W. U. R., Bhatia, S., Mclean, K. A., Khaw, R., Baker, D., Kamarajah, S. K., Bell, S., Nepogodiev, D., Harrison, E. M., Glasbey, J. C., Borakati, A., Burke, J., Drake, T. M., Bath, M. F., Claireaux, H. A., Gundogan, B., Mohan, M., Deekonda, P., Kong, C., Joyce, H., Mcnamee, L., Woin, E., Khatri, C., Fitzgerald, J. E., Bhangu, A., Arulkumaran, N., Duthie, F., Hughes, J., Pinkney, T. D., Prowle, J., Richards, T., Thomas, M., Blanco-Colino, R., Chapman, S. J., Pata, F., Pellino, G., Sgr??, A., Soares, A., van Elst, T., Van Straten, S., Knowles, C. H., Dynes, K., Patel, M., Patel, P., Wigley, C., Suresh, R., Shaw, A., Klimach, S., Jull, P., Evans, D., Preece, R., Ibrahim, I., Manikavasagar, V., Smith, R., Brown, F. S., Teo, R., Sim, D. P. Y., Logan, A. E., Barai, I., Amin, H., Suresh, S., Sethi, R., Gul, W., Bolton, W., Corbridge, O., Horne, L., Attalla, M., Morley, R., Robinson, C., Hoskins, T., Mcallister, R., Lee, S., Dennis, Y., Nixon, G., Heywood, E., Wilson, H., Ng, L., Samaraweera, S., Mills, A., Doherty, C., Belchos, J., Phan, V., Lim, M., Miller, F. A., Chouari, T., Gardner, T., Goergen, N., Hayes, J. D. B., Macleod, C. S., Mccormack, R., Mckinley, A., Mckinstry, S., Milligan, W., Ooi, L., Rafiq, N. M., Sammut, T., Sinclair, E., Smith, M., Wong, J., Ablett, A. D., Tie-Gill, T., Ramsay, G., De Paola, L., Mcguckin, S., Alshakhs, A., Ahmeidat, A., Francis, A. A., Baker, C., Boulton, A. P. R., Collins, J., Copley, H. C., Fearnhead, N., Fox, H., Mah, T., Mckenna, J., Naruka, V., Nigam, N., Nourallah, B., Perera, S., Qureshi, A., Saggar, S., Sun, L., Wang, X., Yang, D. D., Ali, Z., Mullarkey, L., Walshe, R., Lewis, E., Berry, B., Moneim, J., Mookerjee, S., Al-hadithi, A., Caroll, P., Doyle, C., Elangovan, S., Falamarzi, A., Gascon Perai, K., Greenan, E., Jain, D., Lang-Orsini, M., Lim, S., O'Byrne, L., Ridgway, P., Van der Laan, S., Arthur, J., Barclay, J., Bradley, P., Edwin, C., Finch, E., Hayashi, E., Hopkins, M., Kelly, D., Kelly, M., Mccartan, N., Ormrod, A., Pakenham, A., Christy, S., Hayward, J., Hitchen, C., Kishore, A., Martins, T., Philomen, J., Rao, R., Rickards, C., Burns, N., Copeland, M., Durand, C., Dyal, A., Ghaffar, A., Gidwani, A., Grant, M., Gribbon, C., Gruhn, A., Leer, M., Ojofeitimi, O., Carroll, L., Hylands, A., Delaugere, L. P., Reveendran, D., Ahmad, K., Beattie, G., Beatty, M., Campbell, G., Donaldson, G., Graham, S., Holmes, D., Kanabar, S., Liu, H., Mccann, C., Stewart, R., Vara, S., Coulter, C., Ralston, C., Laverty, L., Gallagher, P., Ajibola-Taylor, O., Andah, E. J. E., Ani, C., Cabdi, N. M. O., Ito, G., Jones, M., Komoriyama, A., Titu, L., Ahmed, A., Yeo, Y. Q., Elliott, D., Bennett, J., Mcnamara, M., Sivarajah, S., Dunmore, C., Basra, M., Gallogly, P., Harinath, G., Leong, S. H., Pradhan, A., Siddiqui, I., Zaat, S., Ali, A., Galea, M., Looi, W. L., J. C. K., Ng, Farhan-Alanie, M. M. H., Aitken, G., Nair, M., Aly, M. H., Buari, M., Atkin, G., Azizi, A., Cargill, Z., China, Z., Elliot, J., Jebakumar, R., Lam, J., Mudalige, G., Onyerindu, C., Renju, M., Shankar Babu, V., Ahmed, K., Sheikh, Z., Monks, M., Lehmann, J., Rotimi, O., Hussain, M., Joji, N., Lovett, B., Mownah, H., Dwyer-Hemmings, L., Busuttil, A., Powell, J., Hensher, C., Vivian, F., Ali, B., Cresswell, B., Dhillon, A. K., Dupaguntla, Y. S., Hungwe, C., Lowe-Zinola, J. D., Tsang, J. C. H., Wcislo, K., Bevan, K., Cardus, C., Duggal, A., Hossain, S., Mchugh, M., Scott, M., Millar, Z., Hirosue, S., Ogunmwonyi, I., Nakakande, D., Chan, F., Evans, R., Gurung, E., Haughey, B., Jacob-Ramsdale, B., Kerr, M., Lee, J., Mccann, E., O'Boyle, K., Reid, N., Kwek, I., Gaze, H., Nirmalanantha, A., Bin Amran, M. A., Foulkes, A., Jones, N., Lau, I. S. F., Hayat, F., Hodgson, S., Johnston, R., Jones, W., Khan, M., Linn, T., Long, S., Seetharam, P., Shaman, S., Smart, B., Pillai, S., Khoury, G., Powell, T., Maleyko, I., Sangheli, A., Ransome, M., Isse, M., Aromolaran, O., Bholah, H., Anilkumar, A., Davies, J., Griffith, J., Hughes, B., Islam, Y., Kidanu, D., Mushaini, N., Qamar, I., Robinson, H., Schramm, M., Yan Tan, C., Murray, V., Theocharidou, L., Malik, T., Janmohamed, I., Carhart, B., Khan, A., Apperley, H., Billyard, C., Blazeby, J. M., Cannon, S. P., Carse, S., G??pfert, A., Loizidou, A., Parkin, J., Sanders, E., Sharma, S., Slade, G., Telfer, R., Whybrow Huppatz, I., Worley, E., Asif, A., Hullait, R., Quinn, P., Rylance, A., Butt, S., Leathes, J., Chandramoorthy, L., Friend, C., Harris, L., Jain, P., Karim, M. J., Killington, K., Mcgillicuddy, J., Rafferty, C., Rahunathan, N., Rayne, T., Varathan, Y., Verma, N., Zanichelli, D., Arneill, M., Brown, F., Campbell, B., Crozier, L., Henry, J., Mccusker, C., Prabakaran, P., Wilson, R., Karelia, S., Clements, J. M., Rainey, M., Asif, U., Connor, M., Dindyal, S., Math, N., Pagarkar, A., Saleem, H., Seth, I., Standfield, N., Swartbol, T., Adamson, R., Choi, J. E., El Tokhy, O., Ho, W., Javaid, N. R., Mehdi, A. S., Menon, D., Plumptre, I., Sturrock, S., Turner, J., Warren, O., Joshi, N., Rahman, A., Gallagher, M., Crane, E., Ferris, B., Gadsby, C., Smallwood, J., Vipond, M., Wilson, V., Amarnath, T., Doshi, A., Gregory, C., Kandiah, K., Powell, B., Spoor, H., Toh, C., Vizor, R., Rebuffa, N., Abdelgalil, R., Siaw Yen Lai, R., Smith, E., Common, M., Dunleavy, K., Harris, S., Luo, C., Mesbah, Z., Prem Kumar, A., Redmond, A., Skulsky, S., Walsh, T., Daly, D., Deery, L., Epanomeritakis, E., Harty, M., Kane, D., Khan, K., Mackey, R., Mcconville, J., Mcginnity, K., Wong, H. L., Ang, A., Kee, J. Y., Leung, E., Norman, S., Palaniappan, S. V., Partha Sarathy, P., Yeoh, T., Frost, J., Hazeldine, P., Jones, L., Karbowiak, M., Macdonald, C., Mutarambirwa, A., Omotade, A., Runkel, M., Ryan, G., Sawers, N., Searle, C., Vig, S., Hlukha, L., Pike, G., Kamel, F., Thakkar, R., Mcauliffe, O., Ahmad, A., Mcgartland, R., Sim, R., Song, A., Wayman, J., Brown, R., Chang, L. H., Concannon, K., Crilly, C., Arnold, T. J., Burgin, A., Cadden, F., Choy, C. H., Coleman, M., Lim, D., Luk, J., Mahankali-Rao, P., Prudence-Taylor, A. J., Ramakrishnan, D., Russell, J., Fawole, A., Gohil, J., Green, B., Hussain, A., Mcmenamin, L., Tang, M., Azmi, F., Benchetrit, S., Cope, T., Haque, A., Harlinska, A., Holdsworth, R., Ivo, T., Martin, J., Nisar, T., Patel, A., Sasapu, K., Trevett, J., Vernet, G., Aamir, A., Bird, C., Durham-Hall, A., Gibson, W., Hartley, J., May, N., Maynard, V., Goble, M., Downs, E., Wheldon, L., Baggus, E., Mandal, A., Nayeem, A., Ahmed, S., Fradley, W., Johnson, S., McDonald Wood, C., O'Brien, M., Orbell, J., Stringfellow, T. D., Tenters, F., Tresidder, S., Wilson, C., Gallagher, S., Criswell, T., Ward, J., Mukkavilli, A., Stubbs, B., Fordyce, W., Cheung, W., Grant, A., Tod, N., Yi Tew, Z., Suchdev, N., Wei Lim, S., Bews-Hair, M., Lim, Z. H., Lim, S. W., Vella-Baldacchino, M., Auckburally, S., Chopada, A., Easdon, S., Goodson, R., Mccurdie, F., Narouz, M., Radford, A., Rea, E., Taylor, O., Yu, T., Sookramanien, S. R., Chan, A., Bointas, G., Alfa-Wali, M., Amani, L., Auluck, I., Bruce, P., Emberton, J., Kumar, R., Lagzouli, N., Mehta, A., Murtaza, A., Raja, M., Dennahy, I. S., Frew, K., Given, A., Y. Y., He, Karim, M. A., Macdonald, E., Mcdonald, E., Mcvinnie, D., S. K., Ng, Pettit, A., Berthaume-Hawkins, S. D., Charnley, R., Fenton, K., Jones, D., Murphy, C., J. Q., Ng, Reehal, R., Seraj, S. S., Shang, E., Tonks, A., White, P., Yeo, A., Paul, M., Ward, K. L., Bagnall, M., Chong, P., Gabriel, R., Patel, N., Richardson, E., Symons, L., Aubrey-Jones, D., Dawood, S., Dobrzynska, M., Faulkner, S., Griffiths, H., Mahmood, F., Perry, M., Power, A., Simpson, R., Pherwani, S. A., Wang, K., Mitchell, L., Heyworth, J., Ayyar, S., Brobbey, P., Burrows, A., Elder, P., Ganyani, R., Horseman, C., Hurst, P., Mann, H., Marimuthu, K., Mcbride, S., Pilsworth, E., Powers, N., Stanier, P., Obukofe, R., Polson, R., Mason, D., Mackenzie, E., Innes, R., Kersey, T., Kopczynska, M., Langasco, N., Rajagopal, R., Russell, C., Doyle, N., Habib, Z., Zardab, M., Sartaj, F., Farooq, H., Tabibi, M., Imam, L., Atkins, B., Beasley, W., Cheng Lim, Z., Gill, A., Li Ang, H., Williams, H., Yogeswara, T., Drury, D. J., James, S. J., Barnett, R., Teasdale, A. B., Richardson, E. T. J., Thomas, D. A., Williams, R. L., Najabat-Lattif, H. F., Akram, B., Carter, R., Fam, M., Fong, J., Latter, J., Long, M., Mackinnon, S., Mckenzie, C., Osmanska, J., Raghuvir, V., Shafi, A., Tsang, K., Walker, L., Cahya, E., Lou, G., Coyle, M., Homyer, K., Zhu, L. Y., Woods, M., Bountra, K., Coldicutt, O., Fletcher, D., Hudson, S., Iqbal, S., Lopez Bernal, T., Martin, J. W. B., Moss-Lawton, F., Suchett-Kay, I., Chang, J., O'Callaghan, H., Suchett-Kaye, I., Mihailidis, T. H., Cardwell, A., Edgerton, K., Laws, J., Rai, A., Robinson, K., Waite, K., Youssef, H., Alawattegama, H., Seite, E., Barrett, A., Riordan, E., Lam, W., Dowdeswell, M., Mulvenna, C., Knight, C., Koo, P. Y., Lazarou, A., Stanger, S., Thorn, C., Triniman, M. C., Netke, T., Awokoya, O., Gurowich, L., Dhera, K., Hossaini, S., Botha, A., Boyles, L., Cumming, S., Deepak, S., Ezzat, A., Fowler, A. J., Gwozdz, A. M., Hussain, S. F., Khan, S., Li, H., Lu Morrell, B., Neville, J., Nitiahpapand, R., Pickering, O., Sagoo, H., Sharma, E., Welsh, K., Williams, L., Hayat, S., Tincknell, L., Spazzapan, M., Teeling, F., Sysum, K., Denley, S., Latter, M., Agarwal, M., Al-Saadi, N., Bhambra, R., Gupta, A., Jawad, Z. A. R., Jiao, L. R., Mahir, G., Singagireson, S., Thoms, B. L., Tseu, B., Wei, R., Yang, N., Britton, N., Leinhardt, D., Mahfooz, M., Palkhi, A., Price, M., Sheikh, S., Barker, M., Bowley, D., Cant, M., Datta, U., Farooqi, M., Lee, A., Morley, G., Naushad Amin, M., Parry, A., Patel, S., Strang, S., Yoganayagam, N., Guruswamy, M., Beedham, W., Brazier, E., Elghobashy, M., Bajaj, M., Etel, E., Adlan, A., Chandramoorthy, S., Choudhary, Y., Das, K., Feldman, M., France, B., Grace, R., Puddy, H., Soor, P., Kisiel, A., Woodmass, M., Hayden, H., Ali, Y., Husain, S., Ali, M., Dhillon, P., Faraj, A., Gerard, L., Glover, M., Imran, H., Kim, S., Patrick, Y., Peto, J., Prabhudesai, A., Tang, A., Vadgama, N., Dhaliwal, R., Ecclestone, T., Harris, A., Ong, D., Patel, D., Philp, C., Stewart, E., Wang, L., Wong, E., Xu, Y., Ashaye, T., Fozard, T., Galloway, F., Kaptanis, S., Mistry, P., Nguyen, T., Olagbaiye, F., Osman, M., Philip, Z., Rembacken, R., Tayeh, S., Theodoropoulou, K., Liu, F. Y., Arnold, A., Pedersen, A. C., Cunha, P., Ahmed, M., Al Zawawi, S., Kudva, V., Herman, A., Lau, J., Saha, A., Trotter, M., Miscampbell, M., Robinson, A. V., Johnston, J., Dharni, A., Lamb, S., Westerman, T., Adeleye, O., Cave, D., Gunwa, T., Magalh??es, J., Makwana, S., Mason, R., Parish, M., Regan, H., Renwick, P., Roberts, G., Salekin, D., Sivakumar, C., Tariq, A., Liew, I., Mcdade, A., Stewart, D., Evans, E., Campbell, L., Gillespie, M., Cheong, C. M., Hague, M., Hudson-Peacock, N., Jackson, C. E. S., James, F., Pitt, J., Walker, E. Y., Kulathevanayagam, K., Varghese, A., Ike, S. I., Aftab, R., Ang, J. J., Anwar, S., Battle, J., Budd, E., Chui, J., Crook, H., Davies, P., Easby, S., Hackney, E., Ho, B., Imam, S. Z., Rammell, J., Chu, T. S. M., Baljer, B., Mogg, J. A. W., Rai, P., Andrews, H., Perry, C., Schinle, P., Ahmed, P., Aquilina, T., Balai, E., Church, M., Cumber, E., Curtis, A., Davies, G., Dumann, E., Greenhalgh, S., Kim, P., King, S., Metcalfe, K. H. M., Passby, L., Redgrave, N., Soonawalla, Z., Waters, S., Zornoza, A., Claireaux, H., Williams, M., Smillie, R., Goetz, J., Appleby, E., Fadipe, T., Vaughan-Burleigh, S., Davies, R., Gulzar, I., Hole, J., Hull, K., Ishaq, H., Karaj, J., Kelkar, A., Love, E., Thakrar, D., Vine, M., Waterman, A., James, P., Puri, G., Hussain, P., Flather, R., Cutler, A., Pathak, S., Sheldon, J., Collicott, T., al-Ausi, M., Ko, M., Dib, N. P., Francis, N., Hanson, M., Ingleton, R., Sadanand, K. S., Sukirthan, N., Mondal, A., Jovaisaite, A., Shah, S. M., Khalid, N., Gutmann, D., Davison, S., Alame, Y. J., Syed, L., Owen, W. J., Arnell, S., Ball, M., Bassam, N., Beghal, G., Chang, A., Dawe, V., George, A., Huq, T., Ikram, B., Kanapeckaite, L., Ramjas, D., Rushd, A., Sait, S., Serry, M., Yardimci, E., Kalderon, R., Ahsan, S. D., Anthony-Uzoeto, U., Macleod Hall, C., Zheng, S., Wynter, K., Capella, S., Chenciner, L., Episkopos, C., Karam, E., Mccarthy, C., Moore-Kelly, W., Watson, N., Nadama, H. H., James, C., Sapre, D., Ghosh, R., Baird, J., Cockburn, L., Blackwood, O., Simpson, W., Ahluwalia, V., Barnfield, J., Ben-Gal, O., Bloom, I., Gharatya, A., Khodatars, K., Merchant, N., Moonan, A., Moore, M., Patel, K., Spiers, H., Sundaram, K., Jeong, S., Bishop, S., Black, J., Chadwick, H., Huisman, L., Ingram, H., Martin, L., Metcalfe, M., Sangal, P., Seehra, J., Thatcher, A., Venturini, S., Whitcroft, I., Bate, R., Hobson, C., Adam, A. H., Redclift, C., Do, J., Poli, F., Batterham, A., Brown, S., Pandya, A., Afzal, Z., Gani, A., Gomaa, A., Hussein, N., S. Y., Oh, Pazhaniappan, N., Sharkey, E., Sivagnanasithiyar, T., Williams, C., Yeung, J., Parekh, J. N., Clay, W., Pieri, K., Jackson, A., Saxena, A., Gurung, B., Oyebola, T., O'Brien, F., Reilly, S., Cruddas, L., Gurjar, S., Pau, A., Prakash, R., Randhawa, R., Djeugam, B., Gardezi, S., Ul-Hasan, S., Martin-Hernandez, M. P., Sisley, M., Modi, S., Antakia, R., Archer, J., Chen, L., Eiben, I., Naylor, M., Osei-Bordom, D., Trenear, R., Bannard-Smith, J., Griffiths, N., Patel, B. Y., Saeed, F., Al-Saraff, Z., Elbayouk, A., Soh, Y. J., Mather, J., Yusuf, Z., Al-Sarraf, Z., Naja, M., Rassool, S. B., Convill, J., Auty, C., Abdikadir, H., Bennett, M., Church, R., Clements, S. E., Court, J., Delvi, A., Hubert, J., Macdonald, B., Mansour, F., Patel, R. R., Perris, R., Small, S., Tam, J. P. H., Nikookam, Y., Warsame, A., Pace, C., Kiandee, M., Ridwan, R., Carey, C., Hirri, F., Betts, A., Brown, N., Chong, A., Croitoru, C., Grey, A., Hickland, P., Ho, C., Hollington, D., Mckie, L., Nelson, A. R., Stewart, H., Eiben, P., Nedham, M., Ali, I., Brown, T., Hunt, C., Joyner, C., Mcalinden, C., Roberts, J., Rogers, D., Thachettu, A., Tyson, N., Vaughan, R., Yasin, T., Powell-Chandler, A., Mcmillan, M. J. A., Ling, J. J., Pendelbury, L., Kerimzade, K., Howard, E. O., Humayun, S., Wadsworth, O. J., Roche, C. D., Andrew, K., Bhamra, N., Leong, S., Mistry, R., Noble, H., Rashed, F., Walker, N. R., Watson, L., Worsfold, M., Yarham, E., Wood, F., Arshad, A., Barmayehvar, B., Cato, L., Chan-lam, N., Do, V., Leong, A., Zheleniakova, T., Tan, K., Abdelhameed, F., Haglund, C., Radnaeva, I., Hu, N., Rambhatla, S., Waldron, D., Madahar, P., Malik, S., Coppel, J., Hussain, S. T., Mahmood, R., Nourzaie, R., Sheik-Ali, S., Thomas, A., Alagappan, A., Ashour, R., Bains, H., Diamond, J., Gordon, J., Ibrahim, B., Khalil, M., Mittapalli, D., Neo, Y. N., Patil, P., Peck, F. S., Reza, N., Swan, I., Whyte, M., Campbell, A., Meney, L. C., Kang, C. K., Chiu, J. Z. J., Livie, V., Livie, J., Chaudhry, S., Hernon, J., Khawar, H., O'Brien, J., Pullinger, M., Rothnie, K., Ujjal, S., Gorgievska, R. e. b. e. c. c. a., Pooley, G., Shishkin, B., Gorgievska, R., Docherty, J., Southgate, A., Coomes, A., Chaudhry, F. 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E., Kechagias, A., Turunen, A., Katunin, J., Niskakangas, M., Ojak????r, A., Venara, A., Lenaoures, P., Duchalais, E., Vignaud, T., Frey, S., Ricolleau, C., Ioannidis, A., Konstantinidis, M., Antonakopoulos, F., Mathioulaki, A., Chrysoheris, P., Athanasopoulos, P. G., Koutserimpas, C., Tenconi, S. M., Rausei, S., Maioli, D., Marchionini, V., Pasquali, S., Simioni, A., Farina, V., Podda, M., Lorenzon, L., Tirelli, F., Fico, V., Santullo, F., Belia, F., Schaeff, V., Otto, A., Jakubauskas, M., Po??kus, E., Danys, D., Kry??auskas, M., Mikalauskas, S., Rackauskas, R., Drungilas, M., Po??kus, T., Jotautas, V., Strupas, K., Petrulionis, M., van Elst, T. R., Abdulrahman, Z., Chu, M., Fagan, P. V. B., Wells, C. I., Alagoa Jo??o, A., Apar??cio, D. J., Fragoso, M., Guimar??es, J., Cruz, G., Ribeiro, J., Borges da Ponte, I., Almeida, S., Martins, A. R., Juloski, J., Cuk, V. V., Radulovic, R., Milo??evic, K., Bojicic, J., Gencic, M., Jankovic, U., Jovanovic, M., El Kasmy El Kasmi, Y., G??mez Jurado, M. J., Alberti Delgado, P., Bordanova Reverter, A., G??mez del Pulgar, A., Belzunce-Cap??, J. F., Verdaguer Tremolosa, M., Lin, Q., P??rez-Ajates, S., Ramayo D??az, N., Gonz??lez Caraballo, I., Pascual Vicente, T., Orue-Echebarria, M. I., S??nchez-Calvo, L., Wang, D., Trueba-Collado, C., Morales Bernaldo de Quir??s, J. T., Anabitarte Bautista, O., Yebes, A., Espin-Basany, E., Clerc, D., Mignon, G., Vanoni, A., Henkens, A., Jarrar, G., Odovic, M., Willemin, M., Milliet, O., Hahnloser, D., Demartines, N., Curchod, P., Ciubotaru, C., Popescu, S., Popescu, S. S., Piras, K., Ciubotaru, C. I., Yanishev, A., Luzan, R., Lutovinova, E., Gavrilina, A., Barkovskaya, A., Kudelkina, N., Topchubaev, D., Ozkan, B. B., Yagiz Sen, A., Aktas, M. K., Aykun, N., Agca, M. H., Bilen, C., Kilinc, I., Atar, C., Kilic, V., Aktuna, C., Aba, M., Eray, I. C., Baki, B. E., Arslan, E., Alemdag, G., Ulusahin, M., Gul, E. B., Yildirim, R., Semiz, A., Bektur, G., Tomas, K., Bodur, S., Y??ksek, B., Serin, H., Erd??nmez, H., G??rsoy, F., Kara, H., nsal, U., zbek, M., Kasar, P. A., Ipor, A., etin, M. F., Khaw, R. A., Mills, E., Manley, L. R., Vutipongsatorn, K., Thakral, N., Adra, M., Khan, S. M., Badran, A., Ramjeeawon, A., Tan, H. L., Rye, D. S., Rajaraman, N., Norman, J. G., Solomou, G., Baker, D. M., Brandao, B. D., Stainer, B., Onafowokan, O. O., Gharooni, A., Dabab, N., Carlton-Carew, S., Kungwengwe, G., Gabriel, M., Sewart, E., Lawday, S, Pockney, P., Chrimes, A., Agarwal, A., Zhao, J., Jayalath, J. M. S. N., Liebenberg, P., Khor, S., Muddasani, T., Dawson, A., Taylor, N., Stevenson, C., Drane, A., Pahalawatta, U., Lai, L. T., Debiasio, A., Jung, M., Brumfitt, C. D., Beh, Y. Z., Dudi-Venkata, N. N., Lee, Y. D., Stewart, P., Thirugnanasundralingam, V., Muir, K., Ng, B., Mendis, D. M., Robb, P. M., Lee, H. J., Wyche, A. A. B., Davis, L. T., Luong, J. K., Jegathees, T., Coulter-Nile, S. M. C. J., Gosselink, M. P., Wang, Y. L., Maciaszek, M., Chrapko, P. S., White, S., Ivanov, V., Borisova, A., Kuncarov??, K., Ri??ko, J., Ludvik, M., Stercz, M., Treskon, R., Posp????il, M., Hlav??cov??, L., Tomanov??, D., Kolo??ov??, B., Sobotkov??, K., Cha, S., uta Kimle, K., Jirankova, K., Bujda, M., Pacl??k, A., Chrz, K., Antonova, T., Chodora, S., Houdek, O., Novick??, R., Skalick??, A., Farka??ov??, M., Jozaf, V., Klail, T., Prochazka, V., Harbjerg, J. L., Enevoldsen, M., H??jgaard Pedersen, J., Brandsborg, S., Amiri, S., Brinck, S., Jepsen, B. N., Hillgaard, T. K., Erichsen, S. B., Nielsen, C. V., Madsen, C. P., Bjerke, J., Skej??, C. D., Aabling, R. R., Kjaer, M. D., Unbehaun, K. P., Mark-Christensen, A., Dalsgaard, P., Trap, A., J??rgens-Lahnstein, J., Storm, M., Damgaard, I., Olawi, F., Ehlern, F., Raos, M., Ravn, S., Lycke, K. D., Kristensen, F. P., B??nnerup, K., Brigand, C., Dumange, E., Gout, M., Moehwald, C., Prem, M., Krupp, J., Alhalabi, O., Sliwinski, S., Gablenz, E., Seiboldt, T., Beck, L., Pohl, L. J., Zamzow, K., Betge, F., Poncelet, A., Truant, M., Hauschild, H., Neugebauer, N., D??rr-Harim, C., Schmitzer, L., Kopp, A., Steinle, J., Gsenger, J., Riccardi, M., Christodoulou, I. M., Zoikas, A., Machairas, N., Paspala, A., Papaconstantinou, D., Spartalis, E., Arkadopoulos, N., Prodromidou, A., Garoufalia, Z., Balalis, D., Manatakis, D. K., Kalles, V., Spyrou, I., Barkolias, C., Aguilera, M. L., Mendez, D., Rosales, J., Flores, M., Garcia, M., Garcia, A., Noriega, Z., Torselli, D., Rodriguez, J., Argenti, F., Milani, M. S., Malabarba, S., Giambartolomei, G., Vella, I., Gronchi, F., Ruggieri, A., Marano, L., Fleres, F., Lovisetto, F., Barberis, A., Serra, D., Sasia, D., Geretto, P., Pellegrino, L., Borghi, B., Marano, A., Corino, C., Cannata, G., Giuffrida, M. C., Landra, F., Giraudo, G., Segalini, E., Monti, M., Magnoli, M., Pata, G., Lucchi, A., Grassia, M., Cufari, M. E., Sagnotta, A., Di Cintio, A., Gemini, A., Trastulli, S., De Luca, M., Desiderio, J., Gubbiotti, F., Campagnaro, T., Pedrazzani, C., Turri, G., Lazzarini, E., Conti, C., Ruzzenente, A., Petrelli, F., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Gallo, G., Clerico, G., De Santi, G., Bitonti, M. F., Trompetto, M., Realis Luc, A., Papandrea, M., Cerra, C., Pirillo, M., Cravano, S., Libri, I., Laquatra, N., Isabello, A., De Luca, E., Testa, V., Morino, M., Mistrangelo, M., Sinibaldi, G., Angelucci, G. P., Scaramuzzo, R., Larcinese, A., Fioriti, C., Picone, E., Nardi, M., Di Candido, F., Spinelli, A., Marco, M., Bevilacqua, M., Maroli, A., Colombo, F., Cigognini, M., Zaffaroni, G., Maffioli, A., Colombo, S., Bondurri, A., Sampietro, G., Foschi, D., Perrone, G., Bonati, E., Aresu, S., Saba, A., Biancafarina, A., Angelini, M., Andolfi, E., Miranda, E., Scricciolo, M., Provenza, G., Cavallina, G., Frezza, B., Fontani, A., Malatesti, R., Pellican??, G. A., Ceccarelli, G., Canonico, G., Falsetti, E., Pagnanelli, M., De Nardi, P., Rosati, R., Marcocci, G., Vignali, A., Quattromani, R., Curletti, G., Galleano, R., Malerba, M., Percivale, A., Ghazouani, O., Reggiani, L., Spirito, C., Bini, R., de Manzoni Garberini, A., Impellizzeri, H., Moretto, G., Bacchion, M., Casaril, A., Inama, M., Creciun, M., Vitali, M., Cillara, N., Mosino, L., Peddis, M., Melis, S., De Donno, G., Aru, A. C., Loche, G. A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcian??, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Gr??ter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paix??o, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patr??cio, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., L??rias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Bai??o, J. M., Rocha, B. S., Lopes, N. M. R. O., Jord??o, D. M., ngelo, M. D., Caro??o, T., Vieira, B. N., Silva, A. G., Galv??o, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gon??alves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., B??rtolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., M??nica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimar??es, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eir??, F., Borges, F., Sim??es, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., S??, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paix??o, I., Frade, S., Guerreiro, I., Tom??, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., M??sz??rosov??, K., Zubowicz, M., Such??n, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovsk??, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., Cardo, J. Garc??a., Mora-Guzm??n, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodr??guez, I., Jim??nez Escovar, F., Calvo Fern??ndez, M., Portugal Mart??nez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andr??s, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerd??n, C., Jimenez Vi??as, C., Alconchel, F., Mart??nez D??az, J. M., Ruiz Manzanera, J. J., Navarro Barrios, ??., Rodr??guez Pedre??o, L., Moreno, P. Garc??a., G??mez, M. Garc??a., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Oro, C. Fair??n., L??pez Otero, M., Toimil, C. Samart??n., Primo ??lvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Se??orans, M., Figueroa Jim??nez, S., Livianos Arias-Camis??n, P., Nieto Arranz, J. M., Mateos Sexmero, M. J., Diego Alonso, E., Gonz??lez Amor, L., Claramonte Bellmunt, O., Mart??nez Caballero, J., Rubio-P??rez, I., Ramos Martin, P., Mate Mate, P., Marcano Chavez, C., Rubio-Perez, I., Ayllon, H., Aguilar-Mart??nez, M. M., Arroyo, A., Segura-Sampedro, J. J., Jer??-McFarlane, S., Soldevila-Verdeguer, C., Pine??o-Flores, C., Ambrona-Zafra, D., Fern??ndez-Vega, L., Gil-Catal??n, A., Craus-Miguel, A., Pujol-Cano, N., Sena-Ruiz, F., Olmedo Moreno, C., Pastor Idoate, C., Negre Parra, D., Soriano Li??bana, M. M., Campo Betancourth, C. F., Sevila Mico, S., Est??vez Diz, A. M., Mart??n-Balbuena, R., Garc??a-Vico, A., Roman-Rando, A., S??nchez-G??lvez, M. ??., Bersabe-Alonso, I. M., Vadillo-Bohorquez, A., Bustamante Recuenco, C., Calzada, M. G., Recuenco, C. B., Martin, M. C., Licardie Bola??os, R. E., Garcia Orozco, J. J., Ferrusola Diaz, D. A., Garcia Jimenez, M. L., Castro Diez, L., Mosquera Fernandez, C., Fern??ndez, P., Platero Diago, J., Veras Lista, M., Rif?? Terricabras, S., Butler Sanz, L., Alberch Camprub??, E., Rico Ferr??ndez, M., Puig Lao, E., De Pablo Mir??, M., D??az Padillo, A., Padilla Zegarra, E. D., Franco, M., Martinez, A., Forero-Torres, A., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Alberdi San Rom??n, I., Ramos Jim??nez, F. A., P??rez Ortega, A., Trujillo Barbadillo, A., Romero Pujana, E., Fernandez Illera, M. V., Salvador Ros??s, H., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., damez, J. Garc??a., Caula Freixa, C., G??mez Romeu, N., Merayo ??lvarez, M., Merayo Alvarez, M., Alonso Batanero, E., Canales, I. Cifri??n., Villarejo Campos, P., Alberca-Paramo, A., Alia Verdejo, T., Ca??ete-Manzanares, J., Molina-Florez, M., Hern??ndez, L. C. Garc??a., Orozco Nu??ez, S., Suarez-Sanchez, M., Martin-Fernandez, J., Estaire Gomez, M., Lopes Moreira, C. C., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Iba??ez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., N????ez O??Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornell?? Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripoll??s-Melchor, J., Garcea, A., G??mez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., P??rez Guarinos, C. V., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., K??rkl??, ??., Ceylan, C., Yilmaz, S., alar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karag??z, E., Sabanci, R., T??mer, S. S., Sarig??l, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilin??, A., Isik, K., Kocer, M. D., G??ner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Bas??avus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Karip, B., Uslu, ??., Seker, M. C., Erten, V., Memis, U., Ko??ak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., K??seoglu, E., Yeni, M., Uygur, F. A., Kaya, Y., zen, D., lmez, M., Altintas, E., Toklu, R., Sari??i??ek, T., Isik, A. E., Demirci, K., Suresh, G., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Finch, B. J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Bhahirathan, Y., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Herron, J., Thakrar, C., Rojoa, D., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., James, A., Bugelli, M., Chechelnitskaya, Y., Bylinski, T., Findlay, J. M., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Sloper, W., Burford, C., Coey, J., Akbari, K., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Yumurtaci, ??., Emin, A., Girit, ??. a. g. r. i., Yildirak, M. K., Senyigit, E., G??ldag, A., S??yleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., To, N., Laurence, N., Green, C., Frostick, R., Khera, R., Povey, M., Mahapatra, S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., M. P. E., Ng, Wong, R. T. W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., S. Y., Ng, Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., P??s, M., Adel, A., Sotona, O., Barto??, M., Amjad, T., Mal??, O., Berec, S., Hanu??ov??, M., Hurn??, M., rhalmi, J., S??rensen, J. S., Chanut, F., Magnin, J., Sch??ning, L., CS Simon, S., Galata, C., Karampinis, I., Th??wel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Fig??, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Tru??kovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., M??ller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., Hart, E. 't., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. 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E., Camarero, E., Mart??nez Ill??n, M., Aranda Garc??a, L., L??zaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ram??rez, A., Margarida, A., Pando, B., Liquete Mar??n, L., P??rez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., S??nchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ram??rez, M., De La Llave Serralvo, A., S??nchez, M. J., Mart??n-Borreg??n, P., Quevedo, A., Mart??nez, J., Mar??n, J. M., Rodr??guez, P., Esteban Avenda??o, I., Jim??nez Relimpio, C., Lancho Lavilla, P., Blanco Bartolom??, I., G??mez Cano, I., Blasco Andr??s, C., Abad-Motos, A., Mar??nez-Hurtado, E., Salvachua-Fern??ndez, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Nav??o, A., Abell??, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., Psychiatry, Surgery, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tampere University, Kanta-Häme Central Hospital Hämeenlinna, Ahmed, W, Bhatia, S, Mclean, K, Khaw, R, Baker, D, Kamarajah, S, Bell, S, Nepogodiev, D, Harrison, E, Glasbey, J, Borakati, A, Burke, J, Drake, T, Bath, M, Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, Chapman, S, Pata, F, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, Brown, F, Teo, R, Sim, D, Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, 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A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcianò, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Grüter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paixão, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patrício, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., Lérias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Baião, J. M., Rocha, B. S., Lopes, N. M. R. O., Jordão, D. M., Ângelo, M. D., Caroço, T., Vieira, B. N., Silva, A. G., Galvão, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gonçalves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., Bártolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., Mónica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimarães, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eiró, F., Borges, F., Simões, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., Sá, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paixão, I., Frade, S., Guerreiro, I., Tomé, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., Mészárosová, K., Zubowicz, M., Suchán, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovský, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., García Cardo, J., Mora-Guzmán, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodríguez, I., Jiménez Escovar, F., Calvo Fernández, M., Portugal Martínez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andrés, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerdán, C., Jimenez Viñas, C., Alconchel, F., Martínez Díaz, J. M., Ruiz Manzanera, J. J., Navarro Barrios, Á., Rodríguez Pedreño, L., García Moreno, P., García Gómez, M., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Fairén Oro, C., López Otero, M., Samartín Toimil, C., Primo Álvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Señorans, M., Figueroa Jiménez, S., Livianos Arias-Camisón, P., Nieto Arranz, J. M., Mateos Sexmero, M. 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D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Ibañez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., Núñez O´Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornellà Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripollés-Melchor, J., Garcea, A., Gómez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., V Pérez Guarinos, C., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., Kürklü, Ö., Ceylan, C., Yilmaz, S., Çalar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karagöz, E., Sabanci, R., Tümer, S. S., Sarigül, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilinç, A., Isik, K., Kocer, M. D., Güner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Basçavus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. 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W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. 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S., Chanut, F., Magnin, J., Schöning, L., CS Simon, S., Galata, C., Karampinis, I., Thäwel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Figà, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Truškovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., Müller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., 't Hart, E., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. N., Rachadell, J., Amorim, E., Vareda, R., Roseira, J., Americano, M., Correia, D., Capella, V., Moinhos, T., Costa, F., Gil, I., Morgado, J., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., O'Connor, D. B., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Hoo, M., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Griffin, S., Dockry, É., Khogali, E., Aly, A. K., Mcphedran, R., O'Gorman, D., Vermeulen, D., Gopaul, A., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Scanlon, K., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., O'Dwyer, N., Mana, O. C., Gomez, H., Riba, L., Perez, J., Centeno, A., Ortega, C., Ossola, M. E., Camarero, E., Martínez Illán, M., Aranda García, L., Lázaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ramírez, A., Margarida, A., Pando, B., Liquete Marín, L., Pérez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., Sánchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ramírez, M., De La Llave Serralvo, A., Sánchez, M. J., Martín-Borregón, P., Quevedo, A., Martínez, J., Marín, J. M., Rodríguez, P., Esteban Avendaño, I., Jiménez Relimpio, C., Lancho Lavilla, P., Blanco Bartolomé, I., Gómez Cano, I., Blasco Andrés, C., Abad-Motos, A., Marínez-Hurtado, E., Salvachua-Fernández, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Navío, A., Abelló, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Mondzorg Kaak Aangezicht Chirurgie (9), Kindergeneeskunde, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Faculteit Medische Wetenschappen/UMCG
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renal failure ,cohort studies ,humans ,kidney ,postoperative complications ,prognosis ,prospective studies ,retrospective studies ,risk assessment ,risk factors ,acute kidney injury ,digestive system surgical procedures ,Prognosi ,Acute Kidney Injury/diagnosis ,Digestive System Surgical Procedures/adverse effects ,3121 Internal medicine ,Kidney ,Risk Assessment ,Cohort Studies ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,All institutes and research themes of the Radboud University Medical Center ,Postoperative Complications ,Retrospective Studie ,Risk Factors ,Gastrointestinal Surgery ,Humans ,preoperative care ,Prognostic Model ,Prospective Studies ,Digestive System Surgical Procedures ,Retrospective Studies ,Science & Technology ,Risk Factor ,MORTALITY ,General Medicine ,STARSurg Collaborative and EuroSurg Collaborative ,Acute Kidney Injury ,Prognosis ,surgical procedures ,Prospective Studie ,aki ,OAKS ,Postoperative Complications/etiology ,colorectal surgery ,Surgery ,Postoperative Complication ,Cohort Studie ,Life Sciences & Biomedicine ,Human - Abstract
Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK).
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30. Automated News Reading in the Neural Age: Audience Reception and Perceived Credibility of a News Broadcast Read By a Neural Voice
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L. Heiselberg, J. N. Blom, and A. van Dalen
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Communication - Published
- 2022
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31. Differences in treatment and survival of older patients with operable breast cancer between the United Kingdom and the Netherlands – A comparison of two national prospective longitudinal multi-centre cohort studies
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Willeke G. van der Plas-Krijgsman, Jenna L. Morgan, Nienke A. de Glas, Anna Z. de Boer, Charlene L. Martin, Geoffrey R. Holmes, Susan E. Ward, Tim Chater, Malcolm W. Reed, Jos W.S. Merkus, Thijs van Dalen, Annelie J.E. Vulink, Leander van Gerven, Onno R. Guicherit, Eugenie Linthorst-Niers, Titia E. Lans, Esther Bastiaannet, Johanneke E.A. Portielje, Gerrit Jan Liefers, and Lynda Wyld
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Aged, 80 and over ,Cancer Research ,Survival ,Breast Neoplasms ,United Kingdom ,Breast cancer ,Oncology ,Chemotherapy, Adjuvant ,Older patients ,Humans ,Geriatric oncology ,Female ,Prospective Studies ,Aged ,Netherlands - Abstract
Background: Previous studies have shown that survival outcomes for older patients with breast cancer vary substantially across Europe, with worse survival reported in the United Kingdom. It has been hypothesised that these differences in survival outcomes could be related to treatment variation. Objectives: We aimed to compare patient and tumour characteristics, treatment selection and survival outcomes between two large prospective cohorts of older patients with operable breast cancer from the United Kingdom (UK) and The Netherlands.Methods: Women diagnosed with operable breast cancer aged >70 years were included. A baseline comprehensive geriatric assessment was performed in both cohorts, with data collected on age, comorbidities, cognition, nutritional and functional status. Baseline tumour characteristics and treatment type were collected. Univariable and multivariable Cox regression models were used to compare overall survival between the cohorts. Results: 3262 patients from the UK Age Gap cohort and 618 patients from the Dutch Climb cohort were included, with median ages of 77.0 (IQR: 72.0-81.0) and 75.0 (IQR: 72.0-81.0) years, respectively. The cohorts were generally comparable, with slight differences in rates of comorbidity and frailty. Median follow-up for overall survival was 4.1 years (IQR 2.9-5.4) in Age Gap and 4.3 years (IQR 2.9-5.5) in Climb. In Age Gap, both the rates of primary endocrine therapy and adjuvant hormonal therapy after surgery were approximately twice those in Climb (16.6% versus 7.3%, p < 0.001 for primary endocrine therapy, and 62.2% versus 38.8%, p < 0.001 for adjuvant hormonal therapy). There was no evidence of a difference in overall survival between the cohorts (adjusted HR 0.94, 95% CI 0.74-1.17, p Z 0.568). Conclusions: In contrast to previous studies, this comparison of two large national prospective longitudinal multi-centre cohort studies demonstrated comparable survival outcomes between older patients with breast cancer treated in the UK and The Netherlands, despite differences in treatment allocation.(C) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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32. In memoriam: Richard P. Lorch (1942–2021)
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Henry Zepeda, Benno van Dalen, and Menso Folkerts
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History ,General Mathematics - Published
- 2022
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33. Los rituales funerarios en San Miguel de Vichaycocha, Huaral – Lima
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Pieter Dennis Van Dalen Luna and Marita Pilar Marcelo Mellado
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Este artículo identifica las características de los rituales funerarios que se mantienen vigentes en la comunidad Campesina de San Miguel de Vichaycocha, ubicada en la sierra del departamento de Lima. En base a un estudio etnográfico se ha registrado el proceso ritual seguido en los funerales y aquellos desarrollados tras su finalización, incluido la celebración del Día de los muertos. Existe en esta Comunidad, numerosas prácticas funerarias, las cuales son desarrolladas a través de complejos rituales en que participan los miembros de la sociedad local que conjugan elementos prehispánicos y cristianos, buscando integrar los mitos ancestrales con la significación de la memoria de los ancestros. Para el desarrollo de la presente investigación nos estamos basando en las propuestas teóricas y metodológicas de la Antropología ritual y de la muerte.
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34. Bivariate copula monitoring
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Andrew Easton, Okki van Dalen, Rainer Goeb, and Alessandro Di Bucchianico
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ddc:510 ,Management Science and Operations Research ,Safety, Risk, Reliability and Quality - Abstract
The assumption of multivariate normality underlying the Hotelling T\(^{2}\) chart is often violated for process data. The multivariate dependency structure can be separated from marginals with the help of copula theory, which permits to model association structures beyond the covariance matrix. Copula‐based estimation and testing routines have reached maturity regarding a variety of practical applications. We have constructed a rich design matrix for the comparison of the Hotelling T\(^{2}\) chart with the copula test by Verdier and the copula test by Vuong, which allows for weighting the observations adaptively. Based on the design matrix, we have conducted a large and computationally intensive simulation study. The results show that the copula test by Verdier performs better than Hotelling T\(^{2}\) in a large variety of out‐of‐control cases, whereas the weighted Vuong scheme often fails to provide an improvement.
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35. Sex Differences in the Relation Between Subjective Memory Complaints, Impairments in Instrumental Activities of Daily Living, and Risk of Dementia
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Herrer Abdulrahman, Eric P. Moll van Charante, Jan Willem van Dalen, Willem A. van Gool, Edo Richard, Neurology, Public and occupational health, 10 Public Health & Methodologie, APH - Mental Health, APH - Methodology, APH - Aging & Later Life, Amsterdam Neuroscience - Neurodegeneration, General practice, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, and ACS - Diabetes & metabolism
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Male ,Activities of daily living ,Epidemiology ,Instrumental Activities of Daily Living ,Subjective memory ,Neuropsychological Tests ,Competing risks ,Cellular and Molecular Neuroscience ,All institutes and research themes of the Radboud University Medical Center ,Developmental Neuroscience ,Risk Factors ,mental disorders ,Activities of Daily Living ,medicine ,Risk of mortality ,Dementia ,sex ,Humans ,Cognitive Dysfunction ,Aged ,Proportional Hazards Models ,Memory Disorders ,Sex Characteristics ,subjective memory complaints ,business.industry ,Proportional hazards model ,General Neuroscience ,Health Policy ,General Medicine ,Alzheimer's disease ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,medicine.disease ,Clinical Psychology ,Psychiatry and Mental health ,Increased risk ,Geriatric Depression Scale ,Female ,Independent Living ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Mental Status Schedule ,human activities ,Demography - Abstract
Background: Older people with subjective memory complaints (SMC) and Instrumental Activities of Daily Living impairments (IADL-I) have an increased risk of developing dementia. Previous reports suggest that the predictive value of SMC and IADL-I may differ between sexes, leaving possible consequences for personalized risk prediction and prognosis. However, none of these studies addressed the competing risk of death, which may substantially differ between sexes. Objective: We investigated sex-differences in the association between IADL-I, SMC, and incident dementia and mortality as competing risk. Methods: 3,409 community-dwelling older people without dementia (mean age 74.3±2.5), were followed for 6.7 years (median). Baseline SMC were assessed using the 15-item Geriatric Depression Scale memory question, and IADL-I using the Academic Medical Center Linear Disability Score. Potential sex-differences in the predictive value of SMC and IADL-I were assessed using Cox regression models with an interaction term for sex. Results: HRs for isolated SMC and SMC + IADL-I and risk of dementia were higher in women (HR: 2.02, 95% CI = 0.91–4.46, p = 0.08; HR:2.85, 95% CI = 1.65–4.91, p
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36. Improving teamwork and communication in the operating room by introducing the theatre cap challenge
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Anne Sophie HM van Dalen, Jan A Swinkels, Stan Coolen, Robert Hackett, Marlies P Schijven, Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, APH - Digital Health, and APH - Quality of Care
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Patient Care Team ,Operating Rooms ,Surgical Safety Checklist ,Surgical safety ,Attitude of Health Personnel ,Communication ,Pilot Projects ,Closed-loop communication ,Original Articles ,General Medicine ,Checklist ,Name stickers ,Teamwork ,Patient Safety ,Quality improvement ,Operating room - Abstract
Objective One of the steps of the Surgical Safety Checklist is for the team members to introduce themselves. The objective of this study was to implement a tool to help remember and use each other’s names and roles in the operating theatre. Methods This study was part of a pilot study in which a video and medical data recorder was implemented in one operating theatre and used as a tool for postoperative multidisciplinary debriefings. During these debriefings, name recall was evaluated. Following the implementation of the medical data recorder, this study was started by introducing the theatre cap challenge, meaning the use of name (including role) stickers on the surgical cap in the operating theatre. Findings In total, 41% (n = 40 out of 98) of the operating theatre members were able to recall all the names of their team at the team briefings. On average 44.8% (n = 103) was wearing the name sticker. Conclusions The time-out stage of the Surgical Safety Checklist might be inadequate for correctly remembering and using your operating theatre team members’ names. For this, the theatre cap challenge may help.
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37. Data from Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study
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Leontien C.M. Kremer, Huib N. Caron, Antonia H. Bouts, Caro C.E. Koning, Helena J.H. van der Pal, Elvira C. van Dalen, Ronald B. Geskus, Sebastiaan L. Knijnenburg, and Renée L. Mulder
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Background: Impaired glomerular function is one of the health problems affecting childhood cancer survivors (CCS). It is unclear whether glomerular function deteriorates or recovers. We investigated time trends and predictors of glomerular function in CCS.Methods: We evaluated repeated observations of estimated glomerular filtration rate (GFR) and glomerular dysfunction (GFR 2) among adult five-year CCS treated in the EKZ/AMC between 1966 and 2003. Ifosfamide, cisplatin, carboplatin, high-dose (HD) methotrexate, HD-cyclophosphamide, radiotherapy to the kidney region, and nephrectomy (i.e., potentially nephrotoxic therapy) were investigated as predictors of glomerular function patterns over time in multivariable longitudinal analyses.Results: At a median follow-up of 21 years after diagnosis, glomerular function was assessed in 1,122 CCS aged ≥18 years. CCS treated with potentially nephrotoxic therapy had a significantly lower GFR and higher glomerular dysfunction probability up to 35 years after cancer diagnosis compared with CCS treated without nephrotoxic therapy (P < 0.001). Especially ifosfamide, cisplatin, and nephrectomy were associated with worse glomerular function that persisted during the entire follow-up period (P < 0.001). Glomerular function deteriorated over time in all CCS (P < 0.001). CCS treated with higher doses of cisplatin seem to have a higher deterioration rate as compared with other CCS (P < 0.005).Conclusions: The loss in glomerular function starts early, especially for CCS treated with ifosfamide, higher doses of cisplatin, and nephrectomy, and seems to be persistent. We have an indication that CCS treated with higher doses of cisplatin experience faster decline than other CCS.Impact: As glomerular function continues to deteriorate, CCS are at risk for premature chronic renal failure. Cancer Epidemiol Biomarkers Prev; 22(10); 1736–46. ©2013 AACR.
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38. Supplementary Figure 4 from Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study
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Leontien C.M. Kremer, Huib N. Caron, Antonia H. Bouts, Caro C.E. Koning, Helena J.H. van der Pal, Elvira C. van Dalen, Ronald B. Geskus, Sebastiaan L. Knijnenburg, and Renée L. Mulder
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PDF - 209KB, Predicted time trends in glomerular dysfunction probability among 1122 adult survivors of childhood cancer by cumulative ifosfamide and cisplatin dose measured by the multivariable logistic regression model.
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39. Supplementary Figure 1 from Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study
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Leontien C.M. Kremer, Huib N. Caron, Antonia H. Bouts, Caro C.E. Koning, Helena J.H. van der Pal, Elvira C. van Dalen, Ronald B. Geskus, Sebastiaan L. Knijnenburg, and Renée L. Mulder
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PDF - 81KB, Flowchart of childhood cancer survivors included in this study.
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- 2023
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40. Supplementary Figure 3 from Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study
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Leontien C.M. Kremer, Huib N. Caron, Antonia H. Bouts, Caro C.E. Koning, Helena J.H. van der Pal, Elvira C. van Dalen, Ronald B. Geskus, Sebastiaan L. Knijnenburg, and Renée L. Mulder
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PDF - 159KB, Predicted time trends in glomerular filtration rate among 1122 adult survivors of childhood cancer by nephrectomy and age at diagnosis measured by the multivariable linear random effects model.
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41. Supplementary Table 1 from Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study
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Leontien C.M. Kremer, Huib N. Caron, Antonia H. Bouts, Caro C.E. Koning, Helena J.H. van der Pal, Elvira C. van Dalen, Ronald B. Geskus, Sebastiaan L. Knijnenburg, and Renée L. Mulder
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PDF - 60KB, Screening characteristics of 1122 adult survivors of childhood cancer.
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42. Supplementary Figure 2 from Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study
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Leontien C.M. Kremer, Huib N. Caron, Antonia H. Bouts, Caro C.E. Koning, Helena J.H. van der Pal, Elvira C. van Dalen, Ronald B. Geskus, Sebastiaan L. Knijnenburg, and Renée L. Mulder
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PDF - 193KB, Predicted time trends in glomerular filtration rate among 1122 adult survivors of childhood cancer by cumulative ifosfamide and cisplatin dose measured by the multivariable linear random effects model.
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43. Supplementary Figure 5 from Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study
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Leontien C.M. Kremer, Huib N. Caron, Antonia H. Bouts, Caro C.E. Koning, Helena J.H. van der Pal, Elvira C. van Dalen, Ronald B. Geskus, Sebastiaan L. Knijnenburg, and Renée L. Mulder
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PDF - 189KB, Glomerular filtration rate of 1403 individual childhood cancer survivors.
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44. The challenge of dementia prevention trials and the role of quasi‐experimental studies
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Josephine E. Lindhout, Jan Willem van Dalen, Willem A. van Gool, Edo Richard, Graduate School, Neurology, Public and occupational health, ANS - Neurodegeneration, APH - Aging & Later Life, APH - Mental Health, 10 Public Health & Methodologie, and APH - Methodology
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quasi-experiment ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,study design ,prevention ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology ,dementia - Abstract
Observational studies have shown consistently that modifiable risk factors during life are associated with increased dementia risk in old age but randomized controlled trials (RCTs) on dementia prevention evaluating the treatment of these risk factors did not find consistent effects on cognitive outcomes. The discrepancy in findings is potentially attributable to inherent differences between the two study designs. Although RCTs are the gold standard for establishing causality, designing and conducting an RCT for dementia prevention is complex. Quasi-experimental studies (QESs) may contribute to investigating causality without randomization. QESs use variation in exposure to a risk factor or intervention in an observational setting to deduct causal effects. Design-specific approaches are used to control for confounding, the main caveat of QESs. In this article we address the challenges, opportunities, and limitations of QESs for research into dementia prevention. Highlights: Despite consistent associations between modifiable risk factors and dementia, the mostly neutral effects of randomized controlled trials (RCTs) challenge the causality of these associations. RCTs in the field of dementia prevention are often problematic due to ethical, practical, or financial constraints, and their results may have limited generalizability. Four quasi-experimental study (QES) designs may be suitable to study causality between risk factors and dementia; we critically appraise these study designs for dementia-prevention studies. We describe how specific QES designs can be used to study the effects of risk-factor modification for 12 known risk factors for dementia.
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- 2023
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45. Physical Function and Physical Activity in Older Breast Cancer Survivors: 5-Year Follow-Up from the Climb Every Mountain Study
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Annelieke A Lemij, Gerrit Jan Liefers, Marloes G M Derks, Esther Bastiaannet, Marta Fiocco, Titia E Lans, Carmen C van der Pol, Annelie J E Vulink, Leander van Gerven, Onno R Guicherit, Eugenie M H Linthorst-Niers, Jos W S Merkus, Thijs van Dalen, Johanneke E A Portielje, and Nienke A de Glas
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Cancer Research ,Oncology - Abstract
BackgroundA decline in physical activity and the ability to perform activities of daily living (ADL) and instrumental activities of daily living (IADL) could interfere with independent living and quality of life in older patients, but may be prevented with tailored interventions. The aim of the current study was to assess changes in physical activity and ADL/IADL in the first 5 years after breast cancer diagnosis in a real-world cohort of older patients and to identify factors associated with physical decline.MethodsPatients aged ≥70 years with in situ or stages I-III breast cancer were included in the prospective Climb Every Mountain cohort study. Linear mixed models were used to assess physical activity (according to Metabolic Equivalent of Task (MET) hours per week) and ADL/IADL (according to the Groningen Activity Restriction Scale (GARS)) over time. Secondly, the association with geriatric characteristics, treatment, quality of life, depression, apathy, and loneliness was analyzed.ResultsA total of 239 patients were included. Physical activity and ADL/IADL changed in the first 5 years after diagnosis (mean change from baseline −11.6 and +4.2, respectively). Geriatric characteristics at baseline were strongly associated with longitudinal change in physical activity and ADL/IADL, whereas breast cancer treatment was not. A better quality of life was associated with better physical activity and preservation of ADL/IADL, while depression and loneliness were negatively associated with these outcomes.DiscussionGeriatric characteristics, loneliness, and depressive symptoms were associated with physical decline in older patients with breast cancer, while breast cancer treatment was not.
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46. Visit-to-visit blood pressure variability and progression of white matter hyperintensities over 14 years
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Esther Janssen, Jan-Willem van Dalen, Mengfei Cai, Mina A. Jacob, José Marques, Marco Duering, Edo Richard, Anil M. Tuladhar, Frank-Erik de Leeuw, and Nina Hilkens
- Abstract
There is evidence that blood pressure variability (BPV) is associated with cerebral small vessel disease (SVD) and may therefore increase the risk of stroke and dementia. It remains unclear if BPV is associated with SVD progression over years. We examined whether visit-to-visit BPV is associated with White Matter Hyperintensity (WMH) progression over 14 years and MRI markers after 14 years.We included participants with SVD from the Radboud University Nijmegen Diffusion tensor Magnetic resonance imaging Cohort (RUNDMC) who underwent baseline assessment in 2006 and follow-up in 2011, 2015 and 2020. BPV was calculated as coefficient of variation of BP at all visits. Association between WMH progression rates over 14 years and BPV was examined using linear-mixed effects model. Regression models were used to examine association between BPV and MRI markers at final visit in participants.A total of 199 participants (60.5 SD 6.6 years) who underwent four MRI scans and blood pressure measurements were included, with mean follow-up of 13.7 (SD 0.5) years. Systolic BPV was associated with higher progression of WMH (β = 0.013, 95% CI 0.005 – 0.022) and higher risk of incident lacunes (OR: 1.10, 95% CI 1.01-1.21). There was no association between systolic BPV and grey and white matter volumes, Peak Skeleton of Mean Diffusivity (PSMD) or microbleed count after 13.7 years.Visit-to-visit systolic BPV is associated with increased progression of WMH volumes and higher risk of incident lacunes over 14 years in participants with SVD. Future studies are needed to examine causality of this association.
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- 2023
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47. Tibial Nerve Block as Treatment of Chronic Foot Pain
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Michael W J Ritt, Henk Koning, Bella V van Dalen, and Bas C ter Meulen
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Anesthesiology and Pain Medicine - Abstract
Background: Minimally invasive therapies can alleviate pain and improve walking in individuals with persistent foot and ankle pain. Objectives: The current study aimed to define the protracted consequences of tibial nerve blocks with steroids for individuals with persistent foot pain and to investigate the link between the thermography of the plantar foot and the beneficial effect of a tibial nerve block with steroids. Methods: All patients with chronic foot pain (n = 45) in this cohort underwent a block of the tibial nerve in the Department of Pain Therapy of Pain Clinic De Bilt, Utrecht, Netherlands, within November 2019 to April 2020. The thermographic images of patients were taken before and after injection. Results were retrospectively evaluated after 18 months. Results: In this study, 53% of the patients had pain relief at 7 weeks of follow-up with a unilateral or bilateral block of the tibial nerve. An improvement in walking distance was reported by 22% of the patients. Side effects of the tibial nerve block reported at 7 weeks of follow-up increased pain (5%) and the occurrence of leg cramps (5%) among the treated patients. At 18 months, 45% of the successfully treated feet still had benefits. A difference between the big toe’s temperature and the foot’s average temperature of less than -0.9°C on thermography before and after the tibial nerve block can predict a beneficial result of therapy. Conclusions: Tibial nerve block provides a safe, minimally invasive treatment option for almost half of the patients with painful feet in this cohort, and when successful, it can last a long term. Thermographic imaging of the plantar foot can predict only to a small extent the beneficial effect of the tibial nerve block with steroids on foot pain. Tibial nerve block should be considered when custom foot orthoses have been inadequate for pain relief or restricted walking distance.
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- 2023
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48. Machine learning based model to diagnose obstructive coronary artery disease using calcium scoring, PET imaging, and clinical data
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van Dalen, J.A., Koenders, S.S., Metselaar, R.J., Vendel, B.N., Slotman, D.J., Mouden, M., Slump, C.H., van Dijk, J.D., Robotics and Mechatronics, and Digital Society Institute
- Subjects
Machine learning ,2023 OA procedure ,UT-Hybrid-D ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,Coronary artery disease ,PET myocardial perfusion imaging - Abstract
Introduction: Accurate risk stratification in patients with suspected stable coronary artery disease is essential for choosing an appropriate treatment strategy. Our aim was to develop and validate a machine learning (ML) based model to diagnose obstructive CAD (oCAD). Method: We retrospectively have included 1007 patients without a prior history of CAD who underwent CT-based calcium scoring (CACS) and a Rubidium-82 PET scan. The entire dataset was split 4:1 into a training and test dataset. An ML model was developed on the training set using fivefold stratified cross-validation. The test dataset was used to compare the performance of expert readers to the model. The primary endpoint was oCAD on invasive coronary angiography (ICA). Results: ROC curve analysis showed an AUC of 0.92 (95% CI 0.90-0.94) for the training dataset and 0.89 (95% CI 0.84-0.93) for the test dataset. The ML model showed no significant differences as compared to the expert readers (p ≥ 0.03) in accuracy (89% vs. 88%), sensitivity (68% vs. 69%), and specificity (92% vs. 90%). Conclusion: The ML model resulted in a similar diagnostic performance as compared to expert readers, and may be deployed as a risk stratification tool for obstructive CAD. This study showed that utilization of ML is promising in the diagnosis of obstructive CAD.
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- 2023
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49. COVID-19 risk-perception in long-distance travel
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Geržinič, Nejc, van Dalen, Maurizio, and Cats, Oded
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Physics - Physics and Society ,FOS: Physical sciences ,Physics and Society (physics.soc-ph) - Abstract
Long-distance travel has seen little attention in the past, largely due its sporadic nature. A single long-distance trip can amount to a distance equivalent to a year's worth of commute trips, resulting in a similar, if not worse, environmental footprint. Understanding travellers' behaviour is thus just as relevant for such trips. As international travel is slowly picking up from the COVID-19 pandemic, it has been marred by an abundance of national and regional pandemic-related safety measures. While their primary goal is to protect the local population from infection, these safety may also make travellers feel safer while travelling. This perceived safety can - and likely does - differ from the true efficacy of the measures. In this research, we investigate people's perception of eight COVID-19-related safety measures related to long-distance trips and how subjective perception of safety impacts their mode choice among car, train and aircraft. We employ a Hierarchical Information Integration (HII) approach to capture subjective perceptions and then model the obtained data by means of a Latent Class Choice Model, resulting in four distinct segments. To extrapolate the segments onto the rating experiment of HII, we apply a weighted least squares (WLS) regression, to obtain segment-specific safety perception. Two segments show a relatively high value-of-time (72EUR/h and 50EUR/h), tend to be more mode-agnostic and prefer determining the level of risk by themselves (relying primarily on infection and vaccination rate). The remaining two segments have a lower value-of-time (38EUR / h and 15EUR/h) and have strong mode affinity, for the train and car respectively. Future research could look into a way that segments the sample based on both the mode choice and rating experiment, providing additional insights into the heterogeneity of individuals in their perceptions.
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- 2023
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50. Mental Health Outcomes in Older Breast Cancer Survivors: Five-Year Follow-Up from the CLIMB Study
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Annelieke A. Lemij, Nienke A. de Glas, Marloes G.M. Derks, Eugenie M.H. Linthorst-Niers, Onno R. Guicherit, Carmen C. van der Pol, Titia E. Lans, Thijs van Dalen, Annelie J.E. Vulink, Jos W.S. Merkus, Leander van Gerven, Frederiek van den Bos, Nathaly Rius Ottenheim, Gerrit-Jan Liefers, and Johanneke E.A. Portielje
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Cancer Research ,Oncology - Published
- 2023
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