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LMS (Learning Management System) 'Virlenda' is one of the options of PGRI University Adi Buana Surabaya in developing modern learning (e-learning). The LMS Virlenda 'will be studied whether to have an effect on the variable specified by using the Technology Acceptance Model (TAM). There are 4 variables studied, namely the  perceived usefulness (X1), perceived ease of use (X2), Internet access (X3), and actual usage (Y1). Researchers took 174 sample students of LMS users 'virlenda'. The study also uses data analysis technique with the Structural Equation Model (SEM) approach with AMOS Graphics count tools for Technology Accepted Model (TAM) modeling. The results show that the technology acceptance model accepts the effect of perceived usefulness with actual usage with CR = 3.118 or CR > 1.96 for a significance level of 5% and the resulting p-value is 0.002. The technology acceptance model does not accept the effect of perceived ease of use on actual usage because CR = -0.475 or CR 1.96 for a significance level of 5% and the resulting p-value is 0.634. And the technology acceptance model accepts the effect of internet access on actual usage with CR = 2.633 or CR > 1.96 for a significance level of 5% and the resulting p-value is 0.008.LMS (Learning Management System) VIRLENDA menjadi salah satu pilihan Universitas PGRI Adi Buana Surabaya dalam mengembangkan pembelajaran secara modern (e-learning). LMS VIRLENDA ini akan diteliti apakah memiliki pengaruh terhadap variabel yang ditentukan dengan menggunakan Technology Acceptance Model (TAM). Terdapat 4 variabel yang diteliti, yaitu persepsi kegunaan (X1), persepsi kemudahan (X2), akses internet (X3), dan penggunaan sesungguhnya (Y1). Penelitii mengambil 174 sampel mahasiswa pengguna LMS ‘VIRLENDA’. Penelitian ini juga menggunakan teknik analisa data dengan pendekatan Structural Equation Model (SEM) dengan alat bantu hitung AMOS Graphics untuk pemodelan Technology Accepted Model (TAM). Hasil penelitian menunjukkan model penerimaan teknologi menerima pengaruh persepsi kegunaan dengan penggunaan sesungguhnya dengan CR = 3,118 atau CR >1,96 untuk taraf signifikansi 5% dan nilai p-value yang dihasilkan adalah 0,002. Model penerimaan teknologi tidak menerima pengaruh persepsi kemudahan terhadap penggunaan sesungguhnya dikarenakan CR = -0,475 atau CR ≤ 1,96 untuk taraf signifikansi 5% dan nilai p-value yang dihasilkan adalah 0,634. Dan model penerimaan teknologi menerima pengaruh akses internet terhadap penggunaan sesungguhnya dengan CR = 2,633 atau CR > 1,96 untuk taraf signifikansi 5% dan nilai p-value yang dihasilkan adalah 0,008.

Purpose This study aims to reveal the implications that trust, as a key driver of consumer behaviour, might have on consumer acceptance of front-of-pack labels (FOPLs) and policy effectiveness. By conducting three studies on 1956 European consumers with different levels of exposure to FOPLs, this study offers additional theoretical and experimental support through a deep investigation of the central role of trust in consumers’ decision-making towards healthier and more informed food choices. Design/methodology/approach Study 1 used structural equation modelling to assess whether trust is a relevant mediator of the relationship between attitude and behavioural intention (BI), thus upgrading the front-of-pack acceptance model (FOPAM); Study 2 tested the model by comparing two labels at the extremes of the current European scheme (NutrInform Battery [NiB], Nutri-Score [NS]); Study 3 assessed the effect in cases where the connection between trust and algorithms is made transparent and evaluated trust dimensions, focusing on the perception of an algorithm presence behind FOPLs information. Findings Study 1 strengthens the FOPAM model with the mediating role of trust in FOPLs, demonstrating a positive effect of attitude on trust and, in turn, on BI, and resulting in a higher model fit with all the significant relationships; Study 2 revealed that the relative performance of the different labels on the FOPAM can be explained by the trust dimension; Study 3, investigating the dynamics of trust in the FOPAM, revealed that the NS is less effective than the NiB on attitude, BI and trust. Research limitations/implications The sample was limited to Italian, French and English respondents, and two labels at the extreme of the spectrum were examined. Furthermore, the research has relevance to the issue of trust. Other moderators used in previous studies on technology acceptance model, such as actual use versus perceptual use, user experience level or type of users and type of use might be investigated. Practical implications The investigation of trust, with the upgrade of FOPAM, enhances understanding of consumers’ decision-making processes when aided by food labels and makes a new contribution to the European Union “Inception Impact Assessment” in preparation for the finalization of the “From-Farm-to-Fork Strategy”, providing new insights into the role of trust by assessing the relative performance of FOPLs in consumers’ acceptance of food-related information. Furthermore, this study revealed that consumers’ perception of FOPLs worsens when they realize that they are the result of an algorithmic calculation. Finally, the new FOPAM represents a reliable theoretical model for future research on FOPL. Originality/value This study increases the knowledge about the performance of different FOPLs on several dimensions of food decision-making, positions the upgraded FOPAM as a valid alternative to existing theoretical models to assess the relative performance of labels, also extending the literature in the context of algorithm-based FOPL, and could be used as a valid support to policymakers and industry experts in their decision towards a unified label at European level.

Purpose − This study examines the effect of knowledge of Islamic FinTech products and services of Micro, Small, and Medium Enterprises (MSMEs) actors on their intentions to adopt it.Methodology − This study adopts a quantitative method with primary data filled in by MSME actors in Indonesia. A hundred samples were analyzed using Partial Least Square - Structural Equation Modeling (SEM) by SmartPLS software.Findings − The results showed that both Perceived Usefulness (PU) and Perceived Ease of Use (PEoU) were empirically proven to have a significant positive effect on Attitude Toward Behavior (ATB). Likewise, ATB has been proven to be significant in mediating PU and PEoU on the Behavioral Intention (BI) of MSME actors in using Islamic FinTech products and services. The main finding in this research is that the higher the knowledge/literacy of Islamic finance by MSMEs, the more they will strengthen their intention to use FinTech products.Implications − The socialization of Islamic FinTech products and services by regulators such as the Financial Services Authority through collaboration with the industry players, professional and expertise organizations, the Muslim entrepreneur community, and universities need to be continuously to improve Islamic financial literacy. In addition, amid ongoing business digitalization, MSMEs are expected to be integrated with FinTech, not only in terms of funding but also in improving business performance regarding operations, finance, human resources, and others.Originality − This paper extends TAM with product knowledge on objects in the form of MSME actors in Indonesia.

This study aims to determine the factors of acceptance of e-learning technology in students who use the technology acceptance model, namely perceived usefulness (PU), perceived ease of use (PEOU), an attitude of acceptance of use (ATU), and acceptance (IT) of the e-learning acceptance system. The population in this study were students of state Islamic religious institutes who had participated in the e-learning system. The respondents of this study were students of the Ambon State Islamic Institute of Religion, which collected 30 respondents. The method used in this study uses the technology acceptance model method in the process of data processing using quantitative analysis techniques in the process of analyzing data from research results. The analysis results show that the acceptance of e-learning technology by students of the Islamic Institute of Religion is very well received by users of the Ambon State Islamic Institute of Religion students. The study's results showed that the variable utilization percentage of 76.66% was stated to agree strongly. In comparison, the percentage of 61.66% agreed. Attitudes towards users 70.66% agreed. The study's results show that students in the learning process can accept using e-learning systems.

Purpose − This study aims to analyze the effect of variable ease of use, usefulness, perceived risk, and social influence on a recommendation to use sharia e-wallet in Indonesia and Malaysia.Methodology − This study uses a quantitative method. This study uses primary data by conducting a survey through an online questionnaire of 200 respondents with the criteria sharia e-wallet users and living in Indonesia or Malaysia. This research uses the SEM-PLS analysis method.Findings − The results of this study found that variable ease of use, usefulness, and social influence significantly and positively affect the recommendation to use the sharia e-wallet. In contrast, the perceived risk has a negative effect on the recommendation to use a sharia e-wallet. Based on the Multi-Group Analysis (MGA) test, there is no significant difference between Indonesian and Malaysian users for all variables.Originality − This study adds to the literature, especially on the factors influencing recommendation to use in sharia e-wallet. There are limited studies on this topic, especially for sharia e-wallets in Indonesia and Malaysia. The uniqueness of this research is that the primary data used includes respondents in various regions in Indonesia and Malaysia.Practical implications − The results of this study can be used as a reference by the Islamic fintech industry to develop a sharia e-wallet both in terms of product, quality, and others to be better in the future.

Cloud computing electronic learning (CCEL) is a new technology that enables educators and students to extend the storage and access learning materials. The use of this technology is limited worldwide. However, in the time of COVID 19, this technology becomes essential for the educational processes. The purpose of this study is to examine the predictors of using CCEL among academic staff and students in Iraq. Based on literature, this study proposed that perceived ease of use (PEOU), perceived usefulness (PU), and subjective norms (SN) will affect the intention to use (IU) which in turn will affect the actual use (AU). Attitude (AT) is proposed to mediate the relationships while technology readiness (TR) is proposed as a moderator. The data is collected from 331 students and academic staff in three Iraqi universities using stratified sampling. Data analysis is conducted using SmartPLS. The results showed that PEOU, PU, and SN affect positively IU which in turn affected AU. AT mediated partially the effect of PEOU, PU, and SN on IU while TR moderated only the effect of PEOU on IU. Decision makers are recommended to simplify the usage of CCEL and to conduct workshops about the usage and benefits of CCEL.

Purpose Mobile health (mHealth) service is an Australian Government initiative aiming to improve the quality of health-care services. However, little is known about Australian health consumers’ willingness to adopt mHealth. The purpose of this paper is to study the usage behavior of mHealth service users in Australia. While various factors may impact users’ willingness to accept mHealth, this research investigates factors influencing the mHealth adoption decisions of the Australian health-care consumers, and the moderating impact of demographic factors on the usage behavior (UB) of mHealth services which has been rarely addressed in an Australian setting in the past. Design/methodology/approach The theoretical framework is based on the technology acceptance model (TAM). Data were collected from residents of the Australian Capital Territory using a survey questionnaire and examined using partial least squares structural equation modeling. Findings The proposed mHealth usage model demonstrated a good fit and indicated that perceived usefulness, perceived ease of use, social influence, service quality and government influence are critical issues shaping mHealth UB. The moderation analysis revealed that users’ demographics, namely, gender, age and education are instrumental in broadening the understanding of UB of mHealth service in Australia. Practical implications The findings will inform health-care service providers about the critical importance of the key factors driving the usage of mHealth services. Health-care providers and relevant authorities can develop targeted communication strategies that maximize the acceptance of mHealth services. Furthermore, deeper understanding of users’ demographic profiles would enable health-care service providers to promote their services to the right clients. Originality/value The above findings on the factors and user demographics informing the usage of mHealth services have unique practical, contextual and theoretical implications.

PurposeLarge attention surrounds identifying the meaningful blockchain business model on financial services, while a little focus about non-financial organizations and solutions in terms of how the blockchain business model can affect the organization and bring more value. To address the complex structure of businesses that have public goods, it is important to develop sustainable blockchain-based business models.Design/methodology/approachThis study offers the first qualitative research that uses an integrated technological, environmental and organizational (TOE) framework with technology acceptance theory (TAM) to study the adoption of blockchain technology by Spanish firms.FindingsThe results of the paper discuss how that competitive pressure, competence, top management support and relative advantage have a positive impact on intention to adopt blockchain technology while complexity affects the intention to adopt the technology negatively. Contrary to many adoption studies, the findings show that intention to adopt negatively impacts adoption and outline the effect of blockchain on business model elements on the macroeconomic level.Originality/valueThe key contribution of this study lies in providing a comprehensive understanding of the environmental, technological and organizational factors that impact the intention to adopt blockchain that eventually affects adoption.

This study purposed to analyze the application of an extended technology acceptance model (TAM) by combining the influence of brand equity and mobile web quality that are used to predict intention to use m-commerce, through perceived ease of use, perceived usefulness, and attitude toward using. The research was conducted on Indonesian citizens who have used service products on m-commerce Traveloka. The analytical method used is the structural equation modeling (SEM) with Lisrel 8.80 Software. Using a convenient sampling technique, 270 respondents were involved in the study. Only five of the nine hypotheses developed are significant, while the others are not. However, the current study discovers a new finding that brand equity significantly affects the attitude toward using m-commerce. The results of this study are quite different from Chi’s (2018) study, indicating that the model still needs to be reinvestigated using a different sample to test the model consistency.

Verbs like begin, continue, end etc. are called ‘phasal’ or ‘aspectual’ by different authors. The latter denomination seems to indicate the crucial role of aspect in the periphrases built upon them. This paper supports the idea that, despite some overlap with the aspectual component, phasal verbs and periphrases convey a peculiar type of information. PHASE is an autonomous semantic component, collateral to the major complex consisting of actionality, temporality, aspect, and modality. The compatibility between phasal and embedded verb within a periphrasis is also discussed.

The focus of the study is to achieve the maximum advertising value on ecotourists using social media. In this area, the main objective of the “Technology Acceptance Model (TAM)” is to increase the present awareness of social media marketing. This topic is primarily concerned with exploring the context of social media advertisement with knowledge, service, and its behavioural intent to use social media ads within the unique environment of ecotourism in Malaysia. The approach of the study is to analyse a survey of 395 local Malaysian tourists in Klang Valley to test the “Technology Acceptance Model (TAM)”. The empirical findings denote that social media advertisement in ecotourism has positive effects on “Perceived ease of use” and “Perceived usefulness,” in terms of its ‘Informativeness’ and “Service Functionality.” That, in effect, contributes to the behavioural purpose of using social media ecotourism advertisements. The discipline’s findings indicate that advertising in social media in ecotourism needs to be utilized to provide a quick understanding. Also, the advertising is updated continuously to ensure reliable and appropriate sources to meet ecotourists’ information requirements and the support of tourist product ratings. These traits should satisfy travellers, making them likely to re-visit different ecotourism sights. These appearances should satisfy tourists and allow them to re-visit various ecotourist attractions.

Purpose: This study is focused on researching the impact of WOM on the acceptance of mobile banking. This research offers insights into factors that affect the implementation of mobile banking applications. Methodology: The research's inclusion was based on relevancy, authenticity, and reliability of information extracted from publication journals, and exclusion was based on non-relevancy and lack of authentic research. For the analyzes, consumer data were collected through a survey, and structural equations modelling, and path analysis were employed to test the research model. Findings: The findings showed that WOM was the critical factor influencing consumer perceptions towards mobile banking. WOM also positively affects other factors impacting mobile banking acceptance, such as Ease of use, Perceived usefulness, Social Norms, Trust, Attitude, and intention. Limitations: The most significant limitation of this study is that it only concentrates on internet users. Non-users are not considered. Value: Many researchers studied the number of effects on mobile banking, but this work's uniqueness is that this paper focuses on WOM impact on mobile banking adoption. Its impact factor is considered the main contribution of this research., Internal Grant Agency of FaME; TBU in Zlin [IGA/FaME/2020/002]

The e-grocery industry in Indonesia is multiplying and is expected to become one of the most important markets in the world. Massive amount of funding for e-grocery start-ups, the high desire of Indonesian consumers to buy grocery products online, and COVID19 are increasing the growth of e-grocery services in Indonesia. Although the desire to use e-grocery services in Indonesia is high, data shows that e-grocery adoption is still far below other e-commerce product categories such as fashion and electronics. Previous research and surveys also show that consumers will return to shopping for wholesale products offline and stop/reduce the use of e-grocery after the COVID19 pandemic. Therefore, this research is interested in examining the factors that can increase the adoption of e-grocery in Indonesia. Quantitative research was conducted using the purposive sampling method and obtained 135 respondents who have ever used e-grocery service/shopping in the JABODETABEK area. Data were analyzed using PLS-SEM (Partial Least Square – Structural Equation Model). The results of this study indicate that perceived risk has a negative effect on Trust. Social Influence, Perceived Usefulness, and Perceived Ease of Use have a positive effect on Trust. Social Influence and Perceived Ease of Use have a positive effect on Perceived Usefulness. However, it turns out that Trust in this study was not proven to affect the intention to use e-grocery services/shopping for grocery products online.

Mobile banking has been a game changer for financial organizations in terms of remote banking services. However, many customers remain uncertain due to its security. Therefore, improving the comprehension of the customer’s reasons and methods of using bank sites, including their behaviour towards e-banking, is crucial. This article discusses the matter by suggesting a technology acceptance model that integrates the theory of the planned behavior model in the classic TAM model with trust and perceived risk in order to elucidate the aspects that influence users’ acceptance of mobile banking applications in Palestine. This study is designed to give both theoretical and empirical support for e-commerce adoption. We are also capable in providing particular marketing ideas for practitioners in relation to the uptake of mobile banking.

This study investigates: 1) whether using a recycling app increases recycling knowledge and subsequently actual recycling behavior; and 2) what theories (comparing Theory of Planned Behavior vs. Technology Acceptance Model) can explain if, and why, people use a sustainable mobile app.

The COVID-19 pandemic has produced a far-reaching influence on higher education and the teaching activities of teachers in Chinese universities. The intentions of teachers in universities for using the micro-lecture, one of the educational informationization products, and the influencing factors of the intentions for using micro-lectures, are changing in the post COVID-19 era. This paper, based on the Technical Acceptance Model (TAM) and the Unified Theory of Acceptance and Use of Technology (UTAUT), constructed the research hypotheses for the influence factors of micro-lecture usage intentions of teachers in universities in the post COVID-19 era, and made corresponding verifications through the Structural Equation Model (SEM). As shown by the results therefrom: (1) the micro-lecture usage experience before the outbreak of the COVID-19 pandemic significantly affected the usage intentions of teachers in universities; (2) the perceived usefulness influenced the usage intention directly, but the perceived ease of use did not directly produce influence; (3) policy impact had no significant influence on the perceived usefulness and the perceived ease of use of university teachers for micro-lecture use; (4) social relations and personal innovativeness have significant impacts on perceived usefulness, teaching objectives and micro-lecture characteristics have significant impacts on the perceived ease of use. In this paper, suggestions and opinions on popularizing micro-lecture usage in the post COVID-19 era were put forward on the basis of research conclusions therein.

Macrophages in the tumor microenvironment have a substantial impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can either support or constrain tumor progression. It is therefore of therapeutic interest to identify the tumor-derived factors that control macrophage education. With this aim, we correlated the expression of A Disintegrin and Metalloproteinase (ADAM) proteases, which are key mediators of cell-cell signaling, to the expression of protumorigenic macrophage markers in human cancer cohorts. We identified ADAM17, a sheddase upregulated in many cancer types, as a protein of interest. Depletion of ADAM17 in cancer cell lines reduced the expression of several protumorigenic markers in neighboring macrophages in vitro as well as in mouse models. Moreover, ADAM17-/- educated macrophages demonstrated a reduced ability to induce cancer cell invasion. Using mass spectrometry-based proteomics and ELISA, we identified heparin-binding EGF (HB-EGF) and amphiregulin, shed by ADAM17 in the cancer cells, as the implicated molecular mediators of macrophage education. Additionally, RNA-Seq and ELISA experiments revealed that ADAM17-dependent HB-EGF ligand release induced the expression and secretion of CXCL chemokines in macrophages, which in turn stimulated cancer cell invasion. In conclusion, we provide evidence that ADAM17 mediates a paracrine EGFR-ligand-chemokine feedback loop, whereby cancer cells hijack macrophages to promote tumor progression.

Tumor‐associated macrophages (TAMs), one of the most common cell components in the tumor microenvironment, have been reported as key contributors to cancer‐related inflammation and enhanced metastatic progression of tumors. To explore the underlying mechanism of TAM‐induced tumor progression, TAMs were isolated from colorectal cancer patients, and the functional interaction with colorectal cancer cells was analyzed. Our study found that coculture of TAMs contributed to a glycolytic state in colorectal cancer, which promoted the stem‐like phenotypes and invasion of tumor cells. TAMs produced the cytokine transforming growth factor‐β to support hypoxia‐inducible factor 1α (HIF1α) expression, thereby upregulating Tribbles pseudokinase 3 (TRIB3) in tumor cells. Elevated expression of TRIB3 resulted in activation of the β‐catenin/Wnt signaling pathway, which eventually enhanced the stem‐like phenotypes and cell invasion in colorectal cancer. Our findings provided evidence that TAMs promoted colorectal cancer progression in a HIF1α/TRIB3‐dependent manner, and blockade of HIF1α signals efficiently improved the outcome of chemotherapy, describing an innovative approach for colorectal cancer treatment., Our findings provided evidence that tumor‐associated macrophages promoted colorectal progression in a HIF1α/TRIB3‐dependent manner, and blockade of HIF1α signals efficiently improved the outcome of chemotherapy, describing an innovative approach for colorectal cancer treatment.

This paper highlights a successful experience of assessing English as a Foreign Language (EFL) learner’s proficiency at Yanbu English Language Institute (YELI), Kingdom of Saudi Arabia during the Covid-19 restrictions. To investigate the existing problem various interventions were introduced such as replacing Google Classroom with Black Board, implementing online proctoring during the exams, and portfolios. The provision of online assessments was a forced response to Covid-19 restrictions, which brought many challenges and risks without any prior experience and precedence. Addressing these challenges and making well-informed decisions that can potentially affect the performance and career of hundreds of learners, requires judicious justification and reasoning. The paper reflects on the well-informed strategy TAM used to deploy and address the challenges of online graded assessments effectively during the current pandemic for EFL learners to continue their progress toward their specializations while maintaining academic rigor and quality. This paper also intends to provide an insight to language teachers, practitioners, and policymakers to tackle similar challenges in the future. One among many other objectives of this research was to address the role of digital assessment for effective teaching, learners’ motivation, achievements, and transferability.

Previous research has found support for depression and anxiety associated with social networks. However, little research has explored parents’ depression and anxiety constructs as mediators that may account for children’s depression and anxiety. The purpose of this paper is to test the influence of different factors on children’s depression and anxiety, extending from parents’ anxiety and depression in Jordan. The authors recruited 857 parents to complete relevant web survey measures with constructs and items and a model based on different research models TAM and extended with trust, analyzed using SEM, CFA with SPSS and AMOS, and ML methods, using the triangulation method to validate the results and help predict future applications. The authors found support for the structural model whereby behavioral intention to use social media influences the parent’s anxiety and depression which correlate to their offspring’s anxiety and depression. Behavioral intention to use social media can be enticed by enjoyment, trust, ease of use, usefulness, and social influences. This study is unique in exploring rumination in the context of the relationship between parent–child anxiety and depression due to the use of social networks.

This project contains the materials, data, and R code for our psychometric evaluation of the 28-item Creative Behavior Inventory, which was published in Creativity Research Journal. You are welcome to use the data for your own purposes so long as the original paper is cited.

The purpose of the research is to make a deep dive into the perception over technology usage amongst the accounting professionals, while trying to assess its current level of utilization and understanding in the field. The paper tries to snapshot the status quo on the international market of accounting professionals in terms of current level of technological use, understanding and behavioural intention to use new technology, along with contributing factors. Methodology: With this purpose a questionnaire is prepared based on the adapted TAM methodology to understand how the accounting professionals are positioned against the developing technologies. The questionnaire will focus on the accounting function of companies or accounting companies, all in different stages of technological development. The methodological approach to be used within the proposed paper is exploratory, with mixed methods of qualitative research such as questionnaires and in-depth literature review. Originality/value: Originality of the paper comes from performing an extended analysis in a transition period for most companies and trying to go beyond perceptive analysis towards the root causes implied.

This study is unique in its attempt to combine the Technology Acceptance Model (TAM) with external variables and the Information System Continuance Theory, in the context of mobile learning. It extends TAM with the external variables perceived mobility and perceived enjoyment. Mainly, students’ perception of cell phones effect on their academic performance is investigated. The study was conducted at two different universities—in Europe and the Middle East. Cell phone usage is analyzed from the perspective of mobile learning. The data in this study were collected from 103 students from the University of Latvia and 106 students from a Middle Eastern private American University. This study shows that there is no significant difference on how the two groups perceive the use of cell phone and their opinion of its impact on their academic performance. The obtained results are in line with the theoretical model. They show the influence of perceived enjoyment and perceived usefulness on students’ attitudes towards using cell phones. Data shows that there is a positive relationship between cell phone usage and students’ perception of its effect on their academic performance. This study reveals several interesting findings, and it is believed that this research offers the educators and administrators further insight in analysing the current effect of cell phones on students’ academic performance and the possibility of adopting mobile learning as one of the technological tools which supports technology enhanced learning. Supplementary Information The online version contains supplementary material available at 10.1007/s10758-021-09515-4.

Purpose: With the development and increasing adoption of the Internet in the early 21st century, SSTs (Self-Service Technologies) rapidly permeated all aspects of life. Many service providers in China are adopting a wide range of SSTs. This is mainly because they think SSTs improve customer service, increase productivity, and reduce costs. Problem is how potential customers perceive the SSTs and behave. Design/methodology/approach: This study hypotheses that the original TAM and extended TAM would not apply to customers using SSTs in Chinese budget hotels. All the relationships among variables on these models were tested by using a Structural Equation Model (SEM). Findings: Results proved that all of the relationships on the original TAM do apply to customers using SSTs in Chinese budget hotels. However, the extended TAM does not fit into this particular market. Research limitations/implications: This study examined the TAM with perceived risk and perceived playfulness to determine the factors influencing customers' behavioral intention to use SSTs in budget hotels. This approach is likely to ensure a stable theory development. Hence, the proposed model makes an important contribution to the emerging literature on SSTs. Moreover, this study originally hypothesized perceived risk affected on customers' satisfaction and behavioral intention to use SSTs in Chinese budget hotels. But it is rejected. Originality/value: This study offers empirical evidence and makes contribution to future research related to further developing an understanding of the relationship between perceived risk and SSTs adoption.

Invigilation of the examination is one of the important roles and tasks of lecturers appointed as invigilators or proctors. Based on the past semi-annually reports of examination post-mortems meeting, less than 10% of the invigilators were unhappy with the examination duties that have been assigned or appointed to them. The examination committee members who are responsible in the process of assigning the invigilation duties to each invigilator had given a lot of effort and spent a few weeks to ensure that everybody is happy with the invigilation duties assigned to them. Nevertheless, despite the excellent planning of invigilation duties assignment, it cannot make everybody satisfied. Thus, a web-based application system named Examination Invigilation Management Systems (ExIMS) has been developed using the System Development Life Cycle (SDLC) waterfall model methodology to meet the need of invigilation duties exchanged among invigilators or applicants. This system has been developed to control and cross check the request of invigilation duties exchanged using the algorithm named multi selection control. The algorithm could avoid any conflicts or anomalies that could happen after the exchange of duty has been made. The process of duty exchange is examined and verified automatically by the system. The system provides a platform for users or invigilators to give their views or opinions on the invigilation duties and system features or performance through the online survey. The survey uses the TAM method concentrating on the perceived-ease-of-use (PEOU) component. Based on the survey, 95% respondents reported that they were satisfied with the platform for duty exchange among invigilators. The users can easily and flexibly select the new duties, which will be automatically and mutually swapped among invigilators. ExIMS has solved the problem of unsatisfaction of invigilation duties and increased the happiness index among invigilators during the examination period.

Educational institutions worldwide had to shift the teaching delivery mode from face to face to online teaching during COVID-19. Most of the universities in Vietnam were based on face to face learning until the sudden outbreak of COVID-19. This research study was conducted with 145 respondents and Structural Equation Model (SEM) was used for data analysis. The participants were undergraduate and post-graduate students in public and private universities who studied online during the pandemic in Vietnam. The purpose of this study was to understand what factors have an impact on students’ intentions to study online. The results show that institutional support and perceived enjoyment (satisfaction) affects the students’ intentions to study the course online in the future. Perceived enjoyment (PE) affects the online learning intentions (OLI) and PE is affected by ICT infrastructure and internet speed and access. Hence, this research adds new research variable defined as extrinsic factors (ICT infrastructure and access to the internet), which indirectly influences students’ intentions to learn online. Given the increased use of smart phones with this generation, it is advisable to integrate mobile technology in online learning and QR codes can be one of the ways to integrate that in the course materials. It is further recommended that to increase the perceived enjoyment of the students with the online learning, the lecturers might be encouraged to use videos, audios and instant messaging to contact and provide the feedback to the students. It is important for universities to prepare for any such future crisis. This study results will provide a useful insight to design the online courses effectively by considering all the factors impacting students’ intention and satisfaction.

This current empirical study aims at investigating the incorporation of consumer innovativeness in TAM and UTAUT in the development of a golf app and how these influence consumer behavioral intentions in adopting the golf app. These models help illustrate consumer adoption of particular technologies and relate to the concept of innovation diffusion theory. Our research has obtained 394 responses and participants of the questionnaire were evenly divided by gender and age to reach the purpose of the current research. The main statistical methodology used the structural equation modeling (SEM) to evaluate the connection among user’s innovativeness regarding the golf application, technology acceptance model (TAM), unified theory of acceptance and use of technology (UTAUT), behavioral intention, and word of mouth. In contrast to correlation assessments, SEM can measure the strength of the linear causative relationships between factors. Finally, this research concludes that TAM and UTAUT components determine the consumer’s attitude towards accepting and using new technology. Consumers who are open to innovations are more likely to accept emerging technology products and use them with the least resistance.

Employing social media applications for instructional activities has become a trendy topic, with a relatively large number of studies published yearly. However, identifying the factors influencing social media adoption and having a clear taxonomy that guides further research are neglected in the extant literature. Understanding which specific disciplines use specific social media applications also requires further investigations. Therefore, this systematic review retrieved and analyzed 713 studies published on social media adoption that relied on “Technology Acceptance Model” (TAM) as the basic model. After critically evaluating the collected publications against the inclusion and exclusion criteria, 45 studies were eventually shortlisted for in-depth analysis. The main findings indicated that most of the analyzed studies collected data from students enrolled in the business discipline. Facebook is found to be the primary application used in most of the analyzed studies for educational purposes. The influential factors affecting social media adoption were classified into three distinct groups, including external factors, behavioral intention antecedents, and moderating factors. We have also classified the behavioral intention antecedents into three distinct clusters, including user, social, and technology aspects. The majority of the existing literature was conducted in individualistic settings with limited exposure to collectivistic societies. This review is believed to provide a quick grasp of the disciplines, applications, and determinants influencing social media adoption in higher education.

Virtual Reality (VR) is an emerging technology with educational benefits demonstrated in numerous studies. Its integration into the curriculum implies the use of cognitive resources by students and the training of digital skills by teachers. The objective of this study is to determine the degree of acceptance of students with learning objects produced in VR and in 360°, as well as to analyze their evaluation and the established relationships. A sample of 136 medical students who completed questionnaires on the Technology Acceptance Model (TAM) and the quality of the training activity was used. The results show high levels of acceptance, both in VR and 360° objects. The students perceived the usefulness of the training activity as high, with significant correlations between the different dimensions. This study demonstrates the potential of VR as an educational technology and offers new perspectives for future research.

Background: Software engineering research aims to establish software development practice on a scientific basis. However, the evidence of the efficacy of technology is insufficient to ensure its uptake in industry. In the absence of a theoretical frame of reference, we mainly rely on best practices and expert judgment from industry-academia collaboration and software process improvement research to improve the acceptance of the proposed technology. Objective: To identify acceptance models and theories and discuss their applicability in the research of acceptance behavior related to software development.Method: We analyzed literature reviews within an interdisciplinary team to identify models and theories relevant to software engineering research. We further discuss acceptance behavior from the human information processing perspective of automatic and affect-driven processes (“fast” system 1 thinking) and rational and rule-governed processes (“slow” system 2 thinking). Results: We identified 30 potentially relevant models and theories. Several of them have been used in researching acceptance behavior in contexts related to software development, but few have been validated in such contexts. They use constructs that capture aspects of (automatic) system 1 and (rational) system 2 oriented processes. However, their operationalizations focus on system 2-oriented processes indicating a rational view of behavior, thus overlooking important psychological processes underpinning behavior. Conclusions: Software engineering research may use acceptance behavior models and theories more extensively to understand and predict practice adoption in the industry. Such theoretical foundations will help improve the impact of software engineering research. However, more consideration should be given to their validation, overlap, construct operationalization, and employed data collection mechanisms when using these models and theories. open access ELLIIT

This research paper focuses on mobile banking acceptance among Generation Z users by combining the technology acceptance model (TAM) and the unified theory of acceptance and use of technology (UTAUT) theory, as well as extending the theories with perceived trust and risk. During the COVID-19 pandemic, the online questionnaire survey was distributed using Google Forms, and the sample group was Thai Generation Z who were aged between 18 and 25 years old. The research objectives aim to (i) investigate the crucial effects that potentially affect user intention and actual usage of mobile banking, (ii) identify the most influential factor impacting users’ intention and behavior, (iii) further study the trust and risk perception of Generation Z users on mobile-banking intention and actual usage, (iv) discuss the findings with the antecedent studies, and (v) contribute the research findings both theoretically and practically. The proposed constructs include perceived usefulness, perceived ease of use, social influence, facilitating conditions, perceived trust, perceived risk, behavioral intention, and actual usage. There are fourteen proposed hypotheses to be tested. Based on the outcomes and the standardized coefficient beta, perceived usefulness (β = 0.518) was the strongest factor determining Generation Z’s behavioral intention, while perceived ease of use (β = 0.809) impacting perceived usefulness demonstrated the strongest relationship among all of the hypotheses.

Owing to the recent increase in mobile banking customers, studies exploring self-service channels and customer responses as distribution channels in the retail banking industry are also rapidly expanding. Moreover, with the emergence of big data and a series of artificial intelligence (AI) technologies, customer pattern analysis using deep learning, insurance fraud prevention, software development and various types of blockchain-based FinTech technologies, offline banks are disappearing. Accordingly, many commercial banks are attempting to find technological alternatives. However, maintaining a profitable bank branch is a crucial factor in the relationship between service quality and customer satisfaction because excellent service quality prevents existing customers from leaving. This study sought to quantitatively prove the change in customer service quality and profit due to the introduction of technology in the financial industry. We microscopically compared the effects between bank branch closures and changes in net profit using a time-series analysis. Specifically, we quantitatively analyzed actual customer attrition behavior with a time-series analysis across the three quarters before and after the closure of 88 branches of major commercial banks in South Korea in the Seoul metropolitan area and nearby cities. The findings prove that branch closures and multi-channel effects in the financial sector are gradually being resolved through immediate technology acceptance, contrary to popular concern.

Research aims : This study aims to analyze the perceived security dimensions and build a research model using perceived ease of use and perceived usefulness as variables mediating the link between perceived security and the intention to use Indonesia's B2C e-commerce websites. Design/Methodology/Approach : Using a purposive sampling approach, this study conducted an online survey of respondents who had done online transactions, such as business-to-customer (B2C) transactions. Research Findings : The study's results showed that perceived security significantly correlated with buyers' intention to use B2C websites. Theoretical contribution/Originality : This study contributes to developing and validating key dimensions of perceived security and their constructs. Mediation effect test results from TAM, which were perceived ease and perceived use, indicated that only the perceived usefulness variable significantly mediated the relationship between perceived security and intention to use B2C e-commerce websites. Perceived use's mediation was not supported. Practitioner/Policy implication : This research empirically supports the perceived security construct as a second-order construct involving confidentiality, availability, non-repudiation, and privacy. Research limitation/Implication : This study used data from Indonesian individuals, which may differ from other countries' characteristics. It may limit the research' finding generalization. Research aims: This study aims to analyze the perceived security dimensions and build a research model using perceived ease of use and perceived usefulness as variables mediating the link between perceived security and the intention to use Indonesia's B2C e-commerce websites. Design/Methodology/Approach : Using a purposive sampling approach, this study conducted an online survey of respondents who had done online transactions, such as business-to-customer (B2C) transactions. Research Findings : The study's results showed that perceived security significantly correlated with buyers' intention to use B2C websites. Theoretical contribution/Originality : This study contributes to developing and validating key dimensions of perceived security and their constructs. Mediation effect test results from TAM, which were perceived ease and perceived use, indicated that only the perceived usefulness variable significantly mediated the relationship between perceived security and intention to use B2C e-commerce websites. Perceived use's mediation was not supported. Practitioner/Policy implication : This research empirically supports the perceived security construct as a second-order construct involving confidentiality, availability, non-repudiation, and privacy. Research limitation/Implication : This study used data from Indonesian individuals, which may differ from other countries' characteristics. It may limit the research' finding generalization.

ZISWAF is an Islamic-led fundraising instrument aimed at wealth distribution. The existence of technological developments allows the adaptation of payments with all its acceleration. This study aims to determine the digital payment strategy to maximize ZISWAF’s revenue potential in Indonesia. This study uses the TAM, and TPB modification approaches. The methodology used is structural equation modeling (SEM) with a partial least square (PLS) approach. The sample used is the Y generation as a representation of the millennial generation. The results showed that all the variables forming the TAM theory (perceived usefulness, perceived ease of use, attitude) and all the variables creating the TPB theory (subjective norms and perceived behavior control) significantly affect the Intention (INT) of individuals pay for online ZISWAF (sig. 0.05, α=5%). Furthermore, attitude is a mediating variable in a partial/ quasi modification model that links perceived usefulness (PU), perceived ease of use (PEoU) to Intention (INT) (VAF=49.87%).Abstrak: ZISWAF adalah instrumen pengumpulan dana yang dipelopori Islam dengan tujuan untuk distribusi kekayaan. Adanya perkembangan teknologi memungkinkan adaptasi pembayaran dengan segala akselerasinya. Penelitian ini bertujuan untuk mengetahui strategi pembayaran digital untuk memaksimumkan potensi pendapatan ZISWAF di Indonesia. Penelitian ini menggunakan pendekatan modfikasi TAM dan TPB. Metodologi yang digunakan adalah structural equation modeling (SEM) dengan pendekatan partial least square (PLS). Sampel yang digunakan merupakan generasi Y sebagai representasi generasi milenial. Hasil menunjukkan seluruh variabel pembentuk teori TAM yakni perceived usefulness (PU), perceived ease of use (PEoU) dan attitude (ATT) dan seluruh variabel pembentuk teori TPB yakni subjective norms (SN) dan perceived behavior control (PBC) berpengaruh terhadap intention (INT) individu dalam membayar ZISWAF secara online (sig. 0.05, α=5%). Attitude (ATT) merupakan variabel pemediasi dalam model modifikasi yang bersifat partial/ quasy yang menghubungkan perceived usefulness (PU), perceived ease of use (PEoU) terhadap intention (INT) (VAF=49.87%)

Résumé En s’appuyant sur les différentes technologies d’information et de communication, l’egov permet d’accroitre la performance ainsi que la productivité interne des administrations publiques, à travers une plus grande flexibilité dans les processus et les circuits de prise de décision. Il permet également d’améliorer la qualité, l’accessibilité ainsi que la proximité des services rendus aux citoyens et aux entreprises, en passant d’un gouvernement qui repose sur des modes de gestion et de fonctionnement traditionnels, à un gouvernement électronique, basé essentiellement sur les TIC. Cela, ne peut que renforcer la transparence et la confiance dans la relation de l’Etat avec ses différents partenaires. L’objectif de ce travail est d’essayer d’expliquer et de prédire les variables qui influencent la décision d’adoption et d’utilisation du gouvernement électronique par les PME. Pour ce faire, nous avons mobilisé les théories et les modèles les plus fréquemment utilisés dans ce domaine; notamment TAM, TCP et UTAUT; pour aboutir à un modèle théorique conceptuel qui sera; éventuellement; adapté au contexte marocain dans le cadre d’une étude empirique. En fin, l’examen de la revue de la littérature nous a permis de dégager les variables explicatives suivantes: Le contexte de l’entreprise, le contexte technologique, le contexte sécuritaire, le contexte managérial et la perception des utilisateurs. Mots clés : TIC, gouvernement électronique, numérique, TAM, TCP, UTAUT Abstract The emergence of the information society is prompting governments to play a more active role in harnessing ICTs to support the development of the digital economy. By relying on ICT, egov can increase the performance as well as the internal productivity of public administrations, through greater flexibility in decision-making processes. It also improves the quality, accessibility and proximity of services provided to citizens and companies, moving from a government based on traditional management, to an electronic government, essentially based on ICT. which allows to strengthen transparency and trust in the relationship of the State with its various partners. The main objective of this work is to try to explain and predict the variables that influence the decision to adopt and use e-government by SMEs. To do this, we mobilized the most frequently used theories and models in this field; including TAM, TCP, and UTAUT; to arrive at a conceptual theoretical model which will be; eventually ; adapted to the Moroccan context as part of an empirical study. Finally, the examination of the literature review allowed us to identify the following explanatory variables : The context of the company, the technological context, the security context, the managerial context and the perception of users. Keywords : ICT, electronic gouvernement, digital, TAM, TCP, UTAUT

The activation loop (A-loop) plays a key role in regulating the catalytic activity of protein kinases. Phosphorylation in this region enhances the phosphoryl transfer rate of the kinase domain and increases its affinity for ATP. Furthermore, the A-loop possesses autoinhibitory functions in some kinases, where it collapses onto the protein surface and blocks substrate binding when unphosphorylated. Due to its flexible nature, the A-loop is usually disordered and untraceable in kinase domain crystal structures. The resulting lack of structural information is regrettable as it impedes the design of drug A-loop contacts, which have proven favourable in multiple cases. Here, we characterize the binding with A-loop engagement between type 1.5 kinase inhibitor ‘example 172’ (EX172) and Mer tyrosine kinase (MerTK). With the help of crystal structures and binding kinetics, we portray how the recruitment of the A-loop elicits a two-step binding mechanism which results in a drug-target complex characterized by high affinity and long residence time. In addition, the type 1.5 compound possesses excellent kinome selectivity and a remarkable preference for the phosphorylated over the dephosphorylated form of MerTK. We discuss these unique characteristics in the context of known type 1 and type 2 inhibitors and highlight opportunities for future kinase inhibitor design.

Verb inflectional morphology in French exhibits a range of complexities both in the structure of verb stems (stem-final latent consonant; vowel variation; stem-final nasal vowel ; suppletive forms ; etc.) and the organization of the inflectional system, marked for five grammatical categories: tense, aspect, mode, person and number, which in the majority of cases cannot be identified as a morphological or phonological unit. The main objective of this paper is to show that these morphosyntactic properties should be analyzed as a global affix, which operate within the same space, with no fixed order. This strategy has the advantage to 1) take into account all the verb syntactic properties, 2) avoid multiple zero suffixes, 3) avoid the use of different analyses depending on the verb class, 4) avoid non-productive and phonologically unmotivated rules of insertion of theme vowels as in [dorm-i-r-ons] dormirons, and epenthetic consonants as in [ku-d-r-ons] coudrons, 5) account for French verb inflectional system in a simple and more explanatory way than strictly segmental analyses without "motivated" processes, using massive suppletion and/or stems dependencies, where inflected verbal forms are related by arbitrary implicational associations or quantitative measures based on extensive memorization. This analysis also has the property of explaining by means of a very general principle (the Onset principle) the realization of a stem-final FC in front of the affixes 'ions' and 'iez' as in before any suffix beginning with an empty onset. The verb inflectional paradigmatic structures is captured within Construction Morphology (CxM) as stated in Booij, 2010.

PurposeDespite the increased use of wearables in education, little attention has been paid to why some students are more likely to adopt smartwatches than others. The question of what impacts the adoption of smartwatches in educational activities is still neglected. In addition, the question of how security determinants can affect the adoption of smartwatches by students has not been addressed yet. Hence, this study aims to develop a theoretical model by integrating the technology acceptance model (TAM) and protection motivation theory (PMT) to study students' adoption of smartwatches for educational purposes.Design/methodology/approachQuestionnaires were distributed to university students in Malaysia. A total of 679 valid responses were collected. The collected data were analyzed using partial least squares-structural equation modeling (PLS-SEM).FindingsThe results of data analysis provide support for the proposed model. Furthermore, the findings indicated that perceived vulnerability, self-efficacy, response efficacy, response cost, ease of use and perceived usefulness have significant effects on students' behavioral intention to use smartwatches for educational purposes. In addition, perceived ease of use of smartwatches for educational purposes helps students to realize the benefits of this technology.Originality/valueThis is an original study that develops a new holistic theoretical model by combining the PMT and TAM to study the effects of ease of use, usefulness and security-related factors on the adoption of smartwatches for educational purposes. The study offers practical implications for universities and higher education institutions to improve students' learning experiences to ensure their sustainability using new and innovative ways by exploiting new technologies such as smartwatches.

PurposeThis article aims to analyze individual-, organizational- and country-level factors that determine the use of home-based telework across Europe according to the technology acceptance model (TAM) and the technology–organization–environment model.Design/methodology/approachTo examine the impact of individual-, organizational- and country-level factors on telework, multilevel models are estimated to prevent problems derived from biased standard errors when micro- and macro-level data are combined.FindingsThe main findings show that, according to the usefulness side of the TAM, employees with family responsibilities, those that live away from their work and highly qualified workers use more home-based telework. Additionally, and according to the ease of use side of the TAM, empowerment in firms facilitates home-based telework. At the country level, lower power distance, individualism and femininity, better telework regulations and technology developments are also facilitators of home-based telework.Research limitations/implicationsThe study is limited by the cross-sectional nature of the data. This prevents the estimation of causal effects. Additional research would benefit from the use of panel data and from a more detailed analysis of the effects of country dimensions.Practical implicationsFrom an applied perspective, politics related to cultural dimensions are suggested to stimulate home-based telework.Originality/valueThe research contributes to previous literature by: (1) considering a large sample to conduct an empirical analysis of the use of home-based telework across Europe, (2) including micro and macro factors, (3) providing a theoretical framework to explain home-based telework, (4) applying a rigorous definition of home-based telework and (5) focusing on employees who are able to adopt home-based telework.

PurposeThis research introduces the combined use of partial least squares–structural equation modeling (PLS-SEM) and necessary condition analysis (NCA) that enables researchers to explore and validate hypotheses following a sufficiency logic, as well as hypotheses drawing on a necessity logic. The authors’ objective is to encourage the practice of combining PLS-SEM and NCA as complementary views of causality and data analysis.Design/methodology/approachThe authors present guidelines describing how to combine PLS-SEM and NCA. These relate to the specification of the research objective and the theoretical background, the preparation and evaluation of the data set, running the analyses, the evaluation of measurements, the evaluation of the (structural) model and relationships and the interpretation of findings. In addition, the authors present an empirical illustration in the field of technology acceptance.FindingsThe use of PLS-SEM and NCA enables researchers to identify the must-have factors required for an outcome in accordance with the necessity logic. At the same time, this approach shows the should-have factors following the additive sufficiency logic. The combination of both logics enables researchers to support their theoretical considerations and offers new avenues to test theoretical alternatives for established models.Originality/valueThe authors provide insights into the logic, assessment, challenges and benefits of NCA for researchers familiar with PLS-SEM. This novel approach enables researchers to substantiate and improve their theories and helps practitioners disclose the must-have and should-have factors relevant to their decision-making.

Tunjuk Ajar Melayu (TAM) is very important for Malay people, especially in the past trying after all their power to disseminate, bequeath and perpetuate the teaching values ​​referred to through literature (both oral and written). Understanding and living a literary work, one of which is through the study of stylistics. Stylistics as one of the sub-sciences in literature plays a large role in the study of literature because it examines the way the writer uses elements and language rules by looking for the effects caused by the use of language, examining the characteristics of the use of language in literature. Stylistics studied the use of the figure of speeches in its function. In this study, the researcher formulated the research problems, what was the comparative and linkage figure of speeches in TAM by Tenas Effendy?. Therefore, this research was conducted to describe, analyze, and interpret the comparative and linkage figure of speeches contained in TAM by Tenas Effendy. This research used the content analysis method. The data was collected through documentation and hermeneutic techniques. The data was documented by reading, taking notes, then summarizing and grouping according to the type of work. The results of this study were comparative figure of speeches in TAM by Tenas Effendy consisting of simile, personification, metaphor, and allegory. The linkage figure of speech in TAM by Tenas Efendy consisted of synecdoche figure of speech of tutom pro parte category.

Purpose This paper aims to examine the determinants that influence bank users’ acceptance for Islamic financial technology (FinTech) services by extending the technology acceptance model (TAM) in the Malaysian context. Design/methodology/approach The survey was conducted using convenience sampling. Moreover, 205 responses were gathered from users of the Islamic bank. On the same note, the literature on determinants of Islamic FinTech acceptance and TAM was reviewed as well in a bid to contribute to the factors that are instrumental in determining the acceptance of FinTech services. Findings Findings of the study reveal that Islamic FinTech’s services acceptance is determined by perceived ease of use, perceived usefulness and also by another variable, which is consumer innovativeness (CI). On the contrary other factors, self-efficacy and subjective norms are found not to be influential in determining Islamic FinTech’s acceptance by Islamic banking users. Originality/value TAM is extended in the context of Islamic FinTech. A new variable, namely, CI is tested using TAM. CI is yet to be tested, therefore, this paper will be a useful reference for the policymakers, academicians and future researchers.

The primary purpose of the research is to examine and validate determinants of user intention to use AutoCAD software, utilising the constructs from prior studies in a more integrated model. The paper proposes a revised Technology Acceptance Model (TAM) for measuring the adoption of AutoCAD. In the study, a latent construct PPA (perceived physical accessibility) was added to the proposed research model as a new determinant of AutoCAD adoption. An online survey of AutoCAD users was conducted to collect data. This data was empirically used to test the proposed research model. The Structural Equation Modelling (SEM) technique was used to evaluate the causal model, and the confirmatory factor analysis was performed to examine the reliability and validity of the measurement model. The study results show that user behavioural intention to use AutoCAD is significantly affected by three determinants: perceived usefulness, perceived ease of use and perceived physical accessibility of the software. This finding contributes to an expanded understanding of the factors that promote acceptance of AutoCAD software. Moreover, the main contribution of this study is to verify the impact of the added PPA variable on the behavioural intention to use and the actual use of AutoCAD, and also to create measurement scales for this new latent variable in TAM.

Background Prevention of metabolic complications of long‐term adjuvant endocrine therapy in breast cancers remained a challenge. We aimed to investigate the molecular mechanism in the development of tamoxifen (TAM)‐induced fatty liver in both estrogen receptor (ER)‐positive and ER‐negative breast cancer. Methods and results First, the direct protein targets (DPTs) of TAM were identified using DrugBank5.1.7. We found that mitogen‐activated protein kinase 8 (MAPK8) was one DPT of TAM. We identified significant genes in breast cancer and fatty liver disease (FLD) using the MalaCards human disease database. Next, we analyzed the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of those significant genes in breast cancer and FLD using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING). We found that overlapping KEGG pathways in these two diseases were MAPK signaling pathway, Forkhead box O (FoxO) signaling pathway, HIF‐1 signaling pathway, AGE‐RAGE signaling pathway in diabetic complications, and PI3K‐Akt signaling pathway. Furthermore, the KEGG Mapper showed that the MAPK signaling pathway was related to the FoxO signaling pathway. Finally, the functional relevance of breast cancer and TAM‐induced FLD was validated by Western blot analysis. We verified that TAM may induce fatty liver in breast cancer through the MAPK8/FoxO signaling pathway. Conclusion Bioinformatics analysis combined with conventional experiments may improve our understanding of the molecular mechanisms underlying side effects of cancer drugs, thereby making this method a new paradigm for guiding future studies on this issue.

This study aims to examine and prove empirically the effect of perceived usefulness, perceived ease of use, social influence, facilitating conditions on tax compliance. The sample selection technique uses convenience sampling obtained 100 samples taxpayers in Directorate General of Taxation III East Java. Data analyzed using partial least square. The result shows that (1) perceived ease of use does not affect tax compliance. (2) Perceived usefulness has a positive effect on tax compliance. (3) Social influence has a positive effect on tax compliance. (4) Facilitating conditions does not affect tax compliance.

The modern automobile industry is rapidly shifting toward the era of self-driving cars. Due to rapid technological development, many mechanical parts in automobiles have been switched to electronic devices. Therefore, the proportion of electronic devices in modern cars is increasing. Even though many parts have been replaced by electronic devices, vehicles still require the periodic maintenance not only for mechanical parts, but also for automotive electronics. To guarantee the high reliability of automotive Application-Specific Integrated Circuits (ASICs), automotive chips are tested during manufacturing for functional and structural defects. Moreover, automobile chips are also tested using several in-field diagnostic techniques (e.g., online Built-In Self-Test (BIST), Software-Based Self-Test (SBST)) while the chips are operating. By using these in-field diagnostic techniques, functional and structural defects in automotive ASICs, which occur in the early-life cycle and normal operation, can be detected. However, automotive semiconductor devices still require testing for aging-induced defects and soft errors to prevent critical functional failures. Moreover, aging-induced defects are hard to detect with conventional in-field diagnostic techniques which is based on BIST techniques. Thus, this work presents a secure Controller Area Network (CAN) -based Test Access Mechanism (TAM) for aging defect diagnosis with efficient soft-error resilient scan cell design for automotive ASICs. The proposed TAM incurs area overhead of 6% to 9% depending upon the selection of mode identification. Further, the proposed Aging monitoring and Soft Error Resilience Flip Flop (ARFF) incurs 22% less area and power as compared to separate implementation of the Built-In Soft Error Resilience (BISER) and the Early Capture Flip Flop (ECFF).

The tumor microenvironment (TME) plays a critical role in promoting the growth and metastasis of glioblastoma (GBM). Tumor-associated macrophages (TAMs), the most abundant myeloid cells infiltrating in TME, produce proinflammatory cytokines, regulate glioma cell pools, and lead to GBM progression. Understanding the mechanism of GBM-TAMs regulation can help to find new targeted therapeutic strategies against GBM. Based on the CGGA and TCGA GBM cohorts, ARPC1B was defined as the key macrophage-associated gene with prognostic value. Higher ARPC1B expression was associated with progressive malignancy, poor outcomes and TAM infiltration. We demonstrated that macrophage-expressed ARPC1B promoted the migration, invasion, and epithelial–mesenchymal transition of glioma cells. Glioma-intrinsic ARPC1B also maintained the malignant phenotype and promoted macrophage recruitment. Positive feedback signaling between macrophages and glioma cells via ARPC1B was determined to be under control of the IFNγ-IRF2-ARPC1B axis. This study highlights the important role of ARPC1B in GBM malignancy progression and the regulation network between GBM and TAMs, suggesting ARPC1B as a novel biomarker with potential therapeutic implications.

Industrial developments that occurred today are fast; we are living in an era of sophisticated technology. Indonesia ranked second (24.3%) among countries where the adoption of mobile payment apps is growing most fast. One of the most developed services is the mobile wallet. Observing this phenomenon, researchers decided to examine what factors influence mobile wallet adoption and whether the offers made by mobile wallet platforms affect the adoption of technology. This research employs an extended Technology Acceptance Model (TAM) to understand what influences the intention to adopt the mobile wallet. We investigated those variables-perceived usefulness, perceived ease of use, perceived risk, social influence, mobility and price sensitivity. Online questionnaires were distributed, and a sample of 221 respondents was collected for analysis through the structural equation model (SEM) approach with AMOS software. The findings from the study revealed that perceived ease of use, social influence, and mobility significantly impact society's behavioral intention to adopt mobile wallets. In contrast, perceived usefulness and perceived risk do not significantly impact society to adopt a mobile wallet. Perceived ease of use, social influence, and mobility have a positive relationship with adopting a mobile wallet. However, the price sensitivity variable was eliminated.

La transición hacia un mundo más sostenible, sobre todo, ecológicamente parece ser que se está acelerando y que, lo tenemos a la vuelta de la esquina. Para ello, el sector de los automóviles ha ido, poco a poco, desarrollándose para ofrecer modelos mucho menos contaminantes, como son los híbridos y los eléctricos. En España, se encuentra que existe una notable carencia de investigaciones sobre la aceptación de los consumidores y el por qué el número de usuarios de la tecnología avanza tan lentamente. Para solventar esta significativa falta, se desarrolla este estudio, con el objetivo de comprender la aceptación de los clientes de los coches eléctricos e híbridos con base en el modelo TAM. A partir de esta línea, se ha desarrollado una investigación que rodea a todo el mercado gracias a su doble perspectiva de la oferta y la demanda, usando la entrevista como técnica cualitativa y la encuesta como cuantitativa, respectivamente. Usando diferentes análisis, y teniendo en cuenta las limitaciones del modelo creado, se concluye que la desinformación, la infraestructura reducida de carga, la autonomía de los coches y el precio suponen importantes inhibidores para la intención de uso. Asimismo, se observa que la facilidad de uso y la utilidad de estos coches, una vez probados, la actitud y los incentivos socioeconómicos son promotores para la intención de compra.