1. High pretreatment neutrophil-to-lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta-analysis
- Author
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Lin Yang, Yuhong Dai, Yu Huang, Lie Zhou, and Guangyuan Hu
- Subjects
0301 basic medicine ,Oncology ,Male ,medicine.medical_specialty ,Clinical Review ,Neutrophils ,platelet‐to lymphocyte ratio ,head and neck squamous cell carcinoma ,Disease-Free Survival ,Clinical Reviews ,03 medical and health sciences ,0302 clinical medicine ,Survival prognosis ,Internal medicine ,Overall survival ,Biomarkers, Tumor ,Medicine ,Humans ,Prognostic biomarker ,Lymphocyte Count ,Neutrophil to lymphocyte ratio ,business.industry ,Squamous Cell Carcinoma of Head and Neck ,Hazard ratio ,medicine.disease ,Prognosis ,neutrophil‐to‐lymphocyte ratio ,Head and neck squamous-cell carcinoma ,Survival Analysis ,Confidence interval ,Neoadjuvant Therapy ,030104 developmental biology ,Otorhinolaryngology ,Head and Neck Neoplasms ,meta‐analysis ,030220 oncology & carcinogenesis ,Meta-analysis ,Female ,business - Abstract
Background The prognostic roles of neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) have been reported in head and neck squamous cell carcinoma (HNSCC), but their results remain controversial. Methods A total of 25 literatures with 28 cohorts involving 6847 HNSCC patients were included. The hazard ratio (HR) was pooled with 95% confidence interval (CI) using fixed‐effects or random‐effects models. Results High pretreatment NLR predicted poor overall survival (OS: HR = 1.68; 95% CI = 1.39‐2.03; P
- Published
- 2017