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Aim: Intraventricular hemorrhage (IVH) is a serious complication of premature births, especially in newborns with very low birth weight. It's important to be able to predict IVH. In this study, the relationship between platelet lymphocyte rate (PLR) and intraventricular hemorrhage in premature infants born under 28 weeks was examined.Material and methods: In the last 5 years, the medical records of infants with less than 28 weeks of gestational age (n=78) born in our hospital have been retrospectively examined. Obtained parameters from the whole blood count, especially the relationship between TLO and IVH were examined.Results: White blood cell and lymphocyte counts were significantly higher in severe IVH (grade 3-4), while TLO was found to be significantly lower (16048±5265 & 11972±10915, p=0.043; 10705±4537 & 6329±8101, p=0.007; 36.9±22.7 & 56.7±37.9 p=0.012, respectively). When the white blood cell, lymphocyte count, and PLR's diagnostic performance in predicting severe IVH were evaluated by ROC curve analyses, it was observed that the strongest performance belonged to the PLR (Area under the curve, AUC for WBC: 0.644; ALS: 0.687; PLR:0,691, respectively). PLR can estimate severe IVH with 94% sensitivity and 43% specificity at a cut-off value below 55.84.Conclusion: PLR can be used as a valuable marker for predicting IVH in extremely premature infants., Amaç: İntraventriküler hemoraji (IVH), özellikle çok düşük doğum ağırlıklı yeni doğanlarda prematüre doğumların ciddi bir komplikasyonudur. IVH’i tahmin edebilmek oldukça önemlidir. Bu çalışmada 28 hafta altında doğan prematüre bebeklerde doğumda bakılan trombosit lenfosit oranı (TLO) ve intraventriküler hemoraji (IVH) arasındaki ilişki incelenmek istenmiştir.Gereç ve yöntem: Son 5 yılda hastanemizde yatan 28 hafta altı prematüre bebeklerin (n=78) dosyaları geriye dönük incelendi. Doğum sonrası bakılan tam kan verilerinden elde edilen parametreler ve özellikle TLO ve IVH arsındaki ilişki incelendi.Bulgular: Beyaz küre ve lenfosit sayıları ciddi IVH’te (grade 3-4) anlamlı yüksek bulunurken, TLO anlamlı düşük bulunmuştur (sırasıyla 16048±5265 & 11972±10915, p=0,043; 10705±4537 & 6329±8101, p=0,007; 36,9±22,7 & 56,7±37,9 p=0,012). Beyaz küre, lenfosit sayısı ve TLO’nun ciddi IVH’i öngörmede tanısal performansları ROC eğrisi analizleri ile değerlendirildiğinde en güçlü performansın TLO’ya ait olduğu gözlemlendi (sırasıyla eğri altında kalan alan WBC: 0,644; ALS: 0.678; TLO:0,691). TLO kesme değeri 55,84 altındaki değerlerde %94 sensitivite ve %43 spesifite ile ağır IVH’i tahmin ettirebilir.Sonuç: TLO ileri derecede immatur bebeklerde ciddi IVH’i öngörmede değerli bir belirteç olarak kullanılabilir.

Background: Chronic inflammation has been linked to the development and prognosis of neuroendocrine tumors (NETs). The current study intended to evaluate the role of peripheral hematological inflam...

Background Sepsis is the most common cause of death in infants and children worldwide. Identification of patients with a high risk of death and accurately anticipating outcomes in the early phase is very important in order to provide adequate intervention to the patient. Predictors and scoring systems have been used to determine the prognosis of sepsis n children. The platelet-lymphocyte ratio (PLR), a newly-used marker for inflammation, has received recent attention, as it can act as an indicator in a variety of diseases, including sepsis. Objective o investigate the relationship between PLR and clinical outcomes in pediatric patients with sepsis. Methods This study was conducted using an analytic, observational method with a prospective cohort approach in children with sepsis in the Pediatric Intensive Care Unit (PICU) of Prof. Dr. R. D. Kandou Central General Hospital, Manado, North Sulawesi, from February to August 2020. We analyzed patients’ platelet-lymphocyteratio (PLR), mortality rate, and length of stay using SPSS software. The PLR were recorded once within the first 24 hours of PICU admission. Results Of 96 PICU patients, 87 patients were eligible for this study. In total, 50 patients (57.47%) died. Mean PLR was 77.53 among sepsis survivors and 157.2 among non-survivors (rpb=0.566, P

Introduction:Acute pulmonary embolism (APE) is a common and sometimes fatal form of venous thromboembolism. The fact that patients do not consult with a specific clinical picture and accompanying comorbid conditions make the diagnosis difficult. Chronic renal failure is one of the comorbid conditions with increased susceptibility to thrombosis. Due to clinical presentation variabilities, the limited use of the d-dimer test in patients with renal dysfunction, and the limitation of use of computed tomography (CT) angiography due to potential renal side effects, an easily accessible, inexpensive, sensitive and specific guide laboratory parameter within acceptable limits is needed in the diagnosis of patients with impaired renal function. In this study, neutrophil/lymphocyte ratios (NLR) and platelet/lymphocyte ratios (PLR) will be compared between two patient groups with and without renal dysfunction and APE attack. It is aimed to demonstrate the usability of these rates together with clinical, laboratory and radiological evaluations in the diagnosis of pulmonary embolism.Methods:In the selection of patient groups, the retrospective files of patients with chronic renal failure who applied to the emergency service of our hospital between January 2015 and 2019 and then were diagnosed with APE were examined. The control group consist of the patients with chronic renal failure who applied to the nephrology and internal medicine outpatient clinic without any additional pathology. Information such as gender, age, existing diseases, laboratory tests such as hemogram, D-dimer, troponin, creatinine glomerular filtration rate, lower extremity venous Doppler ultrasonography and thorax CT angiography results of the patients were recorded. NLR and PLR ratios were calculated in all groups. The results were evaluated with SPSS.Results:NLR and PLR values were found to be significantly higher in the case group diagnosed with pulmonary embolism (p=0.000). At NLR 3.50 cut-off value, sensitivity was 70.6%, positive prediction was 84.6%, specificity was 86.8%, and negative prediction was 74.2%. Sensitivity was 68.8%, positive prediction was 67.0%, specificity was 65.1%, negative prediction was 67% at PLR 125 cut-off value.Conclusion:NLR and PLR values can be used in addition to clinical, laboratory and imaging methods in the diagnosis of APE in patients with chronic renal failure and can give results that may help the clinician. However, more comprehensive studies should be conducted with larger case groups

BACKGROUND Cardiovascular disease is a significant health problem in India with an estimate 3.7 million deaths each year. Mechanisms of myocardial ischemia include inflammation, endothelial dysfunction, platelet aggregation and coagulation. Acute coronary syndrome occurs due to rupture of atherosclerotic plaque. Platelets play a role in both development and rupture of the atherosclerotic plaque. Lymphocytes play a role in chronic inflammation of atherosclerosis. Lower lymphocyte count has increased mortality after acute myocardial infarction. METHODS The study was conducted in Department of General Medicine, Karnataka Institute of Medical Sciences, Hubli from February 2019 to December 2020. It is a prospective observational study. Patients aged ≥ 18 years with ST-elevated myocardial infarction (STEMI) were included in the study. Total 156 cases were selected based on inclusion and exclusion criteria. Cardiovascular events during the in-hospital period were noted. The study population was divided into tertiles based on the platelet-lymphocyte ratio (PLR) values. The low PLR group (n = 104) was defined as having values in the lower 2 tertiles (PLR ≤ 148.4) and the high PLR group (n = 52) was defined as having values in the highest tertile (PLR > 148.4). A ‘P’ value < 0.05 was considered statistically significant. RESULTS Out of 156 patients, 103 (66 %) were males and 53 (34 %) cases were female. Mean age group was 59 ± 10 years. Percentage of patients who underwent thrombolysis was higher in high PLR group (65.38 % vs. 48.07 %, P = 0.041). Death rate was higher in high PLR group (28.84 % vs. 8.65 %, P = 0.001). PLR > 148.4 was found to be an independent predictor of in-hospital cardiovascular mortality in multivariate analyses (hazard ratio: 13.222 (2.113-21.749) P = 0.006 with 95 % confidence interval). Receiver operating curve (ROC) analyses, a PLR value of 148.4 for in-hospital mortality rate had sensitivity of 62.5 % and a specificity of 72 % (area under the curve = 0.627, 95% confidence interval 0.485 – 0.769). CONCLUSIONS In our study, higher PLR had significant association with in-hospital mortality in patients with STEMI. KEYWORDS ST Elevation Myocardial Infarction (STEMI), Platelet/Lymphocyte Ratio (PLR), Ischemic Heart Disease (IHD)

Background: Early identification of risk factors for short-term mortality in patients with in-hospital cardiac arrest (IHCA) is crucial for early prognostication. This study aimed to explore the association of early dynamic changes in inflammatory markers with 30-day mortality in IHCA patients.Methods: This study retrospectively collected demographic and clinical characteristics and relevant laboratory indicators within 72 h after recovery of spontaneous circulation (ROSC) of IHCA patients from December 2015 to December 2020 at the First Affiliated Hospital of Chongqing Medical University. The outcome was 30-day mortality. A linear mixed model was used to analyze the dynamic changes in laboratory indicators within 72 h after ROSC, and Cox regression was used to identify the independent risk factors for 30-day mortality.Results: Overall, 85 IHCA patients were included. The 0-72h and 0-30day cumulative mortality rates were 25.88% and 57.65%, respectively, and the median survival time was 13.79 days. There was no association of inflammatory markers before IHCA with mortality. Within 72 h after ROSC, inflammatory markers showed various changes: the absolute monocyte count (AMC) showed no significant change trend, and the absolute lymphocyte count (ALC) showed an overall upward trend, while the absolute neutral count (ANC), white blood cell (WBC) count, platelet (PLT) count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) showed an overall downward trend. Cox multivariate analysis showed that Charlson comorbidity index (CCI) (HR = 2.366, 95%CI (1.084, 5.168)), APACHE II score (HR = 2.550, 95% CI (1.001, 6.498)), abnormal Cr before IHCA (HR = 3.417, 95% CI (1.441, 8.104)) and PLR within 72 h after ROSC (HR = 2.993, 95% CI (1.442, 6.214)) were independent risk factors for 30-day mortality. When PLR ≥ 180, the risk of 30-day mortality increased by 199.3%.Conclusions: This study clarified the dynamic change trends of inflammatory markers within 72 h after ROSC. The PLR was an independent risk factor for 30-day mortality in IHCA patients; it can be used as a predictor of short-term mortality and provide a reference for early prognostication.Trial registration: ChiCTR1800014324

Background/Aim: Stroke is a major cause of death and disability worldwide. Inflammatory markers for poor outcomes in stroke patients have been widely studied, but these examinations are often constrained by limited costs and facilities. Platelet lymphocyte ratio is one of the markers of inflammation that is easily examined, only a few researches were studied on stroke patients, especially ischemic type. This article aimed to understanding high platelet lymphocyte ratio as a risk factor for poor outcome in acute ischemic stroke patients. Method: The design of this research is literature review by literature from 32 journal and 5 textbooks. Journals obtained from search engines Pubmed, Google Scholar, and NCBI. Result: Based on the results of the literature review, circulating platelets play an important role in the development and resolution, not only because of their direct effect on the endothelium but also by releasing inflammatory mediators. Acute ischemic stroke will induce lymphocyte apoptosis, which causes impaired immune system. High platelet counts and low lymphocytes contribute to micro-thrombus formation, which increases the risk of stroke and has a poor prognosis in patient. Conclusion: There is an increase platelet lymphocyte ratio can be an independent predictor of poor outcome in acute ischemic stroke patient Keywords: acute ischemic, stroke, platelet lymphocyte ratio, poor outcome

PURPOSE To evaluate complete blood count (CBC)-derived inflammatory indices in central retinal artery occlusion (CRAO). METHODS A total of 42 patients with CRAO (CRAO group) and 42 age- and sex-matched subjects without CRAO (Control group) were included. CBC parameters including red cell distribution width (RDW) levels were assayed. Platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and neutrophil/ lymphocyte ratio (NLR) were calculated. RESULTS RDW, PLR, SII and NLR values were significantly higher in CRAO group than control group [15.2 ± 1.47% vs 13.96 ± 1.13% (p < .001), 127.94 ± 48.21 vs 101.16 ± 24.84 (p = .008), 667.11 ± 357.84 vs 493.44 ± 207.07 (p = .008), 2.70 ± 1.27 vs 2.13 ± 0.83 (p = .018), respectively]. In multivariate analysis only RDW was independent predictor for CRAO (OR 2.317, p < .001). On ROC analysis, area under curve of RDW, PLR, SII, and NLR for CRAO were 0.761, 0.685, 0.622 and 0.618, respectively. CONCLUSION RDW seems superior to other inflammatory indices to predict CRAO.

To evaluate the association between two inflammatory biomarkers of neutrophil -lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) with gestational diabetes mellitus (GDM).Systematic search was performed up to June 2020 in databases such as PubMed, Embase, Scopus, Web of Science, and Google scholar. The random-effects model was utilised to combine the weighted mean differences (WMDs) and their 95% confidence intervals (CIs).Out of a total of 849 articles, sixteen studies were eligible. Our findings indicated higher NLR (WMD = 0.48, 95% CI: 0.25, 0.71) and PLR (WMD = 8.22, 95% CI: -0.50, 16.94) values in pregnancies diagnosed with GDM compared with non-GDM control pregnancies. However, the difference in PLR value did not reach a statistically significant level (Z = 1.85,The current meta-analysis is the first, to our knowledge, to show that NLR value is significantly associated with GDM. However, PLR showed no significant association with GDM.

Objective: To investigate neutrophil/lymphocyte (NLR), lymphocyte/monocyte (LMR), platelet/lymphocyte (PLR) ratios, and the value of these parameters in determining disease severity and progression in hospitalized COVID-19 patients. Materials and Methods: Study was conducted retrospectively with 182 in-patients and 91 controls due to COVID-19 between April-September 2020 in the chest diseases clinic. Hematological parameters and rates were compared with controls’ parameters. Correlations and differences between hematological parameters and other parameters were investigated. Results: Lymphocyte, monocyte, eosinophil, basophil, hemoglobin, thrombocyte, and LMR were significantly lower. NLR and PLR were higher. There were significant increases in hematological parameters and PLR on discharge. A positive correlation existed between radiological pneumonia severity score, and NLR (r=0.234, p=0.001) and PLR (r=0.128, p=0.042), and significant inverse correlation with LMR (r=-0.206, p=0.003). Positive correlations were detected between NLR (r=0.140, p=0.030) and PLR (r=0.125, p=0.046), and symptom-discharge time, and inverse correlation between LMR, and both symptom-discharge (r=-0.137, p=0.032) and hospital stay time (r=-0.135, p=0.034). A positive correlation existed between CRP, and NLR and PLR on admission and discharge. Conclusion: NLR, LMR and PLR were found as hematological predictors to be used with CRP in following-up COVID-19, showing a significant correlation with disease severity, monitoring responses to treatment and predicting prognosis.

Introduction: Acute Coronary Syndrome (ACS) has morbidity and mortality significantly increase, it requires risk stratification for the assessment and selection of initial invasive strategies. The Global Registry of Acute Coronary Events (GRACE) scores recommended as risk stratification of ACS. Some of studies found that the combination of GRACE scores with other clinical and laboratory parameters can increase predictive value of ACS. Platelet Lymphocyte Ratio (PLR) and Neutrophil Lymphocyte Ratio (NLR) act as parameter of systemic inflammation in ACS. Aims of the study to determine the association between PLR and NLR with risk stratification GRACE score. Method: This study is analytical with a cross-sectional retrospective design. This study included 70 patients with a diagnosis of ACS based on medical record data. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) 22.0. P-value

This work aimed to analyze the value of serum platelet/lymphocyte ratio (PLR), carbohydrate antigen 125 (CA125), and diffusion-weighted imaging (DWI) in the diagnosis of recurrent ovarian cancer.Forty-three patients with suspected recurrence of ovarian cancer were deemed as research objects, and 5 healthy people were set as controls. PLR, DWI, and CA125 level before surgery were analyzed. Pearson correlation analysis was implemented to explore the correlation between CA125 and lymphocyte count, platelet count, and PLR. Neuropathic Pain Scale was adopted to analyze the analgesic effect of patients with recurrent ovarian cancer before treatment and 7 days after treatment. Moreover, the quality of life scores of patients with recurrent ovarian cancer were evaluated before treatment and 30 days after treatment.The platelet and PLR values of patients with recurrent ovarian cancer were significantly higher relative to healthy people (P0.001), while the lymphocyte count was relatively lower (P = 0.002). There were considerable differences in PLR and CA125 levels in patients with recurrent ovarian cancer before and after treatment (P0.001). The single detection of CA125 was significantly better than that of DWI and PLR (P = 0.034). The sensitivity and specificity of CA125 detection alone was 77.3% and 81.8%, respectively, while those of the joint detection of DWI + PLR + CA125 was 92.4% and 79.9%, respectively. PLR was proved to be positively correlated with CA125 before and after treatment (r = 0.687, P0.001). Pain scores in all aspects of patients with recurrence of ovarian cancer after treatment were lower than that before treatment (P0.001), and the quality of life score was significantly higher than that before treatment (P0.001).CA125 and PLR combined with DWI had the best diagnostic effect for patients with recurrent ovarian cancer. After treatment, the levels of PLR and CA125 were reduced and the quality of life of patients was improved.

Objectives:Neutrophil/lymphocyte (NLR), Monocyte/HDL (MHR), lymphocyte/monocyte (LMR) and platelet/lymphocyte ratios (PLR) are inflammation markers with proven prognostic values in various cardiovascular diseases. However, a clinical study demonstrating the prognostic value of these markers in heart failure (HF) patients treated with an implantable cardioverter-defibrillator (ICD) is not yet available. It is aimed to demonstrate the relationship between NLR, MHR, LMR, PLR and mortality development in patients with HF with ICD.Materials and Methods:One hundred and ninety-four patients who underwent ICD implantation due to systolic HF between January 2015 and December 2019 were included in the study.Results:The mean age was 59.84±13.26 years. The female gender ratio was 25.3%. Death developed in 16 patients (8%) after a median follow-up of 27 months. While basal urea, uric acid, gamma-glutamyl transferase, C-reactive protein and neutrophil levels were found to be high, hemoglobin and lymphocyte levels were found to be low in the exitus developing group. While the rates of NLR, MHR and PLR were statistically significantly higher in the group with death during follow-up (p=0.001, p=0.049, p=0.020, respectively ), LMR was significantly lower (p

Introduction:The platelet/lymphocyte ratio (PLR) has been studied frequently to determine the prognosis of cardiovascular diseases, chronic inflammatory diseases, and malignancies. Particularly, the PLR is an indicator of systemic inflammation and atherosclerosis. In this study, we aimed to evaluate the value of the PLR and its relationship with mortality, cerebral hemorrhagic transformation, and short-term prognosis in patients with stroke treated with intravenous thrombolysis.Methods:Two hundred fifty stroke patients treated with intravenous thrombolysis were included in the study. Initial symptoms, comorbidities, and localization of cerebral ischemia were recorded. Disability was scored on the National Institutes of Health (NIH) stroke scale. At the 24th and 72nd hours after treatment, hemorrhagic transformation was evaluated by brain computed tomography. The in-hospital mortality rate was calculated. Patients were divided into groups according to the difference in the NIH stroke scale (between admission and discharge). Serum platelet and lymphocyte levels and PLR values were determined.Results:There were 128 (51.2%) female and 122 (48.8%) male patients included in the study. Their mean age was 71.88±12.36 years. The lymphocyte count was low and the PLR was high in patients with a high level of initial disability (p

Patient prognosis in hypopharyngeal carcinoma remains difficult to predict, necessitating new, readily available biomarkers.Platelet-lymphocyte ratio (PLR)'s effects on recurrence-free survival (RFS) and overall survival (OS) were evaluated in individuals undergoing radical resection for advanced hypopharyngeal squamous cell carcinoma (HSCC).A total of 89 patients were retrospectively assessed. PLR, and derived neutrophil-lymphocyte (dNLR) and neutrophil-lymphocyte (NLR) ratios were determined based on complete blood count. Then, the prognostic values of PLR, dNLR and NLR were assessed by univariate and multivariate Cox regression analyses adjusted for disease-specific prognostic factors. Endpoints of interest were RFS and OS.The optimal cutoff of PLR was 98.815, based on which individuals were categorized into the high- (PLR ≥98.815) and low- (PLR98.815) PLR groups. High PLR (Elevated PLR has associations with increased risk of recurrence and reduced survival in advanced HSCC cases undergoing radical resection. High presurgical PLR may independently predict RFS. Therefore, further multi-institutional prospective studies are needed to better characterize the role of pre-operative blood PLR as prognostic factors in HSCC.

BACKGROUND We aimed to examine the effects of pre-operative blood values on varicocelectomy success. MATERIALS AND METHODS A total of 130 patients who underwent varicocelectomy in our clinic were retrospectively analyzed. Operation success was defined as the return of all semen parameters (concentration, progressive motility, and morphology) to normal values 6 months after surgery. The patients were separated as two groups as benefiting from the treatment (Group A) and not (Group B). RESULTS The best cut-off value for the neutrophil/lymphocyte ratio (NLR), which can predict varicocelectomy success, was assigned to be 2.27, with AUC of 0.859 (%95 CI 0.795-0.922). The highest sensitivity and specificity were 0.857 and 0.731 (p

Background: Platelet / lymphocyte ratio has recently been investigated in different clinical conditions associated with hemodialysis and its association with other diseases has been assessed. The purpose of the study was to assess platelet lymphocyte ratio as a predictor of erythropoietin resistance in hemodialysis patients. Methods: The study population consisted of 60 hemodialysis patients, who were subdivided into two groups according to the response to erythropoietin stimulating agents (ESAs) .treatment. Group 1 included 30 patients treated with ESAs with good response to it and group 2 included 30 patients treated with ESAs but with resistance to it. The platelet/ lymphocyte ratio was calculated for each patient and compared between both groups. Results: Platelet lymphocyte ratio of group 2 was significantly higher compared to that of group 1 (P=0.001). Conclusion: PLR is a useful parameter to predict erythropoietin resistance in hemodialysis patients.

Inflammation plays a role in the initiation and propagation of the atherosclerotic process in coronary artery disease (CAD). A low lymphocyte count has been shown to be related with worse outcome in those patients. The objective of this study is to assess the relationship between platelet/lymphocyte ratio (PLR) and severity of CAD according to angiography findings. During the period from May 2018 to September 2018, a cross-sectional study on 60 CAD patients was performed at two cardiac units belonging to Imamaein Al Khadhmein Medical City—Baghdad and AL Nasiriya Cardiac Centre—Dhi Qar. In addition to demographic data, coronary angiography findings were evaluated for the purpose of calculation of the Gensini score to indicate the severity of atherosclerosis. Patients were classified into low-risk (

Introduction. Inflammatory and anti-inflammatory response are important in pathophysiology and mortality of sepsis. Platelet as first line inflammatory marker was found increasing during early phase of infection. Decrease in lymphocyte was caused by disrupted balance between inflammatory and anti-inflammatory response. Platelet-to-lymphocyte ratio (PLR) is a cheap and accessible biomarker of sepsis mortality. This study aims to find the sensitivity and specificity of PLR as mortality predictor of sepsis in 28 days. Method. This observational analytic study with retrospective cohort design was conducted to 91 sepsis patients in intensive care unit of Dr. Mohammad Hoesin Palembang Central Hospital between January and December 2019. Samples were secondarily collected from medical record during June-July 2020. Data was analyzed using chi-square test, cog regression test, and ROC curve analysis. Results. The result found 50 patients (54,9%) died in 28 days. Morbidity score (Charlson) was the only statistically significant mortality parameter (p=0,009). The study reported PLR cut-off point of >272,22. The sensitivity and specificity of PLR as 28-days sepsis mortality predictor are 84% and 80,49% respectively. Conclusion. PLR is alternatively reliable mortality predictor in sepsis patient, accounted to its relatively high sensitivity and specificity.

Aim: We aimed to show whether easily accessible NLR, PLR, PNR and MPV values can be used as prognostic markers in lymphoma subtypes and whether they can contribute to existing prognostic scoring systems. Material and Methods: The records of all lymphoma patients between 2005-2019 were reviewed retrospectively. NLR, PLR, PNR and MPV values at the time of diagnosis were compared with Progression-Free Survival (PFS) and Overall Survival (OS) durations. Results: PLR and NLR values in Marginal Zone Lymphoma (MZL) and PNR and MPV values in Diffuse Large B-cell Lymphoma (DLBCL) were found to be associated with prognosis and to have a direct effect on PFS and OS. Except for these parameters, we found that lactate dehydrogenase (LDH), MPV, age, stage and histological subtype had an effect on prognosis for all patients. Conclusion: It has been concluded that PLR and NLR can be used as prognostic factors in MZL, whereas PNR and MPV can be used as prognostic factors in DLBCL, and that these values can be used as easily accessible methods in disease prognosis scores.

To assess the severity of major depression in relation to neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. A total of 186 patients gave their consent to participate in this study. The symptoms and the severity of depression were assessed by using the “Hamilton rating scale for depression” (HAM-D). Blood samples were collected for biochemical analysis and were subjected to measure the values of neutrophils, lymphocytes, platelets, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. The mean values of neutrophil-lymphocyte ratio in mild, moderate, severe and very severely depressed individuals were found to be 1.40 (±0.24), 2.52 (±0.27), 3.53 (±0.3) & 4.39 (±0.3) respectively and it was observed that the values of neutrophil-lymphocyte ratio was increased as the severity of the depression increases (r=0.9995, p=0.0005). The mean values of platelet-lymphocyte ratio in mild, moderate, severe and very severely depressed individuals were observed to be 147.21 (±34.25), 217.83 (±12.09), 267.31 (±15.86) & 316.29 (±18.44) respectively and it was found that the values of platelet-lymphocyte ratio was increased as the severity of the depression increases (r=0.9993, p=0.0007). Increase in severity of depression positively correlated with increase in the values of both neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR). Increased values of PLR showed a significant impact when compared to the values of NLR, as more than two third of the patients (71.5%) reported an increased values of PLR beyond their normal range when compared to the increased values of NLR which was just confined to only 4.8% of the study population.

Amaç: Bu çalışmada amacımız; Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi (SÜEAH) Pediatrik Dermatoloji Polikliniklerine müracaat eden pediatrik yaş grubunda Atopik Dermatit (AD) hastalarında, periferik kandan ölçülebilen nötrofil lenfosit oranı (NLO), trombosit lenfosit oranı (TLO), eozinofil lenfosit oranı (ELO) ile serum total immün globobülin E (T-IgE) değerleri ve kan eozinofil sayısını tespit etmek AD ile bu parametreler arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntemler: Çalışmaya dahil ettiğimiz hastalara ait veriler 01.01.2018 ile 31.10.2019 tarihleri arasında müracaat eden AD hastalarından hastane bilgi yönetimi sistemi (HBYS) üzerinden retrospektif olarak elde edildi. Kontrol grubuna alerjik hastalığı, enfeksiyonu veya kronik bir hastalığı olanlar dahil edilmedi.Bulgular: Çalışma kriterlerine uyan 30 AD hastasının 8 kız, 22 erkek olup, yaş ortalaması 9.33±5.84 olarak tespit edildi. Kontrol grubunda 30 olgunun 12’si kız, 18’i erkek olmak üzere yaş ortalaması 10.69±4.69 olarak belirlendi. AD hastalarının T-IgE değerleri 304.48±25.81 IU/mL, eozinofil düzeyleri ortalama 1.39±0.29 K/uL, NLO 2.23±1.19, TLO 123.69±41.99, ELO 0.133±0.111 olarak tespit edildi. Kontrol grubunun T-IgE değerleri 41.03±6.18 IU/mL, eozinofil düzeyleri ortalama 0.39±0.09 K/uL, NLO 1.73±0.61, 107.66±35.30, ELO 0.071±0.049 olarak tespit edildi. AD hastaları ile kontrol grubu istatistiksel olarak karşılaştırıldığında T-IgE, Eozinofil, NLO, ELO değerleri arasında (p0.05) olarak tespit edildi.Sonuç: Çalışmamızda AD hastalarında NLO, TLO, ELO ile T-IgE değerleri ile kan eozinofil düzeyleri yüksek bulunmuştur. Bu parametrelerin bu hastalığın teşhis ve takibinde önemli olduğunu ortaya koymaktadır. Bu değerlerin yüksek saptanması, daha sonraki çalışmalarda bu değerlerin referans olarak alınabilmesine katkı sağlayacaktır, Aim: Our aim in this study; In Atopic Dermatitis (AD), patients in the pediatric age group who applied to the Pediatric Dermatology Polyclinics of Sakarya University Training and Research Hospital (SUTRH), to determine neutrophil lymphocyte ratio (NLO), platelet lymphocyte ratio (TLO), eosinophil lymphocyte ratio (ELO) and serum total immune globobulin E (T-IgE) values and blood eosinophil count to investigate the relationship between AD and these parameters.Materials and Methods: The data of the patients we included in the study were obtained retrospectively from the AD patients who applied between 01.01.2018 and 31.10.2019 through the hospital information management system (HIMS). Those with allergic disease, infection or chronic disease were not included in the control group.Results: Of the 30 AD patients who met the study criteria, 8 were girls and 22 were boys, with an average age of 9.33 ± 5.84. In the control group, the average age of the patients was 12.6 girls and 18 boys, 10.69 ± 4.69. T-IgE values of AD patients were determined as 304.48±25.81 IU / mL, eosinophil levels were 1.39 ± 0.29 K / uL, NLO 2.23±1.19, TLO 123.69±41.99, ELO 0.133±0.111. T-IgE values of the control group were determined as 41.03±6.18 IU / mL, eosinophil levels on average 0.39±0.09 K / uL, NLO 1.73±0.61, 107.66±35.30, ELO 0.071±0.049. When AD patients and control groups were compared statistically, T-IgE, Eosinophil, NLO, ELO values were determined as (p 0.05).Conclusion: In our study, NLR, TLR, ELR and T-IgE values and blood eosinophil levels were found high in AD patients. It reveals that these parameters are important in the diagnosis and follow-up of this disease. High determination of these values will contribute to the reference of these values in future studies.

BACKGROUND: Breast cancer tends to respond differently to treatments, which are usually determined by clinicopathological characteristics. Several studies evaluated the role of the peripheral blood test as diagnostic and prognostic markers in several types of solid cancer and neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) are two of them which already tested. However, the evidence in breast cancer is still lacking. AIM: Therefore, the study aimed to investigate the value of NLR and PLR as biomarkers concerning breast cancer stage. METHODS: A retrospective study was conducted using breast cancer patients’ medical records from 2014 to 2019 at Sanglah General Hospital. The histopathological records and complete blood counts of the patients were collected and analyzed risk analysis model, receiver operator characteristics analysis, and correlation of NLR and PLR with cancer staging analysis used correlation test. RESULT: One hundred five patients data were used in this study, with 35 subjects had early-stage breast cancer while 70 subjects had an advanced stage. Breast cancer staging with NLR and PLR showed significant associations (p < 0.001). Both NLR and PLR had area under the curve >0.7 (p < 0.001). The cutoff, sensitivity, and specificity values of NLR and PLR were 2.504 (71%; 70%) and 157.1 (73%; 70%). Advanced stage of breast cancer was mostly found in high NLR and PLR value with (OR: 4.231; CI = 1.791-9.995, p < 0.001) and (OR: 3.949; 95% CI = 1.679–9.287; p < 0.001). CONCLUSION: From this preliminary study, pretreatment NLR and PLR values might determine the breast cancer stage. Further research is needed to evaluate the association between grade and patient survival.

Left ventricular thrombosis (LVT) is a potentially devastating complication in post-acute myocardial infarction (AMI) patients. Previous studies have demonstrated that inflammation may contribute to thrombus formation, but its role on thrombus resolution is uncertain. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are easily accessible haematological markers of inflammation.We aimed to identify differences between post-AMI LVT patients with and without LVT resolution, and to evaluate the utility of NLR and PLR in predicting LVT resolution.We included 289 consecutive post-AMI patients with LVT. Acute LVT was diagnosed based on echocardiogram. Patients were stratified based on LVT resolution. Logistic regression was performed to evaluate for independent predictors of thrombus resolution.Compared to post-AMI patients with eventual LVT resolution, those with unresolved LVT had more co-morbidities such as hypertension (p = 0.003) and ischaemic heart disease (p 0.001), fewer underwent percutaneous coronary intervention (PCI) (p 0.001) or were treated with triple therapy (p 0.001). NLR (p = 0.064) and PLR (p = 0.028) were higher in unresolved LVT patients. In non-PCI patients, NLR (OR 0.818, 95% CI 0.674-0.994, p = 0.043) and PLR (OR 0.989, 95% CI 0.979-0.999, p = 0.026) were independent predictors of thrombus resolution after adjustment for age and anticoagulation use.Post-AMI patients not receiving PCI may have a greater inflammatory response and a higher NLR and PLR, which is associated with less LVT resolution despite anticoagulation. Further studies are required to study this association.

Aim: Our aim was the evaluation of neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels in the patient and control groups with hypothyroidism. Methods: Our study was conducted with 111 participants; 68 patients and 43 healthy individuals as the control group. Thyroid hormones, lipid panel and hemogram levels of the participants were examined. Neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels were calculated. Results: Neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels were similar between the patients with subclinical and overt hypothyroidism and the control group. A positive correlation was found between neutrophil-lymphocyte ratio and platelet lymphocyte ratio. A negative correlation was found between platelet lymphocyte ratio and mean platelet volume. While there was no relationship between thyroid stimulating hormone and neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume; a negative correlation was found between neutrophil-lymphocyte ratio and free thyroxine. Conclusion: Neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels were similar in the hypothyroidism and control groups. We believe that prospective studies that evaluate neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume together with other inflammatory parameters are needed to predict the risk of microinflammation and cardiovascular disease in patients with hypothyroidism. Keywords: Neutrophils, lymphocytes, platelets, mean platelet volume, hypothyroidism

The purpose of this study was to evaluate the prognostic values of pathological tumor size and preoperative blood-based inflammation biomarkers, including the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR), in upper tract urothelial carcinoma (UTUC).From 2007 to 2017, retrospective data of 449 patients with UTUC who underwent radical nephroureterectomy were assessed. Use of Kaplan-Meier and univariable/multivariable analyses evaluated the effect of preoperative blood-based inflammation biomarkers on overall (OS), cancer-specific (CSS), and progression-free survival (PFS) in pathological tumor sizesand ≤3 cm.Kaplan-Meier analyses showed that high-level NLR, PLR, or MLR had significantly shorter OS, CSS, and PFS for tumor sizes3 cm (all P .05), but not for ≤3 cm. For UTUCs with tumor sizes3 cm, multivariable analyses showed simultaneously high-level PLR and MLR to be independent predicators of poor OS, CSS, and PFS (all P .05). Moreover, receiver operating characteristic (ROC) analyses revealed that the predictive accuracy of the combination of PLR and MLR for OS, CSS, and PFS with the area under the ROC curve of 0.836, 0.871, and 0.806, respectively, in tumor sizes3 cm (all P .001).Our study demonstrated that a high-level PLR and MLR can serve as an independent predicator of worse outcomes in UTUCs with tumor sizes3 cm. This combination can clinically help enhance the prognostic discrimination of UTUCs with tumor sizes3 cm and further may guide physicians in selecting patients for postoperatively systemic chemotherapy.

Background: Deep vein thrombosis (DVT) is a blood clot that occurs in the inner veins caused by heart disease, infection, cancer, and prolonged immobilization of the limbs. Neutrophil-Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) have been known as a marker of the primary hemostasis process related to the inflammatory pathway. This study aims to evaluate the correlation of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio compared to D-dimer as a diagnostic test in Deep Vein Thrombosis (DVT)Methods: A cross-sectional approach has been conducted in this diagnostic study at the Sanglah General Hospital by using secondary data from medical records during July 2018-2019. The study sample consisted of 49 patients with suspected DVT originating from a population who met the inclusion and exclusion criteria. The variables assessed in this study were NLR, PLR, and D-Dimer. Data collection and data analysis were performed by SPSS version 17 for Windows.Results: The average age of respondents was 53.10±13.40 years old. Most of the respondents were male (59.20%), having edema in the lower extremity (61.20%), left unilateral laterality (53.10%), and D-Dimer levels ≥ 0,5 µg/ml (76.1%). There was a statistically significant relationship between the average value of NLR (9,07±4,2) and PLR (183,55±66,52) with the occurrence of DVT (P

Objective: Radiotherapy is a one cura­tive method for prostate cancer. Ionizing radiation can cause inflammation of tissues in and around the irradiated sites. But it is also suggested that low-dose radiation has anti-inflammatory effects. The present study was aimed at investigating the effects of radiotherapy on some inflammatory markers in prostate cancer patients. Material and Methods: A total of 42 patients with prostate cancer and 30 healthy subjects were included in the present study. The day prior to radiotherapy (pre radiotherapy group) and the day radiotherapy was completed (post radiotherapy group) venous blood samples were collected. Neutrophil, lymphocyte, platelet, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) levels were detected. Results: Neutrophil values of the pre radiotherapy group were higher than the control group (p

Objective: The primary aim of this study was to investigate the role of platelet-lymphocyte ratio (PLR) to predict bleeding risk in nonvalvular atrial fibrillation (NVAF). Secondary aim was to determine the possible relation between PLR and thromboembolic and bleeding risk scores. Tertiary aim was to evaluate the predictive value of PLR for the patients in the therapeutic international normalized ratio (INR) range. Method: PLR was calculated from the complete blood count of 228 patients who were under warfarin management for NVAF. The patients were called and it was questioned whether they had experienced the bleeding event within six months after measurement of the PLR values. Correspondence/Yazışma Adresi: Kahraman Cosansu, Deparment of Cardiology, Sakarya University, Education and Research Hospital Sakarya, Turkey, 54100 e-mail: kahraman141@gmail.com DOI: 10.5798/dicletip.705814 Results: Bleeding event was observed in 48 patients after the PLR was calculated. It was found significantly correlation between PLR and CHA2DVAS2C (p165,9 was determined significant indicator for bleeding (p 165,9 değeri kanama için önemli bir gösterge olarak belirlendi (p

Purpose: To evaluate whether the C-reactive protein (CRP)/albumin ratio (CAR) in patients with uveitis during an attack is a marker that can give information about the activity, severity and progno...

Although the pathogenesis of Teno-Synovial Giant Cell Tumor (TSGCT) is not known, inflammation is thought to play a role in the etiology beside some other factors. Many researchers have found a close relationship between hematological parameters such as Mean Platelet Volume (MPV), Platelet/MPV Ratio (Plt/MPV), Monocyte/Neutrophil Ratio (MNR), Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratio (PLR) and certain inflammatory, autoimmune and neoplastic diseases. The aim of the present study was to assess the relationship of hematological parameters (NLR, MNR and Plt/MPV) to tumor recurrence and spread after TSGCT surgery. Data from 102 patients who matched the inclusion criteria comprised preoperative hematological parameters, tumor size, anatomic region, side, presence of bone invasion, proximity to joints or neurovascular structures, and postoperative recurrence and complications. The mean follow-up was 54.2 months (±26.5). Recurrence was observed in 12 (11.8%) of the 102 cases. No significant correlation was found between recurrence and hematologic parameter, age, laterality (right-left) or zone (volar-dorsal). There were no significant differences in NLR, Plt/MPV or MNR between patients with and without bone, capsular, nerve or total involvement. The study thus showed that the various inflammatory parameters (NLR, Plt/MPV and MNR) calculated from blood count were not predictive of tumor invasion into anatomical structures or of digital TSGCT recurrence. © 2022 SFCM

Objectives: To investigate the value of 18 F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) combined with the platelet-lymphocyte ratio (PLR) in predicting the prognosis of nasopharyngeal carcinoma (NPC). Methods: This was a retrospective analysis of the data of 73 patients with NPC who underwent 18 F-FDG PET/CT before treatment from January 2010 to December 2014. The maximum standard uptake value (SUVmax) of NPC and the PLR within 1 week before treatment were both measured. The Mann-Whitney U-test was used to compare the differences between the SUVmax and PLR among the different clinical characteristics of patients with NPC and the 5-year progression-free survival (PFS) rate; according to the receiver operating characteristic (ROC) curve, the best cutoff values of the SUVmax and PLR were obtained and used to group patients. The Kaplan-Meier method and Log-rank test were used to conduct univariate analysis of 5-year PFS in patients with NPC, and Cox regression was used to conduct multivariate analysis; differences in the 5-year PFS of patients with different SUVmax values combined with the PLR were compared. Results: The SUVmax and PLR of patients with disease progression within 5 years were higher than those of patients without disease progression (p = 0.006 and p = 0.026). SUVmax = 9.7 and PLR = 132.98 had the best prognostic diagnostic efficiency for patients. Cox multivariate analysis showed that the SUVmax and PLR are independent factors affecting the prognosis of NPC. The 5-year PFS of patients with SUVmax Conclusions: Both the SUVmax of the primary tumor and the PLR before treatment have an important influence on the prognosis of NPC. Combining the SUVmax and the PLR can more accurately predict the prognosis of patients with NPC. Advances in knowledge In this study, we evaluated the prognostic value of combining pretreatment tumor 18F-FDG uptake on PET/CT imaging and PLR in NPC patients. We found that both SUVmax and PLR are independent factors for the PFS of NPC patients, and a low SUVmax (SUVmax

Background: Neutrophil lymphocyte Ratio (NLR) and Platelet lymphocyte Ratio (PLR) are an indicator of the status of inflammation. The objective of this study was to evaluate the relationship between recipient pre-operative Neutrophil lymphocyte Ratio (NLR) and Platelet lymphocyte Ratio (PLR) with delayed graft function in the kidney transplant patient. Methods: The preoperative full blood count, data regarding patient demographics and postoperative graft function was retrospectively evaluated from the database of our institution. All statistical calculations were carried out using SPSS 20.0 version (SPSS Inc., Chicago, IL, USA). A p-value3.5 and PLR>120 independently responsible for DGF. Conclusion: Recipient preoperative NLR and PLR can predict the occurrence of DGF following DBD renal transplantation. In addition, NLR is better than PLR in predicting DGF. DGF prolongs the total ICU and in-hospital stay.

BackgroundThe platelet-lymphocyte ratio (PLR), a novel inflammatory marker, is generally associated with increased in-hospital mortality risk. We aimed to investigate the association between PLR and postoperative in-hospital mortality risk in patients with type A acute aortic dissection (AAAD).MethodsPatients (n = 270) who underwent emergency surgery for AAAD at Xiangya Hospital of Central South University between January 2014 and May 2019 were divided into three PLR-based tertiles. We used multiple regression analyses to evaluate the independent effect of PLR on in-hospital mortality, and smooth curve fitting and a segmented regression model with adjustment of confounding factors to analyze the threshold effect between PLR and in-hospital mortality risk.ResultsThe overall postoperative in-hospital mortality was 13.33%. After adjusting for confounders, in-hospital mortality risk in the medium PLR tertile was the lowest (Odds ratio [OR] = 0.20, 95% confidence interval [CI] = 0.06–0.66). We observed a U-shaped relationship between PLR and in-hospital mortality risk after smoothing spline fitting was applied. When PLR P = 0.001). When the PLR was between 108 and 188, the mortality risk was the lowest (OR = 1.02,P = 0.288). When PLR > 188, the in-hospital mortality risk increased by 6% per unit increase in PLR (OR = 1.06,P = 0.045).ConclusionsThere was a U-shaped relationship between PLR and in-hospital mortality in patients with AAAD, with an optimal PLR range for the lowest in-hospital mortality risk of 108–188. PLR may be a useful preoperative prognostic tool for predicting in-hospital mortality risk in patients with AAAD and can ensure risk stratification and early treatment initiation.

Introduction Biomarkers such as the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) are associated with the colon tumor stage and prognosis. Therefore, in our study, we investigated whether these biomarkers are important in determining the colon cancer stage. Materials and methods The outcomes in 268 patients operated on with the diagnosis of colon cancer between January 2011 and March 2019 were retrospectively analyzed. The relationship of the stage of the patients with the NLR or PLR was evaluated. In addition, according to the stage of colorectal tumors, stage I and other stages (stages II, III, and IV) were compared in terms of NLR and PLR. Groups that had lymph node (LN) metastasis were compared with those that did not. Finally, groups with and without metastasis were also compared. Results In our cohort, 144 patients (57.6%) were male, and 84 (42.4%) were female. The mean age was found to be 68.28 ±12.71 years. The patients were evaluated according to their stages: 26 patients were stage I, 78 patients were stage II, 75 patients were stage III, and 19 patients were stage IV. There was a significant difference in NLR values between the groups (p: 0.05). Also, 104 patients were LN-negative (stages I-II), and 94 patients were LN-positive (stages III-IV). When PLR was compared between the two groups, no significant difference was found between tumor stages and these values (p: 0.099). However, there was a significant difference in NLR values (p: 0.034). Conclusion Based on our findings, it has been concluded that increased PLR may not be associated with the colon cancer stage. However, the increase in NLR was found to be correlated with tumor stage and LN metastasis.

INTRODUCTION In breast cancer, the most important prognostic factor is axillary lymph node metastasis. However, there is no method which can diagnose axillary lymph node metastasis preoperatively with high sensitivity. The aim of this study was to evaluate the relationship between platelet/lymphocyte ratio (PLR) and sentinel lymph node metastasis in early-stage breast cancer. METHODS In total, 202 cases which were operated under early-stage breast cancer diagnosis in Ankara City Hospital General Surgery Department were evaluated in retrospectively. We separated the patients into two categories according to their PLR. PLR groups were evaluated for relationship with sentinel lymph node metastasis. At the last part, sentinel lymph node positive sensitivity was evaluated in PLR and preoperative USG groups. RESULTS Results showed that patients above PLR cut-off value had 0.43 times more risk of having a positive SLN in comparison with patients who had a PLR lower than cut-off (OR = 0.435, 95%CI:0.221-0.856, P

Introduction The relationship between clinical prognostic factors and blood neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in some tumors has been investigated. In this study, we examined whether there is a relationship between pathological prognostic factors and NLR as well as PLR only in neuroendocrine tumors (NETs). Methods A total of 115 patients with a NET diagnosis between 2014-2020 were included in the study. The efficiency of NLR and PLR in predicting distant metastases was determined by analyzing the receiver operating characteristic (ROC) curve. The relationship between histopathological parameters was also compared. Results The cut-off value of NLR was 3.01 for predicting distant metastasis. At this value, the specificity was 73.7%, the sensitivity was 70.7%, and the likelihood ratio was 2.51. There was a significant relationship between NLR and tumor localization, histological grade, mitosis, Ki-67, distant metastasis, and lymphovascular invasion (all p0.05). Conclusions In our study, a high histological grade, high mitosis, a high Ki-67 proliferation index, distant metastasis, and lymphovascular invasion were found in patients with NLR at a cut-off value above 3.01. However, we could not attain the same results for PLR. For trucut and endoscopic biopsies in particular, follow-up of patients with grades 1 and 2 NETs along with histopathological findings and evaluation of NLR in peripheral blood may be useful. NLR, which is an easily accessible inflammatory marker, can be used as an independent predictive factor in NETs.

Background: It has been discovered that both inflammation and platelet aggregation could cause crucial effect on the occurrence and development of cardiovascular diseases. As a combination of platelet and lymphocyte, platelet-lymphocyte ratio (PLR) was proved to be correlated with the severity as well as prognosis of cardiovascular diseases. Exploring the relationship between PLR and in-hospital mortality in cardiac intensive care unit (CICU) patients was the purpose of this study. Method: PLR was calculated by dividing platelet count by lymphocyte count. All patients were grouped by PLR quartiles and the primary outcome was in-hospital mortality. The independent effect of PLR was determined by binary logistic regression analysis. The curve in line with overall trend was drawn by local weighted regression (Lowess). Subgroup analysis was used to determine the relationship between PLR and in-hospital mortality in different subgroups. Result: We included 5577 CICU patients. As PLR quartiles increased, in-hospital mortality increased significantly (Quartile 4 vs Quartile 1: 13.9 vs 8.3, P Conclusion: PLR was independently associated with in-hospital mortality in CICU patients.

OBJECTIVE: To determine the differences in the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in pregnant women with and without COVID-19. METHODS: Observational, cross-sectional, retrospective, comparative, open, controlled study done from January to April 2021 at the UMAE Hospital de Gineco Obstetricia "Luis Castelazo Ayala" Instituto Mexicano del Seguro Social. Mexico City, Mexico: Patients were divided into those with a negative test for COVID-19 and those with a positive test, with the latter then being divided according to disease severity into mild, moderate, and severe groups. In all the NLR and PLR were calculated. Symptoms, vital signs, and oxygen saturation were documented. STATISTICAL ANALYSIS: Central tendency and dispersion measures, Kruskal-Wallis test, Mann-Whitney U test, and chi-squared test were used. Sensitivity, specificity, positive predictive value, negative predictive value, and odds ratio (OR) were calculated. RESULTS: Seventy-seven patients were included, 24 without COVID-19 and 53 with COVID-19. There were 33, 10, and 10 patients in the mild, moderate, and severe disease groups, respectively. There was no difference in NLR between the groups and the PLR was significantly higher in the severe disease group. With a 5.1 NLR cutoff point, between normal and those with severe disease, the sensitivity was 70% and specificity 63%, whilst with a 221 PLR cutoff point, the sensitivity was 90% and the specificity 83% (OR 45, 95% CI 4.40-461.7). CONCLUSION: PLR more than NLR was useful to detect pregnant patients with COVID-19 with severe disease.