1. Short anogenital distance is associated with testicular germ cell tumour development
- Author
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Moreno-Mendoza D., Casamonti E., Riera-Escamilla A., Pietroforte S., Corona G., Ruiz-Castañe E., and Krausz C.
- Subjects
Male ,Anal Canal ,cancer risk ,penis ,single nucleotide polymorphism ,androgen receptor ,AR protein, human ,Cryptorchidism ,Testis ,genetics ,cryptorchism ,Prospective Studies ,pathophysiology ,scrotum ,Hypospadias ,adult ,seminoma ,risk assessment ,Neoplasms, Germ Cell and Embryonal ,priority journal ,spermatozoon count ,Receptors, Androgen ,non seminomatous germinoma ,luteinizing hormone ,Androgens ,follitropin ,carcinogenesis ,prospective study ,hormone determination ,phenotype ,androgen ,sperm ,Polymorphism, Single Nucleotide ,Article ,semen analysis ,histology ,Testicular Neoplasms ,Semen ,Humans ,controlled study ,anogenital distance ,human ,gonadotropin ,testis tumor ,spermatozoon motility ,case control study ,major clinical study ,human tissue ,sensitivity and specificity ,Spain ,testosterone ,physiology ,metabolism ,neoplasm ,anatomy and histology - Abstract
Background: Testicular germ cell tumour is a multifactorial disease in which various genetic and environmental factors play a role. Testicular germ cell tumour is part of the testicular dysgenesis syndrome which includes also cryptorchidism, hypospadias, oligo/azoospermia and short anogenital distance. Objectives: The primary objective was to examine anogenital distance in testicular germ cell tumour cases and healthy fertile controls. The secondary objective was to assess the (CAG)n polymorphism of the Androgen Receptor gene in relationship with anogenital distances and testicular germ cell tumour development. Material and Methods: 156 testicular germ cell tumour patients and 110 tumour-free normozoospermic controls of Spanish origin. All subjects underwent full andrological workup (including semen and hormone analysis) and genetic analysis (Androgen Receptor (CAG)n). The main outcome measures were the anopenile distance (AGDap), the anoscrotal distance (AGDas) and AR(CAG)n. Result: We observed significantly shorter anogenital distances in the group of testicular germ cell tumour patients in respect to controls (P
- Published
- 2020
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