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Recently, cell-free (CF) architectures, in which every user can potentially communicate with every base station, have received a lot of attention. This paper considers the uplink of fully and partially centralized CF networks where unmanned aerial vehicles serve as flying base stations (FBSs). A subset of FBSs participates in the reception of each user and a subset of users is received by each FBS. Deterministic equivalent expressions, exact asymptotically in the subset sizes and approximate for finite dimensions thereof, are derived for the spectral efficiency under Rician fading. Capitalizing on these expressions, the FBS deployment problem is investigated for different receiver architectures. The nonconvex deployment problem, tackled through a combination of gradient-based and Gibbs sampling algorithms, results in a superior performance with respect to a square grid deployment; this superiority extends to the minimum and aggregate spectral efficiency for both fully and partially centralized cell-free networks. This work was supported in part by NSF Award CCF-1815339, in part by European Research Council (ERC) under Grant 694975, in part by the ICREA Academia Program, and in part by the Fractus Chair on Tech Transfer and 6G.

Ending TB, alleviating poverty, and eradicating catastrophic healthcare costs are integral aspects of WHO’s global TB policy and the SDGs. This highly timely pilot and future trial will provide the world’s first, robust evidence regarding the feasibility and acceptability of a socioeconomic support intervention for TB-affected households in Nepal a low-income, TB-endemic country.

Oligodendrocyte progenitor cells (OPCs) are responsible for generating oligodendrocytes, the myelinating cells of the CNS. Life-long myelination is promoted by neuronal activity and is essential for neural network plasticity and learning. OPCs are known to contact synapses and it is proposed that neuronal synaptic activity in turn regulates their behavior. To examine this in the adult, we performed unilateral injection of the synaptic blocker botulinum neurotoxin A (BoNT/A) into the hippocampus of adult mice. We confirm BoNT/A cleaves SNAP-25 in the CA1 are of the hippocampus, which has been proven to block neurotransmission. Notably, BoNT/A significantly decreased OPC density and caused their shrinkage, as determined by immunolabeling for the OPC marker NG2. Furthermore, BoNT/A resulted in an overall decrease in the number of OPC processes, as well as a decrease in their lengths and branching frequency. These data indicate that synaptic activity is important for maintaining adult OPC numbers and cellular integrity, which is relevant to pathophysiological scenarios characterized by dysregulation of synaptic activity, such as age-related cognitive decline, Multiple Sclerosis and Alzheimer's disease.

This study aimed to assess completeness of antenatal care coverage following implementation of a voucher scheme for maternal health in Bangladesh. The investigation used interview findings from a survey of 2,400 randomly selected women aged 15-49 with children 0-23 months in four geographical areas where voucher scheme implementation was under way. Of these, 1,944 had attended at least one antenatal clinic visit so were included in this analysis. A ‘completeness index’ for antenatal visits was constructed as an outcome variable based on recall of 13 elements of care. Bivariate analysis against independent variables of interest was carried-out and developed multivariate linear regression models to examine the influence of voucher scheme participation on completeness of antenatal care adjusting for socio-demographic characteristics. Voucher scheme membership was associated with higher ‘completeness index’ scores with a mean score of 185.2±101.0 for members and 139.6±93.3 for non-members (P

Multiple Input Multiple Output with Antenna Number Modulation (MIMO-ANM) has recently been introduced to the literature as an effective, competitive, and reliable transmission technology that can make the selection of antennas at the transmitter to be not just data-dependent as is the case with other spatial modulation methods, but also channel-dependent without the need to share any side information between the communicating parties. This key merit results in having much more improved performance in terms of reliability compared to index/spatial modulation-based transmission techniques, thus making it a very strong candidate technique for meeting the super ultra-reliability requirements of future 6G networks. Motivated by the great potential of MIMO-ANM and the need to study it in more depth to realize its suitability for future wireless networks such as 5G+, 6G, WiFi7, and WiFi8, this work aims to deeply investigate and quantify the performance of MIMO-ANM under the joint, simultaneous utilization of both Adaptive Transmit Antenna Selection (AAS) and Maximum Ratio Combination (MRC). The conducted mathematical analysis of the considered system model is verified by extensive numerical simulation results, which have precisely revealed the exact levels of gains in the bit error rate (BER) performance compared to a conventional MIMO-ANM system not adopting AAS with MRC. Such promising results are anticipated to greatly combat fading in wireless channels and improve the overall performance of future MIMO-ANM-based systems. No sponsor

We present a framework and an open-source python toolkit to analyse the 2-point statistics of 3D fluctuations in the context of HI intensity maps using the multipole expansion formalism. We include simulations of the cosmological HI signal using N-body and log-normal methods, foregrounds and their removal, as well as instrumental effects. Using these simulations and analytical modelling, we investigate the impact of foreground cleaning and the instrumental beam on the power spectrum multipoles as well as on the Fourier space clustering wedges. We find that both the instrumental beam and the foreground removal can produce a quadrupole (and a hexadecapole) signal, and demonstrate the importance of controlling and accurately modelling these effects for precision radio cosmology. We conclude that these effects can be modelled with reasonable accuracy using our multipole expansion technique. We also perform an MCMC analysis to showcase the effect of foreground cleaning on the estimation of the HI abundance and bias parameters. The accompanying python toolkit is available at https://github.com/IntensityTools/MultipoleExpansion, and includes an interactive suite of examples to aid new users., 21 pages, 14 figures

Increasingly, the rat femoral fracture model is being used for preclinical investigations of fracture healing, however, the effect of gap size and its influence on mechanobiology is not well understood. We aimed to evaluate the influence of osteotomy gap on osteotomy healing between the previously published extremes of guaranteed union (0.5 mm) and non-union (3 mm) using this model.A femoral osteotomy in 12–14 week old female Wistar rats was stabilised with a micro fixator (titanium blocks, carbon fiber bars) with an osteotomy gap of 1.0 mm (n = 5), 1.5 mm (n = 7), 2.0 mm (n = 6). After five weeks, the left femur was retrieved. The osteotomy gap was scanned using X-ray microtomography and then histologically evaluated. The radiographic union rate (complete mineralised bone bridging across the osteotomy) was three times higher for the 1.0 mm than the 2.0 mm gap. The 1.0 mm gap had the largest callus (0.069μm3) and bone volume (0.035μm3). Callus and bone volume were approximately 50% smaller within the 2.0 mm gap.Using cadaveric rat femurs stabilised with the external fixator, day 0 mechanical assessment of construct stiffness was calculated on materials testing machine displacement vs load output. The construct stiffness for the 1.0, 1.5 and 2.0 mm gaps was 32.6 ± 5.4, 32.5 ± 2.4, and 32.4 ± 8.3 N/mm (p = 0.779). Interfragmentary strain (IFS) was calculated using the change in osteotomy gap displacement as measured using microstrain miniature differential reluctance transducer spanning the osteotomy gap. Increasing the gap size significantly reduced the IFS (p = 0.013). The mean ‘day 0’ IFS for the 1.0, 1.5 and 2.0 mm gaps were 11.2 ± 1.3, 8.4 ± 1.5 and 6.1 ± 1.2% respectively.A 1.5 mm gap resulted in a delayed fracture healing by 5 weeks and may represent a useful test environment for fracture healing therapy. Increasing gap size did not affect construct stiffness, but did reduce the ‘day 0’ IFS, with a doubling of non-union and halving of bone volume measured between 1.0 and 2.0 mm gaps.

Supplemental Digital Content is available in the text, Sirtuin1 (Sirt1) and Sirtuin3 (Sirt3) are known to participate in regulating mitochondrial function. However, whether Total Salvianolic Acid Injection (TSI) protects against myocardial ischemia/reperfusion (I/R) injury through regulating Sirt1, Sirt3, and mitochondrial respiratory chain complexes is unclear. The aim of this study was to explore the effects of TSI on I/R-induced myocardial injury and the underlying mechanism. Male Sprague–Dawley rats were subjected to 30 min occlusion of the left anterior descending coronary artery followed by 90 min reperfusion with or without TSI treatment (8 mg/kg/h). The results demonstrated that TSI attenuated I/R-induced myocardial injury by the reduced infarct size, recovery of myocardial blood flow, and decreased cardiac apoptosis. Moreover, TSI protected heart from oxidative insults, such as elevation of myeloperoxidase, malondialdehyde, hydrogen peroxide, ROS, as well as attenuated I/R-elicited downregulation of Sirt1, Sirt3, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex 10 (NDUFA10), succinate dehydrogenase complex, subunit A, flavoprotein variant (SDHA), and restoring mitochondrial respiratory chain complexes activity. The in vitro study in H9c2 cells using siRNA transfection further confirmed the critical role of Sirt1 and Sirt3 in the effect of TSI on the expression of NDUFA10 and SDHA. These results demonstrated that TSI attenuated I/R-induced myocardial injury via inhibition of oxidative stress, which was related to the activation of NDUFA10 and SDHA through the upregulation of Sirt1 and Sirt3.

Objectives - The desire and apparent ‘need’ to succeed can drive a win-at-all-costs mentality in individuals who operate in sport. This approach has given rise to environments where the pursuit of high-level performance has been at the expense of athlete welfare. To redress this balance and to inform the creation and maintenance of sporting environments that promote both high performance and athlete well-being, we sought to (i) provide an exploration of the environmental factors that may promote player thriving in professional sport, and (ii) offer suggestions for how key stakeholders can support these mechanisms.Design - A qualitative research methodology underpinned by ontological relativism and epistemological constructionism.Method - Semi-structured interviews were conducted with 18 players from an English professional rugby union club.Results - Thematic analysis generated thirteen factors that players perceived to promote thriving. These factors were underpinned by two general ideas: (i) Establishing Bonds between Teammates and (ii) Establishing a Connection to the Coaching Staff and the Club. Conclusions - The findings provide the first insight into the type of environment professional rugby players believe can facilitate their development and sporting success. The factors generated in the analysis highlight the players’ desire to operate within an integrated, inclusive, and trusting environment, and a variety of suggestions are forwarded for how this can be achieved. To promote thriving in a professional sport that requires emotion and passion to succeed on the pitch, it appears that rugby union organizations must appeal to the sensitivities and welfare of players’ off it.

As the demand for higher data rates continues to increase exponentially, there is a shift towards exploring contemporary techniques that are likely to offer higher spectral efficiency. A new modulation technique termed as orthogonal frequency division multiplexing with sub‐carrier power modulation (OFDM‐SPM) has recently been introduced. It is an original technique that is still largely under-explored and aims at transmitting more bits per sub‐carrier by manipulating the power of the sub‐carriers in an OFDM block, in addition to those bits that are usually transmitted by conventional modulation schemes such as M-PSK. During the investigation and theoretical testing stages, it was found that the additional data stream conveyed by subcarriers' power has higher bit error rate (BER) performance compared to the data stream conveyed by conventional modulation schemes. To overcome this shortfall, signal space diversity (SSD) along with coordinate interleaving is proposed in this work to be integrated with OFDM‐SPM to help improve the overall BER performance. By doing so, it is shown that a BER performance of 10-3 can be obtained at SNR of 15 dB, which means achieving an improvement of more than 5 dB compared to the case of using OFDM‐SPM without SSD. Furthermore, the performance results of OFDM‐SPM‐SSD is compared with those of OFDM‐SPM with maximal ratio combining (MRC) and the obtained results show that OFDM‐SPM‐SSD offers superior performance. Additionally, a study of the effect of the constellation rotation on OFDM‐SPM is provided and an in‐depth analysis is also carried out for different power polices of sub‐carrier power modulation with regards to two main performance metrics; namely BER and the throughput. Simulation results show that SSD provides a considerable improvement in the BER over both plain OFDM‐SPM and OFDM‐SPM‐MRC. The analysis also reveal that when considering the different power policies of SPM, the BER results are optimum in the case of using power‐reassignment policy. No sponsor

España es uno de los principales exportadores de cítricos de la Unión Europea y por los beneficios económicos generados, se hace altamente necesario disponer de material de referencia (MR) y material de referencia certificados (MRC) adecuados para el análisis en matrices de frutas y zumos de naranja, para asegurar la calidad y confiabilidad de los resultados analíticos. En el presente trabajo, se estudió el contenido en elementos traza de zumos de frutas y se desarrolló un MRC de zumo de naranja, con la finalidad de utilizarlo para validación de procedimientos de análisis y control del contenido de elementos traza en zumos de naranja.

Myelin disruption is a feature of natural aging and of Alzheimer’s disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by oligodendrocyte progenitor cells (OPCs). Here, we examined age-related changes in OPCs in APP/PS1 mice, a model for AD-like pathology, compared with non-transgenic (Tg) age-matched controls. Analysis was performed in the CA1 area of the hippocampus following immunolabelling for NG2 with the nuclear dye Hoescht, to identify OPC and OPC sister cells, a measure of OPC replication, together with Gpr17 and Olig2 for oligodendrocytes and myelin basic protein (MBP) immunostaining as a measure of myelination. The results indicate a decrease in the number of OPCs between 9 and 14 months in natural ageing and this occurred earlier at 9 months in APP/PS1 mice, without further decline at 14 months. The number of OPC sister cells was unaltered in natural aging, but declined significantly at 14-months in APP/PS1 mice. The number of GPR17+ and Olig2+ oligodendrocytes was not altered in APP/PS1, whereas MBP immunostaining increased between 9 and 14 months in natural ageing, but not in APP/PS1 mice. Notably, OPCs displayed marked morphological changes at 14 months in APP/PS1 mice, characterized by an overall shrinkage of OPC process domains and increased process branching, characteristic of reactive pathological changes. The results indicate that OPC and myelin disruption are pathological signs in the APP/PS1 mouse model of AD.

Highlights • Understanding the psychological impact of the COVID-19 pandemic will be vital for service planning and delivery • Initial results in UK show healthcare professionals report more mild anxiety and depression than non-healthcare professionals • Increasing age and female gender are associated with higher compliance with government guidelines • Participants who report suicidal thoughts pre-COVID are less likely to communicate with friends and family, or engage in coping strategies, Background The psychological impact of COVID-19, resultant measures and future consequences to life will be unveiled in time. Aim To investigate the psychological impact of COVID-19, resultant restrictions, impact on behaviours and mental wellbeing globally. This early analysis, explores positive and adverse factors and behaviours with focus on healthcare professionals. Methods This is a cross-sectional survey, using a questionnaire based on published approaches to understand the psychological impact of COVID-19. The survey will be repeated at 6 months because of rapidly changing situation. Results We have presented results from first 3 weeks of the survey. Conclusions may change as more individuals take part over time. 7,917 participants completed the survey in the first 3 weeks; 7,271 are from the United Kingdom. 49.7% of the participants are healthcare professionals. There is high representation of female participants. Participants reporting suicidal thoughts is 32%. Healthcare professionals have reported mild depression and anxiety in higher proportions. Increasing age and female gender report higher compliance with government advice on COVID 19 whereas higher education, homeowners, key worker status, high alcohol, drug use and participants with pre-existing suicidal thoughts reported low compliance with government advice. Participants who reported suicidal thoughts pre-COVID are less likely to communicate with friends and family, or engage in coping strategies. Conclusions Evidence has shown an adverse psychological impact of previous pandemics on the population, especially wellbeing of healthcare professionals. Research should focus on identifying the need, preparing services and determining the factors that enhance and build resilience. Funding This survey is linked to a MRC global health research program of the Portsmouth-Brawijaya Centre for Global Health, Population, and Policy, (MR/N006267/1), University of Portsmouth.

BACKGROUND: Although there is clear evidence of genetic contributions to susceptibility to nicotine addiction, it has proved difficult to identify causal alleles and pathways from studies in humans. Mutagenesis in model species generates strong phenotypes not present in wildtype populations and can be used to identify biological mechanisms underlying quantifiable behaviours. We tested the hypothesis that a forward genetic screen for nicotine preference in zebrafish can predict loci and biological mechanisms influencing human smoking behaviour. METHODS: A population-based forward genetic screen of ethylnitrosurea- mutagenized zebrafish was used to identify lines of fish showing altered nicotine preference. Immunohistochemical, behavioral and quantitative PCR analyses were used to characterize mutant larvae. Focussed SNP analysis of the homologous human locus in cohorts from the UK and a Finnish Twin study assessed the predictive validity of the zebrafish data for human smoking behavior. RESULTS: We show nicotine preference is heritable in fish as in humans and identify loss-of-function mutations in the zebrafish Slit3 gene as associated with increased nicotine preference. Slit3 mutant larval fish showed altered sensitivity of habituation to acoustic startle to dopaminergic antagonists and increased Drd2 and Drd3 mRNA expression. Dopaminergic neuronal pathfinding was unaffected. Analysis of the SLIT3 locus in two independent human cohorts identified 2 genetic markers that predict level of cigarette consumption and likelihood of cessation. CONCLUSION: These findings suggest a role for SLIT3 signaling in development of dopaminergic pathways affecting behaviours associated with nicotine dependence and confirm the translational relevance of the zebrafish model in exploring complex human behaviors.

Background: Despite decent progress in Children Full Immunisation (CFI) in India during the last decade, surprisingly, Gujarat, an economically more developed state, had the second-lowest coverage of CFI (50%) in the country, lower than economically less developed states such as Bihar (62%). Further, the proportion of children with no immunisation in Gujarat has risen from 5% in 2005 to 9% in 2016. This paper investigated factors associated with the low level of CFI coverage in Gujarat.Methods: The study used two types of datasets: (1) the information on immunisation from 7730 children aged 12–23 months and their mothers from the fourth round of the Gujarat chapter of National Family Health Survey (NFHS 2015–16). (2) A macro (district) level data on both supply and demand-side factors of CFI are compiled from multiple sources. Bivariate and multivariate linear and logistic regression techniques were employed to identify the factors associated with CFI coverage.Results: In Gujarat, during 2015–2016, 50% of children aged 12–23 months did not receive full immunisation. The odds of receiving CFI was higher among children whose mothers had a Maternal and Child Protection (MCP) card (OR: 1.97, 95% CI 1.48–2.60) and those who received “high” maternal health services utilisation (OR: 1.59, 95% CI 1.10–2.26) compared to their counterparts. The odds of receiving CFI was about three times higher among the richest households (OR: 6.50, 95% CI 3.75–11.55) compared to their counterparts in the poorer households. Macro-level analyses suggest that poverty, maternal health care, and higher-order births are defining factors of CFI coverage in Gujarat.Conclusions: In order of importance, focusing on poverty, economic inequalities, pregnancy registration, and maternal health care services utilisation are likely to improve receiving CFI uptake in Gujarat. The disadvantageous position of urban areas and non-scheduled tribes in CFI coverage needs further investigation.

There is increasing evidence that myelin disruption is related to cognitive decline in Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by adult oligodendrocyte progenitor cells (OPCs), also known as NG2-glia. To address whether alterations in myelination are related to age-dependent changes in OPCs, we analyzed NG2 and myelin basic protein (MBP) immunolabelling in the hippocampus of 3×Tg-AD mice at 6 and 24 months of age, compared with non-Tg age-matched controls. There was an age-related decrease in MBP immunostaining and OPC density, together with a decline in the number of OPC sister cells, a measure of OPC replication. Notably, the loss of myelin and OPC sister cells occurred earlier at 6 months in 3xTg-AD, suggesting accelerated aging, although there was not a concomitant decline in OPC numbers at this age, suggesting the observed changes in myelin were not a consequence of replicative exhaustion, but possibly of OPC disruption or senescence. In line with this, a key finding is that compared to age-match controls, OPC displayed marked morphological atrophy at 6 months in 3xTg-AD followed by morphological hypertrophy at 24 months, as deduced from significant changes in total cell surface area, total cell volume, somata volume and branching of main processes. Moreover, we show that hypertrophic OPCs surround and infiltrate amyloid-β (Aβ) plaques, a key pathological hallmark of AD. The results indicate that OPCs undergo complex age-related remodeling in the hippocampus of the 3xTg-AD mouse model. We conclude that OPC disruption is an early pathological sign in AD and is a potential factor in accelerated myelin loss and cognitive decline., Graphical abstract, Highlights • Life-long generation of myelin is the function of adult oligodendrocyte progenitor cells (OPCs). • Age-related loss of myelin is accelerated in the 3xTg-AD mouse model of Alzheimer's disease (AD). • OPCs are disrupted at an early stage of 3xTg-AD. • Dysregulation of OPC and myelin loss are important biomarkers for AD-like pathology.

c‐MYC and the SWI/SNF chromatin remodeling complex act as master regulators of transcription, and play a key role in human cancer. Although they are known to interact, the molecular details of their interaction are lacking. We have determined the structure of the RPT1 region of the INI1/hSNF5/BAF47/SMARCB1 subunit of the SWI/SNF complex that acts as a c‐MYC‐binding domain, and have localized the interaction regions on both INI1 and on the c‐MYC:MAX heterodimer. c‐MYC interacts with a highly conserved groove on INI1, while INI1 binds to the c‐MYC helix‐loop‐helix region. The binding site overlaps with the c‐MYC DNA‐binding region, and we show that binding of INI1 and E‐box DNA to c‐MYC:MAX are mutually exclusive.

International audience; In this paper, we thoroughly elaborate on the impact different transmit-antenna selection (TAS) strategies induce in terms of the outage performance of incremental cognitive multiple-input multiple-output (MIMO) relaying systems employing receive maximum-ratio combining (MRC). Our setup consists of three multi-antenna secondary nodes: a transmitter, a receiver and a decode-and-forward (DF) relay node acting in a half-duplex incremental relaying mode whereas the primary transmitter and receiver are equipped with a single antenna. Only a statistical channel-state information (CSI) is acquired by the secondary system transmitting nodes to adapt their transmit power. In this context, our contribution is fourfold. First, we focuson two TAS strategies that are driven by maximizing either the received signal-to-noise ratio (SNR) or signal-to-interferenceplus-noise ratio (SINR), and extend their operating mode into an incremental relaying setup where MRC is carried jointly over both relaying hops. Second, given the inherited complexity, we proceed by the exact outage analysis of the direct (first-hop) transmission as a preliminary yet innovative step pertaining to the SINR-driven TAS strategy. Third, the end-to-end (secondhop) transmission outage performance is also evaluated although shown to entail an involved derivation roadmap for both TAS strategies. Forth, we simplify our exact derivations by means of the asymptotic analysis which reveals that the detrimental effect of mutual interference on the secondary system is originated from the primary transmitter (i.e., co-channel interference) and not from the primary receiver (i.e., interference threshold). That is, even if the secondary system operates at a high tolerated amount of interference, an outage floor will still occur because the primary system will pump a high amount of co-channel interference in return. The SINR-driven TAS shows up as an optimal interference-aware strategy in this regard. It achieves the same diversity gain but a better coding gain compared to its SNR-driven counterpart. The correctness of our results is confirmed by Monte Carlo simulations and the actual outage gap between both TAS strategies is reflected.

Supertree methods merge a set of overlapping phylogenetic trees into a supertree containing all taxa of the input trees. The challenge in supertree reconstruction is the way of dealing with conflicting information in the input trees. Many different algorithms for different objective functions have been suggested to resolve these conflicts. In particular, there exist methods based on encoding the source trees in a matrix, where the supertree is constructed applying a local search heuristic to optimize the respective objective function. We present a novel heuristic supertree algorithm called Bad Clade Deletion (BCD) supertrees. It uses minimum cuts to delete a locally minimal number of columns from such a matrix representation so that it is compatible. This is the complement problem to Matrix Representation with Compatibility (Maximum Split Fit). Our algorithm has guaranteed polynomial worst-case running time and performs swiftly in practice. Different from local search heuristics, it guarantees to return the directed perfect phylogeny for the input matrix, corresponding to the parent tree of the input trees, if one exists. Comparing supertrees to model trees for simulated data, BCD shows a better accuracy (F1 score) than the state-of-the-art algorithms SuperFine (up to 3%) and Matrix Representation with Parsimony (up to 7%); at the same time, BCD is up to 7 times faster than SuperFine, and up to 600 times faster than Matrix Representation with Parsimony. Finally, using the BCD supertree as a starting tree for a combined Maximum Likelihood analysis using RAxML, we reach significantly improved accuracy (1% higher F1 score) and running time (1.7-fold speedup).

Although some studies have been conducted over the past few decades, the existence of mitochondria-rich cells (MRCs) in reptiles is still obscure. This is the first study to uncover the presence of MRCs in the small intestine of Chinese soft-shelled turtles. In this study, we investigated the ultrastructural characteristics of MRCs and the secretion of different ion transport proteins in the small intestine of Pelodiscus sinensis. Transmission electron microscopy revealed that the ultrastructural features of MRCs are clearly different from those of other cells. The cytoplasmic density of MRCs was higher than absorptive epithelial cells (AECs) and goblet cells (GCs). MRCs possessed abundant heterogeneous mitochondria and an extensive tubular system in the cytoplasm, however, the AECs and GCs completely lacked a tubular system. Statistical analysis showed that the diameter and quantification of mitochondria were highly significant in MRCs. Mitochondrial vacuolization and despoiled mitochondria were closely associated with autophagosomes in MRCs. The multivesicular bodies (MVBs) and the exosome secretion pathway were observed in MRCs. Immunohistochemical staining of ion transport proteins indicated positive immunoreactivity of Na+/K+_ATPase (NKA) and Na+/K+/2Cl− cotransporter (NKCC) at the basal region of the mucosal surface. Likewise, the immunofluorescence staining results showed a strong positive localization of NKA, NKCC, and carbonic anhydrase (CA) at the basal and apical region of the mucosal surface of small intestine. Our findings suggest that MRCs provide support and regulate cellular ions for intestinal homeostasis and provide energy for cellular quality control in intestine.

In the last years, wireless communications in industrial scenarios are becoming an increasingly important market. Some of these communications have tight reliability requirements, but harsh propagation conditions in industrial scenarios represent a major challenge. In this paper, multi-connectivity is explored as a solution for assuring high reliability in industrial scenarios. Several multi-connectivity techniques are compared, using real channel measurements from two factories. Multi-connectivity comes at the cost of a reduced throughput in the mobile broadband services on the same network. In this paper, this impact is quantified to assess for the cost of implementing multi-connectivity.

This study explored the regenerative osteogenic response in the distal femur of sheep using scaffolds having stiffness values within, and above and below, the range of trabecular bone apparent modulus. Scaffolds 3D-printed from stiff titanium and compliant polyamide were implanted into a cylindrical metaphyseal defect 15 × 15 mm. After six weeks, bone ingrowth varied between 7 and 21% of the scaffold pore volume and this was generally inversely proportional to scaffold stiffness. The individual reparative response considerably varied among the animals, which could be divided into weak and strong responders. Notably, bone regeneration specifically within the interior of the scaffold was inversely proportional to scaffold stiffness and was strain-driven in strongly-responding animals. Conversely, bone regeneration at the periphery of the defect was injury-driven and equal in all scaffolds and in all strongly- and weakly-responding animals. The observation of the strain-driven response in some, but not all, animals highlights that scaffold compliance is desirable for triggering host bone regeneration, but scaffold permanence is important for the load-bearing, structural role of the bone-replacing device. Indeed, scaffolds may benefit from being nonresorbable and mechanically reliable for those unforeseeable cases of weakly responding recipients.

The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, we have improved the functionality of PEDOT:PSS for neural tissue engineering by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesised using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalised oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone) (PCL), we produce a block co-polymer that is electroactive, processable, and bio-compatible. By combining these properties, we were able to produce electroactive fibrous mats for neuronal culture via solution electrospinning and melt electrospinning writing (MEW). Importantly, we also show that neurite length and branching of neural stem cells can be enhanced on our materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.

Hutchinson-Gilford progeria syndrome (HGPS) is an incurable premature aging disease. Identifying deregulated biological processes in HGPS might thus help define novel therapeutic strategies. Fibroblasts from HGPS patients display defects in nucleocytoplasmic shuttling of the GTP-bound form of the small GTPase Ran (RanGTP), which leads to abnormal transport of proteins into the nucleus. We report that microtubule stabilization in HGPS cells sequestered the nonclassical nuclear import protein Transportin-1 (TNPO1) in the cytoplasm, thus affecting the nuclear localization of its cargo, including the nuclear pore protein NUP153. Consequently, nuclear Ran, nuclear anchorage of the nucleoporin TPR, and chromatin organization were disrupted, deregulating gene expression and inducing senescence. Inhibiting N-acetyltransferase 10 (NAT10) ameliorated HGPS phenotypes by rebalancing the nuclear to cytoplasmic ratio of TNPO1. This restored nuclear pore complex integrity and nuclear Ran localization, thereby correcting HGPS cellular phenotypes. We observed a similar mechanism in cells from healthy aged individuals. This study identifies a nuclear import pathway affected in aging and underscores the potential for NAT10 inhibition as a possible therapeutic strategy for HGPS and perhaps also for pathologies associated with normal aging.

Janani Suraksha Yojana (safe motherhood scheme, or JSY) provides cash incentives to marginal pregnant women in India conditional on having mainly institutional delivery. Using the fourth round of district level household survey (DLHS-4), we have estimated its effects on both intended and unintended outcomes. Our estimates of average treatment effect on the treated (ATT) from propensity score matching are remarkably higher than those found in previous prominent studies using the second and third rounds of the survey (DLHS-2 and DLHS-3). When we apply fuzzy regression discontinuity design exploiting the second birth order, our estimates of local average treatment effect (LATE) are much higher than that of ATT. For example, due to JSY, institutional delivery increases by around 16 percentage points according to ATT estimate but about 23 percentage points according to LATE estimate.

Azacitidine (AZA) prolonged overall survival (OS) in the AZA-AML-001 trial. However, few subjects were randomized to AZA or intensive chemotherapy (IC). The Medical Research Council (MRC) and the Leukemia Research Foundation (LRF) developed a score for older AML patients receiving IC or non-intensive regimens, whereas the E-ALMA study validated a score for survival and response in elderly patients receiving AZA in daily practice. Both identified three groups with different risk estimates. This analysis evaluates the efficacy of frontline AZA in older AML patients (N=710) unfit for IC from different national registries (E-ALMA+series) stratified by the MRC/LRF risk score. Median OS of patients categorized as good, standard and poor-risk groups by the MRC/LRF score was 13.4 (95% CI, 10.8-16), 12.4 (95% CI, 9.9-14.8), and 8.1 months (95% CI, 7-9.1), respectively (p=.0001). In conclusion, this is the largest retrospective cohort of older AML patients treated with AZA.

Reduced-complexity implementations are critical for massive MIMO (Multiple Input, Multiple Output) systems. In this paper we consider the uplink of broadband massive MIMO systems employing SC-FDE (Single-Carrier with Frequency-Domain Equalization) schemes, where multiple users transmit to a single base station with a large number of antennas. We propose low-complexity frequency-domain detection schemes that allow excellent performance, but do not require matrix inversions. info:eu-repo/semantics/acceptedVersion

Background Preservation of function is essential in surgical resection of lesions involving the motor pathways. The aim of this work is to evaluate the effect of anatomic features of lesions located in the motor pathway on neurologic and functional outcome. We propose an evaluation score to assess the risk of postoperative worsening. Methods A total of 92 patients suffering from lesions involving the motor pathways have been studied for what concerns motor functions (muscular strength scale [MRC]) after surgical treatment. Patient-related, surgery-related, and lesion-related data were recorded to identify relations with motor outcomes. Cortical surfacing of the lesion and amount of millimeters of interface between the lesion and corticospinal tract have been investigated with preoperative magnetic resonance imaging sequences and tractographic reconstructions. Results Means of the MRC Scale preoperative and 7 days postoperative were 3.6 ± 2.23 and 3.8 ± 2.28 for the upper limbs, and 4.1 ± 2.31 and 4.4 ± 2.33 for the lower limbs, respectively. Patients that were stable or improved at 7 days from surgery were 82.6%. The anatomic features investigated have been summed up in a single score (envelopment/surfacing [ES]). In cases of ES classes V and VI, a total cumulative predicted worsening rate was 24.2% and 14.8%, respectively. The risk of worsening was 1.682 times greater for the higher ES classes (IV–VI). Conclusions The anatomic features of lesions are crucial in the prediction of motor outcome. The new proposed score (ES score) is useful to stratify motor function prognosis.

Although some studies have been conducted over the past few decades, the existence of mitochondria-rich cells (MRCs) in reptiles is still obscure. This is the first study to uncover the presence of MRCs in the small intestine of Chinese soft-shelled turtles. In this study, we investigated the ultrastructural characteristics of MRCs and the secretion of different ion transport proteins in the small intestine of Pelodiscus sinensis. Transmission electron microscopy revealed that the ultrastructural features of MRCs are clearly different from those of other cells. The cytoplasmic density of MRCs was higher than absorptive epithelial cells (AECs) and goblet cells (GCs). MRCs possessed abundant heterogeneous mitochondria and an extensive tubular system in the cytoplasm, however, the AECs and GCs completely lacked a tubular system. Statistical analysis showed that the diameter and quantification of mitochondria were highly significant in MRCs. Mitochondrial vacuolization and despoiled mitochondria were closely associated with autophagosomes in MRCs. The multivesicular bodies (MVBs) and the exosome secretion pathway were observed in MRCs. Immunohistochemical staining of ion transport proteins indicated positive immunoreactivity of Na+/K+_ATPase (NKA) and Na+/K+/2Cl&minus, cotransporter (NKCC) at the basal region of the mucosal surface. Likewise, the immunofluorescence staining results showed a strong positive localization of NKA, NKCC, and carbonic anhydrase (CA) at the basal and apical region of the mucosal surface of small intestine. Our findings suggest that MRCs provide support and regulate cellular ions for intestinal homeostasis and provide energy for cellular quality control in intestine.

Corporate social responsibility attempts to align organizational and social objectives. Alignment can be achieved by application of cause-related marketing (CRM) methods. Therefore this article seeks to identify main determinants of success in CRM campaigns. This research was qualitative for an in depth study of three Brazilian companies. Results show that widespread communication, use of marketing mix, synergy between the cause and company business and long term action as well as a strong reputation for social responsibility are mainstays for success in CRM objectives.

As neuronal development progresses, GABAergic synaptic transmission undergoes a defined program of reconfiguration. For example, GABAA receptor (GABAAR)-mediated synaptic currents, (miniature inhibitory postsynaptic currents; mIPSCs), which initially exhibit a relatively slow decay phase, become progressively reduced in duration, thereby supporting the temporal resolution required for mature network activity. Here we report that during postnatal development of cortical layer 2/3 pyramidal neurons, GABAAR-mediated phasic inhibition is influenced by a resident neurosteroid tone, which wanes in the second postnatal week, resulting in the brief phasic events characteristic of mature neuronal signalling. Treatment of cortical slices with the immediate precursor of 5α-pregnan-3α-ol-20-one (5α3α), the GABAAR-inactive 5α-dihydroprogesterone, (5α-DHP), greatly prolonged the mIPSCs of P20 pyramidal neurons, demonstrating these more mature neurons retain the capacity to synthesize GABAAR-active neurosteroids, but now lack the endogenous steroid substrate. Previously, such developmental plasticity of phasic inhibition was ascribed to the expression of synaptic GABAARs incorporating the α1 subunit. However, the duration of mIPSCs recorded from L2/3 cortical neurons derived from α1 subunit deleted mice, were similarly under the developmental influence of a neurosteroid tone. In addition to principal cells, synaptic GABAARs of L2/3 interneurons were modulated by native neurosteroids in a development-dependent manner. In summary, local neurosteroids influence synaptic transmission during a crucial period of cortical neurodevelopment, findings which may be of importance for establishing normal network connectivity., Highlights • Upon postnatal maturation GABAA receptor synaptic inhibition is reduced in duration. • Reduced synthesis of local neurosteroids contributes to this cortical plasticity. • The study reveals a potent mechanism to locally regulate cortical neuron activity.

We performed a comparison between Neuropathy Impairment Scale-sensory (NISs) vs. the modified Inflammatory Neuropathy Cause and Treatment sensory scale (mISS), and NIS-motor vs. the Medical Research Council sum score in patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and IgM monoclonal gammopathy of undetermined significance-related polyneuropathy (MGUSP). The ordinal data were subjected to Rasch analyses, creating Rasch-transformed (RT)-intervals for all measures. Comparison between measures was based on validity/reliability with an emphasis on responsiveness (using the patient's level of change related to the individually obtained varying SE for minimum clinically important difference). Eighty stable patients (GBS: 30, CIDP: 30, and MGUSP: 20) were assessed twice (entry: two observers; 2-4weeks later: one observer), and 137 newly diagnosed or relapsing patients (GBS: 55, CIDP: 59, and IgM-MGUSP: 23) were serially examined with 12months follow-up. Data modifications were needed to improve model fit for all measures. The sensory and motor scales demonstrated approximately equal and acceptable validity and reliability scores. Responsiveness scores were poor but slightly higher in RT-mISS compared to RT-NISs. Responsiveness was equal for the RT-motor scales, but higher in GBS compared to CIDP; responsiveness was poor in patients with MGUSP, suggesting a longer duration of follow-up in the latter group of patients.

La recherche empirique sur la dynamique locale peut offrir une importante contribution à la notion de partenariat. Cet article s'inscrit dans une perspective d'« interaction » comme facteur spatial qui influence l'économie. Nous utilisons un cadre d'analyse de réseaux. Les données recueillies auprès des partenaires d'une MRC québécoise et traitées sous forme d'indicateurs permettent de modéliser le processus de flux d'information spatialisé. Celui-ci conduit, d'une part, à l'organisation de l'espace local en question et, d'autre part, à l'émergence de retombées à caractère économique., Empirical research on local development can offer an important contribution for building the notion of partnership. This paper takes place in an interaction perspective as a factor of spatial economies. We use a network analysis framework. The data picked up in a local community (MRC) of Québec make possible the elaboration of a model showing the spatialised information flow process. The dynamics formalized drives partners towards space organization and brings economic activities.

In our previous work maximum throughput in multi stream MIMO is analyzed by overcoming the inter antenna interference. To mitigate the Inter antenna interference spatial modulation can be used. Spatial Modulation(SM) aided MIMO systems are the emerging MIMO systems which are low complex and energy efficient. These systems additionally use spatial dimensions for transmitting information. In this paper a low complex detector based on matched filter is proposed for spatial modulation to achieve near maximum likelihood performance while avoiding exhaustive ML search since MF based detector exhibits a considerable reduced complexity since activated transmitting antenna and modulated amplitude phase modulation constellation are estimated separately. Simulation results show the performance of the proposed method with optimal ML detector, MRC and conventional matched filter methods.

This paper deals with decision fusion in wireless sensor networks (WSNs) over Rayleigh fading channels. The likelihood ratio test (LRT) is considered as the optimal fusion rule when applied at the fusion center (FC). However, applying the LRT at the FC requires both the channel state information (CSI) and the local sensors’ performance indices. Acquiring such information is considered as an overhead in energy and bandwidth constrained systems such as WSNs. To avoid these drawbacks, we propose a modification to the traditional three-layer system model of a WSN where the LRT is applied as a local decision making method at the sensors level. Applying the LRT at the sensors level does not require the CSI or the local sensors’ performance indices. It only requires the signal-to-noise ratio (SNR). Moreover, a new fusion rule based on selection combining (SC) is suggested. This fusion method has the lowest complexity when compared to other diversity combining based fusion rules such as the equal gain combiner (EGC) and the maximum ratio combiner (MRC). Simulation results show that the performance of the proposed model outperforms the traditional model. In addition, applying the EGC at the FC in the proposed model provides comparable performance to the traditional model that applies the LRT at the FC.

Consistent powering is a limiting reagent for many medical implants and sensors. Powering in-vivo devices in animal studies requires either transcutaneous wiring (limiting mobility and increasing the chance of infection) or an implanted battery (limited lifetime and limits size of device). Wireless power transfer (WPT) would be able to overcome these challenges and permit the use of more advanced implantable devices in a research setting. Magnetic resonance coupling (MRC), an advanced form of inductive charging, allows good transfer efficiencies over significant air gaps, but works best a specific location and frequency, limiting mobility in animal studies. Using band-pass filter theory, an MRC system was simulated and optimized, as well as a design for a continuous WPT animal cage system utilizing MRC with 896 cm2. Both the frequency response and the actual power transfer of the systems were tested; downstream rectification circuitry was also developed to demonstrate WPT. Results indicate using multiple coils in series in a circle orthogonal to the individual coils produced a homogenous magnetic field and frequency response, and using passive coils increased coupling and efficient power transfer. While MRC is traditionally not a robust system, our results show the application can be extended charging over a wide range of space, allowing animal mobility and current experiments to be aided with electronic implants.

Introduction Direct comparison of the relative efficacy of different recruitment maneuvers (RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is difficult, due to the heterogeneity of patient populations and disease states, as well as a variety of practical issues. There is also significant uncertainty regarding the minimum values of positive end-expiratory pressure (PEEP) required to ensure maintenance of effective lung recruitment using RMs. We used patient-specific computational simulation to analyze how three different RMs act to improve physiological responses, and investigate how different levels of PEEP contribute to maintaining effective lung recruitment. Methods We conducted experiments on five ‘virtual’ ARDS patients using a computational simulator that reproduces static and dynamic features of a multivariable clinical dataset on the responses of individual ARDS patients to a range of ventilator inputs. Three recruitment maneuvers (sustained inflation (SI), maximal recruitment strategy (MRS) followed by a titrated PEEP, and prolonged recruitment maneuver (PRM)) were implemented and evaluated for a range of different pressure settings. Results All maneuvers demonstrated improvements in gas exchange, but the extent and duration of improvement varied significantly, as did the observed mechanism of operation. Maintaining adequate post-RM levels of PEEP was seen to be crucial in avoiding cliff-edge type re-collapse of alveolar units for all maneuvers. For all five patients, the MRS exhibited the most prolonged improvement in oxygenation, and we found that a PEEP setting of 35 cm H2O with a fixed driving pressure of 15 cm H2O (above PEEP) was sufficient to achieve 95% recruitment. Subsequently, we found that PEEP titrated to a value of 16 cm H2O was able to maintain 95% recruitment in all five patients. Conclusions There appears to be significant scope for reducing the peak levels of PEEP originally specified in the MRS and hence to avoid exposing the lung to unnecessarily high pressures. More generally, our study highlights the huge potential of computer simulation to assist in evaluating the efficacy of different recruitment maneuvers, in understanding their modes of operation, in optimizing RMs for individual patients, and in supporting clinicians in the rational design of improved treatment strategies.

Summary Background Magnetic resonance cholangiography (MRC) has been validated as comparable to endoscopic retrograde cholangiography (ERC) for the diagnosis of sclerosing cholangitis (SC) in adult patients. In children, MRC is widely used based mainly on non-comparative studies. Patients and methods ERCs and MRCs of seven children (median age 9, range: 7–20 years) with SC and 17 controls (median age 6, range: 2 months–20 years) with other chronic liver diseases were reviewed in a blinded, random and independent way. All patients underwent both examinations within a 6-months slot. All ERCs and 17 MRCs were performed under general anesthesia. One radiologist evaluated both ERCs and MRCs and one interventional endoscopist independently reviewed only ERCs. Reviewers did not receive any clinical information. Diagnosis of SC, established on the basis of history, laboratory data, radiological examinations and clinical course, was used as gold standard to compare ERC and MRC diagnostic accuracy. Results Overall image quality was graded as very good in 57% of MRC and in 71% of ERC cases; difference was not statistically significant ( P = 0.24) although the probability for MRC to be diagnostic increased with patient's age. Depiction of first, second and fourth-order intrahepatic bile duct was better in ERC ( P = 0.004, 0.02 and 0.023, respectively); depiction of the extrahepatic bile duct was comparable ( P = 0.052). Diagnostic accuracy of MRC and ERC was very high, without statistically significant difference ( P = 0.61). Conclusion Despite an overall better depiction of the biliary tree by ERC, MRC is comparable for the diagnosis of SC in children. These data support MRC as the first imaging approach in children with suspected SC.

The Medical Research Council grading system has served through decades for the evaluation of muscle strength and has been recognized as a cardinal feature of daily neurological, rehabilitation and general medicine examination of patients, despite being respectfully criticized due to the unequal width of its response options. No study has systematically examined, through modern psychometric approach, whether physicians are able to properly use the Medical Research Council grades. The objectives of this study were: (i) to investigate physicians' ability to discriminate among the Medical Research Council categories in patients with different neuromuscular disorders and with various degrees of weakness through thresholds examination using Rasch analysis as a modern psychometric method; (ii) to examine possible factors influencing physicians' ability to apply the Medical Research Council categories through differential item function analyses; and (iii) to examine whether the widely used Medical Research Council 12 muscles sum score in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy would meet Rasch model's expectations. A total of 1065 patients were included from nine cohorts with the following diseases: Guillain-Barre syndrome (n = 480); myotonic dystrophy type-1 (n = 169); chronic inflammatory demyelinating polyradiculoneuropathy (n = 139); limb-girdle muscular dystrophy (n = 105); multifocal motor neuropathy (n = 102); Pompe's disease (n = 62) and monoclonal gammopathy of undetermined related polyneuropathy (n = 8). Medical Research Council data of 72 muscles were collected. Rasch analyses were performed on Medical Research Council data for each cohort separately and after pooling data at the muscle level to increase category frequencies, and on the Medical Research Council sum score in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. Disordered thresholds were demonstrated in 74-79% of the muscles examined, indicating physicians' inability to discriminate between most Medical Research Council categories. Factors such as physicians' experience or illness type did not influence these findings. Thresholds were restored after rescoring the Medical Research Council grades from six to four options (0, paralysis; 1, severe weakness; 2, slight weakness; 3, normal strength). The Medical Research Council sum score acceptably fulfilled Rasch model expectations after rescoring the response options and creating subsets to resolve local dependency and item bias on diagnosis. In conclusion, a modified, Rasch-built four response category Medical Research Council grading system is proposed, resolving clinicians' inability to differentiate among its original response categories and improving clinical applicability. A modified Medical Research Council sum score at the interval level is presented and is recommended for future studies in Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.

The objective of this thesis is to investigate the performances of digital communication systems that employ complex spreading modulation schemes in a Rayleigh fading channel. First, we examine binary modulation systems with multiple-input, single-output (MISO) configurations. Later, we study MISO systems for complex spreading modulation systems in general. We demonstrate the performances of specific and widely used modulation schemes such as quadrature phase-shift keying (QPSK), 16-quadrature amplitude modulation (16-QAM) and 64-quadrature amplitude modulation (64-QAM). We also investigate the performances of the previous systems for multiple-input, multiple-output (MIMO) configurations for various combinations of transmit and receive antennas. In all systems, we apply maximal ratio combining (MRC) in order to obtain the maximum signal-to-noise ratio for MIMO systems. Finally, for all the different systems and configurations, we evaluate their performances for a Rayleigh fading channel and in the presence of different types of jamming (barrage noise jamming, pulsed-jamming and tone jamming). http://archive.org/details/performanceofcom1094541204 Hellenic Navy author Approved for public release; distribution is unlimited.

The major driver for broadband wireless communications has been reliable, high-data rate services. In wireless communication, the multipath fading constitutes a bottleneck for increasing data rates and causes performance degradation. To combat fading, we can use diversity. Wireless systems with multiple antennas at the transmitter and receiver have much larger capacity in fading channels than standard wireless systems. The objective of this thesis is to investigate the transmission scheme provided by matrix A and B in the 802.16 standard and show how it can be implemented. The research focuses on using maximal-ratio combining (MRC) to demodulate the transmitted symbols. Modifications to the existing matrix by using more frequency bands were introduced; this reduces the number of transmitting antennas and uses fewer time slots to transmit the same number of symbols. The modulator and demodulator design is also discussed. The performance of orthogonal and non-orthogonal space time codes (STC) are evaluated. http://archive.org/details/implementationnd1094555198 Civilian Approved for public release; distribution is unlimited.

We consider multiple-input, multiple-output (MIMO) wireless communication systems that employ multiple transmit and receive antennas to increase the data rate and achieve diversity in fading multipath channels. We begin by focusing on an uncoded system and define optimal and suboptimal receiver structures for this system in Rayleigh fading with and without intersymbol interference. Next, we consider coded MIMO systems. We view the coded system as a serially concatenated convolutional code (SCCC) in which the code and the multipath channel take on the roles of constituent codes. This enables us to analyze the performance using the same performance analysis tools as developed previously for SCCCs. Finally, we present an iterative ("turbo") MAP-based equalization and decoding scheme and evaluate its performance when applied to a system with transmit antennas and receive antennas. We show that by performing recursive precoding prior to transmission, significant interleaving gains can be realized compared to systems without precoding.

In the present study we set out to investigate the expression of E-cadherin, N-cadherin, β 1 -integrin, fibronectin and vitronectin in the mitochondria-rich cells (MRC) of the skin of Salamandra salamandra salamandra . Moreover MRC were stained with five lectins ( Triticum vulgaris; Dolichos biflorus; Glycine max; Arachis hypogaea and Canavalia ensiformis ). Larval MRC expressed both adhesion molecules and extracellular matrix glycoproteins and bound all lectins tested. Juvenile MRC did not react with the antisera utilized, but they stained with the lectins. Both the lectins and the regulatory molecules proved to be good cytochemical markers for distinguishing morphologically differentiated MRC during the larval life of Salamandra salamandra salamandra . The adhesion molecules and matrix glycoproteins are of great utility for maintaining the correct tissue architecture. In Salamandra salamandra salamandra larvae these molecules may be crucial for stability and for the correct localization and fate of all skin elements, including specialized cells such as larval MRC.