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Your search keyword '"di Grazia, C."' showing total 90 results
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90 results on '"di Grazia, C."'

1. Small bowel intussussception due to metastatic melanoma of unknown primary site. Case report

Author

STAGNITTI, F., ORSINI, S., MARTELLUCCI, A., TUDISCO, A., AVALLONE, M., AIUTI, F., DI GIROLAMO, V., STEFANELLI, F., DE ANGELIS, F., COSTANTINO, A., DI GRAZIA, C., NAPOLEONI, A., NICODEMI, S., CIPRIANI, B., CECI, F., MOSILLO, R., CORELLI, S., CASCIARO, G., and SPAZIANI, E.

Subjects
Male, Oncology, Pathology, medicine.medical_specialty, Ileum, Metastasis, Clinical Practice, Internal medicine, medicine, Humans, Malignant melanoma, Unknown primary, Intestinal intussusceptions, Disseminated disease, Melanoma, Gastrointestinal tract, business.industry, Middle Aged, medicine.disease, Ileal Neoplasms, medicine.anatomical_structure, Iron-deficiency anemia, Neoplasms, Unknown Primary, Segmental resection, business, Intestinal Obstruction, Brain metastasis
Abstract

Malignant melanoma is characterized by metastases also to the gastrointestinal tract, especially in the small bowel. The diagnosis is often delayed because unspecific clinical presentation (frequently as chronic iron deficiency anemia, rectal bleeding or intestinal obstruction). We present a case of melanoma of unknown primary site, with clinical presentation of intestinal obstruction. A segmental resection of the ileum was performed including mesentery with lymph nodes. Histology revealed metastatic melanoma from unknown primary. PET and MRI confirmed disseminated disease without brain metastasis.

Published
2014

2. Risk management in surgery

Author

Messano, GIUSEPPE ALESSIO, Spaziani, Erasmo, Turchetta, F., Ceci, F., Corelli, S., Casciaro, Giovanni Enrico, Martellucci, A., Costantino, A., Napoleoni, A., Cipriani, B., Nicodemi, S., Di Grazia, C., Mosillo, R., Avallone, M., Orsini, S., Tudisco, A., Aiuti, F., and Stagnitti, Franco

Subjects
antibiotic therapy, laparoscopic drainage, liver abscesses, percutaneous drainage, risk management, Risk Management, Italy, Surgical Procedures, Operative, Humans, Focus on, Checklist
Abstract

Malpractice is the responsible for the greatest number of legal claims. At the present time, legal actions against physicians in Italy are 15,000 per year, and a stunning increase about costs to refund patients injured by therapeutic and diagnostic errors is expected. The method for the medical prevention is “Risk Management”, that is the setting-up of organizational instruments, methods and actions that enable the measurement or estimation of medical risk; it allows to develop strategies to govern and reduce medical error. In the present work, the reconstruction about the history of risk management in Italy was carried out. After then the latest initiatives undertaken by Italy about the issue of risk management were examined.

Published
2013

3. High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: Absence of correlation with hepatitis C virus infection

Author

Renzo, A., Persico, E., Marino, F., Di Giacomo Russo, G., Rosario Notaro, Di Grazia, C., Picardi, M., Santoro, L., Torella, R., Rotoli, B., Persico, M., DE RENZO, A., Persico, E., DE MARINO, F., DI GIACOMO RUSSO, G., Notaro, R., DI GRAZIA, C., Picardi, Marco, Santoro, L., Torella, R., Rotoli, Bruno, and Persico, M.

Subjects
Hodgkin disease, adult, correlation analysis, prevalence, article, major clinical study, aged, carcinogenesis, comorbidity, controlled study, female, hepatitis C, hepatitis G, human, lymphoproliferative disease, male

32. Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation

Author

Bacigalupo, A., Sormani, M. P., Lamparelli, T., Gualandi, F., Occhini, D., Bregante, S., ANNA MARIA RAIOLA, Di Grazia, C., Dominietto, A., Tedone, E., Piaggio, G., Podesta, M., Bruno, B., Oneto, R., Lombardi, A., Frassoni, F., Rolla, D., Rollandi, G., Viscoli, C., Ferro, C., Garbarino, L., and Lint, M. T.

Subjects
Adult, Male, Neutropenia, Transplantation Conditioning, Multiple Organ Failure, Premedication, Graft vs Host Disease, Infections, Anti-Infective Agents, Actuarial Analysis, Cause of Death, Antineoplastic Combined Chemotherapy Protocols, Humans, Transplantation, Homologous, Bone Marrow Transplantation, Retrospective Studies, Salvage Therapy, Infection Control, Peripheral Blood Stem Cell Transplantation, Leukemia, Remission Induction, Hematopoietic Stem Cell Transplantation, Middle Aged, Combined Modality Therapy, Survival Analysis, Treatment Outcome, Hematologic Neoplasms, Female, Lung Diseases, Interstitial, Immunosuppressive Agents
Abstract

Transplant-related mortality (TRM) following allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be related to disease stage, duratiion of disease and type of donor. Furthermore, the outcome of transplants performed in the 1990s appears to be better than that of transplants done in the previous decade. The aims of this study were to determine whether these relationships still hold and whether the outcome of transplants is continuing to improve.We analyzed 1180 consecutive patients with leukemia (n=979) or other hematologic malignancies (n=201) undergoing HSCT in 4 time periods: before 1990, 1991-1995, 1996-2000, and 2001-2002. Changes during these eras include increasing patient age, more unrelated transplants, more patients with advanced disease, different graft-versus-host disease (GvHD) prophylaxis, and different management of infections.The actuarial 2-year transplant-related mortality (TRM) differed significantly between the transplant eras (p0.001) with a significant interaction with disease phase (p=0.018). In patients in first remission (n=585) TRM was 34%, 25%, 21% and 6% in the four transplant eras. The reduction in TRM was less evident in patients in second remission (n=284) (37%, 35%, 30%, 25%) and absent in relapsed patients (n=311) (TRM=45%, 41%, 29%, 51%). This is a consequence of reductions in GvHD, infections and multiorgan failure among patients in remission but not among those who relapse. The actuarial 2-year survival has improved significantly in patients in first remission (54%, 66%, 72%, 78%) but not in those in second remission (38%, 46%, 52%,45%), or relapsed patients (31%, 25%, 36%, 21%).In conclusion, TRM has been significantly reduced in first remission patients, suggesting an allograft should be considered in this phase, when appropriate, without delay. There has been no improvement in survival for patients beyond first remission, due to persisting high risk of infections and organ toxicity, a possible consequence of prolonged pre-transplant chemotherapy and neutropenia.

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