1. Rotational Three-dimensional OCTA: a Notable New Imaging Tool to Characterize Type 3 Macular Neovascularization
- Author
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Riccardo Sacconi, Giuseppe Querques, Gerd Klose, Enrico Borrelli, Luis de Sisternes, Francesco Bandello, Borrelli, E., Sacconi, R., Klose, G., de Sisternes, L., Bandello, F., and Querques, G.
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Materials science ,genetic structures ,Computed Tomography Angiography ,Fundus Oculi ,lcsh:Medicine ,Retinal Neovascularization ,Article ,Neovascularization ,Macular Degeneration ,03 medical and health sciences ,chemistry.chemical_compound ,Imaging, Three-Dimensional ,0302 clinical medicine ,Imaging Tool ,Ophthalmology ,medicine ,Humans ,lcsh:Science ,Aged ,Retrospective Studies ,Aged, 80 and over ,Multidisciplinary ,lcsh:R ,Retinal Vessels ,Diagnostic markers ,Retinal ,Optical coherence tomography angiography ,Macular degeneration ,medicine.disease ,Choroidal Neovascularization ,Retinal diseases ,eye diseases ,Cross-Sectional Studies ,030104 developmental biology ,chemistry ,030221 ophthalmology & optometry ,lcsh:Q ,Female ,sense organs ,medicine.symptom ,Detection rate ,Tomography, Optical Coherence - Abstract
This study explored whether rotational three-dimensional (3D) visualization of optical coherence tomography angiography (OCTA) volume data may yield valuable information regarding type 3 macular neovascularization (MNV). In this retrospective, cross-sectional study, we collected data from 15 eyes (13 patients) with treatment-naïve type 3 MNV in their post-nascent stage and age-related macular degeneration (AMD). Subjects were imaged with the SS-OCT system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). The OCTA volume data were processed with a prototype volume projection removal algorithm and then analyzed using volumetric visualization techniques in order to obtain a 3D visualization of the region occupied by type 3 MNV. The two-dimensional and three-dimensional OCTA images were investigated. Mean ± SD age was 75.1 ± 7.4 years. BCVA was 0.42 ± 0.21 LogMAR in the study eyes. Considering the cohort of analyzed eyes, on rotational 3D OCTA images, a total of 35 neovascular lesions (vs 22 lesions detected on 2D OCTA images) rising from the deep vascular complex and variably spanning the outer retinal layers and eventually reaching the RPE/sub-RPE space were detected. Nine of 35 lesions had a saccular shape, while the remaining cases had a filiform shape. On rotational 3D OCTA images, these lesions were inclined on the three planes, instead of perpendicular to the RPE/Bruch’s membrane. In conclusion, this study used an algorithm to obtain rotational three-dimensional visualization of type 3 MNV. This approach seems to increase the detection rate for these lesions and to be useful to offer new insight into type 3 MNV.
- Published
- 2019