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While changes in the efficacy of synaptic transmission are believed to represent the physiological bases of learning mechanisms, other recent studies have started to highlight the possibility that a structural reorganization of synaptic networks could also be involved. Morphological changes of the shape or size of dendritic spines or of the organization of postsynaptic densities have been described in several studies, as well as the growth and formation following stimulation of new protrusions. Confocal in vivo imaging experiments have further revealed that dendritic spines undergo a continuous turnover and replacement process that may vary as a function of development, but can be markedly enhanced by sensory activation or following brain damage. The implications of these new aspects of plasticity for learning and memory mechanisms are discussed.

We consider intersecting M-brane solutions of supergravity in eleven dimensions. Supersymmetry turns out to be a powerful tool in obtaining such solutions and their generalizations., Comment: 6 pages, Latex, Presented at Supersymmetry and Quantum Field Theory, International Seminar dedicated to the memory of D. V. Volkov, Kharkov, 1997

Using global constraints and dynamic programming, a new model-based segmentation algorithm was developed to determine myocardial borders and basal plane. The segmented image is transformed to a countrate polar map and the infarct size (I.S.) is determined by comparison with a reference polar map. In order to evaluate our method the algorithm was applied to heart phantoms, to software simulations and to animal studies. In the last experiments, Tc-99m Sestamibi was used as a perfusion agent. The total myocardial volume and infarct size of a Jasczack phantom were overestimated, especially when I.S. was expressed in absolute rather than relative values. It was proven by software simulations of cardiac Spect studies that those errors were mainly due to finite resolution effects causing a clear overestimation of myocardial thickness. Implementation of a constant thickness in the algorithm resulted in a much better correlation with actual values. In a dog experiment the size of total myocardial volume of the area at risk during occlusion and of the final infarct size after thrombolysis was correlated with the histologic values obtained by planimetry after TTC staining. In 8 studies, an excellent correlation between the histologic area at risk versus the estimated perfusion defects was obtained (r = 0.97). The automatic delineation of myocardial borders and valve plane was excellent even when perfusion defects were present. Manual intervention was only necessary in certain slices where a clear overlap between liver and myocardium was present in the dog studies. Segmental polar maps expressing count rate and volume information provided a visual and quantitative tool to evaluate the influence of thrombolysis in acute ligation experiments. It is concluded that the new algorithm is ready to be used in a clinical environment for the quantitative evaluation of perfusion defects after acute myocardial infarction and for the follow-up of the therapeutic strategy.

We quantise the classical gauge theory of $N=2\ w_\infty$-supergravity and show how the underlying $N=2$ super-$w_\infty$ algebra gets deformed into an $N=2$ super-$W_\infty$ algebra. Both algebras contain the $N=2$ super-Virasoro algebra as a subalgebra. We discuss how one can extract from these results information about quantum $N=2\ W_N$-supergravity theories containing a finite number of higher-spin symmetries with superspin $s\le N$. As an example we discuss the case of quantum $N=2\ W_3$-supergravity., 44 pages

We investigate the scalar potential of gauged N=4 supergravity with matter. The extremum in the SU(1,1)/U(1) scalars is obtained for an arbitrary number of matter multiplets. The constraints on the matter scalars are solved in terms of an explicit parametrisation of an SO(6,6+n) element. For the case of six matter multiplets we discuss both compact and noncompact gauge groups. In an example involving noncompact groups and four scalars we find a potential with an absolute minimum and a positive cosmological constant., Comment: 14 pages

(1987). Half-Life of Thyroxine in Dogs: Explanation for the Diurnal Plasma Level Variations? Chronobiology International: Vol. 4, No. 2, pp. 127-128.

This paper summarizes a communication presented at the Second International Conference of Nuclear Cardiology, held in Cannes on 23-26 April 1995. The general evolution of nuclear medicine in Europe is examined within the context of European Union Directives, and the role of the Union of European Medical Specialists/Section of Nuclear Medicine is discussed. Thereafter consideration is given to the technical aspects of cardiovascular nuclear medicine procedures, and the situation with respect to such procedures in European countries is examined. In most European countries, nuclear medicine is a recognized specialty, while "nuclear cardiology" does not exist in its own right. In general, only nuclear medicine specialists have the responsibility for radionuclide studies, and most cardiovascular studies are performed under the direct responsibility of a licensed nuclear medicine specialist.