1. Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects
- Author
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Awadh Kishor, Rita Mourya, Jyoti Shrivastava, Ajay Sharma, Gunjan Jadon, Alka Agarwal, Hemendra Gautam, Sunil K. Singh, Satish Jankie, Shivkanya Fuloria, Neeraj Kumar Fuloria, Sunita Dahiya, Rajiv Dahiya, Sanjay Kumar Karan, Suresh Kumar, Sandeep Maharaj, Suresh V. Chennupati, and Shamjeet Singh
- Subjects
Aquatic Organisms ,Allosteric regulation ,azole-based peptide ,Pharmaceutical Science ,Peptide ,Review ,Computational biology ,010402 general chemistry ,cyanobacteria ,01 natural sciences ,chemistry.chemical_compound ,peptide synthesis ,Drug Discovery ,Peptide synthesis ,Animals ,Humans ,Thiazole ,lcsh:QH301-705.5 ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,chemistry.chemical_classification ,Biological Products ,Oligopeptide ,Molecular Structure ,010405 organic chemistry ,Drug discovery ,0104 chemical sciences ,Thiazoles ,lcsh:Biology (General) ,chemistry ,bioactivity ,cytotoxicity ,Peptides ,thiazole ,marine sponge - Abstract
Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide–peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents.
- Published
- 2020
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