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The aim: To check the e!ectiveness of the methodology for the formation of students’ health culture in the process of their physical education and health recreation activities Materials and methods: The following methods were used to achieve the aim: analysis, synthesis and generalization of literary sources, pedagogical observation, questionnaires, testing, pedagogical experiment, methods of mathematical statistics. 368 students took part in the ascertaining experiment, 93 students were involved in the formative experiment (52 – experimental group, 41 – control group). Results: The existing level of health culture formedness in students was revealed to be insu"cient, which stipulated the development and substantiation of the methodology for the formation of students’ health culture in the process of their physical education and health recreation activities. Conclusions: The implementation of the methodology for students’ health culture formation into the educational process contributed to an increase in the number of students with a high level of health culture and the level of motivation for a healthy lifestyle. The level of physical #tness of the experimental group students signi#cantly improved during the experiment. All this con#rms the e!ectiveness of the developed methodology.

The aim of the study was to evaluate the state of oxidation processes and morphological changes in the heart of castrated rats during the development of epinephrine heart damage (EHD). Materials and methods. The study was performed on 120 white male Wistar rats. The animals were divided into four series: 1 – control, 2 – castration. For EHD, rats were injected once intraperitoneally with a 0.18% solution of adrenaline hydrotartrate at the rate of 0.5 mg/kg of weight. Castration was performed under anesthesia. The concentration of diene and triene conjugates (DC, TC), Schiff’s bases (SB), TBA-active products (TBA-ap), oxidatively modi"ed proteins (OMP), activity of superoxide dismutase (SOD) and catalase (CAT) were determined in the heart. A morphological study of preparations stained with Azantrichrome was carried out. All studies were performed in control, 1, 3, 7, 14 and 28 days after adrenaline injection. Results: In the I series DC and TC increased after 1 day of EHD, fell to control values after 3 days, and then had wave-like character (highest – after 14 days). SB decreased (minimal after 7 days), TBA-ap increase (maximal after 14 days). OMP370 increased after 1 and 3 days, after 7 days they did not differ from the control, after 14 days they were higher than in control, and after 28 days they decreased to the control values. OMP430 and OMP530were greater than the control indicators in all terms, except the last; the maximum was noted after 14 days. The activity of antioxidant enzymes was lower than the control indicators at all times of the study. Castration caused an increase of lipid peroxidation. After 7 days, DC and TC, were lower and SB – higher, than in the I series. Castration caused a decrease in OMP. In EHD all values of OMP, compared to the castrated control rats, were higher at all studed times Castration leads to increase of SOD, and decrase of CAT. All indicators of SOD and CAT exceeded the indicators of animals of the I series at all times of the study. Biochemical changes are consistent with morphological changes. After injection of epinephrine, severe vascular disorders, adventitia edema, perivasal edema, endothelial cell damage, dilatation of hemicapillaries, full blood vessels, stasis, hemorrhages in the surrounding tissues, and sclerosing of the walls of arteries and venules were observed. Cardiomyocytes were swollen, shortening, necrosis was observed, myocytolysis was noted. Edema of the stroma was noted. In the stroma, around the vessels, located cells of connective tissue elements were observed. Indicate more damage to the myocardium in the process of development of EHD in animals of the I series. Conclusions: Castration of rats causes an increase of lipid peroxidation products and CAT activity in the heart, but a decrease in the content of OMP. Adrenaline injection causes activation of lipid peroxidation and an increase in the content of OMP. During the development of EHD, the activity of antioxidants is significantly higher in II group. Biochemical changes are consistent with morphological, and indicate more damage to the myocardium in the development of EHD in animals of the I series.

The article represents methodological substantiation and results of approbation of the diagnostic tool for studying of psychological readiness of preschool age children to training at school. The presented work is a continuation of scientific research in the direction of expanding the structure of psychological readiness for school through addition of its value-semantic component, as well as creation of a tool for its measurement. In the process of developing the methodology for diagnosing the value-semantic component of the psychological readiness for learning, the author relies on the age-related psychological characteristics of a preschool age child, which are oriented toward the choice of projective technology. In addition to this, the theoretical basis for the methodology creation was the author's vision of the content of value-semantic component of psychological readiness for learning, which constitutes an activity dynamic conceptual system of ``study``, containing a set of such values: health, active and productive life, cognition, politeness, education, tenacity. The article provides a thorough description of all the stages of the methodology development, accompanied by the results of an empirical study of its accuracy, reliability, and validity. Author's methodology of studying the value-semantic readiness for learning contains two sets of twenty-four pictures in each according to the gender of the testee with the instruction to them. Based on the results of the methodology standardization, the forms for fixing the results of the study, as well as the decil norms for each component of the value-semantic readiness for learning (affective and cognitive), and its general index are presented.

Aim: To investigate the impact of pedagogical means of working capacity restoration on students’ results in exercises of a cyclic nature. Materials and Methods: Research methods: theoretical analysis and generalization of literary sources, pedagogical observation, questionnaire, pedagogical experiment, methods of mathematical statistics. 58 students engaged in kettlebell lifting took part in the pedagogical experiment (28 students formed the experimental group, 30 – the control group). 123 coaches and 139 athletes who specialized in cyclic kinds of sports were involved in the survey. Results: It was found out that pedagogical means of restoration and improvement of working capacity are the main ones in the process of training athletes in cyclic kinds of sports. It was determined that with the growth of the athletes’ qualifications, the level of their knowledge and skills regarding the use of pedagogical means of restoration during the training process increases. It was established that the students of the experimental group achieved significantly better results in competitive exercises. Conclusions: Scientifically based, purposeful and constant use of pedagogical means of restoration and improvement of working capacity both in the training process and beyond the educational and training process is a mandatory condition for improving competitive results in cyclic kinds of sports and is a good basis for maintaining high working capacity of student-athletes and preserving their health.

The article is aimed at analyzing modern approaches to management of IT projects and revealing the possibilities for their improvement based on the use of fuzzy logic in the overall decision-making circuit. Based on the analysis of the main rating sites, a conclusion has been made about the powerful development of IT outsourcing in Ukraine. The main international and domestic ratings regarding the Ukrainian IT outsourcing market are analyzed, criteria of success and reasons for rapid development are allocated. Upon analyzing a sufficient number of works and materials, the authors generalized, synthesized and classified the main difficulties that arise in the process of developing a portfolio of IT projects in terms of outsourcing companies. The most common instruments used to overcome these difficulties are analyzed. Focus is set on the Stage-Gate framework as the most appropriate for both adaptation and use in the process of managing the portfolio of outsourcing IT projects. A modification of Stage-Gate framework is proposed, which takes into account peculiarities of managing outsourcing IT projects and uses a fuzzy logic apparatus for decision-making when navigating between stages of the framework. The purpose of the modification is the possibility to create on its basis an expert system to support decision-making in the process of managing the portfolio of projects. This, in turn, leads to an overall increase in the level of project portfolio management. Prospects for further research are the introduction of the expert system into the practice of work of domestic IT outsourcing firms. The parallel direction consists in analyzing the international IT outsourcing market. This will help to increase the efficiency of the proposed modification and provide favorable conditions for the integration of the Ukrainian IT outsourcing market into the international practices.

Environmental enrichment is an animal husbandry principle that seeks to provide the stimuli necessary for the optimal physiological and psychological well-being of animals. Due to primates having highly developed visual systems, there have been limited attempts to quantify the benefit of olfactory enrichment on captive primate populations. We aim to investigate how a range of odors may influence the behaviors of two captive New World primate species that have varying reliance on olfactory pathways, black-capped capuchin (Sapajus apella) and common marmoset (Callithrix jacchus), at the National Zoo and Aquarium, Canberra, Australia. We presented three odors (rosemary oil, Salvia rosmarinus, banana essence and white-tailed deer urine, Odocoileus virginianus) four different times to the two species following a 12-week randomized schedule. Using instantaneous scan sampling we collected behavioral and direct cloth interaction (DCI) data on 40 days. We then calculated activity budgets. Results show both species significantly respond to different olfactory conditions. S. apella responded to banana by decreasing inactivity (df = 4, F = 6.600, p = .007), and increasing DCI frequencies (df = 3, F = 116.196, p .0001) whereas C. jacchus was influenced by rosemary and deer urine-also reducing inactivity levels (df= 4, F = 15.938, p .0001), but not changing DCI frequencies. We also tested habituation however it is not significant for either species over the course of the study. This comparative investigation is one of the first of its kind and uncovers the possibility for olfactory stimulus to be successfully used as a type of beneficial environmental enrichment for captive primates, supporting the constructive and ongoing development of enrichment programs at captive facilities.

Trabajo presentado en Weinstein Meeting, celebrado en Marsella (Francia) del 12 al 14 de mayo de 2022.

Objective The aim: To study the association of the polymorphisms VDR gene with high blood pressure in stroke patients in the Ukrainian population. Patients and methods Materials and methods: Venous blood of 170 patients with atherothrombotic ischemic stroke (AIS) and 124 healthy individuals (control group) was used for genotyping. Four polymorphisms (FokI, BsmI, ApaI, TaqI) of gene VDR were examined with PCR-RFLP methodology. Statistical analysis was performed by using SPSS-17.0 program. Results Results: The correlation of genotypes of polymorphic variants of FokI, BsmI, ApaI and TaqI of the VDR gene with the development of ischemic atherothrombotic stroke in individuals with normal and high blood pressure was detected. Statistical analysis of the obtained data revealed that among carriers of genotypes F/F, b/b, a/a, a/A, and T/T patients with AI have statistically significantly higher incidence of hypertension than patients in the control group. Conclusion Conclusions: It was found that persons with genotypes F/F, b/b, a/a, a/A, and T/T showed a statistically significant relationship between hypertension and the development of IAS. The application of logistic regression has made it possible to establish that the risk of IAS in people with normal blood pressure and genotype F/f is 3.2 times higher than in normotensive homozygotes for the F-allele.

The aim: To study the association of the polymorphisms VDR gene with high blood pressure in stroke patients in the Ukrainian population.Materials and methods: Venous blood of 170 patients with atherothrombotic ischemic stroke (AIS) and 124 healthy individuals (control group) was used for genotyping. Four polymorphisms (FokI, BsmI, ApaI, TaqI) of gene VDR were examined with PCR-RFLP methodology. Statistical analysis was performed by using SPSS-17.0 program.Results: The correlation of genotypes of polymorphic variants of FokI, BsmI, ApaI and TaqI of the VDR gene with the development of ischemic atherothrombotic stroke in individuals with normal and high blood pressure was detected. Statistical analysis of the obtained data revealed that among carriers of genotypes F/F, b/b, a/a, a/A, and T/T patients with AI have statistically significantly higher incidence of hypertension than patients in the control group.Conclusions: It was found that persons with genotypes F/F, b/b, a/a, a/A, and T/T showed a statistically significant relationship between hypertension and the development of IAS. The application of logistic regression has made it possible to establish that the risk of IAS in people with normal blood pressure and genotype F/f is 3.2 times higher than in normotensive homozygotes for the F-allele.

The aim is to analyze the factors that affect the students' health both positively and negatively and to evaluate the real health status of Ukrainian student youth.Materials and methods: The research was conducted at Zhytomyr Ivan Franko State University and University of State Fiscal Service of Ukraine, 647 students of the 1st - 4th years of study were examined. To study both negative and positive factors, we conducted a survey of the students of different genders of several education departments, using original questionnaires. To analyze the results of the students' self-assessment of their health state, the methodology of V. P. Voitenko, which contains 27 questions that characterize the most important aspects of well-being, mood, activity, sleep quality, pain senses and lifestyle of students, was applied.Results: It was determined that the most important factors for the preservation of health included nutrition, physical activity, active leisure, sleep, love and sex. 56.3 % of male students and 49.9 % of female ones indicated that motor activity is of great importance for health care. The students stated that the most dangerous health factors included drug use, radioactive contamination of the environment, smoking, alcohol abuse, stress, etc. It was found that the highest percentage of students had satisfactory and poor health levels - 44.8-54.9 % and 17.8-29.5 % respectively.Conclusions: A wide range of specific components of the educational process and the healthy lifestyle of students can have different effects on life. Lifestyle is one of the many factors that affect students' health. The students' self-assessment of their health state lets to manage the educational process of physical education efficiently, allocate physical activity and apply individual tasks rationally.

The aim is to find out the role of motor activity in developing a healthy lifestyle of student youth in the process of physical education.Materials and methods: The study involved 647 students, aged 18-22. The research methods are the analysis and synthesis of the literature, analysis of curricula, programs, methodological support and quality of training, questionnaires, and the methods of mathematical statistics.Results: It is determined that the majority of the students had no need for a healthy lifestyle, the lack of knowledge in this area, low activity while performing the requirements of a healthy lifestyle, irrational organization of educational activities, bad habits and other factors that negatively affect their health.Сonclusions: The current system of physical education in the higher education institutions of Ukraine cannot change the attitude of students to a healthy lifestyle. The purpose of physical education, in addition to the formation of physical skills and development of students' physical qualities, should be educational work aimed at forming a positive attitude towards a healthy lifestyle.

This article aims to give a methodological contribution - with considerable operational implications - to economic time series analysis resting on a frequency-domain approach, which finds its roots into Granger's seminal paper (1966). The novelty of the proposal is the introduction of the notion of stylized spectrum, whose estimate reflects the main features of the power distribution of the latent series components over the frequency axis. The stylized spectrum arises transforming the observed series by a battery of filters which cause a sufficiently]v fine partition of the frequency axis; thus enabling us to detect the power contribution of the frequency ranges corresponding to the components of interest, i.e trend, cyclical and seasonal - possibly evolutive - components. The stylized spectrum estimate is an efficient tool to solve some crucial problems of time series analysis, such as: - setting clear criteria to evaluate the contribution of the latent component to the series dynamics; - comparing the actual performances of alternative procedures of components estimation; - evaluating the definition degree corresponding to different filtering methods, and the relevant accuracy of procedures outcomes., Statistica; Vol 56, No 1 (1996)

Background: Variations in the prevalence of respiratory symptoms according to geo-climatic factors could provide important clues to the knowledge of the aetiology of asthma. Methods: Geo-climatic variations in the prevalence of current asthma, allergic rhinitis and chronic cough, and phlegm were assessed on a random sample of 18 873 subjects (response rate = 72.7%) from different climatic regions of Italy. An ecological analysis, supported by robust statistical methods, was employed to investigate potential trends. Results: The prevalence of all symptoms was significantly heterogeneous throughout the peninsula. Only asthma-like symptoms showed a north–south trend: the prevalence increased at a decreasing latitude [odds ratio (OR) varies from 0.92 to 0.96, P

The knowledge of the natural history of asthma from birth to adulthood could provide important clues for its cause and for the understanding of epidemiologic findings.This study is aimed at assessing the incidence and remission of asthma from birth to the age of 44 years by using data from 18,873 subjects involved in a large, nationally representative, cross-sectional study carried out in Italy from 1998 through 2000.The onset of asthma was defined as the age at the first attack, and remission was considered present when a subject was neither under treatment nor had experienced an asthma attack in the last 24 months. Person-years and survival techniques were used for the analysis.The average annual incidence rate for the 1953 to 2000 period was 2.56/1000 persons per year. Incidence peaked in boys less than 10 years of age (4.38/1000 persons per year) and in women 30 years of age or older (3.1/1000 persons per year) and showed a generational increase (incident rate ratio = 2.63 and 95% CI = 2.20-3.12 for 1974-1979 vs 1953-1958 birth cohort). The overall remission rate was 45.8% (41.6% in women and 49.5% in men, P.001). Asthmatic patients in remission had an earlier age at onset (7.8 vs 15.9 years, P.001) and a shorter duration of the disease (5.6 vs 16.1 years, P.001) than patients with current asthma. The probability of remission was strongly (P.001) and inversely related to the age at onset (62.8% and 15.0% in the10- andor =20-years age-at-onset groups, respectively).With respect to its natural history, asthma presents 2 different forms: early-onset asthma, which occurs early in childhood, affects mainly boys, and has a good prognosis, and late-onset asthma, which generally occurs during or after puberty, mainly affects women, and has a poor prognosis. The minority of patients with early-onset asthma who do not remit represents more than 35% of patients with current asthma in the general young adult population.

We evaluated the sensitivity and specificity of different indices drawn from the forced expiratory curve in order to detect the best one for evaluating bronchial reactivity in the general population, and particularly, for distinguishing between normal and asthmatic subjects. 654 subjects, between 15 and 64 years of age, who were representative for age and sex of the general population of a small Lombardy town (Italy), were studied. Of the total sample, 448 subjects were clinically normal and asymptomatic, 87 were symptomatic or with acute upper respiratory disease within 30 days before the challenge with methacholine, 43 with allergic rhinitis, 26 asthmatics and 50 chronic bronchitics. All the subjects who had a baseline FEV1 greater than 85% predicted underwent methacholine challenge. Provocative LnDoses of a 6, 10, 15% fall in FEV1 (LnPD6, LnPD10, LnPD15) and provocative LnDose causing FEV1 to fall more than 2 SD below the mean of 5 FEV1 measurements following buffer inhalation (LnTD) were evaluated. Furthermore we calculated the "Dose-Response slope" (SL) proposed by O'Connor. The cut-off value of each index to define a responder was calculated by discriminant analysis of the response to the challenge in normal and in the asthmatic group. Sensitivity, specificity and predictive value of LnPD6, LnTD and SL were 79, 74, 14%; 71, 74, 13% and 46, 97, 48% respectively. LnPD10 had the best sensitivity (83%) with a high specificity (83%), but, as compared to LnPD15, whose sensitivity was 79% and specificity 89%, a lower predictive value (21% vs 27%).(ABSTRACT TRUNCATED AT 250 WORDS)

A possible relationship between Na+ intake and increased prevalence and mortality from asthma and chronic obstructive pulmonary disease (COPD) has been suggested but not clearly proven for several reasons (difficulty in assessing Na+ and K+ both by 24 h excretion and dietary recall, too small an effect of these ions on the pathology, and the role of potential confounders). We wanted to determine the relationship of Na+ and K+ intake, assessed by means of a 7 day recall, with chronic respiratory symptoms and bronchial responsiveness in a sample of the general population. Two hundred and five subjects were studied, with complete dietary and respiratory questionnaires, and baseline respiratory function tests, together with a subsample of 146 subjects who underwent histamine challenge. The 7 day recall consisted of two parts: the first assessed discretionary Na+; and the second assessed Na+ and K+ contained in food. The whole sample was split into two groups based on the levels of consumption, and the statistical analysis was performed contrasting the three lower quartiles vs the highest. Smoking habit, social economic status, age and body mass index (BMI) were not confounders for Na+ and K+ intake. The prevalence of symptomatic subjects and baseline respiratory function values were not significantly different in the two groups of quartiles for Na+ and K+. Baseline respiratory values and dose-response slope of the subsample were also not significantly different. We did not prove a relationship between these dietary factors and either bronchial responsiveness or chronic respiratory symptoms. Although we consider that our questionnaire is more reliable than other methods for Na+ and K+ assessment, several potential biases still remain.(ABSTRACT TRUNCATED AT 250 WORDS)

The term connective tissue diseases (CTD) defines a group of illnesses characterized by the presence of immune abnormalities and by widespread inflammation involving various organs and tissues including the lung. These diseases are not frequent in the paediatric age group. Very few data on pulmonary function are available in paediatric CTD. We investigated possible early lung function abnormalities and any likely relationship with clinical activity of the disease in a group of 81 paediatric CTD patients, without clinical or radiological evidence of pulmonary involvement. Measurement of lung volumes and diffusion lung capacity were performed. A sample of 65 subjects, defined as normal on the basis of history and clinical examination, and matched by age and height with the group of patients, was chosen as control group. CTD patients did not show significant deviations from the control distribution with respect to functional residual capacity (FRC) and maximal expiratory flow at 75% of the forced vital capacity (MEF75) values. On the contrary, both vital capacity (VC) and diffusing capacity of the lungs for carbon monoxide (DLCO) were quite impaired in most CTD during the active phase of the disease. Our results show a functional lung impairment in most children with clinically active CTD, even in absence of abnormalities on chest X-ray pictures.