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1. Quality of life, depression and fatigue in mildly disabled patients with relapsing–remitting multiple sclerosis receiving subcutaneous interferon beta-1a: 3-year results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study

Author

Patti, F., Lo Fermo, S., Maimone, D., Messina, S., D'Amico, E., Cimino, V., Gasperini, C., Galgani, S., Orefice, V., Brescia Morra, V., Florio, C., Amato, M., Goretti, B., Portaccio, E., Zipoli, V., Bertolotto, A., Bramanti, P., Sessa, E., Centonze, D., Cottone, S., Salemi, G., Falcini, M., Gallo, P., Perini, P., Gigli, G., Giuliani, G., Pucci, S., Grimaldi, L., Murri, L., Lugaresi, A., Monaco, F., Montanari, E., Motti, L., Neri, S., Paciello, M., Provinciali, L., Ragno, M., Rosati, G., Ruggieri, S., Bell'Antonio, P., Tola, M., Caniatti, L., Tonali, P., Batocchi, A., Trojano, M., Di Monte, E., De Caro, M., Ghezzi, A., Zaffaroni, M., Zolo, P., Zorzon, M., Signorino, M., Scarpini, E., Durelli, L., Carolei, A., Todaro, M., Todaro, R., Spitaleri, D., Tartaglione, A., Patti, F, Amato, Mp, Trojano, M, Bastianello, S, Tola, Mr, Picconi, O, Cilia, S, Cottone, S, Centonze, D, Gasperini, C, BRESCIA MORRA, Vincenzo, Lo Fermo, S, Maimone, D, Messina, S, D'Amico, E, Cimino, V, Galgani, S, Orefice, V, Brescia Morra, V, Florio, C, Amato, MP, Goretti, B, Portaccio, E, Zipoli, V, Bertolotto, A, Bramanti, P, Sessa, E, Salemi, G, Falcini, M, Gallo, P, Perini, P, Gigli, GL, Giuliani, G, Pucci, S, Grimaldi, LM, Murri, L, Lugaresi, A, Monaco, F, Montanari, E, Motti, L, Neri, S, Paciello, M, Provinciali, L, Ragno, M, Rosati, G, Ruggieri, S, Bell'antonio, P, Tola, MR, Caniatti, L, Tonali, P, Batocchi, AP, Di Monte, E, De Caro, MF, Ghezzi, A, Zaffaroni, M, Zolo, P, Zorzon, M, Signorino, M, Scarpini, E, Durelli, L, Carolei, A, Todaro, M, Todaro, R, Spitaleri, D, Tartaglione, A, Patti F, Amato MP, Trojano M, Bastianello S, Tola MR, Picconi O, Cilia S, Cottone S, Centonze D, Gasperini C, COGIMUS Study Group, and Lugaresi A

Subjects
Adult, Male, Quality of life, Longitudinal study, medicine.medical_specialty, Injections, Subcutaneous, multiple sclerosis, Relapsing-Remitting Multiple Sclerosis, Interferon beta 1a, Young Adult, Multiple Sclerosis, Relapsing-Remitting, Adjuvants, Immunologic, Internal medicine, medicine, Humans, Young adult, Fatigue, Depression (differential diagnoses), Aged, Depression, business.industry, Cognitive function, Multiple sclerosis, Cognitive disorder, Interferon beta-1a, Interferon-beta, Middle Aged, medicine.disease, Clinical trial, Neurology, Physical therapy, multiple sclerosis, cognition, interferon beta, Female, Settore MED/26 - Neurologia, Neurology (clinical), Cognition Disorders, business, medicine.drug
Abstract

Background: The precise relationships among quality of life, depression, fatigue and cognitive impairment in multiple sclerosis (MS) are complex and poorly understood. Objective: To assess the effects of subcutaneous interferon beta-1a on quality of life, depression and fatigue over 3 years in the COGIMUS study, and to examine the relationship between these outcomes and baseline cognitive status. Methods: COGIMUS was an observational 3-year trial assessing cognitive function in 459 patients with relapsing–remitting MS treated with subcutaneous interferon beta-1a. Results: In total, 331 patients completed the study (168 received interferon beta-1a, 44 µg subcutaneously three times weekly, and 163 received interferon beta-1a, 22 µg subcutaneously three times weekly). Mean MS Quality of Life-54 (MSQoL-54) composite scores did not change over time. There were no significant differences between groups in MSQoL-54 composite scores when patients were grouped by treatment dose and baseline cognitive status. Mean (standard deviation) Hamilton Depression Rating Scale score decreased from 6.8 (4.9) at baseline to 5.8 (5.9) at year 3. Mean total Fatigue Impact Scale scores were low ( Conclusion: Quality of life, depression and fatigue remained largely stable over 3 years; no effects of treatment dose or baseline cognitive status were found.

Published
2011

2. Reliability, practice effects, and change indices for Rao’s brief repeatable battery

Author

Portaccio, E., Goretti, B., Zipoli, V., Iudice, A., Pina, D. D., Malentacchi, G. M., Sabatini, S., Annunziata, Pasquale, Falcini, M., Mazzoni, M., Amato, M. P., TUSCIMS STUDY GROUP, Siracusa, G., Masini, M., Ancona, A. L., Bartolini, S., Annunziata, P., Pucci, B., Pasquali, L., Malentacchi, M., Plewnia, K., Della Pina, D., Vista, M., Ulivelli, Monica, Bartalini, Sabina, DE STEFANO, Nicola, Stromillo, MARIA LAURA, Spera, C., Mortilla, M., Fonda, C., and Bugarini, G.

Subjects
Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Paced Auditory Serial Addition Test, Intraclass correlation, Neuropsychological Tests, Audiology, Developmental psychology, symbols.namesake, medicine, Humans, Effects of sleep deprivation on cognitive performance, Cognitive rehabilitation therapy, Reliability (statistics), cognitive impairment, cognitive impairment, multiple sclerosis, practice effects, reliability, reliability, medicine.diagnostic_test, Reproducibility of Results, Repeated measures design, Bonferroni correction, Neurology, symbols, Female, Neurology (clinical), practice effects, Cognition Disorders, Psychology, Stroop effect
Abstract

The role of cognitive impairment in multiple sclerosis is now widely recognized. However, there is a dearth of research on variability and practice effects of neuropsychological measures when repeated over time. The objective was to assess reliability and practice effects for Rao’s Brief Repeatable Battery of neurophysiological tests and the Stroop Test, and to provide data for correction for variability and practice effects in serial assessments.In 54 healthy controls (34 women, mean age 38.3 ± 9.1 years, mean education 12.9 ± 3.3 years), the Brief Repeatable Battery and Stroop Test were administered 3 times with an 18-month interval. Reliability was assessed by intraclass correlation coefficient and practice effects by an analysis of variance with Bonferroni’s correction for repeated measures. Test—retest reliability was from adequate to good on the Symbol Digit Modalities Test, the Stroop Test, and the Paced Auditory Serial Addition Test. The great majority of tests showed at least a moderate practice effects. Data for calculation of an individual’s change in cognitive performance for each test of the Brief Repeatable Battery and the Stroop Test were provided. Our results provide relevant information for planning and interpreting longitudinal studies on cognition and cognitive rehabilitation in multiple sclerosis.

Published
2010

3. Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone

Author

Martinelli V, Cocco E, Capra R, Salemi G, Gallo P, Capobianco M, Pesci I, Ghezzi A, Pozzilli C, Lugaresi A, Bellantonio P, Amato MP, Grimaldi LM, Trojano M, Mancardi GL, Bergamaschi R, Gasperini C, Rodegher M, Straffi L, Ponzio M, Comi G, Italian Mitoxantrone G.r.o.u.p. COLLABORATORS: Radaelli M, Esposito F, Moiola L, Colombo B, Rossi P, Marrosu MG, Frau J, Lorefice L, Coghe G, Savettieri G, Ragonese P, Cusimano V, Perini P, Rinaldi F, Vidali A, Bertolotto A, Malucchi S, Di Sapio A, Montanari E, Guareschi A, Rizzo A, Zaffaroni M, Baldini S, De Rossi N, Cordioli C, Rasia S, Salvetti M, Buttinelli C, Ausili Cefaro L, De Luca G, Tommaso D, Farina D, Fantozzi R, Ruggieri S, Hakiki B, Zipoli V, Portaccio E, Bartolozzi ML, Scandellari C, Stecchi S, Marchello LP, Palmeri B, Vitello G, Iaffaldano P, Lucchese G, Dattola V, Buccafusca M, Sola P, Simone AM, Barreca F, Patti F, Laisa P, Cavalla P, Masera S, Tavazzi E, Galgani S, Sacco R, Provinciali L, Maura D, LUS, Giacomo, Alfieri G, Ticca A, Piras ML, Maimone D, Bianca M, Iudice A, Giro ME, Galeotti M, Florio C, Spitalieri P, La Mantia L, Motti L, Rottoli MR, Granella F, Solaro C, Scarpini E, Servillo G, Cavalletti G., TEDESCHI, Gioacchino, Martinelli, V, Cocco, E, Capra, R, Salemi, G, Gallo, P, Capobianco, M, Pesci, I, Ghezzi, A, Pozzilli, C, Lugaresi, A, Bellantonio, P, Amato, Mp, Grimaldi, Lm, Trojano, M, Mancardi, Gl, Bergamaschi, R, Gasperini, C, Rodegher, M, Straffi, L, Ponzio, M, Comi, G, COLLABORATORS: Radaelli M, Italian Mitoxantrone G. r. o. u. p., Esposito, F, Moiola, L, Colombo, B, Rossi, P, Marrosu, Mg, Frau, J, Lorefice, L, Coghe, G, Savettieri, G, Ragonese, P, Cusimano, V, Perini, P, Rinaldi, F, Vidali, A, Bertolotto, A, Malucchi, S, Di Sapio, A, Montanari, E, Guareschi, A, Rizzo, A, Zaffaroni, M, Baldini, S, De Rossi, N, Cordioli, C, Rasia, S, Salvetti, M, Buttinelli, C, Ausili Cefaro, L, De Luca, G, Tommaso, D, Farina, D, Fantozzi, R, Ruggieri, S, Hakiki, B, Zipoli, V, Portaccio, E, Bartolozzi, Ml, Scandellari, C, Stecchi, S, Marchello, Lp, Palmeri, B, Vitello, G, Iaffaldano, P, Lucchese, G, Dattola, V, Buccafusca, M, Sola, P, Simone, Am, Barreca, F, Patti, F, Laisa, P, Cavalla, P, Masera, S, Tavazzi, E, Galgani, S, Tedeschi, Gioacchino, Sacco, R, Provinciali, L, Maura, D, Lus, Giacomo, Alfieri, G, Ticca, A, Piras, Ml, Maimone, D, Bianca, M, Iudice, A, Giro, Me, Galeotti, M, Florio, C, Spitalieri, P, La Mantia, L, Motti, L, Rottoli, Mr, Granella, F, Solaro, C, Scarpini, E, Servillo, G, and Cavalletti, G.

Published
2011

4. Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study

Author

Patti, F, Amato, Mp, Trojano, M, Bastianello, S, Tola, Mr, Goretti, B, Caniatti, L, DI MONTE, E, Ferrazza, P, BRESCIA MORRA, V, LO FERMO, S, Picconi, O, Luccichenti, G, Vecchio, R, Maimone, D, Messina, S, Gasperini, C, Orefice, V, Florio, C, Portaccio, E, Zipoli, V, Bertolotto, A, Bramant, P, Sessa, E, Centonze, D, Cottone, S, Salemi, G, Falcini, M, Gallo, P, Perini, P, Gigli, Gian Luigi, Giuliani, G, Grimald, Lm, Murri, L, Lugaresi, A, Monaco, F, Montanari, E, Motti, L, Neri, S, Paciello, M, Provinciali, L, Ragno, M, Rosati, G, Ruggieri, S, Tonali, P, Batocchi, Ap, DE CARO MF, Ghezzi, A, Zaffaroni, M, Zolo, P, Zorzon, M, Signorino, M, Scarpini, E, Durelli, L, Carolei, A, Todaro, M, Spitaleri, D, Tartaglione, A., Patti, F, Amato, Mp, Trojano, M, Bastianello, S, Tola, Mr, Goretti, B, Caniatti, L, Di Monte, E, Ferrazza, P, BRESCIA MORRA, Vincenzo, Lo Fermo, S, Picconi, O, Luccichenti, G, COGIMUS Study, Group, Vecchio, R, Maimone, D, Messina, S, Gasperini, C, Orefice, V, Brescia Morra, V, Florio, C, Amato, MP, Portaccio, E, Zipoli, V, Bertolotto, A, Bramanti, P, Sessa, E, Centonze, D, Cottone, S, Salemi, G, Falcini, M, Gallo, P, Perini, P, Gigli, GL, Giuliani, G, Grimaldi, LM, Murri, L, Lugaresi, A, Monaco, F, Montanari, E, Motti, L, Neri, S, Paciello, M, Provinciali, L, Ragno, M, Rosati, G, Ruggieri, S, Tola, MR, Tonali, P, Batocchi, AP, De Caro, MF, Ghezzi, A, Zaffaroni, M, Zolo, P, Zorzon, M, Signorino, M, Scarpini, E, Durelli, L, Carolei, A, Todaro, M, Spitaleri, D, Tartaglione, A, DI MONTE, E, BRESCIA MORRA, V, LO FERMO, S, and Zorzon, Marino

Subjects
Male, Pediatrics, Intelligence, Relapsing-Remitting, Neuropsychological Tests, Severity of Illness Index, Disability Evaluation, Cognition, Risk Factors, Odds Ratio, Prevalence, Neuropsychological assessment, Prospective Studies, Neurologic Examination, medicine.diagnostic_test, Cognitive impairmet. Cognitive function. Multiple Sclerosis. Neuropsychological assessment, Cognitive disorder, Neuropsychology, Age Factors, Middle Aged, Magnetic Resonance Imaging, Cognitive test, Treatment Outcome, Neurology, Italy, Female, Settore MED/26 - Neurologia, Psychology, Adult, medicine.medical_specialty, Multiple Sclerosis, Adolescent, Neurological examination, Risk Assessment, Young Adult, Multiple Sclerosis, Relapsing-Remitting, Predictive Value of Tests, Immunologic Factors, Humans, Interferon-beta, Cognition Disorders, Cross-Sectional Studies, medicine, Expanded Disability Status Scale, Multiple sclerosis, McDonald criteria, medicine.disease, Physical therapy, Neurology (clinical)
Abstract

Background Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing–remitting (RR) MS is unclear. Objectives To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods Patients aged 18–50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao’s battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.

Published
2009

5. The glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosis

Author

Lolli, F, Mazzanti, B, Pazzagli, M, Peroni, E, Alcaro, Mc, Sabatino, G, Lanzillo, R, Morra, Vb, Santoro, L, Gasperini, C, Galgani, S, D'Elios, Mm, Zipoli, V, Sotgiu, S, Pugliatti, Maura, Rovero, P, Chelli, M, Papini, Am, RI Lolli Francesco/C 6439 2008, Lolli, F, Mazzanti, B, Pazzagli, M, Peroni, E, Alcaro, Mc, Sabatino, G, Lanzillo, Roberta, BRESCIA MORRA, Vincenzo, Santoro, L, Gasperini, C, Galgani, S, D'Elios, Mm, Zipoli, V, Sotgiu, S, Pugliatti, M, Rovero, P, Chelli, M, and Papini, Am

Subjects
Adult, Male, Multiple Sclerosis, Anti-nuclear antibody, Adolescent, diagnosis, Immunology, Enzyme-Linked Immunosorbent Assay, myelin autoantibodies, medicine.disease_cause, multiple sclerosis, glycosylated antigen, B cell, autoimmunity, Aged, Analysis of Variance, Antibodies, Female, Flow Cytometry, Humans, Middle Aged, ROC Curve, Sensitivity and Specificity, Glycopeptides, Subclass, Autoimmunity, medicine, Immunology and Allergy, biology, business.industry, Multiple sclerosis, medicine.disease, Glycopeptide, Neurology, biology.protein, Neurology (clinical), Antibody, business, Meningitis, Encephalitis
Abstract

Synthetic glycopeptides have the potential to detect antibodies in multiple sclerosis (MS). In the present study, we analyzed the antibodies (IgM class, IgG class and IgG subclasses) to the synthetic glycopeptide CSF114(Glc) in the serum of 186 MS patients, 166 blood donors (BDs), 25 patients affected by meningitis/encephalitis, 41 affected by systemic lupus erythematosus (SLE) and 49 affected by rheumatoid arthritis (RA). The IgM antibody level to CSF114(Glc) was significantly increased in MS patients versus BDs (p

Published
2005

6. Reliability, practice effects, and change indices for Rao's Brief Repeatable Battery

Author

Portaccio, E, Goretti, B, Zipoli, V, Iudice, Alfonso, Pina, Dd, Malentacchi, Gm, Sabatini, S, Annunziata, P, Falcini, M, Mazzoni, M, PIA AMATO, M, TUSCIMS STUDY GROUP AMATO MP, Siracusa, G, Masini, M, Ancona, Al, Bartolini, S, Pucci, B, Iudice, A, Pasquali, Livia, Malentacchi, M, Plewnia, K, DELLA PINA, D, Vista, M, Ulivelli, M, Bartalini, S, DE STEFANO, N, Stromillo, Ml, Spera, C, Mortilla, M, Fonda, C, and Bugarini, G.

Published
2010

7. Cognitive and psychosocial features in childhood and juvenile MS Two-year follow-up

Author

Amato, Mp, Goretti, B, Zipoli, V, Portaccio, E, Centorrino, S, Contri, V, Lori, S, Falcini, M, Comi, G, Moiola, L, Falautano, M, Trojano, M, De Caro MF, Viterbo, R, Patti, F, Vecchio, R, Gallo, Paolo, Grossi, P, Bertolotto, A, Borghi, M, Pozzilli, C, Bianchi, V, Manca, I, Masia, C, Bergamaschi, R, Veggiotti, P, Ghezzi, A, and Roscio, M.

Published
2010

8. RELEVANCE OF COGNITIVE DETERIORATION IN EARLY RELAPSING-REMITTING MS: A 3-YEAR FOLLOW-UP STUDY

Author

Amato, Mp, Portaccio, E, Goretti, B, Zipoli, V, Siracusa, G, Falcini, M, Masini, M, Ancona, Al, Bartolini, S, Annunziata, P, Pucci, B, Iudice, Alfonso, Pasquali, Livia, Malentacchi, Gm, Malentacchi, M, Plewnia, K, Della Pina, D, Mazzoni, M, Vista, M, Ulivelli, M, Bartalini, S, De Stefano, N, Stromillo, Ml, Sabatini, S, Spera, C, Mortilla, M, Fonda, C, and Bugarini, G.

Published
2010

9. COGNITIVE AND PSYCHOSOCIAL FEATURES OF CHILDHOOD AND JUVENILE MS

Author

Hussain, H, Usman, A, Raza, Q, Amato, Mp, Goretti, B, Ghezzi, A, Lori, S, Zipoli, V, Portaccio, E, Moiola, L, Falautano, M, DE CARO MF, Lopez, M, Patti, Francesco, Vecchio, R, Pozzilli, C, Bianchi, V, Roscio, M, Comi, G, and Trojano, M.

Subjects
Neurology (clinical)
Published
2009

10. Validation of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis

Author

Bergamaschi, R., Rezzani, C., Minguzzi, S., Amato, M. P., Patti, F., Marrosu, M. G., Bonavita, S., Grasso, M. G., Ghezzi, A., Rottoli, M., Gasperini, C., Restivo, D., Maimone, D., Rossi, P., Stromillo, M. L., Cristina Montomoli, Solaro, C., Romani, A., Bargiggia, V., Crivelli, P., Tavazzi, E., Zipoli, V., Giannini, M., Portaccio, E., Hakiki, B., D Amico, E., Cocco, E., Frau, J., Lorefice, L., Della Corte, M., Finamore, L., Annovazzi, P., Galgani, S., Judica, E., and Stefano, N.

Subjects
Adult, Male, Multiple Sclerosis, Adolescent, Reproducibility of Results, Middle Aged, Severity of Illness Index, Disability Evaluation, Young Adult, Surveys and Questionnaires, Humans, Female, Child, Deglutition Disorders, Factor Analysis, Statistical, Aged
Abstract

Swallowing problems can complicate the course of multiple sclerosis (MS). However, no validated questionnaire for the assessment of dysphagia in MS is currently available. We previously developed a 10-item DYsphagia in Multiple Sclerosis questionnaire (DYMUS). In the present study, this questionnaire was submitted to a validation process. Thirteen Italian MS centres took part in this research in which DYMUS was administered to 1734 consecutive MS patients during routine checkups outside relapse. The questionnaire showed very good internal consistency (Cronbach's alpha = 0.914). It was then subdivided into two subscales, both of which also showed very good internal consistency: Cronbach's alpha was 0.885 for the 'dysphagia for solids' subscale and 0.864 for the 'dysphagia for liquids' subscale. The DYMUS questionnaire was found to be an easy and reliable tool for detecting dysphagia and also for the preliminary selection of patients requiring more specific instrumental analyses, and those suitable for aspiration prevention programmes.

12. Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire)

Author

Claudio Solaro, Claudio Gasperini, Valentina Zipoli, C. Rezzani, Erika Trabucco, Pasquin Rossi, L. Finamore, Pietro Annovazzi, A. Ghezzi, M. L. Stromillo, Maria Pia Amato, Roberto Bergamaschi, Jessica Frau, Simona Bonavita, Davide Maimone, Marta Giannini, M. Rottoli, Emanuele D'Amico, Maria Grazia Grasso, Domenico A. Restivo, M. Della Corte, Lorena Lorefice, Emilio Portaccio, Francesco Patti, Solaro, C, Rezzani, C, Trabucco, E, Amato, Mp, Zipoli, V, Portaccio, E, Giannini, M, Patti, F, D'Amico, E, Frau, J, Lorefice, L, Bonavita, Simona, Corte, Md, Grasso, Mg, Finamore, L, Ghezzi, A, Annovazzi, P, Rottoli, M, Gasperini, C, Restivo, D, Maimone, D, Rossi, P, Stromillo, Ml, and Bergamaschi, R.

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Multiple Sclerosis, Design data, Adolescent, Disease duration, Statistics as Topic, QUESTIONNAIRE, Disease, DYSPHAGIA, Disease course, Disability Evaluation, Young Adult, Surveys and Questionnaires, otorhinolaryngologic diseases, medicine, Prevalence, Humans, Child, business.industry, Multiple sclerosis, Infant, Middle Aged, medicine.disease, Dysphagia, Clinical Practice, Cross-Sectional Studies, Neurology, Multicenter study, Italy, Child, Preschool, Physical therapy, Female, Neurology (clinical), Self Report, medicine.symptom, business, Deglutition Disorders
Abstract

OBJECTIVE: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a chronic course. Dysphagia represents one of the current challenges in clinical practice for the management of MS patients. Dysphagia starts to appear in mildly impaired MS subjects (EDSS 2-3) and becomes increasingly common in the most severely disabled subjects (EDSS 8-9). The aim of the present study was to evaluate the frequency and characteristics of patient-reported dysphagia in MS patients with a multicenter study using the recently developed DYMUS (DYsphagia in MUltiple Sclerosis) questionnaire. DESIGN: Data were collected in a multi-centre, cross-sectional study using a face-to-face structured questionnaire for clinical characteristics and the DYMUS questionnaire. RESULTS: 1875 patients were interviewed. The current study has shown a correlation between patient-reported dysphagia and EDSS and disease course but not with age, gender and disease duration. Questionnaires were divided into "patient-reported dysphagia-yes" (587, 31.3%) and "patient-reported dysphagia-no" (1288, 68.7%). Compared with the patient-reported dysphagia-no group, patients in patient-reported dysphagia-yes group had higher EDSS score (mean EDSS 4.6 vs. 2.8; p

Published
2012

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