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Your search keyword '"Zinhle Ngcobo"' showing total 3 results
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3 results on '"Zinhle Ngcobo"'

1. Complementary non-sputum diagnostic testing using oral swabs and urine LAM testing for TB in people with HIV

Author

Adrienne E. Shapiro, Alaina M. Olson, Lara Kidoguchi, Xin Niu, Zinhle Ngcobo, Zanele P. Magcaba, Mduduzi W. Ngwane, Grant R. Whitman, Kris M. Weigel, Rachel C. Wood, Doug P.K. Wilson, Paul K. Drain, and Gerard A. Cangelosi

Abstract

Testing for mycobacterial lipoarabinomannan (LAM) in urine is a practical but insensitive alternative to sputum testing to diagnose tuberculosis (TB) in people with HIV (PWH). We evaluated urine LAM testing conducted in parallel with tests for Mycobacterium tuberculosis DNA in oral swabs. In a cohort of 131 South Africans (92% with HIV), combined urine LAM and oral swab testing was significantly more sensitive than either sample tested alone (57% vs. 35% and 39%, respectively), and 97% specific, compared to reference sputum testing (TB culture and Xpert Ultra). Complementary non-sputum sample testing increased sensitivity of TB diagnosis, without sacrificing specificity.

Published
2022

2. Diagnosing Pulmonary Tuberculosis by Using Sequence-Specific Purification of Urine Cell-Free DNA

Author

Zinhle Ngcobo, M. William Ngwane, Paul K. Drain, Zanele P. Magcaba, Douglas Wilson, David J. Horne, Diana Marangu, Barry R. Lutz, Amy Oreskovic, Nuttada Panpradist, Sindiswa Ngcobo, and Adrienne E Shapiro

Subjects
Microbiology (medical), medicine.medical_specialty, Tuberculosis, DNA purification, DNA hybridization, HIV Infections, Urine, Gastroenterology, Sensitivity and Specificity, Cohort Studies, cell-free DNA, South Africa, Pulmonary tuberculosis, Internal medicine, diagnostics, Medicine, Humans, Tuberculosis, Pulmonary, Lipoarabinomannan, sample preparation, business.industry, Sputum, Mycobacteriology and Aerobic Actinomycetes, Mycobacterium tuberculosis, medicine.disease, DNA extraction, urine, PCR, Cell-free fetal DNA, tuberculosis, Biomarker (medicine), medicine.symptom, business, Cell-Free Nucleic Acids, transrenal DNA
Abstract

Transrenal urine cell-free DNA (cfDNA) is a promising tuberculosis (TB) biomarker, but is challenging to detect because of the short length (

Published
2021

3. Diagnosing pulmonary tuberculosis using sequence-specific purification of urine cell-free DNA

Author

Nuttada Panpradist, Adrienne E Shapiro, Zinhle Ngcobo, Douglas Wilson, David J. Horne, M. William Ngwane, Diana Marangu, Barry R. Lutz, Amy Oreskovic, Paul K. Drain, Zanele P. Magcaba, and Sindiswa Ngcobo

Subjects
Tuberculosis, business.industry, Urine, Short length, medicine.disease, Molecular biology, Biomarker, chemistry.chemical_compound, Cell-free fetal DNA, chemistry, Pulmonary tuberculosis, medicine, business, DNA, Sequence (medicine)
Abstract

Transrenal urine cell-free DNA (cfDNA) is a promising tuberculosis (TB) biomarker, but is challenging to detect because of the short length (

Published
2021

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