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The control system of an open-type headbox has a high complexity, which is associated with the need not only to stabilize the parameters of the object, but also to carry out coordinated control of it in the case of automatic transfer of a paper machine from one type of product to another for a minimum time. A mathematical model of an open-type headbox as an object of mass level control has been developed. In the model, the output variable of the control object is the level of mass in the injection chamber, and the control action is the mass flow rate supplied to the injection chamber. The model takes into account the disturbing action - the area of the discharge slot. On the basis of the developed model, two options for constructing an algorithm for controlling the pressure box during its transfer from one mode to another are considered. The structure of the algorithm for coordinated control of the pressure box is developed. An illustrative example of application of the developed algorithm is given. The calculations of the optimal transient process in the object confirm the effectiveness of the developed control algorithm. The algorithm of coordinated control is applied to the standard pressure box YANO-180. The development of the algorithm for transferring the pressure box from the working (0.485 m) to the maximum (0.575 m) height of the mass level in the pressure box for 180 seconds is demonstrated. The calculation results show that the coordinated control algorithm provides the transfer of the mass level to the maximum height for a given time. The algorithm developed on the basis of the obtained mathematical model allows to control the level of mass in such a complex object as an open-type headbox when transferring a paper machine from one mode of operation to another for the time specified by the coordinated control system.

International audience; Codoped (Tb,Eu) ZnO films grown by magnetron sputtering on a silicon substrate and annealed up to 1200 °C showed intense photoluminescence (PL) emission from Eu3+ ions. The high-temperature annealing led to diffusion and segregation of rare earth (RE) elements toward the bottom of the film, which induced the formation of nanometric Zn-free inclusions responsible for remarkable PL emission intensity. Combined electron diffraction, chemical contrast imaging, and optical studies of these nanometric phases have been carried out. Large inclusions of zinc silicates and RE silicates a few hundreds of nanometers in size were observed, embedded in a silica phase. The structural determination of these RE-rich inclusions was carried out by combining atomic Z contrast imaging (high-angle annular dark-field imaging) and precession electron diffraction data. Upon annealing at 1200 °C, it appeared that the structure was related to an F-type disilicate structure. Energy-dispersive X-ray spectroscopy and electron energy loss spectroscopy experiments were carried out to determine the ratios between elements and the oxidation states of the RE elements in the abovementioned inclusions. A (Tb,Eu)2Si2O7 formulation is proposed from dynamical precession electron diffraction tomography refinements, leading to a +III valence state for the RE species in agreement with spectroscopic results. PL modeling is also in good agreement with the experimental data. These results complete those obtained at 1100 °C for which the inclusions were identified as some RE10–x(SiO4)6O2–x oxyapatite structures and pointed out a combined structural and PL properties’ evolution between 1100 and 1200 °C annealing temperatures.

The status of Lake Baikal as a UNESCO World Heritage Site, due to its unique ecology and value as a global aquatic resource have resulted in strict environmental regulations to protect the watershed and biota it supports. Despite this, the ecosystem of the lake is being exposed to negative anthropogenic impact and deteriorating water quality. In this article, we describe the bioecological state of Mukhor Bay − the warmest bay of Lake Baikal and one which is actively visited by tourists. We try to highlight the environmental problems of Baikal and aim to change attitudes towards water resources in this unique ecosystem. We present data on the taxonomic, genetic, and biochemical characteristics of cyanobacteria blooms that develop in the plankton of the bay. Further, we establishing their risk to human health and provide information for the environmental state management. Toxic blooms of Dolichospermum lemmermannii (cyanobacteria) were detected in the phytoplankton of Mukhor Bay. The nutrients content and chlorophyll concentration was low and corresponded to the oligo-mesotrophic status. Microcystins were detected in the dried phytoplankton biomass and the water, coastal samples contained a higher amount of this toxin. We hypothesize that one of the factors contributing to toxic cyanobacteria growth in the Mukhor Bay is the nutrient loadings due to surface and groundwater runoff from surrounding area.

Ця стаття присвячена забезпеченню доступним житлом як важливому фактору управління охороною здоров’я, інклюзивного зростання та ЦСР. Мета – емпірично обґрунтувати зміни системи охорони здоров’я населення країни в залежності від рівня забезпеченості доступним житлом. Емпірична база включає часові ряди та панельні дані для 27 країн ЄС протягом 2011–2019 років. Завдяки кореляційному аналізу (тестування Шапіро-Вілка, кореляція Спірмена чи Пірсона, часові лаги), регресійному аналізу, побудові динамічної моделі оцінки панельних даних та за допомогою тестування Саргана в STATA дослідження емпірично підтвердило та формалізувало вплив фінансування доступного житла на зміни в системі охорони здоров'я населення країни. Зокрема, дослідження виявило залежність між рівнем перенаселеності та часткою власників житла з іпотекою (зменшення рівня перенаселеності в середньому на 0,61% з часовим лагом у 2 роки за рахунок зростання на 1%); частка орендарів на пільгових/безкоштовних умовах (0,41% з часовим лагом 3 роки); та частка державних витрат на розвиток ЖКГ (0,25% з часовим лагом 3 роки). Також виявлено прямий зв'язок між перенаселеністю та смертністю від небезпечних захворювань (туберкульоз, СНІД, вірусні гепатити, розлади психіки та поведінки, цукровий діабет, пневмонія). Найменш ефективними виявилися державні витрати на житло за програмами соціального захисту (субсидії тощо). Перевагу слід віддавати розвитку доступного іпотечного кредитування (швидше та з більшим ефектом). Загалом це впливає на державні управлінські рішення в системі охорони здоров'я, соціальній та житлово-комунальній сферах. Статья посвящена обеспечению доступного жилья как важному фактору управления общественным здравоохранением, инклюзивного роста и ЦУР. Цель – эмпирически обосновать изменения в системе охраны здоровья населения страны в зависимости от уровня обеспеченности доступным жильем. Эмпирическая база включает временные ряды и панельные данные по 27 странам ЕС за 2011–2019 гг. Благодаря корреляционному анализу (тестирование Шапиро-Уилка, корреляция Спирмена или Пирсона, лаги во времени), регрессионному анализу и построению динамической модели панельной оценки с тестированием Саргана в STATA, исследование эмпирически подтвердило и формализовало влияние финансирования доступного жилья на изменения в системе здравоохранения населения страны. В частности, выявлена зависимость между уровнем перенаселения и долей собственников жилья с ипотекой (снижение уровня перенаселенности в среднем на 0,61% с временным лагом 2 года за счет увеличения на 1%); доля арендаторов на льготных/бесплатных условиях (0,41% с временным лагом 3 года); доля государственных расходов на жилищное строительство (0,25% с временным лагом 3 года). Выявлена также прямая связь между перенаселенностью и смертностью от опасных заболеваний (туберкулез, СПИД, вирусные гепатиты, психические и поведенческие расстройства, сахарный диабет, пневмония). Наименее эффективными оказались государственные расходы на жилье в рамках программ социальной защиты (субсидии и т.п.). Предпочтение следует отдать развитию доступного ипотечного кредитования (быстрее и больший эффект). В целом это влияет на решения государственного управления в системе здравоохранения, социальной и жилищной сферах. This paper is devoted to providing affordable housing as a significant factor in public health management, inclusive growth, and SDG. The purpose is to empirically prove changes in the system of country’s population health care depending on the level of providing affordable housing. The empirical base includes time series and panel data for 27 EU countries during 2011–2019. Due to correlation analysis (Shapiro-Wilk testing, Spearman or Pearson correlation, lags in time), regression analysis, and building a dynamic panel estimation model with Sargan testing in STATA, the study empirically confirmed and formalized the impact of affordable housing funding on changes in the system of country’s population health care. In particular, the study found the dependence between overcrowding level and the share of homeowners with mortgages (a decrease of overcrowding level by an average of 0.61% with a time lag of 2 years due to an increase by 1%); the share of tenants on concessional terms/free (0.41% with a time lag of 3 years); and the share of public spending on housing development (0.25% with a time lag of 3 years). The direct relationship between the overcrowding and mortality from dangerous diseases (tuberculosis, AIDS, viral hepatitis, mental and behavioral disorders, diabetes, pneumonia) was also revealed. Public spending on housing under social protection programs (subsidies, etc.) proved to be the least effective. Preference should be given to the development of affordable mortgage lending (faster and greater effect). Generally, it impacts public management decisions in the health care system, social, and housing spheres. The study was funded by the Ministry of Education and Science of Ukraine and performed the results of the project “Economic and mathematical modeling and forecasting, development of methodological and methodological foundations for creating a roadmap for reforming the health care system in Ukraine, taking into account behavioral, social, economic and legal determinants” (Agreement БФ / 24-2021). This study received funding under the research subsidy of the Department of Applied Social Sciences of the Faculty of Organization and Management of the Silesian University of Technology for the year 2022 (13/020/BK_22/0072).

The pricing policy of the fuel and energy market is constantly growing. The urgency of research is to adjust the optimization of fuel consumption in the glass furnace to obtain the maximum economic effect of production. Using the developed mathematical model of the glass furnace, the analysis was carried out: temperature modes of the furnace, temperature fields of glass and masonry. The temperature distribution in the sections of the glass furnace is performed by means of simulation modeling. The object of research consists of glass mass, gas space, masonry and divided into conditional sections (zones), according to the installation of temperature measuring instruments. In cross sections, the main ones are those that correspond to the position of the burners. In sections on the layers of glass mass, the starting point of the measurement is the surface of the glass mass, and the final bottom of the furnace. The longitudinal sections show the melting behavior of the charge pieces to the state of homogeneity - the transition of glass mass from the loading point of the charge to full melting. The dynamics of glass mass temperature change in the depth of the glass mass layer is the heating curve, the lower the layer considered - the lower the temperature due to the distance from the burners, but within one layer the temperature increases the closer the section to the point. Glass furnace refers to reversible - switching burners to the left or right group. Accordingly, the reverse switching takes place according to a given algorithm, which consists in adjusting the operating time of the group of burners depending on the temperature of the glass mass. The temperature distribution in the glass mass according to the temperature field at a depth of 0.1 m from the upper level of the glass mass is lower by 5-6% from the data of technological regulations. To do this, increased fuel consumption on the burners of the left group, made it possible to optimize fuel consumption. The study of the temperature field of the vault masonry made it possible to avoid problems with overheating and possible collapse of the masonry. Heating of the masonry within the permissible limits from a temperature of 10000C at the edges of the vault and 13800C in the central zone. The cross-section shows the loading channel of the charge, which borders the gas space, so the charge at the entrance to the cooking zone of the furnace receives additional heating and reduces fuel consumption in the first zone for heating the charge. The temperature distribution in the surface layer of the glass mass contains inhomogeneity in the first zone, to achieve uniformity increases fuel consumption on the first pair of burners, which optimizes the consumption of other pairs of burners and prevents excessive gas consumption. The overlap of two thirds of the corresponding plane when leaving the burner of the first section is increased from the required by 5%. In the second section, due to underheating of the selected plane, the value of fuel consumption increased by 12%. The temperature distribution is the lowest in the loading zone, the highest - after the third zone to the fifth (in the cave point). If the composition of the charge is changed (the action of uncontrolled perturbation), and the gas flow through the burners remains unchanged, it is impossible to achieve the value of temperature fields in accordance with the technological regulations. A scientific novelty is the study of cross-sections of glass mass in different planes, made it possible to analyze the temperature fields of glass mass at points where it is technologically impossible to organize measurements.

The production of carbon products is largely resource- and energy-intensive. That is why increasing the efficiency of this production is an urgent scientific and practical task, especially in modern conditions of constant growth of energy costs. An effective way to solve this problem is to create a modern process control system, taking into account the possible failures of system elements. The practice of operating hydraulic presses in carbon graphite production, the control valve of the hydraulic press sometimes fails or works with errors. That is why this paper considers the stage of loading the process of forming carbon products in terms of building a fault-tolerant pressing speed control system. The article investigates the fault-tolerant control system of carbon products, which is synthesized on the basis of traditional fault-tolerant systems for non-cyclic processes and control systems with iterative learning, which have demonstrated their effectiveness in control technological processes of cyclical nature. A method using linear matrix inequalities has been developed for optimal adjustment of control system parameters. Based on the combination of control with iterative learning and control that takes into account the failures of regulators, built a control system for the formation of carbon products, which takes into account both the cyclical nature of the technological process and possible failures of regulators. The research of the effectiveness of the control system by comparing its work with traditional fault-tolerant systems and control systems with iterative learning in the event of faults and disturbances of various kinds showed that the proposed system improves control quality not only over time during each cycle, but also from cycle to cycle. Further research should be aimed at the practical application of the proposed control system for different technological processes in different types of failures of regulatory bodies and the action of disturbances of different nature.

The results of developing post-quantum algorithms of McEliece and Niederreiter crypto-code constructs based on LDPC (Low-Density Parity-Check) codes are presented. With the rapid growth of computing capabilities of mobile technologies and the creation of wireless mesh and sensor networks, Internet of Things technologies, and smart technologies on their basis, information security is becoming an urgent problem. At the same time, there is a need to consider security in two circuits, internal (directly within the network infrastructure) and external (cloud technologies). In such conditions, it is necessary to integrate threats to both the internal and external security circuits. This allows you to take into account not only the hybridity and synergy of modern targeted threats, but also the level of significance (degree of secrecy) of information flows and information circulating in both the internal and external security circuits. The concept of building security based on two circuits is proposed. To ensure the security of wireless mobile channels, it is proposed to use McEliece and Niederreiter crypto-code constructs based on LDPC codes, which allows integration into the credibility technology of IEEE 802.15.4, IEEE 802.16 standards. This approach provides the required level of security services (confidentiality, integrity, authenticity) in a full-scale quantum computer. Practical security technologies based on the proposed crypto-code constructs, online IP telephony and the Smart Home system based on the use of an internal server are considered

The article presents the substantiation that the development of the event potential of the tourist destination «Dubno» is a tool for innovative development of the region. The study used general and special scientific research methods, including structural and functional analysis, statistical method and comparative analysis. Substantiation of the research results was carried out on the basis of information sources of the State Statistics Service of Ukraine, the State Service of Tourism and Resorts of Ukraine, Dubno City Council and data from other scientific and official sources. The concept of potential potential of the tourist direction is defined, which is proposed to be a complex concept that includes a set of resources of a certain area that are used or can be used in the practice of events to attract tourists, as well as conditions that have direct or indirect impact on resource base. The main components of the event potential of the tourist direction of Dubno are analyzed and the main problems of its use are given. Natural and anthropogenic tourism and recreational-resource, natural and socio-economic conditions influencing the development of event potential of the studied tourist direction are also described. The role of the event industry in the development of tourism of the territory and its part in the increase of tourist flows as a result of the organization of tours with the use of event potential is characterized. An analysis of the development potential of the Dubno tourist destination was carried out, based on the results of which it was determined that its use will fully contribute to the growth of tourist flows, as the city has many opportunities to organize events of both local and national importance. The shortcomings that may hinder the rapid growth of the destination as a developed center of event tourism, including large-scale festival events, including insufficient accommodation and catering facilities, lack of large entertainment centers and bad-quality roads, which reduced additional investment in development of the tourist infrastructure. It is proved that the development of the event potential of a tourist destination is a tool for innovative development of the region, as it involves achieving sustainable growth of gross domestic product, industrial production and investment as a necessary basis for forming a system of necessary conditions to improve social and innovation sphere.

The early stages of basic–ultrabasic magmatism in Sarmatia are characterized by the appearance of ultrabasic rocks formed from the mantle with an abnormally high iron content. Therefore, it is important to study them as the source of information about the stages and causes of the activity of the mantle and its possible composition. This magmatism has been recorded in Sarmatia since the beginning of the Eoarchean. The relics of Eo- and Paleoarchean basic and ultrabasic rocks were found in the Dniester–Bug, Kursk, and Azov provinces, which underwent tectonic reconstruction in the Mesoarchean and Paleoproterozoic. Mesoarchean basic–ultrabasic magmatism is manifested in all provinces of Sarmatia and is represented by effusive and intrusive facies. The Mesoarchean greenstone belts composed of komatiites and basalts have been well preserved in the Middle Dnieper province; in other provinces, they are strongly deformed and form narrow linear structures. The Paleoproterozoic endogenous activity in Sarmatia differs from that in other regions in the almost complete absence of magmatism in the period 2.5–2.3 Ga and its significant manifestation 2.1–2.0 Ga. The magmatism in Sarmatia at this stage is similar in the ratios of basic–ultrabasic and granitoid complexes to the magmatism in South Africa but differs from that in Fennoscandia and Canada. The volume of granitoids coeval with basic rocks is larger than the volume of mantle magmatism. The igneous complexes formed 2.1–2.0 Ga in Sarmatia and South Africa are also similar in the presence of norites, the enrichment in Ni and platinum group elements, and the ratio of granitoids and basic–ultrabasic rocks. Magmatic activity (first of all, basic–ultrabasic magmatism in ancient cratons) is not a synchronous phenomenon on a planetary scale and varies greatly in the volume of produced material within the same time intervals. Early Precambrian basic–ultrabasic rocks (volcanics of greenstone belts, intrusions of large igneous provinces, and layered massifs) resulted from plumes, whose derivates formed within the lower and upper mantle and/or the upper mantle and crust, which determined the heterogeneous composition of igneous rocks. The spatial heterogeneity and nonsynchronic occurrence of basic–ultrabasic magmatism might have been due to impact events serving as the triggers of plumes.

The aim: Among the adverse psychological changes associated with medical work, a significant place belongs to the emotional burnout syndrome, which significantly affects a doctor’s social functioning. The purpose of the study was to determine the behavioural activity types and to study the muscular sensitivity threshold of family doctors with the formed emotional burnout syndrome. Materials and methods: We examined 83 female family doctors with diagnosed emotional burnout syndrome. The treatment was carried out with the help of the Taiji-Quan eastern wellness system. Results: The analysis of indicators of the behavioural activity revealed before treatment in 72,5% of women in the intervention group and in 69,8% of women in the control group (p>0,05) signs of the high probability of type A behaviour. After a three-month course of treatment, the percentage of manifestations of type A behaviour in women in the intervention group decreased from 72,5% to 40,0% (p 0,05). When examining the features of muscular tone at the beginning of treatment, it was found that 69,9% of women in the intervention group and 65,1% of the control group had a high degree of muscle blocks (p>0,05). After treatment, the percentage of women with a high degree of muscle blocks decreased to 37,5% (p 0,05) in the control group. Conclusions: The taiji-Quan treatment made it possible to significantly reduce type A behaviour and to decrease the amount of “muscle blocks”.

At present, mathematical methods are becoming a necessary tool for geological research. Computer processing of geological data is widely used in modern methods of studying the oil and gas content of the subsoil. Therefore, the description of the structures as possible oil and gas traps, we conducted as an analysis of their quantitative parameters, which allowed to substantiate certain established patterns. In order to identify patterns in the relationships between the numerical parameters of folded structures, we conducted computer geological and statistical modeling of the studied objects of the Boryslav-Pokutska zone using correlation and cluster analysis. In general, correlation analysis allows the analysis of a set of defined quantities and is aimed at identifying and studying the systems that form some of the quantities included in this set. Classification of any objects by content groups is carried out by the method of cluster analysis. A large volume of quantitative indicators has been developed to model the processes that have formed local structures and to determine the patterns of their distribution. Quantitative indicators can be used to evaluate the results of studies of the distribution of tectonic stresses and strains, which will contribute to a more reliable prediction of oil and gas potential. In turn, this will significantly increase the geological efficiency of oil and gas exploration in the areas of the Boryslav-Pokutska zone of the Pre-Carpathian Foredeep. The modern shape of structures and their spatial location is a consequence of tectonic forces over a fairly long period of geological time. Different manifestations of tectogenesis activity in different epochs cause certain changes in the structural plan of geological bodies and thus affect their possible oil and gas potential (formation, disintegration and reshaping of traps and, accordingly, deposits). The structures of the Boryslav-Pokutska zone have undergone a complex and long path of formation: from sedimentary flysch folds to very complex post-sedimentary structural forms, which is due to the influence of the magnitude and nature of the application of formative tectonic forces. Under the influence of tectonic forces of different nature, various morphological structural forms were formed. The morphological varieties of structures can be described by numerical parameters, which can be used as a basis for the classification of structures of the Boryslav-Pokutska zone.

At the present stage of technical progress, all industries face an extremely complex problem of creating reliable barriers that prevent the penetration of industrial emissions into the environment. Currently, the issues of stabilizing the quality of wastewater treatment have become especially important in connection with the task of developing wastewater-free industrial complexes. Among the complex scientific and technical problems associated with this task, the problem of stable and reliable maintenance of water quality parameters at the outlet of technological systems is crucial, as leakage of pollutants immediately affects the state of basic production, disrupting its technology and infecting ecosystems. The focus of industry on a sharp reduction in emissions and on the creation of industrial cycles with circulating water supply requires intensive efforts to improve the wastewater treatment technology, the introduction of high-performance processes and devices, as well as the synthesis of control systems for typical wastewater treatment processes. For the performance of automated control systems for typical cleaning processes, it is necessary to develop a software package on the basis of appropriate mathematical models of typical processes. To obtain them, methods of mathematical and simulation modeling and variance analysis were used. In order to assess the quality of modeling, the presented mathematical model describing the statics of the neutralization process for ferrous sulfate water was tested for compliance. To do this, two experiments were performed (the first at an initial concentration of sulfuric acid of 800 [mg/l] and ferrous sulfate of 4000 [mg/l] and the second at an initial concentration of sulfuric acid of 800 [mg/l] and ferrous sulfate of 2000 [mg/l]). First of all, a precondition for the reproducibility of experimental results was verified using the Cochrane test. The mathematical model was verified for adequacy on the basis of Fisher's criterion for the significance level q = 0.05 with degrees of freedom j1 = 16 and j2 = 17. For the first experiment, Grozr = 0.50557 and Gmab = 0.73; i.e., Grozr < Gmab and dispersions are homogeneous. Frozr = 1.0225 and Fmab = 2.4 and thus Frozr < Fmab, and there is no reason to say that the model is inadequate. For the second experiment, Grozr = 0.50308 and Gmab = 0.73; i.e., Grozr < Gmab and dispersions are also homogeneous. Frozr = 1.0005 and Fmab = 2.4 and thus Frozr < Fmab, which also indicates that the model is adequate. The issue related to the performance of technological systems for wastewater treatment in non-stationary modes is directly dictated by the specific operating conditions of treatment facilities, which are expressed by the instability of parameters at their inlet. The inability to apply the necessary technological action to the flow in time is a serious obstacle to the implementation of the cleaning depth, which is guaranteed by the physicochemical basis of the methods incorporated in technological systems and requiring cleaning standards. The operator cannot handle this complex task manually. On the basis of the proposed mathematical model, a structural-parametric diagram of the automated process control system has been developed, which makes it possible to proceed to the elaboration of algorithms and software for the control system necessary for automated control of the wastewater treatment process.

The production of carbon products is largely resource- and energy-intensive. That is why increasing the efficiency of this production is an urgent scientific and practical task, especially in modern conditions of constant growth of energy costs. An effective way to solve this problem is to create a modern process control system, taking into account possible failures of system components. A method for the synthesis of a fault-tolerant control system for the cyclic formation of carbon products has been developed, which takes into account control errors that are caused by malfunctions of controllers under conditions of unknown disturbances. According to the cyclic nature of the technological process under consideration, a control method with iterative learning was used in the synthesis of the control system. This method considers cyclic processes based on a two-dimensional model (2D model). The proposed control algorithm ensures the convergence of the control process with the task both in time and in each work cycle in order to promote the required quality of control even in the event of unknown disturbances and errors in the performance of controllers. The synthesis of the control system is based on the solution of a system of linear matrix inequalities. Based on the combination of a control method with iterative learning and a control method that takes into account failures in controllers, a method of constructing a fault-tolerant control system for the cyclic formation of carbon products has been synthesized to ensure acceptable operation of the control object in abnormal conditions. The control system has been synthesized by solving a system of linear matrix inequalities with the MATLAB software. In the future, it is necessary to consider optimal settings of the proposed control system and examine its effectiveness in comparison with conventional fault-tolerant systems for non-cyclic processes.

Today in modern medicine the study of human health is reoriented to the individual principle, which is based on the identification and study of constitutionally determined patterns of manifestation of certain diseases. The purpose of the study is to establish and analyze the features of the girth body sizes in men and women with generalized fatty form of seborrheic dermatitis of varying severity. The comprehensive body size of 40 men and 40 young women (25-44 years) with generalized fatty seborrheic dermatitis (mild and severe) was determined. The control group consisted of the girth sizes of practically healthy men (n=82) and women (n=154) of the same age group, which were selected from the database of the research center National Pirogov Memorial Medical University. Statistical processing of body circumference was performed in the licensed package “Statistica 6.0” using non-parametric evaluation methods. As a result of studies in patients with seborrheic dermatitis of varying severity of men, compared with practically healthy men, found only greater values of the girth of the shoulder in a relaxed state and thighs, neck (only mild), shin in the upper part and waist (in both cases only with a severe degree), as well as smaller values of the girth of the shoulder in a tense state; and in patients of varying severity of women – greater values of the girth of the shoulder in a relaxed state, thighs, lower legs, neck, waist and all girths of the chest and both thighs (only severe), as well as smaller values of the girth of the hand (only with mild). In both men and women with seborrheic dermatitis, differences in girth body sizes are more pronounced in people with severe disease. Between men or women with seborrheic dermatitis of varying severity, there are no significant or trends in differences in girth body sizes. In the analysis of the manifestations of sexual dimorphism of the circumferential body size between men and women with seborrheic dermatitis found greater values in men with mild and severe disease of the upper extremities, hands, shin, feet and neck (in most cases more pronounced in representatives with mild severity), as well as only in men with mild severity – greater values of all chest girths. For a more correct understanding of changes in girth body sizes in Ukrainian men or women with seborrheic dermatitis of varying severity, it is necessary to analyze other constitutional parameters of the body.

The work is aimed at solving the applied problem of developing an automatic control system for the evaporator using the principle of D-partition. Since there is always uncertainty in real problems, the solution of the problem of synthesis of the control system is reduced to the synthesis of a robust regulator. As a result, the area of robust stability of the object was obtained and an array of PI controller settings was formed, which ensures the stability of the object in the entire range of uncertainty.

The aim of the research was to study the response of various flax genotypes to the treatment of plants with a sulfonylurea herbicide – Magnum (active ingredient is metsulfuron-methyl) and to identify resistant forms for use in breeding programs for herbicide resistance. In 2018-2020 an assessment of 24 varieties and promising lines of fiber flax of domestic and foreign selection for resistance to this herbicide was carried out, the treatment of crops with the preparation was carried out at the recommended consumption rate of 0.01 kg/ha in the “herringbone” phase. It has been proved that the use of this herbicide leads to uneven plant growth during the “herringbone – flowering” period, which negatively affects the yield and quality of flax fiber. The decrease in the main indicators of the productivity and quality of the fiber in the variant with the use of the herbicide in comparison with the control, depending on the genotype was: in plant height – up to 44.4 %, in the weight of the technical part – 71.1 %, in the fiber mass – 74.8 %, in «myklost» (the ratio of the technical length of stem to its diameter)– 46.3 %, in the length of the elementary fiber – 27.7 %. A high level of resistance (over 80 %) to the herbicide Magnum for all analyzed traits was shown by the varieties Atlant (Russia) and Mogilevsky (Belarus). It was shown that when treating fiber flax plants with the herbicide, as a rule, an increase in inflorescence occurs due to a decrease in the technical length of the stem. It results in rise of the main indicators of seed productivity in most of genotypes under the influence of the Magnum preparation – the number of bolls and seeds per plant (up to 3.2 times). The exception was the variety Vega 2 (Lithuania), which had a decrease in the number of bolls per plant in the variant with herbicide treatment compared with the control by 1.8 times, and in the number of seeds by 5.3 times. This varietywasalso the most sensitive to the effect of Magnum in all parameters of productivity and fiber quality. The results are consistent with the data obtained whentreating various collection samples of fiber flax with a tank mixture Magnum + Herbitox L + Miura at the recommended consumption rates (0.007 + 0.6 + 1.0 kg(l)/ha).

A study of the degradation profiles of drugs based on recombinant monoclonal antibodies under stress conditions made it possible to determine the dynamics and mechanisms of degradation processes, to identify drug degradation products, and to reveal differences in the stability of biosimilar drugs for relatively short times. A strategy for accelerated (35 d) stability assessment under stress conditions of the original product Soliris® (Switzerland) and its biosimilar PRK-001 (Russia) was proposed. Their degradation profiles after exposure to extreme pH, oxidative stress, and UV radiation were studied. Antibody fragments were analyzed using size-exclusion chromatography, capillary isoelectric focusing, electrophoresis, and mass spectrometry. Both products showed similar degradation profiles and similar changes in isoform contents.

Flax is grown worldwide for seed and fiber production. Linseed varieties differ in their oil composition and are used in pharmaceutical, food, feed, and industrial production. The field of application primarily depends on the content of linolenic (LIN) and linoleic (LIO) fatty acids. Inactivating mutations in the

In Ukraine, the condition of surface water near industrial enterprises is extremely critical. The operation of enterprises leads to intensive water pollution with industrial and domestic wastewater. Therefore, improving the quality of treatment facilities through the introduction of automated control systems is an urgent problem. For the operation of automated control systems for typical cleaning processes, a software package is required, which is developed on the basis of appropriate algorithmic software and mathematical models of processes. To obtain them, methods of mathematical and simulation modeling and block diagram method of algorithmization were used. In order to assess the quality of the developed algorithm for controlling the process of buffer wastewater neutralization during operation, a comparison of control system operation based on this algorithm with the most successful foreign variants of neutralization control systems was made. Simulation for the average values of operating parameters Q = 75 m3 / h, CP = 75 g / l, and Ck = 2 g / l at minimum b = 0.02 g / l pH and maximum buffer value b = 0.47 g / l pH, and also with unidirectional extreme combination of parameters Q = 50 m3 / h, CP = 100 g / l, b = 0,02 g / l pH and Q = 100 m3 / h, CP= 50 g / l, for minimum b = 0.02 g / l pH and maximum buffering value b = 0.47 g / l pH shows that the best quality of transient processes is for the control system operating on the basis of the developed algorithm. For any combination of parameters, the transients for this control system provide better quality transients. Studies have shown that the control system based on the developed algorithm in comparison with the previously proposed systems provides better process control by reducing the time of transients and reducing the dynamic deviation of the output parameters, which improves the quality of wastewater treatment. Given the non-stationary process and high requirements for the cleaning parameters, manual control of this process is beyond the power of even an experienced operator. The developed mathematical model describing the dynamics of the wastewater neutralization reactor with buffer properties and the process control algorithm made it possible to proceed to the development of the control system software, which is necessary for the automated control of this process.

Theoretical fundamentals of product portfolio diversification in the frames of recrea­tional tourism were disclosed. The main attractive properties of recreationaltourism resources were substantiated. The potential advantages and disadvantages of recreation tourism product diversification were investigated. The product portfolio diversification and marketing processes in recreation tourism wereanalyzed via the example of the clinical sanatorium "Kuialnik" and the resort association "Perlyna Chornomoria" located in Odesa region of Ukraine. Keywords: recreation tourism, resort, sanatorium, product portfolio, diversification.

High-quality genome sequences help to elucidate the genetic basis of numerous biological processes and track species evolution. For flax (

The issue of psychological feasibility of distance learning is understudied and remains relevant both in theoretical and practical terms. The purpose of the study viewed in the article is to identify the connection between students’ preferences to study using the Internet and electronic textbooks with their personal psychological traits. Presumably, confident, self-organized students have a positive attitude towards their use, while anxious, emotionally unstable students have a negative attitude. The study involves 1st–4th year students (N = 270, aged from 17to 21years; 61.3% women) students, who specialize in Economics and Agricultural Industry in Izhevsk State Agricultural Academy. We used the following techniques: questionnaire developed by O. N. Malakhova, O. A. Zhuchenko, aimed at studying students’ preferences and Cattell’s Personality Factor Questionnaire (16-PF), form C, which has the goal to study personality traits that are significant for the research. It was found that there was a direct interconnection between students’ preference to use digital educational resources with their personal psychological traits. The study revealed that students with self-discipline and analytical mindset have a negative attitude to the use of electronic textbooks and distance learning. It was found that among the main personal psychological characteristics of students, which influence their preferences, are sensitivity and radicalism, anxiety and lack of self-discipline. We did not confirm the hypothesis put forward in the study. The applied aspect of the problem under study can be implemented in educational practice to increase the efficiency of educational process and in the development of digital training courses. The research perspectives are related to the study of teacher preferences.

In the work, (i) the danger of the contact between the fan impeller blades and the body of a gas turbine engine (GTE) is justified, (ii) the factors affecting the value of the radial clearance in flight are established, (iii) the main causes of contact are revealed, (iv) the modern tools for determining the radial clearance of GTEs are analyzed, and (v) the in-flight method for identifying the contact between the fan blades and the body of a GTE is proposed based on the complex processing of vibration signal of the fan body and pressure sensor signals behind the fan. Introduction of the identification method based on processing the vibration and pressure pulsation signals improves the flight safety, especially for prototype GTEs at first stages of flight tests without the need for additional preparation and mounting of complex clearance control systems. This method may be applied for identifying the contact at excessive decrease in the radial clearance, which allows in-time decision making about relieving the flight mode (if it is possible at the flight stage when the contact occurs) in order to avoid substantial damage caused by contacts.

A series of silica mesoporous molecular sieves SBA-15 with a 7.7 ± 0.8 nm pore diameter, the surface of which is hydrophobized with methylsilyl groups, and polymethylsiloxane derivatives with a 1.6 ± 0.8 nm pore diameter were obtained. These sieves are characterized by X-ray phase analysis, adsorption of nitrogen at 77 K and water at 293 K, as well as IR spectroscopy. It is established that there is a significant resistance to water intrusion (absorption) only in the case of substances characterized by the nitrogen adsorption potential value ∆μ0 ≤ 6.4 kJ/mol. The studied systems can be used as “molecular springs” in shock load damping devices due to their functional properties.

We studied the regularities of distribution of siderophile elements, including platinum group elements (PGE), in rock and in sulfides from Archean (2814 ± 51 Ma) peridotites collected in a fragment of deformed dike within the Bug granulite complex, Ukrainian Shield. In comparison with the primitive mantle, the studied rocks are enriched in Rh, Pd, Ni, Fe, and Co, and are characterized by low concentrations of other PGE. Sulfides are represented by a high-temperature variety of pentlandite and a small amount of chalcopyrite, with an inhomogeneous PGE distribution in them. Pd/Ir ratio typical of superchondrite is revealed for rocks and some sulfides. It is supposed that enrichment in Pd was not resulted from fractionation, but was rather related to mantle metasomatism. Saturation of the melt with sulfides and liquation process were favored by contamination of harzburgite with the host gneissic enderbite and fractionation of olivine. Solid sulfide solutions formed from sulfide melts at temperatures close to the crystallization temperature of magnesium phlogopite from a silicate melt.

This review article offers an analysis of application of cell-free fetal DNA non-invasive prenatal screening test for chromosome abnormalities in the mothers blood in different countries. The diagnostic capacities of the method, its limitations, execution models and ethical aspects pertinent to its application are discussed. The data for the discordant results is shown and analyzed. The advantages of the genome-wide variant of cell-free fetal DNA analysis and the problems concerning its application in the mass screening are described. The main suggestion is to implement the contingent cell-free fetal DNA testing model for the common trisomies (for the chromosomes 21, 18 and 13) into the prenatal diagnostic screening programs in the Russian Federation. This novel model is based on the results of the mass combined first trimester prenatal screening in four federal subjects of the country completed by 2019 and is offered as an additional screening in the mid-level risk group (with cut-off from 1 : 100 to 1 : 500 or from 1 : 100 to 1 : 1000) defined according to the first trimester prenatal screening results. The basic requirements for the implementation of the contingent model in the Russian Federation are stated.

In the article the authors consider general social and special-criminological measures of prevention of criminal offenses in the field of road safety. It is pointed out that, for the most part, such criminal offenses are the result of criminally unlawful negligence and arrogance. Therefore, it cannot be said that the lion's share is committed by drivers with direct intent in order to obtain socially dangerous consequences. There are still cases caused by traffic violations by pedestrians, which significantly complicates the forecasting of such illegal acts, and therefore the timely creation of precautionary measures. The author points out that conditionally all the reasons related to the violation of traffic rules can be divided into: 1) the reasons due to the negligent attitude of the driver to perform their duties on the road (intoxication, loss of attention, etc.); 2) the reasons caused by careless attitude of pedestrians to traffic rules; 3) the reasons caused by the careless attitude of employees of service centers of the Ministry of Internal Affairs to performance of the duties. Thus, the main unifying factor is the negligence of the subjects involved in the organization of traffic. It is concluded that a number of criminological strategies for the prevention of criminal offenses in the field of traffic have been successfully implemented in our country. However, most of these strategies do not meet the requirements and realities of today, and therefore the criminological picture of traffic accidents remains consistently negative. This indicates the need to revise general social and special criminological measures and means of prevention, which will not only reduce the number of such socially dangerous acts, but also improve the general criminal law and criminological statistics.

AIM to determine the efficiency of different doses of erythropoietin and carbamylated darbepoetin, to prove experimentally the possibility of increasing the efficiency of carbamylated darbepoetin when using the levorotatory stereoisomer of ethoxidol. MATERIALS AND METHODS On the model of ischemia-reperfusion injury in male CD-1 mice that were undergone to contralateral nephrectomy, the nephroprotective effect of different doses of erythropoietin alfa, carbamylated darbepoetin, L-ethoxidol (the levorotatory enantiomer of ethylmethylhydroxypyridine malate), and the combined use of L-ethapylated carboxypyridine malate and L-etapoietin alfa was studied. The parameters of microcirculation and glomerular filtration rate were studied one day after 30-minute ischemia. RESULTS It has been established that the prophylactic use of erythropoietin alfa and carbamylated darbepoetin in the model of ischemia-reperfusion injury of a single kidney reduces the severity of microcirculatory impairment and ensures the preservation of the glomerular filtration rate in dose-dependent manner. The synergistic effect of L-ethoxidol and carbamylated darbepoetin was found when these substances were used together. CONCLUSION Prevention of ischemia-reperfusion kidney injury by analogs of human erythropoietin and their combination with ethylmethylhydroxypyridine derivatives is experimentally-proved.

Context. The problem of forming complex signal ensembles on the basis of frequency band filtering and research of their properties is considered. The object of research is the process of synthesis of signal ensembles based on frequency filtering of pseudo-random sequences of short video pulses with low interaction in the time domain.Objective. It is to form complex signal ensembles with satisfactory values of intercorrelation properties, which are close to the signals with minimal energy interaction. Method. The results of the application of forming complex signal ensembles method by frequency filtering of pseudo-random sequences with low interaction in the time domain are presented. As a result of the spectral band selection of the studied pseudorandom short video pulse sequences due to the use of bandpass filters based on the Chebyshev filter of the first kind, new samples of sequences with spectrum restriction are obtained. By applying intercorrelation analysis to the obtained sequence samples, the values of the maximum emissions of the side lobes of the cross-correlation functions (CCF) for all possible signal pairs are estimated. If the values of the maximum emissions of the side lobes of the CCF signals exceed the limit values, the sequence of the analyzed pair with a smaller value of the number of pulses is removed from the ensemble. In case of satisfactory value – the received signals are accepted for the signal ensemble formation with the minimum power interaction. Thus, a new set of values of the maximum emissions of the side lobes of the CCF is formed. This approach increases the number of signals in ensembles with satisfactory values of statistical characteristics with limited signal spectrum width, and the correlation properties of such sequences approach the signals with minimal energy interaction, which reduces the level of multiple access interference. As a result, complex signal ensembles obtained by frequency filtering should be used in cognitive radio systems with code division multiplexing.Results. Based on the software implementation of the method of forming complex signal ensembles by frequency filtering of pseudo-random sequences with low interaction in the time domain, signals with satisfactory values of statistical characteristics with limited signal spectrum width with intercorrelation properties close to signals with minimal energy interaction and higher ensemble volume were selected.Conclusions. The application of frequency filtering to pseudo-random sequences of short video pulses with a low level of crosscorrelation allows to obtain complex signal ensembles, which will be similar in correlation properties to sequences with minimal energy interaction. It will reduce the level of multiple access interference. The analysis revealed that the use of frequency filtering of sequences will slightly worsen the mutual correlation properties of signals, possibly due to suboptimal synthesis of values of maximum emission levels of side lobes of CCF signals, but, nevertheless, it is possible to use such signals in modern cognitive systems radio access multiple access with code division multiplexing.

The correction of free radical oxidation processes is one of the most promising strategies of neuroprotection in acute cerebrovascular disorders.The aim of the study is an experimental study of the neuroprotective effects of 3-hydroxypyridine and erythropoietin derivatives, as well as their combined use.Materials and methods. The study was performed on 109 male Wistar rats. The neuroprotective effect of the substances was studied on a hemorrhagic stroke model. The study drugs were administered to the animals intraperitoneally. Carbamylated darbepoetin was administered three times in advance at the dose of 100 µg/kg within intervals of 3 days, the last injection took place 1 hour before the operation (the total dose was 300 mg/kg). Etoxidol was administered once 1 hour before the surgery at the dose of 50 mg/kg. The survival rate, behavioral features and the state of the animals on the 1st, 3rd, 7th and 14th days were recorded, and the morphological assessment of the brain was carried out.Results. The investigated substances had a positive effect on both the survival rate of the animals during the first day and on the 14th day. The best survival rates on the 14th day were recorded in the group of a combined use of ethoxydol and carbamylated darbepoetin (75%). Thus, in this group of rats, a faster recovery of neurological disorders was already distinguished from the first day on. By the 7th day, more than 50% of the rats receiving the combination of the studied drugs, had had a slight neurological deficit (up to 3 points on the McGrow scale); by the 14th day there had been only minor changes in the neurological status in the rats of this group. A pronounced neuroprotective effect of the combination of 3-hydroxypyridine and erythropoietin derivatives has been confirmed by a histological examination of brain slices – a more rapid decrease in the size of perifocal edema and microcirculation disorders, less damage to neurons and glial elements, and faster processes of resorption and organization of hemorrhage. A macroscopic examination of the brain sections stained with triphenyltetrazolium chloride of the dying rats, showed that perifocal necrosis had been the main cause of high mortality in the control group after the 3rd day.Conclusion. As a result of the experiment, the nephroprotective effect of the studied derivatives of 3-hydroxypyridine and erythropoietin has been proved. Moreover, the combination of these drugs has shown a greater neuroprotective activity than their isolated use. The additive effect of these drugs was due to their action mechanism resulting from the synergism of various structures and components of the cells.