43 results on '"Zhihuang Qiu"'
Search Results
2. Identification of potential hub genes for the diagnosis and therapy of dilated cardiomyopathy with heart failure through bioinformatics analysis
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Xinghui Zhuang, Mengyue Tian, Liming Li, Shurong Xu, Meiling Cai, Xiaojie Yang, Zhihuang Qiu, Tianci Chai, and Liangwan Chen
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Dilated cardiomyopathy (DCM) is a common cause of heart failure. However, genetic-level treatments are not available for this condition. In this study, we searched for biological markers and therapeutic targets for DCM from a genetic perspective. We chose microarray datasets of idiopathic DCM with heart failure tissues and normal function (NF) heart tissues, which were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were analyzed by the GEO2R tool. Gene ontology (GO) and gene set enrichment analysis were used to analyze the functions of DEGs and the pathways in which they are involved. Next, protein-protein interaction networks were built to filter out the hub genes from DEGs. The expression of hub gene was validated by other GEO datasets. Receiver operating characteristic (ROC) curves were plotted to verify the accuracy of the genetic diagnosis. In the end, the mRNA-miRNA-lncRNA network was built to find potentially correlative genes. Twenty-eight common DEGs in total were screened, and GO analysis showed that DEGs were mainly associated with neutrophil degranulation and activation, regulation of Wnt signaling pathway and the development of cardiac cell and tissue. Five hub genes (asporin [ASPN], osteoglycin [OGN], secreted frizzled-related protein 4 [SFRP4], membrane metalloendopeptidase [MME], and natriuretic peptide gene [NPPA]) were shown to be highly expressed in the validation sets and accurate in distinguish between DCM and NF by ROC curves. miRNA prediction of the hub genes revealed that hsa-mir-28b-5p was associated with SFRP4, ASPN, and MME. All of them may serve as biological diagnostic indicators and provide direction for treatment at the genetic level.
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- 2022
3. Comparison of valvuloplasty and replacement for surgical treatment of tricuspid infective endocarditis
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Linfeng Xie, Xiaodong Chen, Jian He, Sixian Lin, Xingfeng Chen, Qingsong Wu, Ling Chen, Jingxiang Zhuang, Zhihuang Qiu, and Liangwan Chen
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Cardiology and Cardiovascular Medicine - Abstract
Background Owing to the increase in both intravenous drug injections and intracardiac and vascular interventional treatments among drug users, the incidence of infective endocarditis (IE) involving the tricuspid valve, which sits between the two right heart chambers, has gradually increased. This study aimed to compare the clinical outcomes of different surgical procedures for tricuspid infective endocarditis (TIE). Methods We retrospectively analyzed fifty-six patients who underwent tricuspid valve surgery at our hospital from January 2006 to August 2019. All patients were diagnosed with TIE and indicated a need for surgery. Perioperative and follow-up data were collected to summarize and analyze the clinical outcomes of different surgical approaches, including tricuspid valvuloplasty (TVP) and tricuspid valve replacement (TVR) for TIE. Results Cardiopulmonary bypass (CPB) time, aortic cross-clamp (ACC) time, postoperative mechanical ventilation time, and intensive care unit (ICU) stay time were shorter in the TVP group than in the TVR group. Additionally, the incidence of red blood cell transfusion and postoperative complications was lower in the TVP group than in the TVR group. The postoperative 30-day mortality rates were similar between both the groups. Fifty-two patients were followed up for an average of 5.50 ± 3.79 years. The postoperative 3-, 5-, and 7-year survival rates were 100%, 100%, and 95.5% in the TVP group and 96.7%, 96.7%, and 96.7% in the TVR group, respectively. The 5-year and 10-year reoperation rates were 0% and 0% in the TVP group and 6.7% and 20% in the TVR group, respectively. Conclusion Both TVR and TVP for TIE significantly improved the functional status of the heart with satisfactory efficacy. TVP was found to be superior to TVR in reducing the need for postoperative blood transfusions, reducing the risk of postoperative complications, and reducing the need for long-term reoperations.
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- 2023
4. Benefits of sacubitril/valsartan use in patients with chronic heart failure after cardiac valve surgery: a single-center retrospective study
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Jian Zheng, Qingsong Wu, Qianzhen Li, Mirong Tang, Jian He, Zhihuang Qiu, Linfeng Xie, and Liangwan Chen
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Pulmonary and Respiratory Medicine ,Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Objectives To evaluate the efficacy of sacubitril/valsartan for the treatment of patients with chronic heart failure (CHF) after cardiac valve surgery (CVS). Methods Data were collected from 259 patients who underwent CVS due to valvular heart disease and were admitted to the hospital with CHF from January 2018 to December 2020. The patients were divided into Group A (treatment with sacubitril/valsartan) and Group B (treatment without sacubitril/valsartan). The duration of treatment and follow-up was 6 months. The two groups’ prior and clinical characteristics, post-treatment data, mortality, and follow-up data were analysed. Results The effective rate of Group A was higher than that of Group B (82.56% versus 65.52%, P Conclusions Sacubitril/valsartan can effectively improve the cardiac function of patients with CHF after CVS by increasing LVEF and reducing LVEDD, LVESD, NT-proBNP, and BP, with good safety.
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- 2023
5. The role of integrins in atherosclerosis complicated with abdominal aortic aneurysm: A bioinformatics study
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Likang Ma, Xinghui Zhuang, Tianci Chai, Qingsong Wu, Liangwan Chen, and Zhihuang Qiu
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Background Increasingly, the shared risk factors and pathological processes of atherosclerosis and abdominal aortic aneurysm (AAA) are being recognized. However, the exact mechanism underlying the shared pathogenesis of atherosclerosis and AAA formation remains unclear. Methods The aim of our study was to identify the hub genes involved in the pathogenesis of atherosclerosis and AAA. Our analysis was based on two gene expression profiles for atherosclerosis (GSE28829) and AAA (GSE7084), downloaded from the Gene Expression Omnibus (GEO) database. Common differential genes were identified and an enrichment analysis of differential genes was conducted, with construction of protein-protein interaction networks, and identification of common hub genes and predicted transcription factors. Results The analysis identified 133 differentially expressed genes (116 upregulated and 17 downregulated), with the enrichment analysis identifying a potential important role of integrins and chemokines in the common immune and inflammatory responses of atherosclerosis and AAA. Regulation of the complement and coagulation cascades and regulation of the actin cytoskeleton were associated with both diseases, with 10 important hub genes identified: TYROBP, PTPRC, ITGB2, ITGAM, PLEK, CTSS, LY86, ITGAX, CCL4, and FCER1G. Conclusions Findings identified a common pathogenetic pathway between atherosclerosis and AAA, with integrin-related genes playing a significant role in both diseases. The common pathways and hub genes identified provide new insights into the shared mechanisms of these two diseases and can contribute to identifying new therapeutic targets and predicting the therapeutic effect of biological agents.
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- 2022
6. Preoperative Blood Urea Nitrogen-to-Serum Albumin Ratio for the Prediction of In-hospital Mortality in Patients who Underwent Emergency Surgery for Acute Type A Aortic Dissection
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Qingsong Wu, Jianling Lin, Zhihuang Qiu, Mirong Tang, Linfeng Xie, and Liangwan Chen
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Background: Blood urea nitrogen (BUN) and serum albumin (SA) are related to mortality in patients with cardiovascular diseases, such as acute aortic dissection. However, there are no data on the relationship between BUN-to-albumin ratio (BA-R) and mortality in patients with acute type A aortic dissection (ATAAD). Thus, the aim of this study was to evaluate the prognostic value of BA-R for the prediction of in-hospital mortality in patients who underwent emergency surgery for ATAAD.Methods: Patients who were diagnosed with ATAAD and underwent emergency surgery within 48 h of onset at our hospital between January 2015 and December 2021 were included in this study. The primary endpoint of this study was postoperative in-hospital mortality (POIM). The data of the survivors and non-survivors were retrospectively compared. Univariate and multivariable logistic regression analyses were performed to investigate the association between BA-R and POIM.Results: A total of 557 patients with ATAAD were enrolled in this study. Of these, 505 survived and 52 did not. The preoperative BA-R of the non-survivor group was significantly higher than that of the survivor group (0.27 [0.18, 0.46] vs. 0.12 [0.10, 0.16] mmol/g; P < 0.001). Univariate regression analysis showed that preoperative BA-R ≥0.155 mmol/g, serum creatinine level ≥96.3 µmol/mL, SA level Conclusion: Preoperative BA-R is a simple, rapid, and potentially useful prognostic indicator of POIM in patients with ATAAD.
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- 2022
7. Supplementation with Tex261 provides a possible preventive treatment for hypoxic pulmonary artery hypertension
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Shaokun Chen, Xiaozhen Wei, Xu Zhang, Mengge Yao, Zhihuang Qiu, Liangwan Chen, and Li Zhang
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Pharmacology ,Pharmacology (medical) - Abstract
Objectives: Pulmonary artery hypertension (PAH) is a serious disease for which there is no effective treatment. Its pathogenesis is complex and has not yet been clarified. Tex261 is a protein-coding gene whose functional enrichment nodes include the transporter activity of COP II. However, the role of Tex261 in PAH remains unknown.Methods: Sugen5416/Hypoxic PAH models were established, and pulmonary arteries (PAs) were isolated for proteomic sequencing. The binding sites between Hif-1α and Tex261 were verified by dual-luciferase reporter gene assay. Cell proliferation was detected by MTS and EdU assays. For determination of the preventive and therapeutic effects of Tex261, intratracheal instillation of adeno-associated virus (AVV6) with Tex261 vectors was performed.Results: Tex261 was screened according to the proteomic sequencing data. Hif-1α inhibited Tex261 promoter activity under hypoxia. Decreased Tex261 expression promoted PASMC proliferation. Tex261 regulated Sec23 via the Ndrg1-mediated Akt pathway. Tex261 overexpression improved the pressure and vessel remodeling of PAs induced by Sugen5416/hypoxia.Conclusion: Hypoxia suppressed Tex261 expression through Hif-1α activation. The decreased Tex261 could promote Ndrg1 and depress Akt activity and then inhibit Sec23 activity, which leads to cell proliferation and vessel remodeling. Elevated Tex261 has some preventive and therapeutic effects on rats with PAH.
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- 2022
8. Benefits of sacubitril/valsartan use in patients with chronic heart failure after cardiac valve surgery: a single-center retrospective study
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Jian Zheng, Qingsong Wu, Qianzhen Li, Mirong Tang, Zhihuang Qiu, and Liangwan Chen
- Abstract
Objective: To evaluate the efficacy of sacubitril/valsartan for the treatment of patients with chronic heart failure (CHF) after cardiac valve surgery (CVS).Methods: Data of 259 patients who underwent CVS due to organic heart disease, and who were admitted to the hospital with CHF from January 2018 to December 2020, were collected. The patients were divided into Group A (treatment with sacubitril/valsartan) and Group B (treatment without sacubitril/valsartan). The duration of treatment and follow-up was 6 months. Prior-treatment clinical characteristics, post-treatment data, mortality, and follow-up data of the two groups were analyzed.Results: The total effective rate of Group A was higher than that of Group B (82.56% versus 65.52%, P < 0.05). The left ventricular ejection fraction (LVEF) was improved in both groups (11.14 ± 10.16 versus 7.15 ± 11.18, P = 0.004). The left ventricular end-diastolic/-systolic diameter (LVEDD/LVESD) in Group A decreased more than that in Group B (3.58 ± 9.21 versus 0.27 ± 14.44, P=0.026; 4.21 ± 8.15 versus 1.14 ± 12.12, P=0.016, respectively). The N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) in both groups decreased (1305.65 ± 2000.85 versus 675.91 ± 1649.84, P=0.012). The systolic and diastolic blood pressure (SBP/DBP) in Group A decreased more than that in Group B (13.13 ± 23.98 versus 1.81 ± 10.89, P < 0.001; 8.28 ± 17.79 versus 2.37 ± 11.41, P = 0.005, respectively). Liver and renal insufficiency, hyperkalemia, symptomatic hypotension, Angioedema or acute heart failure have no statistical differences between the two groups.Conclusion: Sacubitril/valsartan can effectively improve the cardiac function of CHF patients after CVS by increasing LVEF, reducing LVEDD, LVESD, NT-proBNP and BP, with good safety.
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- 2022
9. Single Cell RNA Sequencing Reveals the Pathogenesis of Aortic Dissection Caused by Hypertension and Marfan Syndrome
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Li Zhang, Zhihuang Qiu, Hui Zheng, Xi Yang, Jianqiang Ye, Jian He, Yumei Li, and Liangwan Chen
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Cell Biology ,Developmental Biology - Abstract
Aortic dissection (AD) is mainly caused by hypertension and Marfan syndrome. However, it is unclear whether the cellular components and functions are different between the two causes. A total of 11 aortic samples were collected for single-cell RNA analysis and 20 clusters were disclosed, including VSMCs, fibroblasts, endothelial cells, T cells, B cells, monocytes, macrophages, mast cells, and neutrophils components. There were differences in cell subclusters and function between hypertension and Marfan patients. The cells also had different differentiations. Cellchat identified cell ligand–receptor interactions that were associated with hypertension and Marfan-induced AD involving SMC, fibroblast, mo-macrophages, and T-cell subsets. This study revealed the heterogeneity of cellular components and gene changes in hypertension and Marfan-induced AD. Through functional analysis and the changes in intercellular communication, the possible mechanisms of different causes of AD were explained from a new perspective, so we can better understand the occurrence and development of diseases.
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- 2022
10. Preoperative clinical application of human fibrinogen in patients with acute Stanford type A aortic dissection: A single-center retrospective study
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Jiahui Li, Qingsong Wu, Mirong Tang, Yue Shen, Zhihuang Qiu, Xiaodong Chen, Xingfeng Chen, and Liangwan Chen
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Pulmonary and Respiratory Medicine ,Aortic Dissection ,Risk Factors ,Blood Loss, Surgical ,Fibrinogen ,Humans ,Surgery ,Acute Kidney Injury ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
Objective: To evaluate the perioperative clinical efficacy of preoperative human fibrinogen treatment in patients with acute Stanford type A aortic dissection (ATAAD).Methods: Data of 159 patients with ATAAD who underwent emergency surgical treatment in our hospital from January 2019 to December 2020 were retrospectively analyzed. Patients were divided into two groups according to whether human fibrinogen was administered before surgery. The preoperative clinical data, surgical data, postoperative data, complications related to the coagulation function, and mortality of the two groups were compared and analyzed.Results: The in-hospital mortality was similar in the two groups (2.9% versus 9.3%, P = 0.122). However, group A had a significantly shorter operation time (279.24±39.03 versus 298.24±45.90, P=0.008), lower intraoperative blood loss (240.48±96.75 versus 353.70±189.80, P<0.001), and reduced intraoperative transfusion requirement of red blood cells (2.61±1.18 versus 6.05±1.86, P<0.001). The postoperative suction drainage within 24 hours in group A was significantly decreased (243.24±201.52 versus 504.22±341.08,P=0.002). The incidence of postoperative acute kidney injury (AKI) in group A was lower than that in group B (3.8% versus 14.8%, P =0.023). Similarly, the incidence of postoperative hepatic insufficiency in group A was lower than that in group B (1.9% versus 9.3%, P =0.045). In group A, the mechanical ventilation time was shorter (47.68±28.61 versus 118.21±173.16, P=0.004) along with reduced ICU stay time (4.06±1.18 versus 8.09±9.42, P=0.003), and postoperative hospitalization days (19.20±14.60 versus 23.50±7.56, P=0.004).Conclusion: Preoperative administration of human fibrinogen in patients undergoing ATAAD surgery can effectively reduce the intraoperative blood loss, blood transfusion amount, shorten the operation time, reduce postoperative complications, and improve the early prognosis of patients, in addition to being highly safe.
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- 2022
11. TPI1 Contributes to the Development of Aortic Aneurysm by Promoting VSMC Phenotypic Switching and MMP2/9 Secreting
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Liangwan Chen, Hui Zheng, Zhihuang Qiu, Yuling Zhang, Chaoyun Wang, Yumei Li, and Li Zhang
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Background: Triosephosphate isomerase 1 (TPI1) is a crucial enzyme in glycolysis/gluconeogenesis and has been associated with a variety of diseases. However, there is little information on TPI1 and aortic aneurysms (AA). This study was designed to reveal the association between TPI1 and aortic aneurysms, and the mechanisms underlying TPI1 activity in AAs. Methods: Tandem Mass Tag (TMT)-based Liquid chromatography mass spectrometry/mass spectrometry (LC-MS/MS) and the Mann-Whitney test were used to compare variables between AA and normal aortic tissues. Gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were analyzed using Fun-Rich software. The expression of the TPI1 protein in human aortic tissues was verified by Western blotting. A mouse AA model was established by infusing Ang-II for 4 weeks, then the expression of TPI1, SM22, α-SMA, OPN and MMP2/9 proteins were evaluated by western blotting. TPI1 overexpression was achieved by transfection of TPI mRNA, and its effect on gene expression was studied by RT-qPCR and western blotting, which included SM22, α-SMA, OPN, and MMP2/9. Ang II-induced expression of TPI1 and phenotypic-related genes in VSMCs. Results: TPI1 is closely related to the glycolysis/gluconeogenesis pathway and is higher in AA. Expression of TPI1 was upregulated in AA aortic samples of both human and mouse models, p
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- 2022
12. A Modified Approach with Caval Transection for Supracardiac Total Anomalous Pulmonary Venous Connection: Comparison Between Conventional and Sutureless Surgery in 173 Patients
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Zhihuang Qiu, Lian-Ming Liao, Mi-Rong Tang, Xing-Feng Chen, Liang-Wan Chen, Qiong-Song Wu, Yong-Ping Zhu, Jun Xiao, Dong-San Liao, and Xian-Biao Xie
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Male ,Reoperation ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Sutureless Surgery ,Total anomalous pulmonary venous connection ,Proportional Hazards Models ,Retrospective Studies ,business.industry ,Scimitar Syndrome ,Hazard ratio ,Infant, Newborn ,Infant ,Odds ratio ,Vascular surgery ,medicine.disease ,Venous Obstruction ,Sutureless Surgical Procedures ,Confidence interval ,Surgery ,Cardiac surgery ,030228 respiratory system ,Pediatrics, Perinatology and Child Health ,Pulmonary Veno-Occlusive Disease ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
The efficacy of primary sutureless repair for supracardiac total anomalous pulmonary venous connection (TAPVC) needs to be confirmed. This study aimed to compare the long-term outcomes between the conventional surgery and the sutureless technique with a modified approach in superior TAPVC. Between January 2008 and December 2018, 173 patients with supracardiac TAPVC underwent surgery either with the conventional procedure (n = 130) or the sutureless repair (n = 43). Multivariate analysis and competing-risk analysis were used to identify risk factors for early death and postoperative pulmonary venous obstruction (PVO), respectively. Among 173 patients who underwent repair of supracardiac TAPVC, 46 (28%) had preoperative PVO, and 22 (12.7%) had postoperative PVO. The sutureless group had a lower postoperative PVO rate compared with the conventional group (p = 0.027). The risk factors for death were age ≤ 28 days [odds ratio (OR), 11.56; 95% confidence interval (CI) 1.33–100.47, p = 0.015], weight ≤ 3 kg (OR 9.57; 95% CI 1.58–58.09, p = 0.009), emergency operation (OR 19.24; 95% CI 3.18–116.35, p = 0.002), cardiopulmonary bypass time (OR 2.16; 95% CI 1.36–3.43, p = 0.003), cross-clamp time (OR 1.73; 95% CI 1.20–2.50, p = 0.022), and duration of ventilation (OR 1.11; 95% CI 1.02–1.21, p = 0.027). Age ≤ 28 days [Hazard Ratio (HR) 1.92; 95% CI 1.92–11.02, p
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- 2021
13. High summation of preoperative and postoperative Interleukin-6 levels predicts prolonged mechanical ventilation in patients with acute DeBakey type I aortic dissection: A single center retrospective study
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Qingsong Wu, Qinghua Lin, Linfeng Xie, Zhihuang Qiu, and Liangwan Chen
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Multidisciplinary - Published
- 2023
14. Genome-Wide Identification of Associations of Circulating Molecules With Spontaneous Coronary Artery Dissection and Aortic Aneurysm and Dissection
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Tianci, Chai, Mengyue, Tian, Xiaojie, Yang, Zhihuang, Qiu, Xinjian, Lin, and Liangwan, Chen
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Cardiology and Cardiovascular Medicine - Abstract
Circulating proteins play functional roles in various biological processes and disease pathogenesis. The aim of this study was to highlight circulating proteins associated with aortic aneurysm and dissection (AAD) and spontaneous coronary artery dissection (SCAD). We examined the associations of circulating molecule levels with SCAD by integrating data from a genome-wide association study (GWAS) of CanSCAD and 7 pQTL studies. Mendelian randomization (MR) analysis was applied to examine the associations between circulating molecule levels and AAD by using data from UK Biobank GWAS and pQTL studies. The SCAD-associated SNPs in 1q21.2 were strongly associated with circulating levels of extracellular matrix protein 1 (ECM1) and 25 other proteins (encoded by CTSS, CAT, CNDP1, KNG1, SLAMF7, TIE1, CXCL1, MBL2, ESD, CXCL16, CCL14, KCNE5, CST7, PSME1, GPC3, MAP2K4, SPOCK3, LRPPRC, CLEC4M, NOG, C1QTNF9, CX3CL1, SCP2D1, SERPINF2, and FN1). These proteins were enriched in biological processes such as regulation of peptidase activity and regulation of cellular protein metabolic processes. Proteins (FGF6, FGF9, HGF, BCL2L1, and VEGFA) involved in the Ras signaling pathway were identified to be related to AAD. In addition, SCAD- and AAD-associated SNPs were associated with cytokine and lipid levels. MR analysis showed that circulating ECM1, SPOCK3 and IL1b levels were associated with AAD. Circulating levels of low-density lipoprotein cholesterol and small very-low-density lipoprotein particles were strongly associated with AAD. The present study found associations between circulating proteins and lipids and SCAD and AAD. Circulating ECM1 and low-density lipoprotein cholesterol may play a role in the pathology of SCAD and AAD.
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- 2022
15. Comparison of Early Efficacy of the Percutaneous Presuture Technique with the Femoral Artery Incision Technique in Endovascular Aortic Repair under Local Anesthesia for Uncomplicated Type B Aortic Dissection
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Qingsong Wu, Debin Jiang, Xiaochai Lv, Jiaxin Zhang, Rongda Huang, Zhihuang Qiu, and Liangwan Chen
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Article Subject ,Endovascular Procedures ,Surgical Wound ,Femoral Artery ,Aortic Dissection ,Blood Vessel Prosthesis Implantation ,Postoperative Complications ,Treatment Outcome ,Risk Factors ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,Anesthesia, Local ,Aortic Aneurysm, Abdominal ,Retrospective Studies - Abstract
Objective. To compare the efficacy of the percutaneous presuture technique (PPST) and the femoral artery incision technique (FAIT) under local anesthesia in the treatment of endovascular aortic repair (EVAR) for patients with uncomplicated type B aortic dissection (uTBAD). Method. Two hundred and ninety-five patients diagnosed with uTBAD who underwent EVAR under local anesthesia from June 2017 to December 2021 were consecutively and randomly selected for retrospective analysis. The PPST was performed in 178 cases and the FAIT was performed in 117 cases. The clinical characteristics and surgical and postoperative data from the two groups were analyzed. Results. There were no significant differences in clinical characteristics between the two groups ( p > 0.05 ). The operative time of the PPST group was significantly shorter than that of the FAIT group (46 (33, 58) versus 72 (67.5, 78.0) minutes, p < 0.001 ), as was the operative approach procedure time (6 (4.5, 9.0) versus 38 (36.5, 43.5) minutes, p < 0.001 ), and length of postoperative hospital stay (5.19 ± 2.26 versus 8.33 ± 3.76 days, p < 0.001 ). There were fewer postoperative approach-related procedural complications in the PPST group than in the FAIT group (2 versus 12, p < 0.001 ); similarly, the average frequency of postoperative wound disinfection was significantly lower in the PPST group (1.08 ± 0.39 versus 3.31 ± 0.91 times, p < 0.05 ). Obesity was identified as an independent risk factor for postoperative approach-related procedural complications (OR, 22.26; 95% CI, 4.74–104.49; p < 0.001 ). Conclusions. The PPST has comparable safety and efficacy to the FAIT in EVAR under local anesthesia. It can shorten the length of hospital stay, reduce operation time, lower the risk of wound-related complications, reduce the frequency of postoperative wound disinfection, and hasten postoperative recovery. It can therefore be used as a first-line surgical technique in EVAR of uTBAD under local anesthesia, especially in obese patients.
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- 2022
16. Partial upper sternotomy for extensive arch repair in older acute type A aortic dissection patients
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Qingsong Wu, Li Zhang, Yumei Li, Tianci Chai, Liang-Wan Chen, Jun Xiao, and Zhihuang Qiu
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Aortic dissection ,medicine.medical_specialty ,business.industry ,medicine.disease ,Sternotomy ,Surgery ,Aortic Dissection ,Postoperative Complications ,Treatment Outcome ,Acute type ,Aortic Valve ,Heart Valve Prosthesis ,medicine ,Humans ,Arch ,business ,Cardiology and Cardiovascular Medicine ,Aorta ,Aged ,Retrospective Studies - Abstract
Objectives The partial upper sternotomy (PUS) approach is acceptable for aortic valve replacement, and even aortic root operation. However, the efficiency of PUS for extensive arch repair of acute type A aortic dissection (AAAD) in older adult patients has not been well investigated. Methods Between January 2014 and December 2019, 222 older adult patients (≥ 65 years) diagnosed with AAAD went through extensive arch repair, among which 127 received PUS, and 95 underwent full sternotomy (FS). Logistic regression analysis was used to identify risk factors for early death, and negative binomial regression analysis was applied to explore risk factors related to post-operative ventilator-supporting time and intensive care unit stay time. Results Total early mortality was 8.1% (18/222 patients). The PUS group had shorter Cardiopulmonary bypass time (133.0 vs.155.0 min, P P P P = 0.012) and malperfusion syndromes (OR 65.83; 95% CI 11.53–375.86; P P = 0.003), when compared with the FS group. Conclusions The early results of emergency extensive arch repair of AAAD via PUS in older adult patients were satisfactory. However, the long-term results remain to be investigated.
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- 2022
17. MiR-150-5p Is a Biomarker and Therapeutic Target for Aortic Dissection
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Zhihuang Qiu, Tianci Chai, Xinghui Zhuang, Likang Ma, Xiaojie Yang, Keyuan Chen, Meiling Cai, Yunnan Hu, Qingsong Wu, Xianbiao Xie, Zhaoyang Chen, Yan-juan Lin, and Liangwan Chen
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
18. Meta-Analysis: Shouldn't Prophylactic Corticosteroids be Administered During Cardiac Surgery with Cardiopulmonary Bypass?
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Tianci Chai, Xinghui Zhuang, Mengyue Tian, Xiaojie Yang, Zhihuang Qiu, Shurong Xu, Meiling Cai, Yanjuan Lin, and Liangwan Chen
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Surgery - Abstract
BackgroundCorticosteroids can effectively inhibit systemic inflammation induced by cardiopulmonary bypass. Recently clinical trials and meta-analyses and current guidelines for cardiac surgery do not support corticosteroids prophylaxis during cardiac surgery because of an increase in myocardial infarction and no benefit for patients. The aim of this study is to determine whether specific corticosteroids dose ranges might provide clinical benefits without increasing myocardial infarction.MethodsThe PubMed, Web of Science, Embase, Clinical Trials, and Cochrane databases were searched for randomized controlled trials (RCTs) published before August 1, 2021.Results88 RCTs with 18,416 patients (17,067 adults and 1,349 children) were identified. Relative to placebo and high-dose corticosteroids, low-dose corticosteroids (≤20 mg/kg hydrocortisone) during adult cardiac surgery did not increase the risks of myocardial infarction (odds ratio [OR]: 0.96, 95% confidence interval [CI]: 0.43–2.17; p = 0.93). However, low-dose corticosteroids were associated with lower risks of atrial fibrillation (OR: 0.58, 95% CI: 0.44–0.76; p p = 0.04). Furthermore, low-dose corticosteroids significantly shortened the mechanical ventilation times (mean difference [MD]: −2.74 h, 95% CI: −4.14, −1.33; p = 0.0001), intensive care unit (ICU) stay (MD: −1.48 days, 95% CI: −2.73, −0.22; p = 0.02), and hospital stay (MD: −2.29 days, 95% CI: −4.51, −0.07; p = 0.04).ConclusionLow-dose corticosteroids prophylaxis during cardiac surgery provided significant benefits for adult patients, without increasing the risks of myocardial infarction and other complications.
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- 2021
19. miR‐145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection
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Li Zhang, Yuling Zhang, Hao Zhou, Zhihuang Qiu, Hui Zheng, Jian He, Tianci Chai, Liang-Wan Chen, Yu-Mei Li, and Xiaosong Chen
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Male ,miR145 ,Microbiology (medical) ,Vascular smooth muscle ,Clinical Biochemistry ,Muscle, Smooth, Vascular ,Rats, Sprague-Dawley ,Kruppel-Like Factor 4 ,phenotype transformation ,Downregulation and upregulation ,medicine.artery ,medicine ,Animals ,Humans ,vascular smooth muscle cells ,Immunology and Allergy ,Protein Interaction Maps ,Cells, Cultured ,Research Articles ,Aortic dissection ,Aorta ,Chemistry ,mechanical strain ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,Cell Differentiation ,Hematology ,musculoskeletal system ,medicine.disease ,Phenotype ,Biomechanical Phenomena ,Cell biology ,Aortic Dissection ,Disease Models, Animal ,MicroRNAs ,Medical Laboratory Technology ,Real-time polymerase chain reaction ,Gene Expression Regulation ,Matrix Metalloproteinase 9 ,KLF4 ,cardiovascular system ,Platelet factor 4 ,Research Article - Abstract
Background miR‐145 is closely related to vascular smooth muscle cells (VSMC) phenotype transformation; however, the regulatory mechanisms through which miR‐145 regulates the VSMC phenotype transformation under mechanical stretching are unclear. In this study, we evaluated the roles of miR‐145 in VSMCs subjected to mechanical stretching in aortic dissection (AD). Methods The expression of miR‐145 in the aortic vessel wall of model animals and patients with AD was analyzed by quantitative polymerase chain reaction. miR‐145‐related protein‐protein interaction networks and Wikipathways were used to analyze VSMC phenotypic transformation pathways regulated by miR‐145. We used gain‐ and loss‐of‐function studies to evaluate the effects of miR‐145 on VSMC differentiation under mechanical stretch induction and assessed whether Krüppel‐like factor 4 (KLF4) was regulated by miR‐145 in the aorta under mechanical stretch conditions. Results miR‐145 was abundantly expressed in the walls of the normal human aorta, but was significantly downregulated in animal models and the walls of patients with dissection. We found that contractile phenotype‐related proteins were downregulated in VSMCs subjected to mechanical stretching, whereas the expression of secreted phenotype‐related proteins increased. miR‐145 overexpression also downregulated contractile phenotype‐related proteins in VSMCs and suppressed upregulation of phenotype‐related proteins. Finally, under mechanical stretching, KLF4 expression was significantly increased in VSMCs, and overexpression of miR‐145 blocked this effect. Conclusion Our results confirmed that mechanical stretch‐induced phenotypic transformation of VSMCs to promote AD via upregulation of KLF4; this mechanism was regulated by miR‐145, which directly modulated KLF4 expression and VSMC differentiation., miR‐145 was abundantly expressed in the walls of the normal human aorta, but was significantly downregulated in animal models and the walls of patients with dissection. Contractile phenotype‐related proteins were downregulated in VSMCs subjected to mechanical stretching, whereas the expression of secreted phenotype‐related proteins increased. Mechanical stretch induced phenotypic transformation of VSMCs to promote AD via upregulation of KLF4. This mechanism was regulated by miR‐145, which directly modulated KLF4 expression and VSMC differentiation.
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- 2021
20. Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3
- Author
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Tianci, Chai, Xiaojie, Yang, Xinghui, Zhuang, Zhihuang, Qiu, Hui, Zheng, Meiling, Cai, Yunnan, Hu, Meifang, Chen, Xianbiao, Xie, Keyuan, Chen, Yanjuan, Lin, and Liangwan, Chen
- Subjects
STAT3 Transcription Factor ,Mice ,MicroRNAs ,Aortic Dissection ,Cell Movement ,Becaplermin ,Animals ,Humans ,General Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,General Biochemistry, Genetics and Molecular Biology ,Cell Proliferation ,Up-Regulation - Abstract
This study sought to investigate the differentially expressed miRNAs in Aortic dissection (AD) and explore the downstream mechanisms in regulating AD.Exosomes of AD patients and healthy people were isolated by differential centrifugation, and the differentially expressed miRNAs were evaluated by RNA sequencing. The downstream target of miR-222-3p was predicted by bioinformatics method and validated by dual-luciferase assay. Angiotensin II and Promethazine were used to establish AD mouse model and platelet-derived growth factor BB (PDGF-BB) was used to induce human vascular smooth muscle cells (HVSMCs) to elucidate the effect of miR-222-3p upregulation on AD in vivo and in vitro. The relative level of miR-222-3p was evaluated by RT-qPCR. The level of several proteins was investigated by Western blot. Immunofluorescence staining was used to detect the stress fiber formation. Cell migration was evaluated by wound healing and Transwell assay. The proliferation, cell cycle and apoptosis of HVSMCs were assessed by CCK-8 and flow cytometry, respectively.MiR-222-3p was downregulated in AD and PDGF-BB induced HVSMCs. The upregulation of miR-222-3p alleviated the symptom of AD in vivo by targeting STAT3, and inhibited stress fiber formation, abnormal migration, proliferation and apoptosis of HVSMCs induced by PDGF-BB by regulating the expression of α-SMA, SM22α, MMP2, MMP9 and p-Smad2.The upregulation of miR-222-3p attenuates the progression of AD. Our study provides a theoretical basis for exploring new strategies against AD.
- Published
- 2022
21. Novel Approach for Repair of a Left Atrial Esophageal Fistula After Radiofrequency Ablation
- Author
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Zhihuang Qiu, Guanhua Fang, Liang-Wan Chen, and Jun-yi Chen
- Subjects
Reoperation ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Fistula ,Heart Diseases ,Radiofrequency ablation ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,law.invention ,Esophageal Fistula ,03 medical and health sciences ,Esophagus ,0302 clinical medicine ,Posterior wall ,Left atrial ,law ,Atrial Fibrillation ,Cardiopulmonary bypass ,Humans ,Medicine ,Heart Atria ,cardiovascular diseases ,Cardiac Surgical Procedures ,business.industry ,Surgery ,medicine.anatomical_structure ,Esophagus surgery ,030228 respiratory system ,Median sternotomy ,Catheter Ablation ,cardiovascular system ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
Herein we described a novel repair approach for a left atrial esophageal fistula. Complete mediastinal debridement and simultaneous primary repairs of the left atrial posterior wall and the esophagus were completed under a median sternotomy, central cardiopulmonary bypass, left atrial circular incision around four pulmonary veins, inflamed left atrial posterior wall removal, and posterior pericardial opening.
- Published
- 2021
22. Risk factors of hepatic dysfunction after total arch repair of acute type A aortic dissection with modified triple-branched stent graft implantation
- Author
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Linfeng Xie, Debin Jiang, zhihuang qiu, Qingsong Wu, Jun Xiao, Jian He, Yue Shen, and liangwan chen
- Abstract
Background: Hepatic dysfunction (HD) is a serious complication after cardiovascular surgery. However, risk factors of developing hepatic dysfunction after acute type A aortic dissection (AAAD) are largely unclear. Methods: The clinical data of 227 patients with AAAD repaired by modified triple-branched stent graft implantation from January 2018 to January 2020 were collected retrospectively, including preoperative , surgical and postoperative information. Logistics regression was used to explore the potential risk factors of HD. Results: In the early stage after operation, a total of 57 patients were complicated with HD, accounting for 25.11%. The hospital mortality rate in these patients with HD was 19.30%, while the rate in patients without HD was only 6.5%. We found that preoperative body mass index (BMI)>30kg/㎡(OR: 7.054, 95%CI: 1.798-27.678, P=0.005), preoperative renal insufficiency(OR:7.575,95%CI:2.923-19.629, P=0.000),preoperative moderate/severe pericardial effusion(OR: 16.409, 95%CI: 2.81-93.444, P=0.002) and cardiopulmonary bypass time>180min (OR: 7.190, 95%CI: 3.113-16.608, P=0.000) were independent risk factors for HD after AAAD repaired by modified triple-branched stent graft implantation. Conclusions: Preoperative BMI>30kg/㎡, preoperative renal insufficiency, preoperative moderate/severe pericardial effusion and cardiopulmonary bypass time>180min are independent risk factors for HD after total arch repair with modified triple-branched stent graft implantation in AAAD patients. And the occurrence of HD after operation would prolong the time of mechanical ventilation and the hospitalization time of ICU, and significantly increase the in-hospital mortality of patients. Keywords: risk factors,acute type A aortic dissection,hepatic dysfunction, modified triple-branched stent graft implantation, total arch repair
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- 2021
23. Association of Circulating Cathepsin B Levels With Blood Pressure and Aortic Dilation
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Tianci Chai, Mengyue Tian, Xiaojie Yang, Zhihuang Qiu, Xinjian Lin, and Liangwan Chen
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
Hypertension is a key risk factor for spontaneous coronary artery dissection (SCAD) and aortic dilation. Circulating proteins play key roles in a range of biological processes and represent a major source of druggable targets. The aim of this study was to identify circulating proteins that were associated with blood pressure (BP), SCAD and aortic dilation. We identified shared genetic variants of BP and SCAD in genome-wide association studies, searched for circulating protein affected by these variants and examined the association of circulating protein levels with BP, aortic aneurysm and dissection (AAD) and aortic diameters by integrating data from circulating protein quantitative trait loci (pQTL) studies and genome wide association study (GWAS) in individuals from the UK Biobank using two-sample Mendelian randomization analysis methods. Single nucleotide polymorphisms (SNPs) in JAG1, ERI1, ULK4, THSD4, CMIP, COL4A2, FBN1, FAM76B, FGGY, NUS1, and HNF4G, which were related to extracellular matrix components, were associated with both BP and SCAD. We found 49 significant pQTL signals among these SNPs. The regulated proteins were encoded by MMP10, IL6R, FIGF, MMP1, CTSB, IGHG1, DSG2, TTC17, RETN, POMC, SCARF2, RELT, and GALNT16, which were enriched in biological processes such as collagen metabolic process and multicellular organism metabolic process. Causal associations between BP and AAD and aortic diameters were detected. Significant associations between circulating levels of cathepsin B, a well-known prorenin processing enzyme, and BP and aortic diameters were identified by using several Mendelian randomization analysis methods and were validated by independent data.ConclusionThe present study identified the association between circulating cathepsin B and BP and aortic diameters. The findings indicated that BP-associated genetic variants may influence aortic dilation risk by circulating proteins that regulate BP.
- Published
- 2021
24. Genome-Wide Identification of RNA Modifications for Spontaneous Coronary Aortic Dissection
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Tianci Chai, Mengyue Tian, Xiaojie Yang, Zhihuang Qiu, Xinjian Lin, and Liangwan Chen
- Subjects
0301 basic medicine ,Genetics ,genome-wide association study ,RNA ,artery dissection ,Genome-wide association study ,Single-nucleotide polymorphism ,QH426-470 ,Biology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Gene expression ,Expression quantitative trait loci ,RNA methylation ,gene expression ,circulating protein ,Molecular Medicine ,SNP ,Scad ,Gene ,030217 neurology & neurosurgery ,Genetics (clinical) ,Original Research - Abstract
RNA modification plays important roles in many biological processes such as gene expression control. Genetic variants that affect RNA modification may have functional roles in aortic dissection. The aim of this study was to identify RNA modifications related to spontaneous coronary artery dissection (SCAD). We examined the association of RNA modification-associated single-nucleotide polymorphisms (RNAm-SNPs) with SCAD in summary data from a genome-wide association study (GWAS) of European descent (270 SCAD cases and 5,263 controls). Furthermore, we performed expression quantitative loci (eQTL) and protein quantitative loci (pQTL) analyses for the RNAm-SNPs using publicly available data. Functional enrichment and protein–protein interaction analyses were performed for the identified proteins. We found 11,464 unique RNAm-SNPs in the SCAD GWAS dataset, and 519 were nominally associated with SCAD. Nine RNAm-SNPs were associated with SCAD at p < 0.001, and among them, seven were N6-methyladenosine (m6A) methylation-related SNPs, one (rs113664950 in HLA-DQB1) was m7G-associated SNP, and one [rs580060 in the 3′-UTR of Mitochondrial Ribosomal Protein S21 (MRPS21)] was A-to-I modification SNP. The genome-wide significant SNP rs3818978 (SCAD association p = 5.74 × 10–10) in the 5′-UTR of MRPS21 was related to m6A modification. These nine SNPs all showed eQTL effects, and six of them were associated with circulating protein or metabolite levels. The related protein-coding genes were enriched in specific Gene Ontology (GO) terms such as extracellular space, extracellular region, defense response, lymphocyte migration, receptor binding and cytokine receptor binding, and so on. The present study found the associations between RNAm-SNPs and SCAD. The findings suggested that RNA modification may play functional roles in SCAD.
- Published
- 2021
25. Wharton's jelly mesenchymal stem cell-derived small extracellular vesicles as natural nanoparticles to attenuate cartilage injury via microRNA regulation
- Author
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Penghong, Chen, Shijie, Tang, Hangqi, Gao, Haoruo, Zhang, Caixiang, Chen, Zhuoqun, Fang, Guohao, Peng, Haiyan, Weng, Aizhen, Chen, Chaoyu, Zhang, Zhihuang, Qiu, Shirong, Li, Jinghua, Chen, Liangwan, Chen, and Xiaosong, Chen
- Subjects
Extracellular Vesicles ,MicroRNAs ,Cartilage ,Humans ,Nanoparticles ,Pharmaceutical Science ,Mesenchymal Stem Cells ,Wharton Jelly - Abstract
The main strategy of tissue repair and regeneration focuses on the application of mesenchymal stem cells and cell-based nanoparticles, but there are still multiple challenges that may have negative impacts on human safety and therapeutic efficacy. Cell-free nanotechnology can effectively overcome these obstacles and limitations. Mesenchymal stem cell (MSC)-derived natural small extracellular vesicles (sEVs) represent ideal nanotherapeutics due to their low immunogenicity and lack of tumorigenicity. Here, sEVs harvested from Wharton's jelly mesenchymal stem cells (WJMSCs) were identified. In vitro results showed that WJMSC-sEVs efficiently entered chondrocytes in the osteoarthritis (OA) model, further promoted chondrocyte migration and proliferation and modulated immune reactivity. In vivo, WJMSC-sEVs notably promoted chondrogenesis, which was consistent with the effect of WJMSCs. RNA sequencing results revealed that sEV-microRNA-regulated biocircuits can significantly contribute to the treatment of OA, such as by promoting the activation of the calcium signaling pathway, ECM-receptor interaction pathway and NOTCH signaling pathway. In particular, let-7e-5p, which is found in WJMSC-sEVs, was shown to be a potential core molecule for promoting cartilage regeneration by regulating the levels of STAT3 and IGF1R. Our findings suggest that WJMSC-sEV-induced chondrogenesis is a promising innovative and feasible cell-free nanotherapy for OA treatment.
- Published
- 2022
26. Mid-term outcomes of modified valve-sparing aortic root replacement versus the Bentall procedure for middle-aged Chinese patients with acute DeBakey I aortic dissection: a single-center retrospective study
- Author
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Liang-Wan Chen, Xiaodong Chen, Zhihuang Qiu, Xingfeng Chen, Yue Shen, Qingsong Wu, and Zhisheng Wang
- Subjects
Male ,Valve-sparing aortic root replacement ,Aortic valve ,Time Factors ,medicine.medical_treatment ,Bentall procedure ,030204 cardiovascular system & hematology ,Single Center ,Postoperative Complications ,0302 clinical medicine ,Computed tomography angiography ,Heart Valve Prosthesis Implantation ,Aortic dissection ,medicine.diagnostic_test ,Middle Aged ,Aortic Aneurysm ,Cardiac surgery ,Treatment Outcome ,medicine.anatomical_structure ,Aortic Valve ,Heart Valve Prosthesis ,Acute Disease ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,Reoperation ,China ,Re-operation ,medicine.medical_specialty ,Acute DeBakey I aortic dissection ,Thromboembolism/bleeding events ,Blood Vessel Prosthesis Implantation ,Aortic root surgery ,03 medical and health sciences ,medicine ,Humans ,Diseases of the circulatory (Cardiovascular) system ,Retrospective Studies ,Middle-aged patients ,business.industry ,Research ,Stent ,medicine.disease ,Blood Vessel Prosthesis ,Surgery ,Aortic Dissection ,030228 respiratory system ,Endoleakage ,RC666-701 ,business - Abstract
BackgroundThe mid-term and long-term efficacies of valve preservation in acute DeBakey I aortic dissection (AD) are controversial. Thus, it is unclear whether middle-aged patients with acute DeBakey I AD should undergo modified valve-sparing procedures or the Bentall procedure in an emergency setting.MethodsThis study included 213 middle-aged Chinese patients (under 60 years old) who were treated for acute DeBakey I AD between January 2009 and June 2015. The treatments involved modified valve-sparing aortic root replacement (VSARR) (117 patients) or the Bentall procedure (96 patients). Preoperative, intraoperative, postoperative, and follow-up data were analyzed. Echocardiography and thoracoabdominal computed tomography angiography (CTA) findings were reviewed at 3 months, 1 year, and then annually after surgery.ResultsNo significant differences were observed in terms of the preoperative, intraoperative, in-hospital mortality, and postoperative parameters. There were also no significant differences in aortic regurgitation (AR). However, follow-up examinations using CTA revealed that 6 patients had endoleakage at the distal end of the triple-branched stent (0/110 patients [0.0%] vs. 6/90 patients [6.7%],P = 0.022). The anticoagulation-related thromboembolism/bleeding events was significantly lower in group A than in group B (0/110 patients [0.0%] vs. 11/90 patients [11.1%],P = 0.001). And postoperative aortic valve re-operation rate was significantly lower in group A (1/110 patients [0.9%] vs. 8/90 patients [8.9%],P = 0.020). There was no significant difference in survival during the follow-up period (log-rankP > 0.05).ConclusionFor middle-aged patients with acute DeBakey I AD, VSARR were associated with a lower rate of endoleakage at the distal end of the triple-branched stent, thromboembolism/bleeding events and aortic valve re-operation (vs. the Bentall procedure).
- Published
- 2021
27. Associations of Gene Expressions in Liver and Blood Cells and Circulating Proteins With Coronary Artery Disease
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Zhihuang Qiu, Xiaojie Yang, Zhisheng Wan, Liangwan Chen, and Tianci Chai
- Subjects
Coronary artery disease ,Pathology ,medicine.medical_specialty ,business.industry ,Medicine ,business ,medicine.disease ,Gene - Abstract
Background: Circulating low-density lipoprotein cholesterol (LDL-C) plays a causal role in coronary artery disease (CAD). However, genetic risk factors of CAD were not yet fully understood. The aim of the study was to identify additional factors that contributed to CAD.Methods: We conducted integrative analysis on publicly available data from genome-wide association studies and quantitative trait locus studies by employing two-sample Mendelian randomization methods to examine the associations of gene expression and circulating protein levels with LDL-C and CAD.Results: We found that mRNA expression levels of SORT1, PSRC1 and CELSR2 in liver cells were significantly associated with both LDL-C and CAD (P < 5.0 × 10-8). Higher expression levels of SORT1, PSRC1 and CELSR2 in the liver were significantly associated with lower circulating LDL-C level (beta= -0.142, -0.138 and -0.171, respectively) and CAD risk (beta= -0.10, -0.097 and -0.121, respectively). Expression levels of 31 genes in blood cells associated with LDL-C level were found. Expressions of PSRC1, IL6R, GGCX, VAMP8, LIPA, NT5C2, SWAP70, EIF2B2, FURIN, FES and ATP5G1 in blood cells were significantly associated with CAD. Higher circulating granulins and apolipoprotein B levels, which were strongly affected by PSRC1 and APOB variants, were significantly associated with higher LDL-C level (beta = 0.22 and 1.35) and CAD risk, with odds ratios of 1.15 (1.10-1.19) and 1.45 (1.21-1.74), respectively. Conclusions: This study identified gene expressions in liver and blood cells and circulating granulins and apolipoprotein B that were genetically associated with LDL-C and CAD and provided evidence for exploring the potential causal relationship.
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- 2021
28. Efficacy and safety of corticosteroids prophylaxis in cardiac surgery: A protocol for systematic review and meta-analysis
- Author
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Yuling Zhang, Tianci Chai, Qiuyu Huang, Zhihuang Qiu, Yun-Nan Hu, Guanhua Fang, Fan Xu, Tian Mengyue, Liang Wan Chen, Hao Zhou, Hui Zheng, and Jian He
- Subjects
medicine.medical_specialty ,Pediatrics ,medicine.drug_class ,MEDLINE ,Anti-Inflammatory Agents ,Risk Assessment ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Adrenal Cortex Hormones ,medicine ,Cardiopulmonary bypass ,Humans ,030212 general & internal medicine ,Cardiopulmonary Bypass ,business.industry ,General Medicine ,Systemic Inflammatory Response Syndrome ,Cardiac surgery ,Clinical trial ,030220 oncology & carcinogenesis ,Meta-analysis ,Corticosteroid ,business ,Risk assessment - Abstract
Background Although corticosteroid prophylaxis in adult cardiac surgery has been studied extensively for 40 years, its role remains controversial, and the optimal dose remains uncertain. The objective of this meta-analysis was to estimate the clinical benefits and risks of corticosteroid use in cardiopulmonary bypass. Methods We will search Pubmed, Web of Science, Embase, Clinical Trials, and Cochrane Central Register of Controlled Trials for relevant clinical trials published in any language before August 1, 2020. Randomized controlled trials (RCTs) of interest which meet inclusion criteria published or unpublished will be included. We will divide the included studies into child and adult groups for analysis. If sufficient data are available, the included trials will be divided into 4 subgroups: ≤20 mg/kg (low dose), 20-40 mg/kg (slightly high dose), 40-100 mg/kg (high dose), and >100 mg/kg (ultra high dose) based on the equivalent hydrocortisone dose. INPLASY registration number: INPLASY2020100044. Results The results of this study will be published in a peer-reviewed journal. Conclusion This study will compare the efficacy of tprophylactic corticosteroids for adults and children undergoing cardiac surgery with CPB. Due to the nature of the disease and intervention methods, randomized controlled trials may be inadequate, and we will carefully consider inclusion in high-quality, non-randomized controlled trials, but this may result in high heterogeneity and affect the reliability of the results.
- Published
- 2020
29. Mid-term Outcomes of Valve-sparing Aortic Root Replacement Versus the Bentall Procedure for Middle-aged Chinese Patients with Acute DeBakey I Aortic Dissection: A Single-center Retrospective Study
- Author
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Qingsong Wu, Zhisheng wang, Zhihuang Qiu, Yue Shen, Xiaodong Chen, Xingfeng Chen, and Liangwan Chen
- Abstract
Background: The mid-term and long-term efficacies of valve preservation in acute DeBakey I aortic dissection(AD) are controversial. Thus, it is unclear whether middle-aged patients with acute DeBakey I AD should undergo valve-sparing procedures or the Bentall procedure in an emergency setting.Methods: This study included 213 middle-aged Chinese patients(30-60 years old) who were treated for acute DeBakey I AD between January 2009 and June 2015. The treatments involved valve-sparing aortic root replacement(VSARR)(117 patients) or the Bentall procedure(96 patients). Preoperative, intraoperative, postoperative, and follow-up data were analyzed. Echocardiography and thoracoabdominal computed tomography angiography(CTA) findings were reviewed at 3 months, 1 year, and then annually after surgery. Results: No significant differences were observed in terms of the preoperative, intraoperative, in-hospital mortality, and postoperative parameters. There were also no significant differences in aortic regurgitation(AR). However, follow-up examinations using CTA revealed that 6 patients had endoleakage at the distal end of the triple-branched stent(0/110 patients [0.0%] vs. 6/90 patients [6.7%], P=0.022). The anticoagulation-related thromboembolism/bleeding events was significantly lower in group A than in group B(0/110 patients [0.0%] vs. 11/90 patients [11.1%], P=0.001). And postoperative aortic valve re-operation rate was significantly lower in group A (1/110 patients [0.9%] vs. 8/90 patients [8.9%], P=0.020). There was no significant difference in survival during the follow-up period (log-rank P>0.05).Conclusion: For middle-aged patients with acute DeBakey I AD, VSARR were associated with a lower rate of endoleakage at the distal end of the triple-branched stent, thromboembolism/bleeding events and aortic valve re-operation(vs. the Bentall procedure) .
- Published
- 2020
30. Efficacy and safety of corticosteroids prophylaxis in cardiac surgery: a protocol for systematic review and meta analysis
- Author
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Jian He, Yuling Zhang, Zhihuang Qiu, Tianci Chai, Guanhua Fang, Yunnan Hu, Fan Xu, Qiuyu Huang, Hui Zheng, Hao Zhou, Mengyue Tian, and Liang Wan Chen
- Published
- 2020
31. Long-term outcomes of treatment with different stent grafts in acute DeBakey type I aortic dissection
- Author
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Qingsong Wu, Liang-Liang Yan, Liang-Wan Chen, Yue Shen, Jun Xiao, Zhihuang Qiu, and Jian He
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,Group A ,Group B ,03 medical and health sciences ,Blood Vessel Prosthesis Implantation ,0302 clinical medicine ,medicine ,Long term outcomes ,Humans ,In patient ,Retrospective Studies ,Aortic dissection ,Aortic Aneurysm, Thoracic ,business.industry ,Incidence (epidemiology) ,Endovascular Procedures ,Acute kidney injury ,Stent ,Middle Aged ,medicine.disease ,Surgery ,Aortic Dissection ,Treatment Outcome ,030228 respiratory system ,Acute Disease ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background We developed an integrated triple-branched stent to treat acute DeBakey type I aortic dissection (AD) and modified it to enhance its adaptability. However, whether the patients treated by the modified stent would achieve better long-term prognosis is unknown. Methods This study enrolled 147 patients with acute DeBakey type I AD. The original integrated triple-branched stents were used in 57 patients (Group A) between July 2012 and August 2013, and the modified stents in 90 patients (Group B) between September 2013 and March 2015. Clinical characteristics, surgical data, postoperative complications, mortality, and follow-up data of the two groups were analyzed. Results The two groups presented comparable early death rates (Group A = 7.0%, Group B = 5.9%; p = .719). The incidence of postoperative acute kidney injury (AKI) was lower in Group B (10.0%) versus Group A (24.6%) (p = .018). Compared with the original integrated triple-branched stent graft, the modified stent could reduce the risk of early postoperative AKI (OR [95% CI] = 0.36 [0.14, 0.94]). Early endoleak rates were significantly lower in Group B (1.0%) compared to Group A (9.4%) (p = .004). During follow-up, there were five deaths in Group A (9.4%) and six deaths in Group B (7.2%) (p = .646). Chronic kidney injury (7.5% vs. 3.6%; p = .311), delayed endoleak (11.3% vs. 4.8%; p = .157), and late reinterventions (7.5% vs. 2.4%; p = .155) in the two groups were similar. Conclusions In patients with acute DeBakey type I AD, the modified stent showed feasible and safe treatment outcomes and reduced early endoleak rates. However, the long-term effects were similar to the original treatment.
- Published
- 2020
32. Can high-dose corticosteroids in cardiopulmonary bypass bring more benefits?
- Author
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Jian He, Hui Zheng, Hao Zhou, Yumei Li, Tianci Chai, Fan Xu, Yunnan Hu, Zhihuang Qiu, and Liang-Wan Chen
- Subjects
business.industry ,law ,Anesthesia ,Cardiopulmonary bypass ,Medicine ,business ,law.invention - Published
- 2020
33. Changes in aortic collagen in β-aminopropionitrile-induced acute aortic dissection
- Author
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Jian He, Hao Zhou, Zhihuang Qiu, Qiuyu Huang, Jun Xiao, Yuling Zhang, Yun-Nan Hu, Liang-Wan Chen, and Yan Ren
- Subjects
Aortic dissection ,Aorta ,Pathology ,medicine.medical_specialty ,MMP2 ,business.industry ,General Medicine ,Dissection (medical) ,Aminopropionitrile ,medicine.disease ,Extracellular matrix ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,medicine.artery ,Medicine ,Thoracic aorta ,Original Article ,business ,Fibroblast - Abstract
BACKGROUND: The precise role collagen plays in acute aortic dissection (AAD) was investigated in an animal model of β-aminopropinitrile (BAPN)-induced AAD. METHODS: The 30 3-week-old male specific-pathogen free (SPF)-grade Sprague-Dawley (SD) rats were randomly divided into two groups: 10 in the Control group and 20 in the Model group. The Model group was treated with 0.1% BAPN for 4 weeks, while the Control group received untreated water. Histopathological staining and western blot were used to detect changes of the extracellular matrix (ECM) and collagen content in the aorta. RESULTS: At the end of the experiment, the incidence of AAD was 25%, the aortic ECM of surviving rats was severely damaged, and the arrangement was disordered. Fibroblast cells are unevenly distributed, with wide gaps, collagen fibers were also distributed unevenly in a disordered arrangement and their thickness was uneven. The elastic membrane disappeared over a large area. Compare to Control group, the Collagen types I, III and their subunits were upregulated (P
- Published
- 2021
34. Mechanical Strain Induced Expression of Matrix Metalloproteinase-9 via Stretch-Activated Channels in Rat Abdominal Aortic Dissection
- Author
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Hua Peng, Qiang Chen, Liang-Wan Chen, Hua Cao, and Zhihuang Qiu
- Subjects
Male ,China ,Pathology ,medicine.medical_specialty ,Aortic Diseases ,Pressoreceptors ,030204 cardiovascular system & hematology ,Matrix (biology) ,Rats, Sprague-Dawley ,03 medical and health sciences ,Aortic aneurysm ,0302 clinical medicine ,Stress, Physiological ,medicine.artery ,medicine ,Animals ,Aorta, Abdominal ,Pancreatic elastase ,Aorta ,Messenger RNA ,Receptor Activator of Nuclear Factor-kappa B ,Chemistry ,Animal Study ,NF-kappa B ,General Medicine ,medicine.disease ,Molecular biology ,In vitro ,Aortic Aneurysm ,Rats ,Blot ,Aortic Dissection ,Gene Expression Regulation ,Matrix Metalloproteinase 9 ,030220 oncology & carcinogenesis ,Signal transduction ,Signal Transduction - Abstract
BACKGROUND The aim of the study was to investigate the expression of matrix metalloproteinase-9 (MMP-9) in rat abdominal aortic dissection (AD) induced by mechanical strain, so as to offer a better understanding of the possible mechanisms of AD. MATERIAL AND METHODS Experimental AD in rats was achieved by the injection of porcine pancreatic elastase. At days 0, 1, 3, 5, 7, 14, 21, and 30 after the establishment of AD model, serum MMP-9 levels were measured by enzyme-linked immunosorbent assay (ELISA). Four groups of vascular rings were stretched in vitro with a mechanical strength of 0 g, 1 g, 3 g, or 5 g for 30 min. Another four groups were pretreated with GdCl3, streptomycin, SN50, and SN50M, followed by stretching with 3 g for 30 min. The messenger RNA and the protein of MMP-9 were analyzed by real-time RT-PCR and Western blotting, and NF-κB p65 was detected by ELISA. RESULTS After the establishment of rat abdominal AD model, the serum MMP-9 levels of AD groups increased significantly. The results showed increased expression of MMP-9 in rat AD vessels stretched with mechanical strength of 1 g, 3 g, and 5 g, but this effect was mostly blocked by Gd Cl3 and streptomycin. The NF-κB activity in aortic rings was activated by stretching with a mechanical strength of 3 g and was blocked by SN50, but not by SN50M. CONCLUSIONS The expression of MMP-9 in serum was increased significantly after rat abdominal AD formation. Mechanical strain induced MMP-9 expression in AD vessels, which was mediated through the activation of the stretch-activated channel-induced NF-κB pathway.
- Published
- 2017
35. Efficiency of Modified Triple-Branched Stent Graft in Type I Aortic Dissection: Two-Year Follow-up
- Author
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Jun Xiao, Guanhua Fang, Liang-Liang Yan, Quan-Fang Luo, Qingsong Wu, Zhihuang Qiu, Liang-Wan Chen, Lian-Ming Liao, and Xiao-Fu Dai
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,China ,Time Factors ,medicine.medical_treatment ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,Prosthesis Design ,Imaging data ,03 medical and health sciences ,Blood Vessel Prosthesis Implantation ,0302 clinical medicine ,Postoperative Complications ,Risk Factors ,medicine ,Humans ,Hospital Mortality ,Retrospective Studies ,Aortic dissection ,Aortic Aneurysm, Thoracic ,business.industry ,Incidence (epidemiology) ,Endovascular Procedures ,Stent ,Perioperative ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,Aortic Dissection ,030228 respiratory system ,Female ,Stents ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
The efficacy of hemiarch replacement combined with a modified triple-branched stent graft in Debakey type I aortic dissection remains to be confirmed.From January 2016 to December 2017, 167 patients with acute Debakey type I aortic dissection underwent hemiarch replacement combined with a modified triple-branched stent graft. The clinical and imaging data were retrospectively analyzed. The early composite endpoint was defined to comprise perioperative mortality, permanent neurologic deficits, and renal failure requiring hemodialysis at discharge.The overall 30-day mortality was 4.2% (7 of 167). The incidence of the composite endpoint was 11.4% (19 of 167). The risk factors for the composite endpoint were malperfusion syndrome (odds ratio 5.17; 95% confidence interval, 1.46 to 18.35; P = .011) and creatine greater than 1.5 mg/dL (odds ratio 5.44; 95% confidence interval, 2.27 to 13.06; P.001). The overall survival was 94% at 1 year and 92.2% at 2 years during a median follow-up of 20.9 ± 9.6 months. Three patients required distal aorta reintervention. Complete thrombosis in the false lumen of the descending aorta at the level of the pulmonary bifurcation and at the level of the celiac trunk was observed in 98.8% and 10.8% of the patients, respectively.Hemiarch replacement combined with a modified triple-branched stent graft is a reliable technique for acute Debakey type I aortic dissection as indicated by 2 years of follow-up.
- Published
- 2019
36. Metabolic syndrome increases operative mortality in patients with impaired left ventricular systolic function who undergo coronary artery bypass grafting: a retrospective observational study
- Author
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Xi-Jie Wu, Zhihuang Qiu, Jiahui Li, Liang-Wan Chen, Shuang-Kun Chen, and Qian-Zhen Li
- Subjects
Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Time Factors ,Systole ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Risk Assessment ,Ventricular Function, Left ,Coronary artery disease ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Risk of mortality ,Humans ,Medicine ,030212 general & internal medicine ,Mortality ,Coronary Artery Bypass ,Risk factor ,CABG ,Aged ,Retrospective Studies ,Metabolic Syndrome ,Left ventricular dysfunction ,Ejection fraction ,business.industry ,Stroke Volume ,Middle Aged ,medicine.disease ,Cardiac surgery ,Treatment Outcome ,lcsh:RC666-701 ,Relative risk ,Cardiology ,Female ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,Research Article - Abstract
Background Metabolic syndrome (MetS) is a prevalent risk factor for coronary artery disease progression. Past studies have shown that MetS and its components tends to increase mortality after coronary artery bypass grafting (CABG), but data on the impact of MetS on postoperative outcome in patients with a left ventricular (LV) ejection fraction (EF)
- Published
- 2019
37. Transthoracic Subarterial Ventricular Septal Defect Occlusion Using a Minimally Invasive Incision
- Author
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Liang-Wan Chen, Zhihuang Qiu, Fan Xu, Gui-Can Zhang, Qiang Chen, and Hua Cao
- Subjects
Pulmonary and Respiratory Medicine ,Surgical repair ,Heart septal defect ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Septal Occluder Device ,Perioperative ,030204 cardiovascular system & hematology ,medicine.disease ,Pericardial effusion ,Subarterial ventricular septal defect ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Occlusion ,medicine ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Cardiac catheterization - Abstract
Background This study sought to investigate the feasibility of transthoracic occlusion of a subarterial ventricular septal defect using a minimally invasive incision. Methods Between January 2009 and June 2014, we performed transthoracic subarterial ventricular septal defect occlusion for 81 patients via a minimally invasive incision. A special delivery sheath was used during surgery, and an eccentric occluder was implanted in the ventricular septal defect. Results Successful defect closure was achieved in 74 cases, perioperative arrhythmia occurred in five cases, and a large pericardial effusion was observed in two cases. Open heart surgery was performed for two patients to repair postoperative dislocation of the occluder. Intraoperative conversion to surgical repair was required in seven cases. During one to five years of follow-up, there was no late occluder dislocation, residual leakage, or thrombus-related complications. Conclusions Transthoracic subarterial ventricular septal defect occlusion using a minimally invasive incision may be an alternative to open surgical repair in selected patients. doi: 10.1111/jocs.12754 (J Card Surg 2016;31:398-402).
- Published
- 2016
38. Mechanical stretch aggravates aortic dissection by regulating MAPK pathway and the expression of MMP-9 and inflammation factors
- Author
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Yun-Nan Hu, Qiuyu Huang, Yinhai Chen, Liang-Wan Chen, Lin Lu, and Zhihuang Qiu
- Subjects
0301 basic medicine ,MAPK/ERK pathway ,Male ,medicine.medical_specialty ,MAP Kinase Signaling System ,p38 mitogen-activated protein kinases ,Interleukin-1beta ,Inflammation ,Matrix metalloproteinase ,p38 Mitogen-Activated Protein Kinases ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Western blot ,Internal medicine ,Medicine ,Animals ,Extracellular Signal-Regulated MAP Kinases ,Pharmacology ,Aortic dissection ,medicine.diagnostic_test ,business.industry ,Tumor Necrosis Factor-alpha ,JNK Mitogen-Activated Protein Kinases ,General Medicine ,medicine.disease ,Rats ,Aortic Dissection ,Disease Models, Animal ,030104 developmental biology ,Endocrinology ,Matrix Metalloproteinase 9 ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Stress, Mechanical ,medicine.symptom ,business - Abstract
This study aimed to explore whether mechanical stretch aggravated aortic dissection through regulating MAPK pathway, MMP-9, and inflammation factors. We first established aortic dissection model rats. Mechanical stretch (3 g) was exerted on vascular ring of aortic dissection which was also treated by inhibitors of MAPK pathway (SB203580, SP600125, and U0126). HE and Masson staining showed that aortic dissection severity with 3 g tension was worse than that without tension (0 g); after the treatments of diverse inhibitors, the fracture and breakage of the elastic fibers decreased. The expression of MMP-9, TNF-α, IL-1β) p38/p-p38, JNK1/p-JNK1, and ERK1/2/p-ERK1/2 were determined by immunohistochemical analysis, RT-PCR, and western blot. No matter whether tension was exerted or inhibitors were added, there was no change in the expression of p38, JNK1, and ERK1/2. However, compared to the 0 g group, the expression of MMP-9, TNF-α, IL-1β, p-p38, p-JNK1, and p-ERK1/2 was significantly upregulated in the 3 g group (P 0.05). In both 0 g and 3 g groups, the expression of MMP-9, TNF-α, IL-1β, p-p38, p-JNK1, and p-ERK1/2 was remarkably downregulated after inhibitors treatment (P 0.05). In conclusion, mechanical stretch aggravated aortic dissection by regulating the MAPK pathway and the consequent expression of MMP-9 and inflammation factors.
- Published
- 2018
39. Analysis of Risk Factors for Acute Kidney Injury after Ascending Aortic Replacement Combined with Open Placement of Triple-Branched Stent Graft in Type A Aortic Dissection: A New Technique versus the Traditional Method in a Single Chinese Center
- Author
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Hua Cao, Zhihuang Qiu, Liang-Wan Chen, Fan Xu, Gui-Can Zhang, and Qiang Chen
- Subjects
Adult ,Male ,Aortic arch ,China ,medicine.medical_specialty ,Elephant trunks ,medicine.medical_treatment ,Aorta, Thoracic ,Blood Vessel Prosthesis Implantation ,Young Adult ,Aneurysm ,Risk Factors ,Clinical Research ,Aneurysm, Dissecting ,medicine.artery ,Internal medicine ,medicine ,Humans ,Aortic dissection ,Aorta ,business.industry ,Stent ,General Medicine ,Acute Kidney Injury ,Middle Aged ,medicine.disease ,Aortic Aneurysm ,Blood Vessel Prosthesis ,Surgery ,Aortic Dissection ,Descending aorta ,Cardiology ,Female ,Stents ,Packed red blood cells ,business ,Vascular Surgical Procedures - Abstract
Background We aimed to analyze the risk factors and prognosis of acute kidney injury (AKI) after aortic arch repair in type A aortic dissection. Material and methods We included 155 patients undergoing arch repair surgery for type A aortic dissection from January 2009 to January 2014 in our hospital. Ninety-three patients underwent ascending aortic replacement combined with open placement of triple-branched stent graft and 62 underwent arch replacement with 4-branched Dacron graft combined with stented elephant trunk implantation into the descending aorta. Univariate analysis and multiple logistic regression were performed to evaluate possible parameters associated with AKI according to the AKI Network (AKIN). Results Postoperative AKI occurred in 56 patients, with a morbidity of 36.13%. Advanced age (OR=2.32 per decade, 95% CI; range, 1.47-3.67); aortic arch replacement with 4-branched Dacron graft combined with stented elephant trunk implantation (OR=3.29, 95% CI; range, 1.12-9.67); cardiopulmonary bypass time >180 min (OR=3.91, 95% CI; range, 1.35-11.35) and packed red blood cells >10 U (OR=4.88, 95% CI; range, 2.03-11.76) were independent risk factors. Conclusions AKI is a complication after arch repair in type A aortic dissection. Advanced age; aortic arch replacement with 4-branched Dacron graft combined with stented elephant trunk implantation; cardiopulmonary bypass time >180 min; and packed red blood cells >10 U were independent risk factors for AKI. Ascending aortic replacement combined with open triple-branched stent graft placement could reduce the occurrence of AKI and protect renal function.
- Published
- 2015
40. Star GK Bileaflet Mechanical Valve Prosthesis-Patient Mismatch after Mitral Valve Replacement: A Chinese Multicenter Clinical Study
- Author
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Zhihuang Qiu, Qiang Chen, Dao-zhong Chen, Liang-Wan Chen, and Hua Cao
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,medicine.medical_treatment ,Heart Valve Diseases ,Pulmonary Artery ,Prosthesis Design ,Young Adult ,Postoperative Complications ,Mechanical Mitral Valve ,Clinical Research ,Mitral valve ,Internal medicine ,medicine.artery ,medicine ,Humans ,Arterial Pressure ,Heart valve ,Aged ,Heart Valve Prosthesis Implantation ,Bioprosthesis ,Body surface area ,business.industry ,Hemodynamics ,Mitral valve replacement ,General Medicine ,Perioperative ,Middle Aged ,Surgery ,Cardiac surgery ,Treatment Outcome ,medicine.anatomical_structure ,Heart Valve Prosthesis ,Pulmonary artery ,Cardiology ,Mitral Valve ,Female ,business ,Follow-Up Studies - Abstract
Background The aim of this study was to investigate the incidence and immediate and mid-term effects of heart valve prosthesis-patient mismatch (PPM) after mitral valve replacement using the GK bileaflet mechanical valve. Material/Methods A total of 493 cases of mechanical mitral valve replacement were performed in the departments of cardiac surgery in 7 hospitals from January 2000 to January 2008. The patients included 142 men and 351 women ages 21 to 67 (average age, 48.75). The patients were followed for 3 years after surgery. The effective orifice area index (EOAI), ≤1.2 cm2/m2, was detected during the follow-up period and was defined as PPM. The patients were assigned to either the PPM group or the non-PPM group. Finally, the preoperative, perioperative and postoperative indexes of the 2 groups of patients were compared. Results A total of 157 patients had PPM 3 years after surgery. The incidence of PPM was 31.84%. Sixty-three patients in the PPM group received a 25-mm GK bileaflet valve (40.13%), 82 received a 27-mm valve (52.23%), and 12 (7.64%) received a 29-mm valve. There were significant differences in length of intensive care unit stay, duration of ventilator use, length of hospitalization, body surface area, EOAI, mean transmitral pressure gradient, and pulmonary artery pressure between the PPM and non-PPM group (P0.05). Conclusions PPM after mitral valve replacement influences postoperative hemodynamics. Thus, larger-sized GK bileaflet mechanical valves are often used to reduce the risk of PPM.
- Published
- 2015
41. A clinical study of thoracoscopy-assisted mitral valve replacement concomitant with tricuspid valvuloplasty, with domestically manufactured pipeline products for cardiopulmonary bypass
- Author
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Zhihuang Qiu, Yun-Nan Hu, Dao-zhong Chen, Qian-Zhen Li, Liang-Wan Chen, Gui-Can Zhang, Qiang Chen, Hua Cao, and Jia-jun He
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Mitral valve surgery ,Cardiac Valve Annuloplasty ,law.invention ,Mitral valve stenosis ,Tricuspid Valve Insufficiency ,law ,Internal medicine ,medicine ,Thoracoscopy ,Cardiopulmonary bypass ,Humans ,Mitral Valve Stenosis ,Thoracoscopy assistance ,cardiovascular diseases ,Minimally invasive ,Heart Valve Prosthesis Implantation ,Cardiopulmonary Bypass ,medicine.diagnostic_test ,business.industry ,Mitral valve replacement ,Mitral Valve Insufficiency ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Cardiac surgery ,Treatment Outcome ,Cardiothoracic surgery ,cardiovascular system ,Cardiology ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,Research Article - Abstract
Objective To discuss the feasibility and experience of treating valvular heart diseases with thoracoscopy-assisted mitral valve replacement concomitant with tricuspid valvuloplasty, with domestically manufactured pipeline products for cardiopulmonary bypass. Methods A total of 135 patients with valvular heart disease were admitted to our hospital between January 2011 and January 2013. They received thoracoscopy-assisted mitral valve replacement concomitant with tricuspid valvuloplasty, with domestically manufactured pipeline products. A cardiopulmonary bypass with domestically-manufactured pipeline products was established during the surgery. The procedure was accomplished with the assistance of thoracoscopy through a small incision in the right chest wall. Results All 135 patients underwent a successful surgery, and were followed up for the duration of half a year to two years. None of them displayed any evidence of complications. Our procedure had the advantage of fewer complications and a significantly shortened time period for the patient care and hospitalization. As opposed to imported pipeline products for cardiopulmonary bypass, our procedure had the advantage of similar clinical results at a lower cost. Conclusions Thoracoscopy-assisted mitral valve replacement concomitant with tricuspid valvuloplasty was proved to be a safe and effective method for cardiopulmonary bypass, with the use of domestically manufactured pipeline products. Electronic supplementary material The online version of this article (doi:10.1186/s13019-014-0160-2) contains supplementary material, which is available to authorized users.
- Published
- 2014
42. Percutaneous device closure of atrial septal defect with totally transthoracic echocardiography guide, without x-ray machine
- Author
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Heng Lu, Hua Cao, Zhihuang Qiu, Qiang Chen, Liang-Wan Chen, and Gui-Can Zhang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Percutaneous ,Adolescent ,Septal Occluder Device ,Fistula ,Femoral vein ,Septum secundum ,Observational Study ,030204 cardiovascular system & hematology ,Heart Septal Defects, Atrial ,Atrial septal defects ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Occlusion ,medicine ,Humans ,030212 general & internal medicine ,Cardiac Surgical Procedures ,septal defects ,Heart septal defect ,business.industry ,X-Rays ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,CHD ,Surgery, Computer-Assisted ,Echocardiography ,Female ,business ,cardiac intervention ,Research Article - Abstract
The present study investigated the feasibility of totally transthoracic echocardiography-guided percutaneous device occlusion of atrial septal defects (ASDs) without using x-ray equipment. Between September and December 2014, we performed totally transthoracic echocardiography-guided percutaneous device occlusion for 20 patients with secundum ASD without using x-ray equipment. We carried out percutaneous femoral vein puncture, used a specialized delivery sheath during operation, and closed the ASD by releasing an occluder. All 20 patients experienced successful occlusion and smoothly went through the perioperative period. The average procedure time ranged from 30 to 40 minutes (32.4 ± 3.5 minutes), and the size of the implanted occluder ranged from 20 to 38 mm (25.4 ± 5.8 mm). No occluder displacements, residual fistula, or thrombus-related complications after the procedure. There was no clinical death, no arrhythmia, no hemolysis, no infection, or embolism during patients’ hospitalization and the follow-up period. Totally transthoracic echocardiography-guided percutaneous device occlusion of ASDs without the use of x-ray equipment may be safe and feasible.
- Published
- 2016
43. Closure of perimembranous ventricular septal defects with intraoperative device technique: another safe alternative to surgical repair
- Author
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Zhihuang Qiu, Gui-Can Zhang, Qiang Chen, Liang-Wan Chen, Hua Cao, and Qian-Zhen Li
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Heart Septal Defects, Ventricular ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Septal Occluder Device ,Group ii ,Aortic Valve Insufficiency ,Prosthesis Design ,law.invention ,Young Adult ,law ,Cost Savings ,medicine ,Cardiopulmonary bypass ,Humans ,Minimally Invasive Surgical Procedures ,Cardiac Surgical Procedures ,Hospital Costs ,Atrioventricular Block ,Child ,Aortic valve regurgitation ,Retrospective Studies ,Surgical repair ,Heart septal defect ,business.industry ,Infant ,Retrospective cohort study ,Length of Stay ,Middle Aged ,medicine.disease ,Surgery ,Echocardiography, Doppler, Color ,Intensive Care Units ,Treatment Outcome ,Child, Preschool ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business ,Atrioventricular block ,Shunt (electrical) ,Echocardiography, Transesophageal - Abstract
OBJECTIVES This study aims at assessing the safety and feasibility of intraoperative device closure of the perimembranous ventricular septal defect (VSD). METHODS Total 89 patients in group I with intraoperative device closure and 58 in group II with surgical repair were enrolled in our hospital to participate in the study from January 2009 to December 2010. In group I, the approach involved a minimal inferior median incision that was performed after full evaluation of the perimembranous VSD by real-time transesophageal echocardiographic guidance, and the insertion of an asymmetric or a symmetric domestically made device was used to occlude the perimembranous VSD. RESULTS In group I, 83 patients were occluded successfully under this approach. The size of the occluder implanted ranged from 6 to 14 mm. Complete atrioventricular block occurred in one case and Mobitz type II atrioventricular block occurred in one case during the procedure. One patient presented complete atrioventricular block one week after the operation. Two patients converted to surgical repair because of severe intraoperative aortic valve regurgitation. One patient with significant residual shunt transformed to surgical treatment. In our comparative studies, patients in group II experienced significantly longer operative time, ICU stay, and hospital stay (p < 0.001). The cost of group I was less than that of group II (p < 0.001). CONCLUSIONS Minimally invasive transthoracic device closure of the perimembranous VSD with an asymmetric or a symmetric domestically made device without cardiopulmonary bypass is safe and feasible. It should be considered an acceptable alternative to surgery in selected subgroups. However, it is necessary to evaluate the long-term results.
- Published
- 2012
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