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Supplementary Methods and Supplementary Figs. 1-4

Additional file 1. STROBE Checklist.

Additional file 1: Supplemental Figure 1. This matrix is a summary of 90 ROIs from the Anatomical Automatic Labeling template-based statistical parametric maps of functional connectivity analyzed between the MMD group and HC. The matrix is 90 x 90, and each voxel stores a T statistic value ranging from 6 to -6. The red voxels indicate the functional connectivity of the MMD group is greater than HC, and blue is the opposite. The color bar is located at the right. Supplemental Figure 2. A-C The correlation between functional connectivity and tensor metrics of the SMA-IFGorb in the left hemisphere of MMD patients and HC. Supplemental Table 1. Demographics and clinical characteristics of 22 MMD patients.

Type 2 diabetes mellitus (T2DM), a leading cause of osteoporosis, remains a contraindication for bone implant therapy. Although associated with side effects when systemically administered, biphosphonates (BPs) play a positive role in diabetic osteoporosis treatment. We hypothesized that local BP therapy would prevent decayed implant osseointegration under T2DM conditions. To assess cell proliferation and determine the optimal BP concentration, bone marrow-derived mesenchymal stem cells (BMSCs) and bone marrow macrophages (BMMs) were treated with BPs at various relatively low concentrations (10(-9) mmol/L) for different periods of time. Our in vitro study results demonstrated that BP application reversed the process by which high glucose inhibits bone formation and stimulates bone resorption through osteoclast-specific gene and protein expression (P

Dazu Rock Carvings is an important heritage. In the past, many varieties of damages existed in Dazu Rock Carvings, which impaired aesthetics and safety. Thus, the country is trying to save the rock carvings through preservation of cultural relics. Among those engaged in this endeavor are leaders and experts from Dazu Rock Carving Institute, Chinese Academy of Cultural Heritage, China University of Geosciences, School of Environment of Tsinghua University. In the research hereof, field experiments and field surveys were carried out, and corresponding measures were put forward for analysis of data.

Longmen Grottoes was afflicted with many diseases for a long period such as weathering, seepage water and organism growth. Those adverse factors were threatening to preserve cultural relic. Longmen Grottoes conservation and restoration project being put into effect by UNESCO in 2002. The Longmen Grottoes area environmental monitoring system was built in order to comprehensively master the distribution law of environmental factors over the Longmen Grottoes. The monitoring items contains temperature, humidity, wind direction, wind speed, precipitation, light intensity,water content in soil, the rock surface temperature and so on. At the same time, monitoring three experiment caves, monitoring the inside temperature, humidity, seepage water and the wall face temperature etc. So as to analyze the relationship between cave environment and regional environment. We statistical and arrange the data using Excel software, Kgraph software and DPS software. Through the grey incidence analyze, the incidence matrix and the correlation degree of the environmental factors was obtained[1]. The main environment factors for the formation of the disease had been researched. Based on the existing environmental monitor data, the relevance of seepage water and fracture displacement with other environmental factors had been studied, and the relational order was obtained. Corresponding preventive measures were put forward by the formation mechanism analyze of the disease.