1. Association Between the Triglyceride–Glucose Index and Outcomes of Nonalcoholic Fatty Liver Disease: A Large-Scale Health Management Cohort Study
- Author
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Haiyan Lin, Ling Gao, Liying Guan, Meng Zhao, Jing Liu, An Song, Qihang Li, and Zhao Jiajun
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nonalcoholic fatty liver disease ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Subgroup analysis ,030204 cardiovascular system & hematology ,outcomes ,digestive system ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Insulin resistance ,Internal medicine ,Nonalcoholic fatty liver disease ,Internal Medicine ,medicine ,Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity] ,Original Research ,Pharmacology ,medicine.diagnostic_test ,Triglyceride ,Proportional hazards model ,business.industry ,nutritional and metabolic diseases ,medicine.disease ,digestive system diseases ,triglyceride–glucose index ,Quartile ,chemistry ,Liver biopsy ,business ,Cohort study - Abstract
Jing Liu,1– 3 Liying Guan,4 Meng Zhao,1,2,5 Qihang Li,2,3,5 An Song,6 Ling Gao,2,7,8 Haiyan Lin,4 Jiajun Zhao1,2,5,7 1Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China; 2Shandong Clinical Medical Center of Endocrinology and Metabolism, Affiliated to Shandong Provincial Hospital, Jinan, Shandong, 250021, People’s Republic of China; 3Shandong Institute of Endocrine and Metabolic Disease, Affiliated to Shandong Provincial Hospital, Jinan, Shandong, 250021, People’s Republic of China; 4Health Management Center, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 5Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, People’s Republic of China; 6Peking Union Medical College Hospital, Affiliated to Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China; 7Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Affiliated to Shandong Provincial Hospital, Jinan, Shandong, 250021, People’s Republic of China; 8Department of Scientific Center, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of ChinaCorrespondence: Haiyan LinHealth Management Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing 5 Road, Jinan, Shandong, 250021, People’s Republic of ChinaTel +86-531-68776123 (Clin.)Fax +86-531-87068707Email zxhlhy@126.comJiajun ZhaoDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing 5 Road, Jinan, Shandong, 250021, People’s Republic of ChinaTel +86-531-68776375 (Clin.); +86-531-68776094 (Lab.)Fax +86-531-87068707Email jjzhao@sdu.edu.cnBackground: Nonalcoholic fatty liver disease (NAFLD) is increasingly becoming a major health burden. Due to the difficulty of liver biopsy, there is no reliable indicator to evaluate the outcomes of NAFLD. The triglyceride–glucose (TyG) index is a simple and convenient marker of insulin resistance for use in medical practice. Whether the TyG index is predictive of later risk of NAFLD remains unknown.Objective: To evaluate the relationship between TyG index with NAFLD progression and improvement during a median follow-up period of 21 months.Material and Methods: A total of 11,424 subjects (9327 men) diagnosed with NAFLD were included. The TyG index was calculated as follows: ln [fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. Multivariable Cox regression analysis was applied to analyze the data.Results: In this study, the severity of NAFLD remained the same in 38.8% of subjects, worsened in 17.4% of subjects, and improved in 43.8% of subjects. Compared with the lowest quartile of the TyG index, the adjusted HR of NAFLD progression in the highest quartile (TyG≥ 9.34) was 1.448 (1.229 to 1.706), and the adjusted HR of NAFLD improvement was 0.817 (0.723 to 0.923). Subgroup analysis found that smoking increased the correlation between the TyG index and the risk of NAFLD progression, while female, vegan diet, and weight control enhanced the correlation between the TyG index and the risk of NAFLD improvement.Conclusion: The TyG index may be a simple and helpful indicator for further risk appraisal of NAFLD in daily clinical practice.Keywords: triglyceride–glucose index, nonalcoholic fatty liver disease, outcomes
- Published
- 2021