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Background: The causal direction and magnitude of the associations between blood cell count and coronary heart disease (CHD) remain uncertain due to susceptibility of reverse causation and confounding. This study aimed to investigate the associations between blood cell count and CHD using Mendelian randomization (MR).Methods: In this two-sample MR study, we identified independent blood cell count associated genetic variants from a genome-wide association studies (GWAS) among European ancestry individuals. Summary level data of CHD was obtained from a GWAS consisting of 547261 subjects. Methods of inverse variance weighted (IVW), Mendelian Randomization-Egger (MR-Egger), weighted median, and outlier test (MR-PRESSO) were conducted to investigate the associations between blood cell and CHD.Results: Among all cardiovascular outcomes of interest, blood cell counts were only associated with CHD. Our findings indicated that white blood cell count and neutrophil cell count were significantly associated with increased risk of CHD [odds ratio (OR) = 1.07, 95% confidence interval (CI), 1.01–1.14; OR = 1.09, 1.02–1.16). However, there was no significant association between monocyte cell count, basophil cell count, lymphocyte cell count, eosinophil cell count, and CHD (p > 0.05). The results after excluding outliers were consistent with main results and the sensitivity analyses showed no evidence of pleiotropy (MR-Egger intercept, p > 0.05).Conclusion: Our MR study suggested that greater white blood cell count and neutrophil cell count were associated with a higher risk of CHD. Future studies are still warranted to validate the results and investigate the mechanisms underlying these associations.

Supplemental material, sj-pdf-1-imr-10.1177_03000605221148905 for Prevalence and management of hypertension in Central China: a cross-sectional survey by Wenlu Xing, Shan Wang, Xinyun Liu, Jicheng Jiang, Qiuping Zhao, Yuming Wang, You Zhang and Chuanyu Gao in Journal of International Medical Research

Supplemental material, sj-pdf-1-imr-10.1177_03000605221148905 for Prevalence and management of hypertension in Central China: a cross-sectional survey by Wenlu Xing, Shan Wang, Xinyun Liu, Jicheng Jiang, Qiuping Zhao, Yuming Wang, You Zhang and Chuanyu Gao in Journal of International Medical Research

We tested the feasibility, acceptability, and preliminary efficacy of using an integrated approach combining online and in-person delivery to support colorectal cancer (CRC) patients and their spousal caregivers coping positively with cancer together. We found that this integrated couples-based intervention combining online resources and face-to-face sessions is a unique and important promising new approach. It is feasible and acceptable for couples coping with CRC and shows potential efficacy. The main strengths of the present study were the dyadic data from both CRC patients and their spousal caregivers. Such study might not only provide evidence for the feasibility, acceptability, and preliminary efficacy of using an integrated approach combining online and in-person delivery to support Chinese CRC couples, but could also encourage healthcare professionals to best integrate the advantages of the Internet and traditional delivery to provide all-round support to increase CRC couples’ access to psychosocial oncology care when making adjustments due to cancer.

Zhao, Qiuping, Shi, Eryan, Li, Yue, Eberl, Renate, An, Jianmei (2016): Population genetic structure and demographic history of the Chinese endemic Mongoloniscus sinensis (Dollfus, 1901) (Isopoda: Oniscidea). Zoological Systematics 41 (4): 352-365, DOI: 10.11865/zs.201641