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Additional file 1: Table S1. The follow-up information of the NC subjects included in this study. Table S2. Vascular risk factors of the BABRI and ADNI samples. Table S3. List of regions showing covariance between the seed network regions and whole brain patterns of the grey matter of BABRI. Table S4. List of regions showing covariance between the seed network regions and whole brain patterns of the grey matter of ADNI. Table S5. The differences in structural covariance scores between groups of the ADNI samples, adjusted for age, sex, education level, TIV, field strength, and scan site. Table S6. The prediction results of the development and reversion of MCI of the ADNI samples, adjusted for field strength and scan site. Table S7. The differences in structural covariance scores between groups of the 1.5T field intensity in the ADNI samples, adjusted for age, sex, education level, and TIV. Table S8. The prediction results of the development and reversion of MCI of the 1.5T field intensity in the ADNI samples. Table S9. Prediction of MCI progression, stabilization, and reversion in ADNI samples. Fig. S1. Differences in structural covariance scores of rMCI, sMCI, and pMCI of the ADNI sample. Fig. S2. The relationship between the composite score of the structural covariance network and the APOE4 carrier status of the ADNI sample. Fig. S3. Effect of disease course on MCI reversion of the ADNI sample. Fig. S4. Feature weight distribution of the random forest prediction model of the ADNI sample. Fig. S5. The relationship between the composite score of the structural covariance network and the grey matter density of the hippocampus.

Hypertension has been well recognized as a risk factor for cognitive impairment and dementia. Although the underlying mechanisms of hypertension-affected cognitive deterioration are not fully understood, white matter changes (WMCs) seem to play an important role. WMCs include low microstructural integrity and subsequent white matter macrostructural lesions, which are common on brain imaging in hypertensive patients and are critical for multiple cognitive domains. This article provides an overview of the impact of hypertension on white matter microstructural and macrostructural changes and its link to cognitive dysfunction. Hypertension may induce microstructural changes in white matter, especially for the long-range fibers such as anterior thalamic radiation (ATR) and inferior fronto-occipital fasciculus (IFOF), and then macrostructural abnormalities affecting different lobes, especially the periventricular area. Different regions’ WMCs would further exert different effects to specific cognitive domains and accelerate brain aging. As a modifiable risk factor, hypertension might provide a new perspective for alleviating and delaying cognitive impairment.

Additional file 1: Table S1. Intergroup differences in demographics, health conditions, and living habits. Table S2. Intergroup differences in detailed items of leisure activities. Table S3. Results of the relative importance of influencing factors to each cognitive domain in the full sample (N = 1347). Table S4. Estimated direct and indirect effects of the grouped sample (N = 583) SEM with ECR, LLA, and four cognitive domains as latent factors. Table S5. Estimated direct and indirect effects of the grouped sample (N = 583) SEM with ECR, LLA, and general cognitive function as latent factors. Table S6. Estimated direct and indirect effects of the full sample (N = 1347) SEM with ECR, LLA, and four cognitive domains as latent factors. Table S7. Estimated direct and indirect effects of the full sample (N = 1347) SEM with ECR, LLA, and general cognitive function as latent factors. Table S8. Estimated direct and indirect effects of the multi-group SEM with ECR, LLA, and general cognitive function as latent factors. Figure S1. Structural equation models that reveal relationships among ECR, LLA, and cognitive performance in the full sample (N = 1347).

The interactions within co-carbonization systems are of great importance in the production of premium cokes. In this study, the blending of the heaviest fluidized catalytic cracking slurry oil frac...

The CW RF test of 1.3 GHz 9-cell cavity in liquid helium bath at 2 K is a very important key point in the cavity procurement. Some problems can be found through the test, according which to optimized and improve the process of cavity. Recently, Medium temperature (mid-T) furnace bake of 1.3 GHz 9-cell cavities have been carried out at IHEP. Through the proceed of mid-T bake, the quality factor of cavity has been greatly improved. While the excitation of the parasitic modes in the high Q cavities CW cold test has been encountered, which implies an error source for the cavity gradient and quality factor determination. In order to ensure the testing accuracy of superconducting cavity, we have improved the testing system. Finally, the parasitic mode is completely suppressed and the CW RF cold test of high Q cavity is guaranteed.

Additional file 1.

Recently, heat treatment between 250 C and 500 C has been attempted to improve quality factor of superconducting radio-frequency cavities at FNAL and KEK. Experiments of such medium temperature (mid-T) bake with furnaces have also been carried out at IHEP. Firstly, eleven 1.3 GHz 1-cell cavities were treated with different temperatures at a small furnace. The average quality factor has reached 3.6E10 when the gradient is 16 MV/m. Then, the recipe of mid-T furnace bake at 300 C for 3 hours has been applied to six 1.3 GHz 9-cell cavities at a new big furnace. The average quality factor has reached 3.8E10 when the gradient is 16 MV/m., Comment: 10 pages, 12 figures

A key challenge of chemotherapy in clinical treatments is multidrug resistance (MDR), which mainly arises from drug efflux-induced tumor cell survival. Thus, it is necessary to provide biocompatible chemotherapeutics to improve drug accumulation in MDR cells. Herein, two clinical small molecular drugs, celastrol (CST) and doxorubicin (DOX), were self-assembled into carrier-free and biocompatible nanoparticles (CST/DOX NPs) via a simple and green precipitation method for synergistic combination chemotherapy to overcome DOX resistance. These spherical CST/DOX NPs can improve the water-solubility of CST, reduce the dosage of DOX, and therefore significantly enhance cellular drug accumulation by activating heat shock factor 1 (HSF-1) and inhibiting NF-κB to depress P-gp expression, which results in apoptosis and autophagy of DOX resistant cells through the ROS/JNK signaling pathway. Finally, synergistic combination chemotherapy was attained in both MCF-7/MDR cells and 3D multicellular tumor spheroids. Thus, CST/DOX NPs provide an alternative for overcoming drug resistance in future clinical applications.

Aiming at the power quality problem of voltage sag in distribution network, the control factors and effects of dynamic voltage restorer (DVR) and distribution static synchronous compensator (DSTATCOM) are studied to flexibly configure DFACTS devices and improve the voltage quality of distribution network. Firstly, the basic principle and compensation strategy of DVR and DSTATCOM are elaborated. Then, the performance influencing factors of two compensation devices are deduced. The influence of voltage sag amplitude, system capacity and load capacity is discussed. It is concluded that the voltage compensation performance of DVR is directly related to load capacity and voltage sag amplitude, while DSTATCOM is directly related to system capacity and voltage sag amplitude. Finally, the effectiveness of the proposed method is validated by comparing the control effects of the two compensation devices on voltage sag under different voltage sag magnitude, system capacity and load capacity, which provides a theoretical basis for the reasonable access of DVR and DSTATCOM in distribution network.

A series of W-type hexagonal ferrites with the composition Ba1−xCaxCo2Fe16O27 (x=0, 0.1, 0.3, 0.4 and 0.5) were synthesized using a sol–gel method. The effects of doping on structural and magnetic properties are studied by X-ray diffraction, thermal analyzer, scanning electron microscopy, vibrating sample magnetometer and vector network analyzer, respectively. The X-ray diffraction analysis shows that the samples belong to the W-type hexagonal ferrite. The lattice constants a and c decreases as Ca contents increases. The grains exhibit well defined hexagonal shape. The saturation magnetization and the intrinsic coercive force increases with the increase of the Ca substitution amount. The real part of complex permittivity (e′) and imaginary part (e″) increase with more addition of Ca2+ amount. The imaginary part of complex permittivity (μ′) increases and the real part (μ′′) goes down after Ca2+ is doped. Furthermore, the Ca2+ ions doped in the ferrite improved microwave absorbency.

M type strontium hexaferrites SrFe12 − xCrxO19 (x = 0.0–0.6) were prepared by the ceramic process. The structure, morphology and magnetic properties of the samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and B–H hysteresis curve measurements. The XRD patterns show the formation of the M-type hexaferrite phase in the pre-sintered samples with non-magnetic phase, α-Fe2O3. The SEM results indicate that the Cr substitution does not obviously affect the structure of strontium ferrite. The results of magnetic mensuration, especially for the SrFe11.8Cr0.2O19 samples, reveal that rather high magnetic properties can be obtained in the sintering temperature range of 1135–1165°C.

Strontium ferrites Sr0.70-xLa0.3CaxFe11.7Co0.3O19 (x = 0.00, 0.05, 0.10, 0.15, 0.20, 0.25, 0.30)，according to the formula Sr1-x-yCaxLay∙Fe12-yCoyO19, were prepared by the conventional ceramic process. The structure, morphology, optical, magnetic properties and transverse magneto-optical Kerr effect of the samples were studied by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron microscope (SEM) and magneto-optical ellipsometry. It is found that the samples are single phase except the samples with the largest substitution amount, x = 0.25 and x = 0.30. Doping with Ca2+, the coercivity of these material magnets is increased while their magnetization is nearly unchanged. In all cases, a strong transverse magneto-optical Kerr activity appears according to the optical and magneto-optical spectra of the samples., This work was financially supported by the National Natural Science Foundation of China under [grant numbers. 51272003 and 51472004], the Program of the Education Department of Anhui Province [grant numbers. KJ2012A027 and KJ2013B057], and from the Research Fund for the Doctoral Program of Higher Education of China under [project number 20123401110008], and from the Spanish Ministry of Education and Science under [project number MAT2009-14534-C03-03].

We have analyzed the gold content of 65 samples of mantle-derived xenoliths and their host rocks from eastern China, which is found to be inhomogeneous, falling in the ranges of 1.0times10−9-8.2times10−9 (averaging 3.8 times 10-9) and 0.2times10−9-5.3times10−9 (averaging 2.7times10−9) in the mantle-derived xenoliths and the host basalts respectively. Except the samples from Wanquan County of Hebei Province and Anding County of Hainan Province, the gold content is the highest on the margins of the North China platform and decreases spatially towards the north and south, and temporally the samples of the Tertiary have a higher gold content than those of the Quaternary. The gold content of the mantle-derived xenoliths and the host Paleozoic kimberlites is 3.8times10−9-180times10−9 and 0.1times10−9-38.0times10−9 respectively, which are higher than that in the mantle-derived xenoliths in basalt and the host Cenozoic basalts. The mantle-derived xenoliths have a higher gold content than the host rocks, but their relativity is not very clear, suggesting that the genetic relationship between them is complex. Our data indicate that the average gold content of the lithospheric mantle in eastern China is approximately equal to or approaching 3.8times10−9, which is lower than the average abundance of the upper mantle (5.0times10−9), higher than the average abundance of the continental crust (3.0times10−9) and only slightly higher than the average abundance of the lower continental crust (3.4times10−9). Except the samples from Hainan Province, the mantle-derived xenoliths in basalts with a high gold content are distributed on the two margins of the North China platform, corresponding to the gold deposits-concentrated districts in northwest Hebei Province and Shandong Province, showing the control by the old continental lithospheric mantle and the lower continental crust on the margins of the North China platform. The gold content of the mantle-derived xenoliths from Hainan Province ranges from 7.1times10−9 to 15times10−9, suggesting that some blocks of the lithospheric mantle in Hainan Province may be derived from the ancient gold-rich lithospheric mantle of western Australia and that Hainan Province may possibly be an important gold deposits-concentrated district. Some mantle-derived xenoliths in kimberlite of Shandong Province have an excessively high gold content amounting to 180times10−9, which provides new evidence for the possibility of “finding gold deposits near kimberlite pipes or alkali-basalt volcanic vents”. Thererfore, the gold content of the mantle-derived xenoliths may be an indicator to the distribution of gold deposits-concentrated districts.

A probabilistic teleportation scheme for atomic state via cavity QED [Phys. Rev. A 70 (2004) 054303] is revisited and accordingly some improvements are made.

In sdgIBA-1, E2 and E4 transition operators of 104-110Pd isotopes are worked out in terms of a microscopic approach. Comparisons of them with the corresponding phenomenm logical operators are made. It is found that the microscopic Hamiltonian and E2 transition operator are very close to the phenomenological counterparts while the microscopic E4 transition operator is apparently different from the phenomenological one. Calculations for the low-lying collective excitation spectra and reduced E2 (E4) transition rates are performed within the framework of the sdglBA-1. We find that the microscopic calculations reproduce the experimental data quite well, in addition, their agreement with the experimental data in general is very close to that of the phenomenological results, especially to the reduced E4 transition rates disregarding completely the apparent difference of operator.

Starting from the shell model configurations, valence nucleon effective interactions and fermion M1 transition current density operator, the counterparts in the proton-neutron interacting boson model (sdIBM-2) of the fermion Hamiltonian and M1 transition current density operator are derived microscopically with the help of Dyson expansion technique. The boson g factors are abstracted from the boson M1 transition current density operator. Spectra, g factors of states and M1 matrix elements between and are calculated for the even 192-198Pt isotopes in the sdIBM-2. The theoretical results fit experimental data quite well.

Two qubit operation sharing schemes [J. Phys. B 44 (2011) 165508] are generalized to qutrit ones. Operations to be shared are classified into three different classes in terms of different probabilities (i.e, 1/3, 2/3 and 1). For the latter two classes, ten and three restricted sets of operations are found out, respectively. Moreover, the two generalized schemes are amply compared from four aspects, namely, quantum and classical resource consumption, necessaryoperation complexity, success probability and efficiency. It is found that the second scheme is overall more optimal than the first one as far as three restricted sets of operations are concerned.

We deny with a concrete example the generality of the correlation subadditivity relation conjectured by Modi et al's [Phys. Rev. Lett. {\bf 104}, 080501 (2010)] for any quantum state and point out that the correlation additivity relation is actually super-additive for separable states. This work indicates that any effort on explicitly proving the conjecture and finding the subadditivity source is unnecessary and fruitless.

The current network protecting methods are ineffective in controlling the hosts onf intranet. This paper first analyzes the threats coming from intranet. Then designs and implements an intranet security detecting system which can detect if the intranet is working in a secure state. Finally, it combines the detecting results of this system and those of the vulnerability scanners, constructs a logical modal to evaluate the security of the intranet. This modal integrates as much as the factors that affect the securtiy of intranet, including the vulnerabilities of each host, hosts connected to the Internet illegally, hosts connected to the intranet unauthorized, the filtering rules of the firewall as well as the trust relations among hosts, so it can provide a more reasonable evaluation to the intranet security.

The modeling method called Petri-MPN (Petri Nets for Maintenance Procedure) for maintenance process is proposed in this paper. The maintenance process modeling and its procedure of a type transmitter-receiver based on Petri-MPN are present. The design of virtual maintenance system for the transmitter-receiver is finally described including system logic structure and object architecture.

High-spin states in the odd-proton nucleus 135Pm have been investigated using the 107Ag(32S, 2p2n)135Pm reaction. Seven rotational bands have been observed in 135Pm. The yrast band based on a decoupled h11/2 proton is found to have a band crossing in ωc~0.43 MeV/. Two positive-parity bands based on the two signature components of the πg7/25/2+[413] Nilsson orbital have been observed in the main sidebands. The favoured band with (π,α) = ( + ,-1/2) has been shown to populate below the first pair of proton alignment. Both bands have shown upbend at ω1~0.26 MeV/ and ω2~0.43 MeV/. These crossing frequencies can be attributed to the decoupling of the first pair of h11/2 quasi-proton and h11/2 quasi-neutron, respectively. Four weaker bands have been observed in sidebands too. Among them, two states are possibly built on a πd5/23/2+[411] configuration. PACS: 23. 20. Lv, 25. 70. -z, 27. 60. +j

Formulae of proton and neutron boson structure functions (BSF's) are deduced in terms of a microscopic approach of sdgIBM (namely, microscopic sdgIBM). For the nucleus 190Os, the value of BSF's is worked out. Due to the high similarity, the maximum F-spin truncation is made under the full-symmetry approximation. Thereafter, calculations of E2 and E4 transition charge densities (TCD's) are performed in the sdgIBM-1. It is found that the E2 and E4 TCD's can be reproduced quite satisfactorily in the uniform frame of microscopic sdgIBM-1.

In this paper the correct calculations of the mutual information of the whole transmission, the quantum bit error rate (QBER) are presented. Mistakes of the general conclusions relative to the mutual information, the quantum bit error rate (QBER) and the security in W��jcik's paper [Phys. Rev. Lett. {\bf 90}, 157901(2003)] have been pointed out., In this paper the correct calculations of the mutual information of the whole transmission, the quantum bit error rate (QBER) are presented. Mistakes of the general conclusions relative to the mutual information, the quantum bit error rate (QBER) and the security in W\'{o}jcik's paper [Phys. Rev. Lett. {\bf 90}, 157901(2003)] have been pointed out. Also I hope experts can give me some help in addressing the question I present in this paper

In this letter a deterministic secure direct bidirectional communication protocol is proposed by using the quantum entanglement and local unitary operations on one photon of the Einstein-Podolsky-Rosen (EPR) photon pair.

The paper presents an approach for a supporting system for simulation model (SSSM). It is a supporting platform for simulation models on networks, including model library manager (MLM), graphic editor (GE), real time scheduling and real time agent. SSSM has already been used in the development of a 50 MW power plant simulator on Windows 3.1.

The guarantee of quality of service (QoS) is a key issue for multimedia streams in wireless multimedia communications. QoS parameters required by most of multimedia streams are ranges or in set, [QoS/sub min/, QoS/sub max/]. Computer systems and network systems must allocate enough resources such as CPU, I/O, memory and bandwidth to meet these QoS parameters. These resources are dynamic variations in availability, e.g., bandwidth on radio during multimedia stream transmission. The adaptive session is defined to formularize multimedia stream. It can allocate resources with QoS/sub min/, during establishment of a multimedia stream call and it can dynamically adjust its QoS parameters in [QoS/sub min/, QoS/sub max/] by PID to adapt the variations in resource availability during multimedia transmission. It not only meets the QoS parameters required, but also improves the useful of resources.

The guarantee of quality of service (QoS) of multimedia applications is a kernel issue in the resource management of distributed multimedia computer systems. Some key issues for resource management in multimedia transmission are researched in this paper as follows: (1) the relation between QoS and resource management, (2) the algorithm for scheduling distributed multimedia tasks, (3) the paradigm for session-based distributed multimedia resource allocation.