1. A New Cytosine Glycoside from Streptomyces griseochromogenes Produced by the Use in Vivo of Enzyme Inhibitors
- Author
-
Qibo Zhang, Zabriskie Tm, and Steven J. Gould
- Subjects
Magnetic Resonance Spectroscopy ,Arginine ,Stereochemistry ,Argininosuccinate synthase ,Pharmaceutical Science ,Pyrimidinones ,Spectrometry, Mass, Fast Atom Bombardment ,Streptomyces ,Sugar acids ,Analytical Chemistry ,chemistry.chemical_compound ,Biosynthesis ,Spectroscopy, Fourier Transform Infrared ,Drug Discovery ,Enzyme Inhibitors ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,biology ,Antifungal antibiotic ,Hexuronic Acids ,Organic Chemistry ,biology.organism_classification ,Blasticidin S ,Complementary and alternative medicine ,chemistry ,Biochemistry ,biology.protein ,Molecular Medicine ,Streptomyces griseochromogenes - Abstract
The identification of new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism that produces 1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).
- Published
- 1998