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A new probe DBTD was prepared and showed dual-channel colorimetric detection of N2H4 with a minimum detection limit of 0.438 μM which can be successfully applied to the detection of N2H4 in steam, water, cells and zebrafish.

Ferric ions (Fe

Background In the past, patients with recurrent head and neck cancer (rHNC) who had previously received a high dose of radiation and were unable to undergo surgery were mainly treated with palliative chemotherapy due to the high incidence of side effects from re-irradiation. With the development of radiotherapy technology, re-irradiation of recurrent lesions by radioactive iodine-125 seed implantation (RISI) has been proposed as a feasible therapeutic approach. This study aimed to investigate the safety and efficacy of computed tomography (CT)-guided RISI in the treatment of rHNC after two or more courses of radiotherapy, and to analyze the prognostic factors. Methods Data of 33 patients with rHNC who received CT-guided RISI after two or more courses of radiotherapy were collected and statistically analyzed. The median cumulative dose of the previous radiotherapy was 110 Gy. Short-term efficacy was assessed by Response Evaluation Criteria in Solid Tumors (version 1.1) criteria, while adverse events were evaluated by Common Terminology Criteria for Adverse Events (version 5.0) criteria. Results The median gross tumor volume (GTV) was 29.5 cc, and the postoperative median dose to 90% of target volume (D90) was 136.8 Gy. For adverse reactions, enhanced pain was found in 3 (9.1%) patients, followed by grade 1 to 2 acute skin reactions in 3 (9.1%) patients, grade 2 to 3 late skin reactions in 2 (6.1%) patients, grade 1 to 2 early mucosal reactions in 4 (12.1%) patients, and mandibular osteonecrosis in 1 (3.0%) patient. Regarding the treatment efficacy, the 1- and 2-year local control (LC) rates were 47.8% and 36.4% (median LC time, 10 months), and the 1- and 2-year overall survival (OS) rates were 41.3% and 32.2% (median OS time, 8 months). The absence of adverse events was associated with better LC. Conclusions CT-guided RISI, as a salvage therapy, demonstrated acceptable safety and efficacy in the treatment of rHNC after two or more courses of radiotherapy. Trial registration This study was registered at Chinese Clinical Trial Register database (Registration No. ChiCTR2200063261) in September 2, 2022.

Hydrogen sulfide (H2S) is a toxic gas derived from the sulfur industry and trace H2S in the environment can cause serious ecological damage while inhalation can cause serious damage and lead to disease. Therefore, the real-time and accurate detection of trace sulfur ions is of great significance for environmental protection and early disease detection. Considering the shortcoming of current H2S probes in terms of stability and sensitivity, the development of novel probes is necessary. Herein, a novel metal-organic frameworks （MOF）-based material, UiO-66-NH2@BDC, was designed and prepared for the visual detection of H2S with rapid response (2- (0.13 μM) by hydrogen bonding. Based on its good optical performance, the UiO-66-NH2@BDC probe can detect S2- in various water environments. More importantly, UiO-66-NH2@BDC probe realize imaging S2- in cells and live zebrafish.

To compare the pre-plan and post-plan dosimetric parameter differences of 3D-printed non-coplanar templates (3D-PNCT)-assisted computed tomography (CT)-guided iodine-125 (This was a retrospective study of 15 patients with ILNM carcinomas treated with 3D-PNCT-assisted CT-guided RISI between May, 2015 and April, 2018. All patients underwent prior external beam radiotherapy (EBRT) or surgery. Dosimetric parameters included DThe median gross tumor volume (GTV) in the pre-plan was 8.7 ml (range, 0.8-185.1 ml). There were statistically significant differences in V3D-PNCT-assisted CT-guided RISI is a safe, accurate, and feasible choice in ILNM treatment. The procedure of RISI has significantly improved. The pre-plan can be accurately executed by 3D-PNCT-assisted CT-guided RISI.

Background In the management of head and neck cancer (HNC) patients, local recurrence is a common cause of treatment failure. Only a few patients with recurrent HNC (rHNC) are eligible for salvage surgery and the majority of patients receive systemic therapy and radiotherapy. In recent years, with the development of irradiation technology, radiotherapy for rHNC patients has markedly attracted clinicians’ attention and its therapeutic effects on patients with end-stage cancer are worthy of investigation as well. Methods Several studies have investigated the role of radiotherapy in the treatment of rHNC patients. We reviewed retrospective reports and prospective trials published in recent decades that concentrated on the management of rHNC. Results A growing body of evidence supported the application of irradiation to rHNC patients. According to the results of this review, current radiotherapy could achieve a better efficacy with a lower incidence of toxicity. Conclusion Radiotherapy is a promising treatment for rHNC patients.

Background: Sarcoma is a rare mesenchymal malignant tumor. Recently, pyroptosis has been reported to be a mode of programmed cell death. Nonetheless, levels of pyroptosis-associated genes in sarcoma and its relevance to prognostic outcomes are yet to be elucidated. Results: Sarcoma cases were classified into two subtypes with regards to differentially expressed genes. We established a profile composed of seven genes and classified the sarcoma patients into low- and high-risk groups through least absolute shrinkage and selection operator Cox regression. Survival rate of low-risk sarcoma patients was markedly higher, relative to high-risk group (P

We present a new approach of the passive microwave pulse compression for gigawatt power generation. Two stages of resonant-cavity-based pulse compressors are cascaded and the peak power gain is multiplied to 12. Candidate passive pulse compressors and cascaded schemes are studied theoretically from the perspective of a linear time-invariant (LTI) system. The compact $S$ -band (2.856 GHz) prototype system consists of six correction cavities and two storage cavities, with the ability to flatten the first-stage pulses and generate the two-stage compressed pulses with exponentially decaying waveforms. It compresses power pulses of 100 MW and $3.6~\mu \text{s}$ generated by commercial klystrons to the peak power of 1.2 GW and full-width at half-maximum (FWHM) pulse durations of 100 ns. The pulse phase is controllable and the power can be combined for either input sources or outputs. This would be attractive to various applications, such as high gradient accelerator and hot dense plasma generation.

This article analyzes the accuracy of needle track and dose of a 3-dimensional printing template (3DPT) in the treatment of thoracic tumor with radioactive I-125 seed implantation (RISI). A total of 28 patients were included. The technical process included: (i) preoperative CT positioning, (ii) preoperative planning design, (iii) 3DPT design and printing, (iv) 3DPT alignment, (v) puncture and seed implantation. The errors of needle position and dosimetric parameters were analyzed. A total of 318 needles were used. The mean errors in needle depth, needle insertion point, needle tip and needle angle were 0.52 ± 0.48 cm, 3.4 ± 1.7 mm, 4.4 ± 2.9 mm and 2.8 ± 1.7°, respectively. The differences between actual needle insertion angle and needle depth and those designed in the preoperative were statistically significant (p 0.05). Some dosimetric parameters of preoperative plans such as V100, V200, CI and HI were not consistent with that of preoperative plans, and the difference was statistically significant (p 0.05). We conclude that for thoracic tumors, even under the guidance of 3DPT, there will be errors. The plan should be optimized in real time during the operation.

Background/Aims: To investigate the clinical situation, treatment methods, and clinical predictors of surgical intervention in children with magnetic foreign bodies in the digestive tract. Materials and Methods: From January 2019 to June 2022, we retrospectively analyzed the clinical data of 72 children who ingested magnetic foreign bodies inadvertently in our hospital, including their general information, admissions, clinical manifestations, and treatment methods, as well as pertinent literature and statistical data. Following software processing, univariate and multivariate logistic regression analyses were conducted to determine the independent risk factors of this study, and the receiver operating characteristic curve (ROC) was used to evaluate their predictive performance. Results: Among the 72 children who accidentally ingested magnetic foreign bodies, 59 (86.8%) ingested foreign bodies, with an average of 3.42 days and 11.03 foreign bodies. The predominant symptoms were nausea and vomiting. 19 cases (31.2%), 33 cases (54.1%) with abdominal pain; 9 cases (14.8%) with peritoneal irritation; 13 cases (21.3%) within 24 hours with foreign body movement. Treatment: conservative in 16 cases (22.2%), gastroscope in 19 cases (26.4%), and surgery in 37 cases (51.4%), with gastrointestinal perforation occurring in 26 cases (70.3%). ROC (AUC = 0.808) for predicting surgical treatment plans for children with magnetic foreign body ingestion. Conclusion: We found that nausea、vomiting and intermittent abdominal pain significantly increased the likelihood of surgical treatment in children undergoing surgery.

Microwave pulse compressors based on a single resonant cavity operating at polarized modes can be super compact, and corrugated structures can transmit high-power, high-frequency microwave with very low loss. We present an $X$ -band (11.424 GHz) pulse compressor using a corrugated cavity with quarter-wavelength depth corrugations working at polarized HE 1-1-14 modes. The cavity has a high-quality factor ( $Q_{0}$ ) of 116 000 with an inner diameter of less than 7 cm and a length of less than 20 cm, which is more compact compared with smooth spherical and cylindrical cavities for equivalent quality factors. The klystron power can be compressed to a peak power of 150 MW in order to feed two high-gradient accelerating structures designed for the Tsinghua Thomson-scattering X-ray Source (TTX). Theory, design, measurements, and the high-power demonstration of the corrugated pulse compressor are presented in detail. Limitations such as breakdowns and temperature rise of using the corrugated structure as a storage element are also further analyzed.

The recurrence rate of cervical cancer after primary treatment can reach 60%, and a poor prognosis is reported in most cases. Treatment options for the recurrence of cervical cancer mainly depend on the prior treatment regimen and the location of recurrent lesions. Re-irradiation is still considered as a clinical challenge, owing to a high incidence of toxicity, especially in in-field recurrence within a short period of time. Recent advances in radiotherapy have preliminarily revealed encouraging outcomes of re-irradiation. Several centers have concentrasted on stereotactic body radiation therapy (SBRT) for the treatment of well-selected cases. Meanwhile, as the image-guiding techniques become more precise, a better dose profile can also be achieved in brachytherapy, including high-dose-rate interstitial brachytherapy (HDR-ISBT) and permanent radioactive seed implantation (PRSI). These treatment modalities have shown promising efficacy with a tolerable toxicity, providing further treatment options for recurrent cervical cancer. However, it is highly unlikely to draw a definite conclusion from all of those studies due to the large heterogeneity among them and the lack of large-scale prospective studies. This study mainly reviews and summarizes the progress of re-irradiation for recurrent cervical cancer in recent years, in order to provide potential treatment regimens for the management of re-irradiation.

At the organelle level, pathogenesis due to abnormal concentrations of cysteine (Cys) is of great significance for the early diagnosis and treatment of related diseases. Generally speaking, organelle localization requires the participation of specific target groups, which increases the difficulty of synthesis. Herein, through simple synthesis, a novel biflavone derivative (BFD) that exhibits excited-state intramolecular proton transfer (ESIPT) was obtained and successfully located in mitochondria without target groups. The probe BFD can distinguish Cys from Hcy and GSH with a rapid response (< 5 s) and showed visual detection for Cys with a large Stokes shift (about 260 nm). Because of its nanomorphology in solution and surface functional groups, the probe BFD can enter the cell smoothly and achieve mitochondrial localization. Owing to its excellent optical performance, the probe BFD was successfully applied to the imaging of endogenous Cys in HeLa cells and zebrafish.

Purpose To investigate the accuracy of needle distribution and dosimetric parameter differences of 3D-printing non-coplanar template (3D-PNCT)-assisted computed tomography (CT)-guided iodine-125 seed ablative brachytherapy (125I-SAB) in gynecological cancer patients with non-central pelvic recurrence between pre-operative plan and post-operative plan. Material and methods Thirty-eight patients with forty-one non-central pelvic recurrent gynecological carcinomas after radiotherapy were enrolled in this study. All patients received 3D-PNCT-assisted CT-guided 125I-SAB from January 2016 to January 2019. The position, angle, and depth of seed needles were measured in both pre-operative plan and intra-operative real-time plan in brachytherapy treatment planning system (B-TPS). Dosimetric parameters of D90, D100, V100, V150, and V200 as well as quality parameters of conformal index (CI), external index (EI), and homogeneity index (HI) were compared between pre-operative plan and post-operative plan. Peri-operation complications and radiation-related toxicity were assessed. Results Median follow-up time was 12 months (range, 5-34 months). Prescribed dose was 100-170 Gy (median, 120 Gy). Radioactivity of 125I seed was 0.4-0.7 mCi (median, 0.55 mCi). Mean depth deviation for 499 needles was 0.8 ±1.0 cm. Mean angular deviation was 2.2 ±2.1 degrees. Mean tip distance deviation of needles was 0.4 ±0.3 cm. There were significant differences between pre-operative and post-operative plans in CI (p = 0.001) and EI (p = 0.005). No significant differences were shown in D90, D100, V100, V150, V200, and HI between pre-operative and post-operative plans. Only few patients suffered from ≤ grade 2 toxicities. Conclusions 3D-PNCT-assisted CT-guided 125I-SAB is safe and feasible for non-central pelvic recurrence of gynecological cancer. All complications are tolerable and mild.

Deep eutectic solvents (DESs) are a new class of green solvents with potential applications for the extraction of target compounds from both liquid and solid samples. However, current research in t...

In this paper, Co/Al2O3 composite nanofibers with different Co content are fabricated by electrospinning combined with selective reduction. By controlling the Co content in the composite nanofiber, not only the fiber’s morphology, but also the magnetic properties can be well adjusted to meet different applications’ requirements. The magnetic hysteresis loops of composite nanofiber show two different types of shape, typical ferromagnetism and wasp-waisted ferromagnetism. Interestingly, the saturation magnetization, which has a close relationship with the content of magnetic component, is not simply shows an increasing tendency with the increases of Co content in the composite fiber. For the Co content below 50 wt%, the Ms value increases with the Co content. After that, the saturation magnetization decreases to a valley value at near 60 wt% Co content, then increases again. The coercivity also shows the same tendency. The results indicate that the dipolar coupling interaction plays a key role in the magnetic property adjustment of Co/Al2O3 composite nanofiber.

In order to obtain a material with excellent microwave absorption performance, polyvinyl alcohol (PVA) sponge was employed as the template. The porous structure of the sponge can facilitate faster and more uniform diffusion of the ferric nitrate liquid during the dipping and obtain a uniform distribution of the ferromagnetic particles, which serves as a functional phase to enhance the microwave absorption properties. The Fe@Fe3O4-C nanocomposite can then be fabricated through a dipping/carbonization process. The special core–shell structure effectively improves the dielectric and magnetic loss and provides proper impedance matching. The results indicate that the prepared samples show excellent microwave absorption performance, with maximum effective absorption bandwidth up to 7.9 GHz at a thickness of 2.27 mm. The maximum reflection loss can reach −48.36 dB at 9.6 GHz. Therefore, it is feasible to use PVA sponge as a template to fabricate porous Fe@Fe3O4-C nanocomposite with excellent microwave absorption performance.

The TNF-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in cells by signaling through the O-glycosylated death receptors (DR4 and DR5), but the sensitivity to TRAIL-induced apoptosis of cells varies, and the attributes of this phenomenon are complex. Human carcinoma cells often express truncated O-glycans, Tn (GalNAcα1-Ser/Thr), and Sialyl-Tn (Siaα2-6GalNAcα1-Ser/Thr, STn) on their surface glycoproteins, yet molecular mechanisms in terms of advantages for tumor cells to have these truncated O-glycans remain elusive. Normal extended O-glycan biosynthesis is regulated by a specific molecular chaperone Cosmc through assisting of the correct folding of Core 1 β3 Galactosyltransferase (T-synthase). Here, we use tumor cell lines harboring mutations in Cosmc, and therefore expressing Tn and STn antigens to study the role of O-glycans in TRAIL-induced apoptosis. Expression of Tn and STn in tumor cells attenuates their sensitivity to TRAIL treatment; when transfected with wild-type Cosmc, these tumor cells thus express normal extended O-glycans and become more sensitive to TRAIL treatment. Mechanistically, Tn/STn antigens impair homo-oligomerization and stability of DR4 and DR5. These results represent the first mechanistic insight into how O-glycan structures on cell surface modulate their sensitivity to apoptotic stimuli, suggesting expression of Tn/STn may offer tumor cell survival advantages through altering DR4 and/or DR5 activity.

Objectives To evaluate the dosimetry, efficacy, and safety of radioactive 125I seed implantation (RISI) assisted by three-dimensional printing noncoplanar template (3D-PNCT) and CT for recurrent retroperitoneal lymphatic metastasis (RRLM) after previous external beam radiotherapy. Methods and Materials From June 2016 to August 2018, 32 patients with RRLM successfully underwent 3D-PNCT–assisted and CT-guided RISI. The dosimetry, pain relief rate, performance improvement rate, overall response rate, disease control rate, local control time (LCT), overall survival (OS), and safety profiles were evaluated. Results Dosimetric results showed that the D90, D100, V100, V150, V200, and homogeneity index were consistent in preoperation and postoperation (p > 0.05), except for the external index and conformal index (p = 0.048, p = 0.034). After RISI, 81.3% of the patients achieved pain relief, and 71.9% achieved an improvement of performance. The overall response rate and disease control rate were 85.3% and 94.1%, respectively. The LCT rates reached 66.2% and 43.2% in 1 year and two years, respectively, with a median LCT of 15.8 months. The OS rates were 74.1% and 28.1% in 1 year and two year, respectively, with a median OS reaching 17.6 months. Univariate analysis showed that when D90 > 130 Gy or D100 > 63 Gy or tumor size ≤49.8 cm3, LCT was extended significantly, but not for OS. Except for two patients developing Grade 1 retroperitoneal hematomas, no other severe adverse events were observed. Conclusions 3D-PNCT and CT guidance provide excellent accuracy for RISI, which can be an effective and safe alternative for RRLM after external beam radiotherapy. Radiation dose and tumor size seem to significantly influence the local control.

It is greatly meaningful but remains very challenging to obtain high-performance microwave absorber with thin thickness, lightweight, wide bandwidth, and strong absorption. Here, sulfur-enriched nitrogen-doped carbon nanofibers (S-NCFs) with excellent microwave absorption performance have been constructed through electrospinning technology and heat treatment with sublimed sulfur. Experimental results and the theoretical calculation evidenced that nitrogenous carbon nanofibers doping with sulfur could not only generate a large number of electric dipoles but also favor the promotion of conductivity. Benefiting from the unique architecture and heteroatoms doping that contributed to the well-matched impedance and dielectric enhancement, the S-NCFs exhibited the minimum reflection loss (RL) of − 48.67 dB at 16.1 GHz with a matching thickness of 1.39 mm at a filler loading of as low as 15%. In addition, the samples can obtain the broadest effective absorption bandwidth (EAB, RL

In this paper, Ag/paper-based composites with low dielectric loss were obtained by introduce the concept of metamaterial into the fabrication process. In this kind of metacomposite, single-layer paper was used as basic block to build up a matrix with sandwich structure, in which Ag particles are embedded and silver particles are evenly distributed. The microstructure and phase composition were characterized by scanning electron microscope and X-ray diffractometer. The impedance spectrum of the composites in 20 Hz–1 MHz region was measured by using LCR Meter, which can be well fitted by equivalent circuit method. The results show that, compared to the composite in which Ag particles disorder distributed, the dielectric loss of the layer-by-layer structured metacomposite can be effectively reduced (tan θ ≤ 0.1), without negative effect on the dielectric constant. Moreover, the dielectric properties of metacomposites show obvious anisotropy in the horizontal and vertical directions, which might give a feasible way for flexible smart material in its design.

Background Sarcoma is a rare mesenchymal malignant tumor. Recently, pyroptosis has been reported to be a mode of programmed cell death. Nonetheless, levels of pyroptosis-associated genes in sarcoma and its relevance to prognostic outcomes are yet to be elucidated. Results We established 33 pyroptosis regulatory genes in sarcoma. Sarcoma cases were classified into two subtypes with regards to differentially expressed genes (DEGs). We constructed a polygenic profile using The Cancer Genome Atlas (TCGA) cohort to assess the prognostic significance of pyroptosis-associated genes for survival. We established a profile composed of 7 genes and classified the sarcoma patients into low- and high-risk groups throughleast absolute shrinkage and selection operator (LASSO) Cox regression. Survival rate of low-risk sarcoma patients was markedly higher, relative to high-risk group (P

ObjectiveTo evaluate the dosimetric characteristics and the clinical application of radioactive iodine-125 brachytherapy stent (RIBS) in malignant esophageal obstruction.MethodsThe dose distribution of RIBS with different seed spacing, diameter and length was studied by treatment planning system (TPS) calculation, thermoluminescence dosimeter (TLD) measurement and Monte Carlo (MC) data fitting. And the data of esophageal cancer patients who were treat with this type of RIBS was analyzed retrospectively.ResultsDoses around the RIBS calculated by the TPS lay between those measured by the TLDs and those simulated by the MC, and the differences between the three methods were significant (pConclusionTPS calculations are suitable for clinical applications. RIBS can effectively alleviate obstructive symptoms for patients with malignant esophageal obstruction, but the incidence of fatal complications was high, care should be taken when choosing this treatment.

Viscosity and hypochlorite (OCl

Shortening the pulse length of input power is a possible approach to raise the accelerating gradient limit of normal conducting structures. We present a novel design of a parallel-coupled structure that operates at ultrashort input power pulses. The principle of the design is to shorten the filling time of the whole structure by feeding the cells individually so that the duration of power transmission between cells can be saved. An X-band (11.994 GHz) parallel-coupled structure design with a 10 ns pulse length is presented in this work. Previous high-power tests of X-band structure prototypes show that a gradient of $120\text{ }\text{ }\mathrm{MV}/\mathrm{m}$ could be achieved for a 200 ns pulse length. Based on the law requiring that ${E}^{30}{t}^{5}=\text{constant}$, this 10-ns-structure design should be able to reach a gradient of $200\text{ }\text{ }\mathrm{MV}/\mathrm{m}$. A detailed circuit model and real-time electromagnetic field simulation methods for designing the parallel-coupling structure are also presented and discussed in this paper.

Population genetic assessment is crucial for the conservation and management of threatened species. Xanthocyparis vietnamensis is an endangered species that is currently restricted to karst mountains in southwestern China and Vietnam. This rare conifer was first recorded in 2002 from northern Vietnam and then in 2013 from Guangxi, China, yet nothing is known about its genetic diversity nor ploidy level variation, although previous cytological study suggest that Vietnamese populations are tetraploids. There have been about 45 individuals found to date in Guangxi, China. Here, we genotyped 33 X. vietnamensis individuals using 20 newly developed, polymorphic microsatellite loci, to assess the genetic variability of its extremely small populations. The genetic diversity of X. vietnamensis (HE = 0.511) was lower than that of two other heliophile species, Calocedrus macrolepis and Fokienia hodginsii, which have similar distribution ranges. This is consistent with the signature of a genetic bottleneck detected in X. vietnamensis. Although the population genetic differentiation coefficient across loci is moderate (FST = 0.125), STRUCTURE analysis revealed two distinct genetic clusters, namely the northern and southern population groups; DAPC analysis grouped the southern populations together in one cluster separate from the northern populations; AMOVA analysis detected a significant genetic differentiation between the two population groups (FRT = 0.089, p < 0.05), and BARRIER analysis detected a genetic barrier between them. Moreover, we detected differentiation in ploidy level between northern and southern populations, sampled individuals from the former and the later are all diploid and tetraploid cytotypes with mean genome sizes of 26.08 and 48.02 pg/2C, respectively. We deduced that heterogeneous geomorphology and historical events (e.g., human deforestation, Quaternary climate oscillations) may have contributed to population fragmentation and small population size in X. vietnamensis. Considering both genetic and ploidy level differentiation, we propose that two different management units (northern and southern) should be considered and a combination of in situ and ex situ conservation measures should be employed to preserve populations of this endangered species in southwestern China in the light of our findings.

Objectives The objective of this study was to evaluate the efficacy and safety of CT-guided radioactive 125I seed implantation as a salvage treatment for locally recurrent head and neck soft tissue sarcoma (HNSTS) after surgery and external beam radiotherapy. Methods and Materials From December 2006 to February 2018, 25 patients with locally recurrent HNSTS after surgery and external beam radiotherapy were enrolled. All the patients successfully underwent CT-guided 125I seed implantation. The primary end points included the objective response rate (ORR) and local progression-free survival (LPFS). The secondary end points were survival (OS) and safety profiles. Results After 125I seed implantation, the ORR was 76.0%. The 1-, 3-, and 5-year LPFS rates were 65.6%, 34.4%, and 22.9%, respectively, with the median LPFS of 16.0 months. The 1-, 3-, and 5-year OS rates were 70.8%, 46.6%, and 34.0%, respectively, with the median OS of 28.0 months. Furthermore, univariate analyses showed that the recurrent T stage and histological grade were prognostic factors of LPFS, whereas only the histological grade was a predictor of OS. The major adverse events were skin/mucosal toxicities, which were generally of lower grade (≤Grade 2) and were well tolerated. Conclusions Radioactive 125I seed implantation could be an effective and safe alternative treatment for locally recurrent HNSTS after failure of surgery and radiotherapy. Recurrent T stage and histological grade were the main factors influencing the efficacy.

To ascertain the safety and efficacy of radioactive iodine-125 seed implantation (RISI) for the treatment of thoracic tumors.Clinical patients with primary or metastatic tumors in the chest treated with RISI were analyzed. The RISI process included the following stages: preoperative planning, template design and 3D printing, CT-guided RISI assisted by a template, and postoperative dosimetric verification. The prescribed dose was ≥ 80 Gy. The main analytic measures were the local control (LC) rate and toxicity.From April 2015 to July 2018, a total of 92 patients, including 41 with lung cancer and 51 with lung metastases, were analyzed. The median lesion diameter was 5 cm. The median postoperative D90 was 142.6 Gy. The median follow-up was 10.7 months. The overall survival rates at 1 year and 3 years were 59.7% and 22.2%, respectively. The LC rates at 1 year and 3 years were 64.9% and 32.8%, respectively. The LC rates at 3 years for patients with D90 140 Gy and D90 140 Gy were 23.1% and 54.3%, respectively (P = 0.014). The LC rate of metastatic lung cancer was more favorable than that of primary lung cancer. The multivariate analyses showed that the dose and lesion type were independent factors for LC (P 0.05). No factors were related to OS. The incidence of pneumothorax and hemoptysis was 35.8% and 3.2%, respectively. Few cases of radiotherapy-related toxicity effects were observed.RISI may be safe and efficacious and is associated with few complications during the treatment of thoracic tumors. If patients need local treatment and surgery or radiotherapy is not available, RISI could be considered.

Paper-based electronics offer a simple and cost-effective means to fabricate flexible devices. Here, we report an efficient pen-on-paper approach to construct metasurfaces on paper with silver units. Further, paper-based metasurfaces are employed to shield the electromagnetic interference which create new opportunities in turning waste paper into a solution for eliminating electromagnetic pollution. Experimental measurements and simulations show that waste paper-based metasurface manufactured in this way exhibits remarkable electromagnetic shielding properties with small thickness (thickness reduced more than 90% compared with that of traditional shielding materials), which makes it an ideal candidate for specific frequency electromagnetic filters. In addition, it can be readily extended to other regions of the electromagnetic spectrum, widened the shielding band by simply scaling the silver units' sizes and utilizing appropriate three-dimensional structures. Having taken performance into consideration, production is also taken into account. Paper-based shields offer both economic and energy benefits when considered on electronic printing, in addition, environment friendly nature and pliability of paper as well as simple fabrication procedure make paper-based metasurfaces promising candidates for the future ‘green’ electronics.

Carbon nanofibers embedded with magnetic Fe3C nanoparticles have been synthesized using electrospinning technique, followed by one-step carbonization. By using Fe3C/C nanofibers as filler with 10% content, the sample can achieve a minimum reflection loss (RL) of −54.94 dB with a thickness of 1.36 mm, as well as the broad effective absorption bandwidth (EAB) can reach to 4.5 GHz (13.3–17.8 GHz) at the thickness of 1.55 mm. The superior properties might be due to the synergistic effects of dielectric loss, magnetic loss, multiple scattering and reflection. This work presents a facile and promising method to produce high performance microwave absorption materials with thin thickness, light weight and strong absorption.

In this work, hierarchically porous carbons were synthesized by carbonizing chiffon cake at different carbonization temperature from 600 to 1200 °C. The synthesis method exhibits that bio-derived food waste is more nature-friendly as no external hazardous activators are used during the pyrolysis process, and it takes less cost. The corresponding microwave absorption properties were proved to be dependent on the carbonization temperature, as well as resulting crystal structures and graphitization degrees. With the carbonization temperature of 1000 °C, the obtained samples (C1000) showed excellent microwave absorption performance with a maximum reflection loss − 49.52 dB at 17.7 GHz. The broad effective absorption bandwidth reached 5.1 GHz (12.4–17.5 GHz) at the thickness of 1.52 mm. The optimal absorbing property can be attributed to the strong dielectric loss, good impedance matching and quarter-wavelength cancellation. This work provides a way to prepare low cost, green and sustainable microwave absorbent with efficient microwave absorption property.

Hypochloric acid (HOCl) plays vital roles in cell signaling and homeostasis which involved in many related diseases. Therefore, the accurate detected level of OCl− for discussing the complex contributions of OCl− to human health is of great significance. In this study, a novel mitochondrion-targeting fluorescent probe DMI bearing a carbon-carbon double bond as an OCl−-responsive site has been developed. Probe DMI exhibited specific fluorescence response toward OCl− with fast response (within 4 s) and high sensitivity (detection limit is 0.05 μM), where the obvious color changes could be observed by the naked eye. More importantly, DMI could be applied in the bioimaging of OCl− in living A549 cells successfully benefited from its good sensing properties and low toxicity. Fluorescence co-localization test was further carried out and confirmed mitochondria-targetable ability of DMI which can be used for investigating physiological function of HOCl at organelle levels.

Negative permittivity has taken off as a research topic in percolative composites recent years. Comparing with the common conductive constituent element in the preparation of metamaterials such as metal, one-dimensional conductive carbon nanotubes (CNTs) provide another choice of functional phase. In this paper, barium titanate (BaTiO3) with multi-walled carbon nanotubes (MWCNTs) uniformly dispersed in the ceramic matrix were prepared by traditional ceramic sintering technology. Field emission scanning electron microscopy, X-ray diffraction and Raman spectroscopy were used to characterize microstructures and phase composition of the metacomposites. With the increasing of CNTs content, the percolation phenomenon of electrical conductivity (9.95 wt%) was found and the conductive mechanism changed because of the formation of conductive MWCNTs networks. Moreover, the negative permittivity behavior was observed when the MWCNTs content reached 7 wt% and the plasma-like negative permittivity behavior could be well explained by the low frequency plasmonic state generated from conductive nanotube networks using the Drude model.

Many prototypes of all stainless steel high-power loads have been developed in Tsinghua University to meet the needs of high-power test systems for different microwave bands. The loads, which work at the S-band with a center frequency of 2856 MHz, are based on a waveguide structure with regular grooves. These loads are tested at 290 MW peak power successfully. This study presents the design, simulation, fabrication, high-power test results and analysis of multipactor phenomenon.

Numerous efforts have been made and reported to improve the energy efficiency of liquid desiccant air conditioning (LDAC) in recent studies. This study proposes a novel batch-wise operation strategy for LDAC that desiccant solutions in dehumidifier and regenerator are circulating independently and exchanging intermittently to get a full utilization of solution dehumidification capacity, cooling and heating energy. System models, including heat and mass transfer models of dehumidifier and regenerator, heat exchanger models and solution transfer model, are developed and verified to analyze and estimate the performance of proposed batch-wise strategy. The maximum relative errors between experimental and model predicting results are within 9.69% for outlet air temperature and within 7.97% for outlet air relative humidity. Performance and energy efficiency of proposed strategy are analyzed and compared with normal on-going solution exchange strategy. According to the simulation results, dehumidification rate and regeneration rate can be improved by average of 5.00% and 3.50% due to multiple solution usages in dehumidifier and regenerator. Moreover, the proposed batch-wise strategy demonstrates considerable energy savings with up to 16.81% and 18.60% from dehumidifier and regenerator, respectively.

Surface modification has been proven to be an effective approach for ion exchange membranes to achieve separation of counterions with different valences by altering interfacial construction of memb...

The preparation of quaternary ammonium polysulfone anion exchange membranes (AEMs) with good dimensional stability and alkaline stability is an urgent problem to solve. In response, a series of cross-linked based on polysulfone and 4, 4′-trimethylenedipiperidine (TMDP) as crosslinkers with different degrees AEMs were developed in this work through a simple process. Among the fabricated AEMs, CAPSF-5 exhibits superb alkaline stability in a 1 M KOH aqueous solution at 60 °C for 15 days, whereas the non-crosslinked APSF membrane became tremendously brittle within 24 h and could not be further studied under the same conditions. In addition, even at 60 °C, CAPSF-5 demonstrates a superior dimensional stability compared to the non-crosslinked APSF membrane due to the formation of a dense internal network structure. These observations demonstrate that crosslinked CAPSF membranes can be a viable strategy to improve the deficiency of the polysulfone backbone, especially in terms of alkaline stability.

Although cyanogen ion (CN-) plays important role in industry which also bring acute environmental pollution. More serious, trace CN- enters the human body can cause serious consequences and even death. Therefore, it is of great significance to detect trace CN- with high sensitivity. Herein, a novel aggregation-induced emission (AIE) probe C-BH was synthesized based on coumarin matrix. Probe C-BH showed high selectivity and sensitivity toward CN- by dual channel response due to the excited state intramolecular proton transfer (ESIPT). The low detection limit was calculated to be 0.05 µM. Moreover, probe C-BH was successfully used for imaging CN- in living cells and zebrafish due to its low toxicity and excellent optical properties.

Although cyanogen ion (CN

This paper reports on the design, fabrication, RF measurement, and high-power test of a prototype accelerator—such as 11.424 GHz with 12 cells—and a traveling wave of two halves. It was found that the unloaded gradient reached 103 MV/m during the high-power test and the measured breakdown rate, after $$3.17\times 10^7$$ pulses, was $$1.62\times 10^{-4}$$ /pulse/m at 94 MV/m and a 90 ns pulse length. We thus concluded that the high-gradient two-half linear accelerator is cost-effective, especially in high-frequency RF linear acceleration. Finally, we suggest that silver-based alloy brazing can further reduce costs.

A systematic literature review to validate the conclusions with regard to stranded seeds versus loose seeds. Published data for this review were identified by searching the PubMed databases. PD90, PV100, PV150, UD30, and RV100 acquired during the perioperative period and the postoperative period were analyzed by meta-analysis. Based on these studies, in addition to the reduction of migration and displacement, stranded seeds had some dosimetric advantages, especially in dose homogeneity and coverage of target area due to its connection characteristics. We also noticed implanted seeds usually excessive both in stranded seeds group and loose seed group. Intraoperatively built custom links will prolong operation time, with the proficiency of technology, the prolonged time gradually decreases.

Purpose To evaluate the accuracy of individualized 3D-printing template-assisted I125 radioactive seed implantation (3D-PT assisted I125 RSI) for recurrent/metastatic head and neck cancer. Materials and Methods From February 2017 to January 2020, clinical data of 41 patients (mean age, 58.5 ± 16.1 years; 28 males) with recurrent (48.8%)/metastatic (51.2%) head and neck cancer underwent individualized 3D-PT assisted I125 RSI under CT guidance in a single institute were retrospectively reviewed. Total 430 seed needles [mean, 10.5 (range 3–17) per patient] were inserted. Results All seed needles were inserted manually in a single attempt with the technical success rate of 100% without major perioperative complications. The mean needle’s entrance deviation was 0.090 cm (95% Confidence Interval, 0.081–0.098). The mean intraoperative depth and angle of the needle were consistent with that of planned (6.23 ± 0.24 vs. 6.21 ± 0.24 cm, p = 0.903; 83.14 ± 3.64 vs. 83.09 ± 3.66 degrees, p = 0.985, respectively). The mean deviation between the needle’s planned and intraoperative depth and angle was 0.168 ± 0.024 cm and 1.56 ± 0.14 degrees, respectively. The postoperative dosimetry parameters, including D90, D100, V100, V150, V200, conformity index, external index, and homogeneity index, were all well-coordinated with planned dosimetry without significant difference (p = 0.515, 0.662, 0.958, 0.865, 0.872, 0.278, 0.456, and 0.989, respectively). Conclusions Within the limitation of this study, individualized 3D-PT assisted I125 RSI may be accurate in obtaining favorable postoperative dosimetry for patients with recurrent/metastatic head and neck cancer. Clinical Trial Registration [website], identifier [registration number].