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1. Immunization status in chronic obstructive pulmonary disease: A multicenter study from Turkey

Author

Ozlu, Tevfik, Bulbul, Yilmaz, Aydin, Derya, Tatar, Dursun, Kuyucu, Tulin, Erboy, Fatma, Koseoglu, Handan Inonu, Anar, Ceyda, Sunnetcioglu, Aysel, Gulhan, Pinar Yildiz, Sahin, Unal, Ekici, Aydanur, Duru, Serap, Ulasli, Sevinc Sarinc, Kurtipek, Ercan, Gunay, Sibel, Okutan, O., Yildiz, B. P., Cetinkaya, P. D., Arslan, S., Cakmak, G., Cirak, A. K., Sarioglu, N., Kocak, N. D., Akturk, U. A., Demir, M., Kilic, T., Dalli, A., Hezer, H., Altintas, N., Acat, M., Dagli, C. E., Kargi, A., Yakar, F., Kirkil, G., Baccioglu, A., Gedik, C., Intepe, Y. S., Karadeniz, G., Onyilmaz, T., Saylan, B., Baslilar, S., Sariman, N., Ozkurt, S., Arinc, S., Kanbay, A., Yazar, E. E., Yildirim, Z., Kadioglu, E. E., Gul, S., Sengul, A., Berk, S., Dikis, O. S., Kurt, O. K., Arslan, Y., Erol, S., Korkmaz, C., Balaban, A., Erbay, Toru U., Sogukpinar, O., Uzaslan, E. K., Babaoglu, E., Bahadir, A., Baris, S. A., Ugurlu, A. O., Ilgazli, A. H., Fidan, F., Kararmaz, E., Guzel, A., Alzafer, S., Cortuk, M., Hocanli, I., Ortakoylu, M. G., Erginel, M. S., Yaman, N., Erbaycu, A. E., Demir, A., Duman, D., Tanriverdi, H., Yavuz, M. Y., Sertogullarindan, B., Ozyurt, S., Bulcun, E., Yuce, G. D., Sariaydin, M., Ayten, O., Bayraktaroglu, M., Tekgul, S., Erel, F., Senyigit, A., Kaya, S. B., Ayik, S., Yazici, O., Akgedik, A., Yasar, Z. A., Hayat, E., Kalpaklioglu, F., Sever, F., Sarac, P., Ugurlu, E., Kasapoglu, U. S., Gunluoglu, G., Demirci, N. Y., Bora, M., Talay, F., Ozkara, B., Yilmaz, M. U., Yavsan, D. M., Cetinoglu, E. D., Balcan, M. B., Ciftci, T., Havan, A., Gok, A., Nizam, M., Investigators, R.I.M.P.A.C.T. Study, Acibadem University Dspace, Maltepe Üniversitesi, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Talay, Fahrettin, OMÜ, Tıp Fakültesi, Kırıkkale Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, [Ozlu, Tevfik -- Bulbul, Yilmaz] Karadeniz Tech Univ, Sch Med, Dept Chest Dis, TR-61080 Trabzon, Turkey -- [Aydin, Derya] Pulm Dis Hosp, Chest Dis Clin, Balikesir, Turkey -- [Tatar, Dursun -- Anar, Ceyda] Dr Suat Seren Pulm Dis & Thorac Surg Educ & Res H, Dept Pulm Dis, Izmir, Turkey -- [Kuyucu, Tulin] Sureyyapasa Pulm Dis & Thorac Surg Educ & Res Hos, Dept Pulm Dis, Istanbul, Turkey -- [Erboy, Fatma] Bulent Ecevit Univ, Sch Med, Dept Chest Dis, Zonguldak, Turkey -- [Koseoglu, Handan Inonu] Gaziosmanpasa Univ, Sch Med, Dept Chest Dis, Tokat, Turkey -- [Sunnetcioglu, Aysel] Yuzuncu Yil Univ, Sch Med, Dept Chest Dis, Van, Turkey -- [Gulhan, Pinar Yildiz] Tosya State Hosp, Chest Dis Clin, Kastamonu, Turkey -- [Sahin, Unal] Recep Tayyip Erdogan Univ, Sch Med, Dept Chest Dis, Rize, Turkey -- [Ekici, Aydanur] Kirikkale Univ, Sch Med, Dept Chest Dis, Kirikkale, Turkey -- [Duru, Serap] Diskapi Yildirim Beyazid Educ & Res Hosp, Dept Pulm Dis, Ankara, Turkey -- [Ulasli, Sevinc Sarinc] Hacettepe Univ, Sch Med, Dept Chest Dis, Ankara, Turkey -- [Kurtipek, Ercan] Konya Educ & Res Hosp, Dept Pulm Dis, Konya, Turkey -- [Gunay, Sibel] Afyon State Hosp, Chest Dis Clin, Afyon, Turkey -- [Okutan, O. -- Ayten, O.] Haydarpasa Hosp, Gulhane Mil Med Acad, Dept Chest Dis, Istanbul, Turkey -- [Yildiz, B. P. -- Yazar, E. E. -- Gul, S. -- Bahadir, A. -- Ortakoylu, M. G. -- Bayraktaroglu, M. -- Gunluoglu, G. -- Nizam, M.] Pulm Dis & Thorac Surg Educ & Res Hosp Yedikule, Istanbul, Turkey -- [Cirak, A. K. -- Karadeniz, G. -- Erol, S. -- Erbaycu, A. E. -- Demir, A. -- Yavuz, M. Y. -- Tekgul, S. -- Sever, F. -- Yilmaz, M. U.] Dr Suat Seren, Izmir, Turkey -- [Kocak, N. D. -- Akturk, U. A. -- Arinc, S. -- Sogukpinar, O. -- Duman, D. -- Kasapoglu, U. S.] Sureyyapasa, Istanbul, Turkey -- [Cetinkaya, P. D.] Educ & Res Hosp Numune, Adana, Turkey -- [Dikis, O. S. -- Bora, M.] Sevket Yilmaz, Bursa, Turkey -- [Balaban, A.] Evliya Celebi, Kutahya, Turkey -- [Yuce, G. D.] Diskapi Yildirim Beyazid, Ankara, Turkey -- [Arslan, S. -- Berk, S.] Cumhuriyet Univ, Sch Med, Dept Chest Dis, Sivas, Turkey -- [Sarioglu, N. -- Erel, F.] Balikesir Univ, Balikesir, Turkey -- [Demir, M. -- Senyigit, A.] Dicle Univ, Diyarbakir, Turkey -- [Kilic, T. -- Kaya, S. B.] Inonu Univ, Malatya, Turkey -- [Dalli, A. -- Ayik, S.] Katip Celebi Univ, Izmir, Turkey -- [Altintas, N.] Namik Kemal Univ, Tekirdag, Turkey -- [Acat, M. -- Cortuk, M. -- Yazici, O.] Karabuk Univ, Karabuk, Turkey -- [Dagli, C. E. -- Akgedik, A.] Ordu Univ, Ordu, Turkey -- [Kargi, A. -- Kurt, O. K. -- Yasar, Z. A. -- Talay, F.] Abant Izzet Baysal Univ, Bolu, Turkey -- [Yakar, F. -- Hayat, E.] Bezmialem Vakif Univ, Istanbul, Turkey -- [Kirkil, G.] Firat Univ, Elazig, Turkey -- [Baccioglu, A. -- Bulcun, E. -- Kalpaklioglu, F.] Kirikkale Univ, Kirikkale, Turkey -- [Gedik, C. -- Kanbay, A.] Medeniyet Univ, Istanbul, Turkey -- [Intepe, Y. S.] Bozok Univ, Yozgat, Turkey -- [Sariman, N.] Maltepe Univ, Istanbul, Turkey -- [Ozkurt, S. -- Ugurlu, E.] Pamukkale Univ, Denizli, Turkey -- [Yildirim, Z. -- Demirci, N. Y.] Gazi Univ, Ankara, Turkey -- [Korkmaz, C. -- Yavsan, D. M.] Necmettin Erbakan Univ, Konya, Turkey -- [Erbay, Toru U.] Dumlupinar Univ, Kutahya, Turkey -- [Uzaslan, E. K. -- Cetinoglu, E. D.] Uludag Univ, Bursa, Turkey -- [Baris, S. A. -- Ilgazli, A. H. -- Ciftci, T.] Kocaeli Univ, Kocaeli, Turkey -- [Fidan, F. -- Havan, A.] Fatih Univ, Istanbul, Turkey -- [Guzel, A. -- Gok, A.] Ondokuz Mayis Univ, Samsun, Turkey -- [Alzafer, S.] Acibadem Univ, Bakirkoy Hosp, Istanbul, Turkey -- [Erginel, M. S.] Osmangazi Univ, Eskisehir, Turkey -- [Tanriverdi, H.] Bulent Ecevit Univ, Zonguldak, Turkey -- [Sertogullarindan, B.] Yuzuncu Yil Univ, Van, Turkey -- [Ozyurt, S.] Recep Tayyip Erdogan Univ, Rize, Turkey -- [Sariaydin, M.] Afyon Kocatepe Univ, Afyon, Turkey -- [Onyilmaz, T. -- Sarac, P.] State Hosp Mardin, Mardin, Turkey -- [Arslan, Y. -- Ozkara, B.] Etimesgut Mil Hosp, Ankara, Turkey -- [Ugurlu, A. O. -- Balcan, M. B.] Baskent Univ, Istanbul Hosp, Istanbul, Turkey -- [Yaman, N.] Pulm Dis Hosp, Balikesir, Turkey, intepe, yavuz selim -- 0000-0002-5697-5291, Sertogullarindan, Bunyamin -- 0000-0002-1478-1990, and Bulbul, Yilmaz -- 0000-0002-8488-3650

Subjects
Acute Exacerbations, Pulmonary and Respiratory Medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Coverage, pneumococcal vaccine, Exacerbation, disease exacerbation, influenza vaccine, Influenza vaccine, Copd Exacerbation, Self-Reported Influenza, Chronic Obstructive Pulmonary Disease Exacerbation, Latin-American Cities, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Prevalence, medicine, chronic obstructive pulmonary disease exacerbation, Adults, Mass index, 030212 general & internal medicine, Determinants, lcsh:RC705-779, COPD, business.industry, Chronic obstructive pulmonary disease, chronic obstructive pulmonary, Retrospective cohort study, lcsh:Diseases of the respiratory system, Frequency, medicine.disease, Vaccination, 030228 respiratory system, Pneumococcal vaccine, lcsh:RC666-701, Pneumococcal Vaccination, Original Article, Surgery, Cardiology and Cardiovascular Medicine, business
Abstract

WOS: 000455908800007, PubMed ID: 30745939, OBJECTIVE: The purpose of this study is to detect the prevalence and the factors associated with influenza and pneumococcal vaccination and outcomes of vaccination during 2013-2014 season in patients with chronic obstructive pulmonary disease (COPD) in Turkey. METHODS: This was a multicenter retrospective cohort study performed in 53 different centers in Turkey. RESULTS: During the study period, 4968 patients were included. COPD was staged as GOLD 1-2-3-4 in 9.0%, 42.8%, 35.0%, and 13.2% of the patients, respectively. Influenza vaccination rate in the previous year was 37.9%; and pneumococcus vaccination rate, at least once during in a life time, was 13.3%. Patients with older age, higher level of education, more severe COPD, and comorbidities, ex-smokers, and patients residing in urban areas had higher rates of influenza vaccination. Multivariate logistic regression analysis showed that advanced age, higher education levels, presence of comorbidities, higher COPD stages, and exacerbation rates were associated with both influenza and pneumococcal vaccination. The number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was 2.73 +/- 2.85 and 0.92 +/- 1.58 per year, respectively. Patients with older age, lower education levels, more severe COPD, comorbid diseases, and lower body mass index and patients who are male and are residing in rural areas and vaccinated for influenza had significantly higher rates of COPD exacerbation. CONCLUSIONS: The rates of influenza and pneumococcal vaccination in COPD patients were quite low, and the number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was high in Turkey. Advanced age, higher education levels, comorbidities, and higher COPD stages were associated with both influenza and pneumococcal vaccination.

Published
2019

2. Does gestational age affect ultrasonographic findings of the hip in preterm newborns? A sonographic study of the early neonatal period

Author

Yilmaz, M. U., Erel, F., Senyigit, A., Sever, F., Sarac, P., Ugurlu, E., Kasapoglu, U. S., Gunluoglu, G., Yavsan, D. M., Cetinoglu, E. D., Balcan, M. B., Ciftci, T., Havan, A., Gok, A., Nizam, M., Ozkara, B., ÖZLÜ, TEVFİK, Aydin, Derya, Tatar, Dursun, Kuyucu, Tulin, ERBOY, FATMA, İNÖNÜ KÖSEOĞLU, HANDAN, Anar, Ceyda, Sünnetçioğlu, Aysel, Gulhan, Pinar Yildiz, BÜLBÜL, YILMAZ, Okutan, O., Yildiz, B. P., Cetinkaya, P. D., Arslan, S., Cakmak, G., Cirak, A. K., Yakar, F., Kirkil, G., Baccioglu, A., Gedik, C., Sahin, Unal, EKİCİ, AYDANUR, Duru, Serap, Ulasli, Sevinc Sarinc, Kurtipek, Ercan, Gunay, Sibel, Dalli, A., Sarioglu, N., Kocak, N. D., Akturk, U. A., Demir, M., Kilic, T., Hezer, H., Altintas, N., Acat, M., Dagli, C. E., Kargi, A., Karadeniz, G., Intepe, Y. S., Onyilmaz, T., Saylan, B., Baslilar, S., Sariman, N., Ozkurt, S., Arinc, S., Kanbay, A., Yazar, E. E., Yildirim, Z., Kadioglu, E. E., Gul, S., Sengul, A., Berk, S., Dikis, O. S., Bahadir, A., Baris, S. A., Ugurlu, A. O., Ilgazli, A. H., Ortakoylu, M. G., Erginel, M. S., Yaman, N., Arslan, Y., Kurt, O. K., Erol, S., Korkmaz, C., Balaban, A., Erbay, Toru U., Sogukpinar, O., Uzaslan, E. K., Babaoglu, E., Fidan, F., Kararmaz, E., Guzel, A., Alzafer, S., Cortuk, M., Hocanli, I, Tanriverdi, H., Yavuz, M. Y., Sertogullarindan, B., Ozyurt, S., Erbaycu, A. E., Demir, A., Duman, D., Kaya, S. B., Ayik, S., Yazici, O., Akgedik, A., Yasar, Z. A., Hayat, E., Kalpaklioglu, F., Demirci, N. Y., Bora, M., Talay, F., Bulcun, E., Yuce, G. D., Sariaydin, M., Ayten, O., Bayraktaroglu, M., Tekgul, S., and BURSAL DURAMAZ, BURCU

Subjects
musculoskeletal diseases, Male, medicine.medical_specialty, Birth weight, Gestational Age, 03 medical and health sciences, 0302 clinical medicine, Neonatal Screening, Medicine, Humans, Orthopedics and Sports Medicine, Hip Dislocation, Congenital, Retrospective Studies, Ultrasonography, 030222 orthopedics, Developmental dysplasia, business.industry, Obstetrics, Infant, Newborn, Gestational age, Retrospective cohort study, Early neonatal period, Duramaz A., BURSAL DURAMAZ B., Bilgili M. G. , -Does gestational age affect ultrasonographic findings of the hip in preterm newborns? A sonographic study of the early neonatal period-, JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B, cilt.28, ss.107-110, 2019, Pediatrics, Perinatology and Child Health, Gestation, Female, business, 030217 neurology & neurosurgery, Infant, Premature
Abstract

There are only a few studies in the literature investigating the effects of gestational age on developmental dysplasia of the hip. The aim of this study was to investigate the effects of gestational age on hip ultrasound findings in the early neonatal period in preterm newborns born between 30th and 36th weeks of gestational age. Between January 2008 and December 2013, a total of 788 hips of 394 premature newborns with a gestational age of up to 36th weeks who underwent hip ultrasonography in the first week of their life were retrospectively examined. The distribution of roof angles and hip types in terms of sexes was compared between groups. Birth weight, birth height, a, and beta angles were analyzed in terms of the gestational age. The mean gestational age was 33.07 weeks (SD 2.09; between 30th and 36th). Six hundred and seven hips were classified as type I, 154 as type IIa, 21 as type IIc, and 6 as type III. In the 30th week, type IIc hips in females and type III hips in males were statistically significantly higher (P=0.001). In the 34th week, type IIc hips in males were statistically significantly higher than the females (P=0.013). In the 35th week, type IIa hips in females hips were statistically significantly higher than the males (P=0.008). Among all preterm infants, type IIc hips were more common in the 30th, 31st, 32nd, and 34th weeks, whereas type III hips were statistically significantly more common in the 30th week (P=0.0001). The 30th, 31st, 32nd, and 34th weeks of age are gestational ages that should be considered in terms of dysplastic and subluxed hips in premature newborns. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Published
2018

4. Allopurinol Hypersensitivity Syndrome as a Cause of Hepatic Centrilobular Hemorrhagic Necrosis

Author

Mete, N., Yilmaz, F., OKAN GULBAHAR, Aydin, A., Sin, A., Kokuludag, A., Yuce, G., and Sebik, F.

Subjects
Adult, Necrosis, Allopurinol, Liver Diseases, Hypertension, Humans, Female, Hemorrhage, Acute Kidney Injury, Chemical and Drug Induced Liver Injury, Antihypertensive Agents
Abstract

Extensive and severe hepatic centrilobular hemorrhagic necrosis is a common finding in hepatic vein obstruction and Budd-Chiari syndrome. Some drugs, including allopurinol, can also cause this histopathologic appearance but to our knowledge in this setting the lesions are not so massive. Here we report a case of a 41-year-old female who developed fever, pruritic skin rash, jaundice, eosinophilia, abnormal liver function tests, and acute renal failure 3 weeks after the beginning of allopurinol treatment, complicated with severe hepatocyte necrosis around most terminal hepatic venules suggesting Budd-Chiari syndrome.

5. Geochemistry Of Fluid Inclusions In Travertines From Western And Northern Turkey: Inferences On The Role Of Active Faults In Fluids Circulation

Author

Nur Ozyurt, Andrea Luca Rizzo, I. Tonguç Uysal, Jian-xin Zhao, Abidin Temel, Halim Mutlu, Antonio Caracausi, Francesco Italiano, Ezgi Ünal-İmer, Galip Yuce, Mariagrazia Misseri, Serdar Bayarı, Kadir Dirik, Kıymet Deniz, Rizzo, A, Uysal, T, Mutlu, H, Unal-Imer, E, Dirik, K, Yuce, G, Caracausi, A, Italiano, F, Misseri, M, Temel, A, Bayari, S, Ozyurt, N, Zhao, J, and Deniz, K

Subjects
Low salinity, active fault, fluid inclusion, 010504 meteorology & atmospheric sciences, Rare-earth element, Geochemistry, Active fault, 010502 geochemistry & geophysics, 01 natural sciences, Reşadiye, Mantle (geology), Young age, Geophysics, Pamukkale, Geochemistry and Petrology, Lithosphere, travertine, Fluid inclusions, 3He/4He, Geology, 0105 earth and related environmental sciences
Abstract

The understanding of the relationship between the geochemistry of fluids circulating during travertine deposition and the presence of active faults is crucial for evaluating the seismogenetic potential of an area. Here we investigate travertines from Pamukkale and Resadiye (Turkey), sited in seismic regions and next to thermal springs. These travertines formed similar to 24,500-50,000 (Pamukkale) and similar to 240-14,600 years (Resadiye) BP. We characterize fluid inclusions (FIs) and studied concentration of H2O, CO2, O-2 + N-2, and He-3, He-4, Ne-20, and Ar-40, and bulk composition (trace elements and delta C-13-delta O-18). FIs from both localities are mainly primary with low salinity and homogenization temperature around 136-140 degrees C. H2O is the major component followed by CO2, with the highest gas content measured in Pamukkale travertines. Concentrations of Ne-Ar together with O-2 + N-2 indicate that travertines from both areas precipitated from atmosphere-derived fluids. The He-3/He-4 is 0.5-1.3 Ra in Pamukkale and 0.9-4.4 Ra in Resadiye. Samples with R/Ra > 1 are modified by cosmogenic He-3 addition during exposure to cosmic rays. Excluding these data, FIs of Resadiye are mostly atmosphere-derived. This implies a shallow formation where the circulation was dominated by meteoric waters, which is consistent with their young age. Instead, FIs of Pamukkale show mixing of mantle-, crustal-, and atmosphere-derived He, indicating that these travertines formed in lithospheric fractures. Based on the delta C-13(CO2) and delta O-18 of bulk rocks, we infer that travertines formed involving crustal- (mechanochemical rather than organic) and mantle-derived CO2. Trace elements of Pamukkale and Resadiye show comparable rare earth element patterns. We conclude that travertines formed in response of seismogenetic activity.

Published
2019

6. Noble Gases And Rock Geochemistry Of Alkaline Intraplate Volcanics From The Amik And Ceyhan-Osmaniye Areas, Se Turkey

Author

Giuseppe Sabatino, M. Di Bella, Mauro Martelli, Alessandro Tripodo, Galip Yuce, M. Misseri, Francesco Italiano, Andrea Luca Rizzo, Bora Rojay, Italiano, F, Yuce, G, Di Bella, M, Rojay, B, Sabatino, G, Tripodo, A, Martelli, M, Rizzo, A, and Misseri, M

Subjects
Transtensional Amik Basin, 010504 meteorology & atmospheric sciences, Turkey, Geochemistry, engineering.material, 010502 geochemistry & geophysics, 01 natural sciences, Mantle (geology), Noble gase, Toprakkale volcanic province, Geochemistry and Petrology, Asthenosphere, Lithosphere, 0105 earth and related environmental sciences, Basalt, geography, geography.geographical_feature_category, Olivine, Partial melting, Geology, Fluid inclusion, Volcanic rock, 13. Climate action, engineering, Trace element, Fluid inclusions, Noble gases, Trace elements, Mafic
Abstract

The SE part of Turkey is characterized by a transtensional regime within the complex collision zone between the Anatolian, Arabian and African plates, which is bounded by two main faults, Dead Sea Fault and its splays on east and the Karasu Fault on west. In this tectonic and geodynamic context developed the Amik and further North, Erzin and Toprakkale districts, which are located onshore the Iskenderun Gulf, with the occurrence of a widespread and young alkaline volcanism dated from 1.57 to 0.05 Ma in Amik, and 2.25 to 0.61 Ma in Toprakkale. Here we present the results of a petrochemical and noble gases (He Ar) study performed in basalts and basanites from the Basins in order to constrain the features of the mantle source. The major and trace elements composition indicate that the involved mafic melts could be the result of 0.8–2% partial melting of a predominantly spinel and garnet + spinel mantle, which has typical features of intra-plate OIB magmatism. The 4 He/ 40 Ar* ratios display two distinct ranges, roughly 1, for basalts and basanites respectively. The 3 He/ 4 He ratio of fluid inclusions in olivine crystals ranges from 7.29 to 8.03 Ra (being Ra the atmospheric 3 He/ 4 He ratio of 1.39 × 10 − 6 ), which implies a rather homogenous helium isotope signature of the mantle source. Such values are commonly recorded in MORB-like reservoirs (namely 8 ± 1 Ra), confirming that lavas erupted in SE Turkey did not suffer any important process of crustal contamination. Combining the main evidences from the geochemical data of both rocks and noble gases of fluids inclusions, we suggest that the melt generation of the alkaline magmas was triggered by a stretching lithosphere resulting from asthenosphere upwelling and decompression melting, analogous to geodynamic models of the coeval Syrian alkaline volcanic rocks and the older NW Anatolian rocks, rather than by subduction or plume-related processes. Finally, the combined results of noble gas-rock geochemistry point to a widespread mantle metasomatism as well as absence of crustal assimilation and negligible crustal contamination in contrast to former conclusions based only on the solid rock geochemistry.

Published
2017

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